Abstracts tagged "Lupus"

Abstract Number: 1629 • 2014 ACR/ARHP Annual Meeting
Added Value of the Determination of Anti-Ribosomal and Anti-Ku Antibodies for Diagnosis of Systemic Lupus Erythematosus
Johannes Schulte-Pelkum¹, Diana Carmona-Fernandes², Maria Jose Santos², Roger Albesa¹ and Michael Mahler¹, ¹Research, INOVA Diagnostics, San Diego, CA, ²Rheumatology Research Unit Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
Background/Purpose Anti-dsDNA antibodies (aab) are known as important serological marker to aid in the diagnosis of systemic lupus erythematosus (SLE) and are part of the…
Abstract Number: 698 • 2014 ACR/ARHP Annual Meeting
Grip Strength Identifies Increased Physical Disability in Women with Systemic Lupus Erythematosus
James S. Andrews¹, Mary Margaretten², Jennifer Barton², Jinoos Yazdany², Ed Yelin² and Patricia P. Katz³, ¹Rheumatology, University of California San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Medicine, University of California, San Francisco, CA
Background/Purpose: Muscle weakness is common and contributes to physical disability in women with systemic lupus erythematosus (SLE). Recently, the Foundation for the National Institutes of…
Abstract Number: 77 • 2014 ACR/ARHP Annual Meeting
Epigenome Profiling Reveals Robust Hypomethylation of Interferon Signature Genes in Lupus Neutrophils
Patrick Coit¹, Sri Yalavarthi¹, Wenpu Zhao², Mariana J. Kaplan² and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Lupus neutrophils play an important role in tissue damage (including glomerulonephritis and lupus skin involvement), as well as endothelial damage in lupus patients. Several…
Abstract Number: 2741 • 2014 ACR/ARHP Annual Meeting
The Role of Fli1 in Lupus T Cell Function and Nephritis
Thirumagal Thiyagarajan¹, Ivan Molano² and Tamara K. Nowling³, ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ³Medicine/Rheumatology, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: The Ets factor Fli1 is implicated as a key modulator of lupus disease expression. Over-expressing Fli1 in healthy mice, results in the development of…
Abstract Number: 1625 • 2014 ACR/ARHP Annual Meeting
Interferon Stimulates Transglutaminase Activity on Human Monocytes and Their Microparticles
Kimberly Carroll¹, Elizabeth Mitton-Fitzgerald¹, Brittany Bettendorf², Claudia Gohr¹, Mary E. Cronin¹ and Ann K. Rosenthal³, ¹Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ²Internal Medicine/Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, ³Div of Rheumatology, Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Microparticles (MPs) are circulating membrane-bound vesicles derived from blood and endothelial cells via a highly regulated process. They are immunomodulatory and have been implicated…
Abstract Number: 688 • 2014 ACR/ARHP Annual Meeting
Corticosteroids in Early Treatment Pathways in SLE
John G. Hanly¹, Amyn Sayani², Steve Doucette³, Sandra Iczkovitz² and Jorge Alfonso Ross², ¹Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, ²Medical Affairs, GlaxoSmithKline, Mississauga, ON, Canada, ³Dalhousie University and Capital Health, Halifax, NS, Canada
Background/Purpose: The treatment algorithm for patients with new onset systemic lupus erythematosus (SLE) is more variable than that for other rheumatic diseases (e.g. rheumatoid arthritis).…
Abstract Number: L23 • 2014 ACR/ARHP Annual Meeting
Humoral Immune Response to Pneumococcal Polysaccharide Vaccine in SLE Patients on Immunosuppressive Therapy: Assessment of Serotypes without Protective Antibody Levels
Rodrigo Poubel V. Rezende¹, Francinne M. Ribeiro¹, Luis Eduardo C. Andrade², Carlos Roberto M. Gayer³, Elisa M. N. Albuquerque¹ and Evandro Mendes Klumb¹, ¹Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²Fleury Laboratories, Sao Paulo, Brazil, ³Department of Biochemistry, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
Background/Purpose: Previous works assessing antibody response to pneumococcal polysaccharide vaccine (PPV) in systemic lupus erythematosus (SLE) relied exclusively on the quantitative increase in antibody titers…
Abstract Number: 2676 • 2014 ACR/ARHP Annual Meeting
The E3 Ligase Casitas B Lineage Lymphoma b (Cbl-b) Modulates Peripheral Regulatory T Cell Function Via p27^kip1in Patients with Systemic Lupus Erythematosus
Diana Gómez-Martín¹, Jorge Romo-Tena², Javier Merayo-Chalico³, Ana Barrera-Vargas¹ and Jorge Alcocer-Varela¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The interplay between effector and regulatory T cells (Tregs) is a key element among peripheral tolerance mechanisms in Systemic Lupus Erythematosus (SLE). Resistance to…
Abstract Number: 1605 • 2014 ACR/ARHP Annual Meeting
Elevated Regulatory Mediators and Interferon Gamma Associated Responses, but Not Interferon Alpha, BLyS or IP-10, Accompany High-Titer Anti-Ro Autoantibodies in Asymptomatic Mothers of Children with Neonatal Lupus
Peter M. Izmirly¹, Robert M. Clancy², Melissa Munroe³, Sara Rasmussen², Amit Saxena^2,4, Jose U. Scher², Aikaterini Thanou⁵, Stan Kamp⁶, Joan T. Merrill⁷, Jill P. Buyon² and Judith James⁸, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Rheumatology, New York University School of Medicine, New York, NY, ⁵Arthritis and Clinical Immunology Reseach Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Mothers of children with neonatal lupus offer a unique opportunity to study the drivers and consequences of autoantibody production in the absence of ongoing…
Abstract Number: 687 • 2014 ACR/ARHP Annual Meeting
Effect of Corticosteroid Use By Dose on the Risk of Developing Organ Damage over Time in Systemic Lupus Erythematosus—the Hopkins Lupus Cohort
Sarah Al Sawah¹, Xiang Zhang¹, Baojin Zhu¹, Laurence S. Magder², Shonda A Foster¹, Noriko Iikuni¹ and Michelle Petri³, ¹Eli Lilly and Company, Indianapolis, IN, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Reduction of corticosteroid dose remains an important goal in the management of systemic lupus erythematosus (SLE). Current standard of care in SLE relies heavily…
Abstract Number: 2671 • 2014 ACR/ARHP Annual Meeting
Impact of Glucocorticoid Dose on Maternal and Fetal Outcomes in Lupus Pregnancies
Dafhne Miranda¹, Miguel A. Saavedra², Eduardo Gomez³, Alberto Daniel Rocha Muñoz⁴, Jorge Gaspar Ramos⁵ and Luis Javier Jara⁶, ¹Rheumatology, Rheumatology Unit, Hospital de Especialidades. Centro Médico La Raza, IMSS, Distrito federal, Mexico, ²Rheumatology, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico, ³Institute for Research in Rheumatology and Musculoskeletal System, Guadalajara, Mexico, ⁴Institute for Research in Rheumatology and Musculoskeletal System, Guadalajara, Jalisco, Mexico, ⁵Rheumatology Unit, Hospital de Especialidades. Centro Médico La Raza, IMSS, Distrito federal, Mexico, ⁶Direction of Education and Research in health, Instituto Mexicano del Seguro Social, D.F., Mexico
Background/Purpose Lupus flares during pregnancy can be treated with short courses of low to moderate doses of glucocorticoids (GCs). GCs are associated with several maternal…
Abstract Number: 1311 • 2014 ACR/ARHP Annual Meeting
Lupus Nephritis in Mexican Children
María del Rocío Maldonado-Velázquez¹, Enrique Faugier¹, Fernando Garcia-Rodriguez², Paola Lara¹, Angel Flores¹, Javier Tomala-Haz¹ and Diego Salinas-Encinas¹, ¹Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico, ²Rheumatology, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
Background/PurposeIncidence and disease pattern of childhood-onset systemic lupus erythematosus (SLE) is reported to differ among ethnic groups. Lupus nephritis (LN) strongly affects the outcome in…
Abstract Number: 683 • 2014 ACR/ARHP Annual Meeting
Impact of Lupus on Work Productivity in Patients and Caregivers: Findings from a Cross-Sectional Online Survey in the United States
Sarah Al Sawah¹, R Paola Daly², Shonda Foster¹, April Naegeli¹, Katy Benjamin³, Helen Doll³, Greg Bond³, Olga Moshkovich³ and Graciela Alarcón⁴, ¹Eli Lilly and Company, Indianapolis, IN, ²Lupus Foundation of America, Inc., Washington, DC, ³ICON PRO, Bethesda, MD, ⁴University of Alabama Birmingham, Birmingham, AL
Background/Purpose Lupus imposes a substantial burden on patients’ work productivity1; however, little is known about its impact on the work productivity of those caring for…
Abstract Number: 2644 • 2014 ACR/ARHP Annual Meeting
Carotid Intima-Media Thickness and Plaque in Mexican Mestizos with Systemic Lupus Erythematosus: A Case-Control Study
Iris J. Colunga-Pedraza¹, Dionicio A. Galarza-Delgado¹, Alberto Cardenas-de La Garza¹, Ana L. Sanchez-Nuñez¹, Samantha L. Segarra-Linares¹, Rocío A. Carrillo-Palacios¹, David Vega-Morales¹, Fernando Góngora-Rivera² and Mario Alberto Garza-Elizondo¹, ¹Rheumatology, Hospital Universitario UANL, Monterrey, Mexico, ²Neurology., Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose Systemic lupus erythematosus (SLE) patients are at risk of premature cardiovascular disease (CVD). The specific reason of this situation is still debatable. Subclinical atherosclerosis…
Abstract Number: 1297 • 2014 ACR/ARHP Annual Meeting
Safety and Efficacy of Rituximab in Pediatric Lupus and Other Rheumatic Diseases
Ajay Tambralli¹, Timothy Beukelman², Randy Q. Cron² and Matthew L. Stoll², ¹Medicine, University of Rochester, Rochester, NY, ²Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rituximab (RTX) is a chimeric monoclonal antibody that specifically targets CD20 positive B cells and is used successfully for a variety of pediatric rheumatologic…

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