Abstract Number: 2895 • 2013 ACR/ARHP Annual Meeting
Bacterial Amyloids Promote Type I Interferon Production and Accelerate Autoimmunity
Background/Purpose: Infection is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). This is largely due to the use of…Abstract Number: 1809 • 2013 ACR/ARHP Annual Meeting
Topline Results Of The Biomarkers Of Lupus Disease (BOLD) Study: Clinical and Mechanistic Perplexities Of Lupus Treatment Trials Can Be Mitigated By Eliminating Background Immune Suppressants
Background/Purpose: The BOLD study was designed to test the discriminatory capacity and safety of a trial design eliminating background immune suppressants (IS) in SLE patients…Abstract Number: 890 • 2013 ACR/ARHP Annual Meeting
Quantitative Cell Distance Mapping In Human Nephritis Reveals Organization Of In Situ Adaptive Immune Responses
Background/Purpose: Inflammatory infiltrates contain multiple cell types that could interact in myriad ways to amplify in situ immune responses. However, there currently are no methods…Abstract Number: 556 • 2013 ACR/ARHP Annual Meeting
Depletion Of The Gut Microbiota Prevents β2-Glycoprotein I Antibody Production and Mortality In a Model Of Antiphospholipid Syndrome
Background/Purpose: Infectious triggers have been implicated in transient antiphospholipid antibody production in both mice and humans. The cause of persistent anti-β2-glycoprotein I (β2GPI) antibody production…Abstract Number: 2890 • 2013 ACR/ARHP Annual Meeting
Novel Selective Inhibitors Of Nuclear Export (SINE) Decrease Type I Interferon Activation and Deplete Autoreactive Plasma Cells In The Kidney In Murine Lupus
Background/Purpose: There is great interest in developing new treatment approaches for SLE, but the biologic therapies under investigation over the past several years have yielded…Abstract Number: 1624 • 2013 ACR/ARHP Annual Meeting
Lupus Risk Alleles With High Ethnic Variability Worldwide Are Associated With Renal Disease In Hispanic Patients
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects minority patients. Non-European ancestry is associated with more severe disease, and conversely, European ancestry is associated with a…Abstract Number: 905 • 2013 ACR/ARHP Annual Meeting
Lupus and Reproductive Health Considerations: A Pilot Training For Reproductive Health Care Providers Serving Teens and Young Adults
Background/Purpose: Health disparities (our target communities continue to experience some of the highest rates of sexually transmitted disease and teen pregnancy in the country) related…Abstract Number: 561 • 2013 ACR/ARHP Annual Meeting
Acyl-CoA Synthetase 1 Expression Is Increased In Murine Models Of Lupus As Well As In Human Systemic Lupus Erythematosus
Background/Purpose: The enzyme acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into their biologically active acyl-CoA derivatives. It is induced by lipopolysaccharide and cytokines (including…Abstract Number: 2897 • 2013 ACR/ARHP Annual Meeting
The Risk Of Deep Vein Thrombosis and Pulmonary Embolism In Systemic Lupus Erythematosus: A Population-Based Cohort Study
Background/Purpose: Previous hospital-based studies have shown that patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease, but limited population-based data are…Abstract Number: 1605 • 2013 ACR/ARHP Annual Meeting
Post-Marketing Experience With Belimumab In U.S. Lupus Centers: Data From The Lupus Clinical Trials Consortium, Inc. (LCTC) National Patient Registry
Background/Purpose: Much of the published experience with belimumab in lupus patients has derived from clinical trials. We examined the non-sponsored experience with belimumab in routine…Abstract Number: 849 • 2013 ACR/ARHP Annual Meeting
Reasons For Failure To Obtain Influenza and Pneumococcal Vaccines Among Immunosuppressed Individuals With Systemic Lupus Erythematosus
Background/Purpose: Infection is the third-leading cause of death in individuals with systemic lupus erythematosus (SLE) in developed countries. Nearly half of those deaths are attributed…Abstract Number: 541 • 2013 ACR/ARHP Annual Meeting
An Essential Role For Caspase-1 In The Induction Of Murine Lupus and Its Associated Vascular Damage
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune syndrome associated with organ damage and an elevated risk of cardiovascular disease (CVD) resulting from activation…Abstract Number: 2860 • 2013 ACR/ARHP Annual Meeting
Mir-26a, Mir-30b and HER2: New Players On Lupus Nephritis Pathogenesis
Background/Purpose: microRNAS (miRNAs) are noncoding RNAs responsible for post-transcriptional gene silencing. These key regulatory molecules control the expression of multiple genes, so its dysregulation can…Abstract Number: 1620 • 2013 ACR/ARHP Annual Meeting
Characterization Of a Jamaican Lupus Cohort: Proinflammatory Biomarkers and Disease Activity
Background/Purpose: Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are related systemic autoimmune diseases associated with proinflammatory prothrombotic biomarkers/cytokine (PPM) and antiphospholipid antibodies (aPL). Reports…Abstract Number: 852 • 2013 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosous and Primary Sjogren’s Syndrome May Display Joint Erosions On MRI As Well As Healthy Control, But Cannot Be Considered As Erosive Disease Such As Rheumatoid Arthritis: : An MRI Observational Study Of 90 Subjects
Background/Purpose: Recent studies tend to demonstrate presence of MRI erosion in Systemic Lupus Erythematosous (SLE) and primary Sjogren’s syndrome (pSS). The objective of this study…