Abstracts tagged "Lupus"

Abstract Number: 1611 • 2019 ACR/ARP Annual Meeting
Systemic Lupus Erythematosus Registries: Are the Measures Captured in the Real World Similar to Those in Clinical Trials?
Jennifer Lofland¹, Eric Wan ², Pamela Berry ³ and Chetan Karyekar ⁴, ¹Janssen Scientific Affairs, LLC, Spring House, PA, ²Johns Hopkins Bloomberg School of Public Health, Spring House, PA, ³Janssen Scientific Affairs, LLC, Horsham, PA, ⁴Janssen Global Services, LLC, Horsham, PA
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that causes connective tissue inflammation and can result in multiple organ damage. Registries may be…
Abstract Number: 2530 • 2019 ACR/ARP Annual Meeting
Safety, Pharmacokinetics, and Pharmacodynamics of a Lyophilized Drug Product of KZR-616, a Selective Inhibitor of the Immunoproteasome
Ben Snyder ¹, Darrin Bomba ², Ken Harvey ², Janet Anderl ², Christopher Kirk ², Jinhai Wang ², R Andrea Fan ² and Niti Goel³, ¹Nucleus Network Pty Ltd, Melbourne, Australia, ²Kezar Life Sciences, SOUTH SAN FRANCISCO, CA, ³Kezar Life Sciences, Duke University School of Medicine, South San Francisco, CA
Background/Purpose: KZR-616, a first-in-class selective inhibitor of the immunoproteasome, is being evaluated for the treatment of multiple autoimmune diseases, including LN and PM/DM. At 30…
Abstract Number: 81 • 2019 ACR/ARP Annual Meeting
UV Light Stimulates a Systemic Neutrophil Response Associated with Transient Kidney Injury
Sladjana Skopelja-Gardner¹, Joyce Tai ², Xizhang Sun ², Lena Tanaka ², Payton Hermanson ² and Keith Elkon ², ¹University of Washington, Seattle, WA, ²University of Washington, Seattle
Background/Purpose: Sensitivity to ultraviolet B (UVB) light affects ~70% of SLE patients and exacerbates both skin disease and systemic flares, including lupus nephritis (LN). Our…
Abstract Number: 1022 • 2019 ACR/ARP Annual Meeting
Single Cell Transcriptome Analysis of Circulating Plasmacytoid Dendritic Cells and Switched Memory B-cells in SLE Patients Reveals Transcriptional Subsets Within the Classical Cell Lineages
Amrutesh Puranik¹, Yogita Ghodke-Puranik ², Regine Tipon ², Mark Jensen ¹, Auroni Gupta ³, Jacqueline Paredes ³, Uma Sankaramanchi ⁴, Ilona Nln ³, Amit Saxena ⁵, H. Michael Belmont ⁶, Peter Izmirly ⁷, Robert Clancy ⁷, Jill Buyon ⁵ and Timothy Niewold ², ¹Colton Center for Autoimmunity, NYU School of Medicine, New York, NY, ²Colton Center for Autoimmunity, NYU School of Medicine, New York, ³Colton Center for Autoimmunity, NYU School of Medicine, ny, ⁴Colton Center for Autoimmunity, NYU Langone Medical Center, NY, ⁵New York University School of Medicine, New York, NY, ⁶New York University School of Medicine, Ney York, ⁷New York University School of Medicine, New York
Background/Purpose: Both plasmacytoid dendritic cells (pDCs) and switched memory B cells (SMBCs) are considered to be key effector cells in systemic lupus erythematosus. It seems…
Abstract Number: 1613 • 2019 ACR/ARP Annual Meeting
LDL-cholesterol as a Risk Factor of Progression to ESRD in Patients with Lupus Nephritis
Ji-Hyoun Kang¹, Seong-Eun Choi ¹, Haimuzi Xu ¹, Dong-Jin Park ¹ and Shin-Seok Lee ², ¹Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea, ²Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: There are few data on the effect of dyslipidemia in patients with lupus nephritis (LN). Thus, we investigated the effect of low-density lipoprotein-cholesterol (LDL-C)…
Abstract Number: 2550 • 2019 ACR/ARP Annual Meeting
Impact of Pathogenic and Protective Environmental Exposures on Autoimmune Disease—The Microbiome Effects on Lupus (MEL) Study
Hayley Walter¹, Trevor Faith ², Alexander Alekseyenko ³, Ali Bakhtiari ³, Paula Ramos ² and Diane Kamen ⁴, ¹Division of Rheumatology/Medical University South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Medical University South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic and often severe multi-organ autoimmune disease characterized by the production of autoantibodies and heterogeneous clinical manifestations. African…
Abstract Number: 168 • 2019 ACR/ARP Annual Meeting
Development and Usability Testing of Take Charge: An Email Series to Increase Knowledge of Self-Management Skills in People with Lupus
Karin Tse ¹, Lauren Metelski ¹, Reid Dossinger ¹, Mike Donnelly ¹ and Latifa Boyce¹, ¹Lupus Foundation of America, Washington, DC
Background/Purpose: Email may be a promising approach to expose people with lupus, especially newly diagnosed patients, to educational information, tools, and resources on lupus self-management…
Abstract Number: 1026 • 2019 ACR/ARP Annual Meeting
Interferon Lambda Promotes Age-Associated B Cells
Jennifer Barnas¹, Nida Meednu ¹, Andrew McDavid ¹, Jennifer Albrecht ¹, Christopher Richardson ¹, R. John Looney ² and Jennifer Anolik ¹, ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester Medical Center, Rochester
Background/Purpose: Age-associated B cells (ABC), defined as CD11c+ T-bet+ or CD11c+CD21-, represent a subset of B lymphocytes that are increased in systemic lupus erythematosus (SLE)…
Abstract Number: 1617 • 2019 ACR/ARP Annual Meeting
Platelet Bound Complement Split Product (PC4d) May Be a Marker of Platelet Activation and Cardiovascular Events in Systemic Lupus Erythematosus
Yevgeniya Gartshteyn¹, Adam Mor ², Laura Geraldino ², Teja Kapoor ², Tommy Chen ², Thierry Dervieux ³ and Anca Askanase ⁴, ¹Columbia University School of Medicine, Glen Rock, NJ, ²Columbia University School of Medicine, New York, NY, ³Exagen, Vista, CA, ⁴Columbia University, New York
Background/Purpose: Cell-bound complement activation products (CB-CAPs), including platelet bound C4d (PC4d), are sensitive markers for diagnosis and evaluation of lupus activity. Presence of PC4d is…
Abstract Number: 2552 • 2019 ACR/ARP Annual Meeting
Design and Development of an Online Intervention for Lupus Self-Management Based on the Transtheoretical Model of Change
Sarah Gilman ¹, Deborah Levesque ², Carol Cummins ³, Daniel Wallace ⁴, Victoria Werth ⁵ and Patricia Davidson⁶, ¹Wayfinder Health Strategies, Washington, DC, ²Pro-Change Behavior Systems, Providence, RI, ³Pro-Change Behavior Systems, Inc.,, Providence, ⁴Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, ⁵Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, ⁶Lupus Foundation of America, Washington, DC
Background/Purpose: The Lupus Foundation of America is in Year 4 of a 6-year cooperative agreement with the Centers for Disease Control and Prevention to develop…
Abstract Number: 244 • 2019 ACR/ARP Annual Meeting
Real-World Evidence Associated with the Treatment of Systemic Lupus Erythematosus in the USA, UK, France, and Germany: A Structured Review
Jennifer Lofland¹, Pamela Berry ², Feng Pan ², Chetan Karyekar ³, Hannah Guiang ⁴, Rebecca McTavish ⁴ and Melissa Thompson ⁴, ¹Janssen Scientific Affairs, LLC, Spring House, PA, ²Janssen Scientific Affairs, LLC, Horsham, PA, ³Janssen Global Services, LLC, Horsham, PA, ⁴Cornerstone Research Group, Inc, Burlington, ON, Canada
Background/Purpose: SLE is an autoimmune multi-system disease characterized by flares and more rarely remissions. Emerging biologic therapies for SLE are expected to change the treatment…
Abstract Number: 1036 • 2019 ACR/ARP Annual Meeting
RNA Sequencing of PBMCs Reveals Estrogen-Mediated Upregulation of Micro-RNA Processing Machinery
Nicholas Young¹, Kyle Jablonski ², Ifeoma Okafor ³, Emily Schwarz ³, Peter Harb ³, Caitlin Henry ³, Lai-Chu Wu ³ and Wael Jarjour ⁴, ¹The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, OH, ²The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, ³Ohio State College of Medicine, Columbus, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Studies examining intracellular micro-RNA (miR) expression in PBMCs of patients with Systemic Lupus Erythematous (SLE) have identified distinct disease-associated changes in expression. We have…
Abstract Number: 1618 • 2019 ACR/ARP Annual Meeting
Factors Associated with Damage Accrual in SLE Patients with No Clinical or Serological Disease Activity
Diane Apostolopoulos¹, Rangi Kandane-Rathnayake ¹, Worawit Louthrenoo ², Shue Fen Luo ³, Yeong-Jian Wu ³, Aisha Lateef ⁴, Vera Golder ¹, Sargunan Sockalingam ⁵, Sandra Navarra ⁶, Leonid Zamora ⁷, Laniyati Hamijoyo ⁸, Yasuhiro Katsumata ⁹, Masayoshi Harigai ⁹, Madelynn Chan ¹⁰, Sean O'Neill ¹¹, Fiona Goldblatt ¹², Chak Sing Lau ¹³, Alberta Hoi ¹⁴, Mandana Nikpour ¹⁵ and Eric Morand ¹⁶, ¹Monash University, Melbourne, Australia, ²Chiang Mai University Hospital, Chiang Mai, Thailand, ³Chang Gung Memorial Hospital, Guishan, Taiwan (Republic of China), ⁴National University Hospital, Singapore, Singapore, ⁵University of Malaya, Kuala Lumpur, Malaysia, ⁶University of Santo Tomas Hospital, Manila, Philippines, ⁷Santo Tomas Hospital, Manila, Philippines, ⁸Padjadjaran University, Bandung, Indonesia, ⁹Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan, ¹⁰Tan Tock Seng Hospital, Singapore, Singapore, ¹¹University of NSW, Ingham Institute of Applied Medical Research, Sydney, Australia, ¹²Royal Adelaide Hospital, Adelaide, Australia, ¹³Hong Kong University, Hong Kong, Hong Kong, ¹⁴School of Clinical Sciences, Monash University, Meloburne, Victoria, Australia, ¹⁵St Vincent's Hospital, Melbourne; The University of Melbourne, Melbourne, Australia, ¹⁶Monash University, Melbourne, Victoria, Australia
Background/Purpose: Accrual of irreversible organ damage is a major risk factor for death in SLE. While unmodifiable factors, such as age at disease onset and…
Abstract Number: 2564 • 2019 ACR/ARP Annual Meeting
Adherence to Hydroxychloroquine Influences the Incidence of Organ Damage During Follow-up in Patients with Systemic Lupus Erythematosus
Ji-Hyoun Kang¹, Seong-Eun Choi ¹, Haimuzi Xu ¹, Dong-Jin Park ¹ and Shin-Seok Lee ², ¹Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea, ²Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Hydroxychloroquine (HCQ) is a cornerstone drug in patients with systemic lupus erythematosus (SLE), decreasing the risk of flares and comorbidities and improving survival. This…
Abstract Number: 273 • 2019 ACR/ARP Annual Meeting
Bone Health in Lupus: Findings from the Southern California Lupus Registry
Vaneet Sandhu, MBBS¹ and Sara Johnson ², ¹Loma Linda University, Loma Linda, CA, ²St George's University, Loma Linda, CA
Background/Purpose: The association of vitamin D deficiency with SLE is well established. While disease activity can itself cause pathologic bone remodeling and reduced vitamin D,…

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