Abstracts tagged "Lupus"

Abstract Number: 1064 • 2013 ACR/ARHP Annual Meeting
Trends In Hospitalizations Due To Organ Damage In Patients With Systemic Lupus Erythematosus In Canada, 2006-2010
Amyn Sayani¹, Neerav Monga², Marni Freeman² and Jorge Alfonso Ross Terres³, ¹Medical Affairs, GlaxoSmithKline, Mississauga, ON, Canada, ²Health Economics and Outcomes Research, Medical Division, GlaxoSmithKline, Inc., Mississauga, ON, Canada, ³Medical Affairs, GlaxoSmithKline, Inc., Mississauga, ON, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that can affect multiple organs in the body, including the heart, kidney and lung, leading to…
Abstract Number: 568 • 2013 ACR/ARHP Annual Meeting
Pneumococcal Polysaccharide Vaccination Regulates T and B Lymphocyte Cytokine Responses and Decreases Kidney Stat1 Levels In MRL/Lpr Mice In Vivo
Victor Gazivoda¹, Shikha Mehta², Luhan Wang³, Julia Ash⁴, Kirk E. Sperber³ and Ioannis Tassiulas³, ¹Medicine, New York Medical College, Valhalla, NY, ²New York Medical College, Valhalla, NY, ³Medicine-Rheumatology, New York Medical College, Valhalla, NY, ⁴Rheumatology, New York Medical College, Valhalla, NY
Background/Purpose: Zwitterionic polysaccharides can activate CD4+ T cells after processing and presentation by antigen-presenting cells. The 23-valent capsular polysaccharide pneumococcal vaccine, PneumoVax, protects against invasive…
Abstract Number: 2521 • 2013 ACR/ARHP Annual Meeting
Correlation Of Anti Single and Double Stranded DNA Antibodies and Disease Activity In Systemic Lupus Erythematosus
Cecilia Catoggio, Cecilia Reimundes and Carlos Edgardo Perandones, Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina
Background/Purpose: Anti DNA antibodies are considered a hallmark of systemic lupus erythematosus (SLE). Anti double stranded DNA antibody (dsDNA) is part of the SLE classification…
Abstract Number: 1069 • 2013 ACR/ARHP Annual Meeting
Racial Differences In Systemic Lupus Erythematosus Patients’ Treatment Preferences: A Two-Site Study
Ernest R. Vina¹, Tammy O. Utset², Michael J. Hannon³, Nicole Roberts⁴, Christopher M. Masi⁵ and C. Kent Kwoh⁶, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh and VA Pittsburgh Healthcare System, Pittsburgh, PA, ²Rheumatology, University of Chicago Medical Center, Chicago, IL, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Internal Medicine, NorthShore University Health System, Evanston, IL, ⁶School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Racial disparities in systemic lupus erythematosus (SLE) exist, with African-American (AA) patients experiencing higher lupus damage scores and disease activity than white (WH) patients. …
Abstract Number: 545 • 2013 ACR/ARHP Annual Meeting
Preferential Infiltration Of Double-Negative (DN) T Cells Into The Glomeruli Of NZM 2328 Lupus Mice
Ning Yu, Shunhua Guo, William Stohl and Chaim O. Jacob, Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: Lupus nephritis affects at least 50% of patients with SLE and is a major cause of morbidity. The pathologic picture of lupus nephritis is…
Abstract Number: 2529 • 2013 ACR/ARHP Annual Meeting
Improved Outcomes In High Risk Lupus Pregnancies: Usefulness Of a Protocol Based Multidisciplinary Approach In Kerala, India
Vinod Ravindran¹, S Bhadran², P Shyjus³, M Divakaran⁴ and V Reshma⁵, ¹Department of Rheumatology, MES Medical College, Kerala, INDIA, Perinthalmanna, India, ²Department of Obstetrics, National Hospital, Calicut, India, ³Department of Obstetrics, MES Medical College, Perinthalmanna, India, ⁴Department of Obstetrics, PVS Hospital, Calicut, India, ⁵Department of Obstetrics, Indira Gandhi Hospital, Thalassery, India
Background/Purpose: In patients with SLE who had previous adverse obstetric outcome(s) the risk of an adverse outcome in subsequent pregnancy rises. The primary objective of…
Abstract Number: 990 • 2013 ACR/ARHP Annual Meeting
Utilizing Facebook Chats To Convey Health Information To Lupus Patients At The Systemic Lupus Erythematosus – Antiphospholipid Syndrome Center Of Excellence At Hospital For Special Surgery
Nadine H. Spring¹, Elyse Bernstein², Su Jin Kim³, Monica C. Richey¹, Jessica Rowshandel⁴ and Jane E. Salmon¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Public Relations, Hospital for Special Surgery, New York, NY, ³Department of Social Work Programs, Hospital for Special Surgery, New York, NY, ⁴S.L.E. Lupus Foundation, New York, NY
Background/Purpose: The SLE-APS Center of Excellence at Hospital for Special Surgery (HSS) uses Facebook chats as a means to increase awareness, reach a wider audience,…
Abstract Number: 550 • 2013 ACR/ARHP Annual Meeting
Neutrophil Gelatinase Associated Lipocalin (NGAL/Lipocalin-2) Regulates the Onset Of Serum Autoantibodies In Pristane Induced Lupus
Rahul Pawar¹, Beatrice Goilav², Yumin Xia¹, Haoyang Zuang³, Leal Herlitz⁴, Westley H. Reeves⁵ and Chaim Putterman⁶, ¹Albert Einstein College of Medicine, Bronx, NY, ²Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ³University of Florida, Gainesville, FL, ⁴The Department of Pathology, Columbia University Medical Center, New York, NY, ⁵Medicine, University of Florida, Gainesville, FL, ⁶The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: NGAL (lipocalin-2), a member of the lipocalin superfamily, is expressed by a variety of cells including neutrophils, hepatocytes, alveolar epithelial cells and renal resident…
Abstract Number: 2511 • 2013 ACR/ARHP Annual Meeting
Multicenter Validation Of The Lupus Activity Scoring Tool (LAST) As Compared To The Selena Sledai (SS) Modification
Majed M. Khraishi¹, Rana Aslanov², Sanjay Dixit³, Krista Fudge⁴, Vandana Ahluwalia⁵ and Sarah Khraishi⁶, ¹Nexus Clinical Research, St John's, NF, Canada, ²Clinical Epidemiology Department, Faculty of Medicine, Memorial University of Newfoundland, St.John's, NF, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Medical Consultants of West Newfoundland, Western Memorial Hospital, Corner Brook, NF, Canada, ⁵Past President, Ontario Rheumatology Association, Brampton, ON, Canada, ⁶Nexus Clinical Research, Memorial University of Newfoundland, St.John's, NF, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic immune modulated disease with variable clinical manifestations. New advances in the management of SLE mandated closer monitoring…
Abstract Number: 988 • 2013 ACR/ARHP Annual Meeting
Lupus Education For Providers Serving The Asian American Community: Hospital For Special Surgery’s LANtern® (Lupus Asian Network) Initiative
My-Lan N. Tran¹, Roberta Horton², Michael D. Lockshin³ and Arthur Yee⁴, ¹Social Work Programs, Hospital for Special Surgery, New York City, NY, ²Department of Social Work Programs, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Lupus affects Asian Americans 2-3 times more than their white counterparts, with studies demonstrating health disparities in severity and outcomes. Our hospital’s national support…
Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting
Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…
Abstract Number: 2901 • 2013 ACR/ARHP Annual Meeting
Standardized Incidence Ratios For Cancer After Renal Transplant In Systemic Lupus Erythematosus and Non-Systemic Lupus Erythematosus Recipients
Rosalind Ramsey-Goldman¹, Amarpali Brar², Moro Salifu², Ann E. Clarke³, Rahul M. Jindal⁴ and Sasha Bernatsky³, ¹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, SUNY Downstate, Brooklyn, NY, ³McGill University, Montreal, QC, Canada, ⁴Surgery, Uniformed Services University and George Washington University, Washington, DC
Background/Purpose: Differentiating between effects of drugs vs. disease activity on cancer risk in SLE is difficult. Because all renal transplant recipients are on similar immunomodulatory…
Abstract Number: 2193 • 2013 ACR/ARHP Annual Meeting
Altered Apoptosis Profile and Associated Soluble Factors In Patients With Juvenile-Onset Systemic Lupus Erythematosus
Bernadete Liphaus¹, Maria H. B. Kiss¹, Solange Carrasco² and Cláudia Goldenstein-Schainberg³, ¹Pediatria, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²University of São Paulo, São Paulo, Brazil, ³Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Apoptosis has been demonstrated to be involved in immune dysregulation and development of adult systemic lupus erythematosus (SLE) but less is known about its…
Abstract Number: 913 • 2013 ACR/ARHP Annual Meeting
High Throughput Epitope Mapping Of Autoantibodies In BXD2 Mice Reveals The Generation Of Autoantibodies Against Citrullinated Antigens At The Predicted Major Immunogenic Sites
Jennie Hamilton¹, Qi Wu², PingAr Yang², Hui-Chen Hsu³ and John D. Mountz⁴, ¹University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Increased polyreactive B cells have been identified in patients with systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). Such autoantibodies (autoAbs) were also identified…
Abstract Number: 553 • 2013 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Deficiency Protects Against Development Of Cognitive Impairment In Murine Lupus
Melissa A. Cunningham¹, Jena Wirth¹, Heather A. Boger², Ann-Charlotte Granholm-Bentley³ and Gary S. Gilkeson⁴, ¹Med/Rheumatology, MUSC, Charleston, SC, ²Neuroscience, Medical University of SC, Charleston, SC, ³Neuroscience, MUSC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Up to 80% of SLE patients have cognitive defects or affective disorders. The mechanism of CNS injury responsible for cognitive impairment is unknown. Anti-dsDNA…

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