Abstracts tagged "Lupus"

Abstract Number: 208 • 2015 ACR/ARHP Annual Meeting
Neutrophil-Mediated Mechanisms of Drug-Induced Autoimmunity
Jorge Irizarry-Caro¹, Carmelo Carmona-Rivera¹, Elaine Novakovich¹, Venkataraman Subramaniam², Paul Thompson³, Mariana J. Kaplan⁴ and Peter C. Grayson⁵, ¹National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ³University of Massachusetts, Worcester, MA, ⁴Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Certain medications are known to induce autoimmune disease in humans, triggering clinical features and autoantibody profiles that mirror idiopathic systemic lupus erythematosus (SLE) and/or…
Abstract Number: 776 • 2015 ACR/ARHP Annual Meeting
Sensitivity of Antinuclear Antibody By Immunofluorescence Testing for Detection of Anti-Ro/SSA Antibodies
Ivan Alcantara-Arreola¹, Nina Tello-Winniczuk² and Alejandro Diaz-Borjon³, ¹Hospital Angeles Lomas, Huixquilucan, Mexico, ²Division of Internal Medicine / Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico, ³Med/Div of Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico
Background/Purpose: A positive ANA test is a diagnostic criterion for several rheumatic diseases, although it may appear in other autoimmune disorders and healthy individuals. An…
Abstract Number: 1199 • 2015 ACR/ARHP Annual Meeting
The Charla De Lupus (Lupus Chat)® Program: An Evaluation of a Lupus Support Program for Teens, Young Adults and Parents
Melissa T. Flores¹, Jillian A. Rose¹, Roberta Horton¹, Dariana M. Pichardo¹, Lillian Mendez¹ and Lisa F. Imundo², ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: Research shows that chronic illnesses such as lupus have a multi-level impact on the entire family; it can be challenging for both patients &…
Abstract Number: 1864 • 2015 ACR/ARHP Annual Meeting
H3K4me3 Peak Shape Dictates Transcription and Regulates Differential Expression in SLE
Kathleen E. Sullivan¹, Lihua Shi², Li Song³, Michelle Petri⁴ and Zhe Zhang⁵, ¹Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁵Bioinformatics, Children's Hospital of Philadelphia, Bioinformatics, Philadelphia, PA
Background/Purpose: H3K4me3 is a post-translational modification of histone H3 associated typically with gene activation. We had previously characterized changes in H3K4me3 associated with SLE in…
Abstract Number: 3023 • 2015 ACR/ARHP Annual Meeting
Decreased Intracellular Calcium Flux in Follicular Helper T Cells after T Cell Receptor Stimulation
Abhinav Seth¹, Edward I. Herman², Jason S. Weinstein¹, Jin Young Choi³ and Joseph E. Craft⁴, ¹Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ⁴Dept of Internal Med/Rheum, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells are a specialized subset of CD4+ helper T cells that are required for B cell maturation in germinal centers…
Abstract Number: 385 • 2015 ACR/ARHP Annual Meeting
Urinary Cell-Free Microrna’s As Biomarkers of Lupus Nephritis in Children
Khalid Abulaban¹, Ndate Fall², Jun Ying³, Kasha Wiley⁴, Ravi Nunna³, Prasad Devarajan⁵, Alexei A. Grom⁴, Michael Bennett⁶, Stacy P. Ardoin⁷ and Hermine I. Brunner⁸, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Dept of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁶Division of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁷Pediatric & Adult Rheumatology, Ohio State University, Columbus, OH, ⁸Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: MicroRNAs (miRNAs) are single-stranded RNAs involved in the regulation of host genome expression at the post-transcriptional level. The objective of this study was to…
Abstract Number: 777 • 2015 ACR/ARHP Annual Meeting
SLE-KeyTM Rule-out Test to Assess Lupus in Anti-Nuclear Antibody Positive Subjects Using the Immunarray iCHIP®
D. Scott Batty¹, I.R. Cohen², Chaim Putterman³, Nicole Jordan⁴, Keren Jakobi⁵, Rachel Sorek⁵, Yakov Blumenstein⁵, Pennina Safer⁵ and David Pisetsky⁶, ¹ImmunArray Inc., Richmond, VA, ²Weizmann Institute of Science, Rehovot, Israel, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel, ⁶Duke University Medical Center and Durham VAMC, Durham, NC
Background/Purpose: SLE is associated with a broad spectrum of autoantibodies, but currently there is no single serologic test to diagnose SLE definitively. Diagnosis is thus…
Abstract Number: 1236 • 2015 ACR/ARHP Annual Meeting
Google-Driven Search for Autoimmune Big Data Links Air Pollution and Younger Age at Diagnosis of Systemic Lupus Erythematosus: Geoepidemiological Analysis of 171,000 Adult Patients
Manuel Ramos-Casals¹, Pilar Brito-Zerón¹, Belchin Kostov², Soledad Retamozo¹, Antoni Sisó-Almirall², Xavier Bosh³, David Buss⁴, Courtney Grant⁵, Daphne Superville⁶, Antoni Trilla⁷, Yehuda Shoenfeld⁸, John H. Stone⁹ and Munther Khamashta¹⁰, ¹Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ²Primary Care Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Primary Care Centre Les Corts, CAPSBE, Barcelona, Spain, ³Department of Internal Medicine, ICMiD, Hospital Clínic, Barcelona, Spain, ⁴Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ⁵University of Glasgow, Glasgow, United Kingdom, ⁶Massachusetts Institute of Technology (MIT), Cambridge, MA, ⁷Preventive Medicine and Epidemiology Unit, Hospital Clínic-Universitat de Barcelona-Barcelona Centre for International Health Research, Barcelona, Spain, ⁸Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, ⁹Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹⁰Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Systemic autoimmune diseases (SAD) are characterized by a wide spectrum of demographic patterns with respect to the age at diagnosis, gender distribution and ethnic differences.…
Abstract Number: 1871 • 2015 ACR/ARHP Annual Meeting
Familial Aggregation of Rheumatoid Arthritis, Sjögren’s Syndrome, and Systemic Sclerosis Were Detected in Systemic Lupus Erythematous Families
Rufei Lu¹, Hua Chen¹, Krista Bean¹, Teresa Aberle¹, Joel Guthridge¹ and Judith James^1,2, ¹Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Medicine & Pathology, Univ. of Oklahoma, Okla, OK
Background/Purpose: Many systemic autoimmune diseases share heritable and non-heritable risks, as well as some clinical manifestations. A recent meta-analysis based upon genome-wide genetic studies contrasting…
Abstract Number: 3082 • 2015 ACR/ARHP Annual Meeting
Nanogel Based Delivery of an Inhibitor of Calcium/ Calmodulin- Dependent Protein Kinase 4 Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice
Kotaro Otomo¹, Tomohiro Koga², Nobuya Yoshida³, Masayuki Mizui⁴, Christina Kriegel⁵, Tarek Fahmy⁶ and George C. Tsokos³, ¹Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Department of Biomedical Engineering, Yale University, New Heaven, CT, ⁶Biomedical and Chemical Engineering, Yale University, New Heaven, CT
Background/Purpose: Treatment of autoimmune diseases is still based on the use of general immunosuppressive drugs which invariably cause severe side effects. This fact has compelled…
Abstract Number: 2623 • 2014 ACR/ARHP Annual Meeting
Treatment Patterns and Resource Utilization of Systemic Lupus Erythematosus Patients Newly Initiating Standard of Care: United States Commercial and Medicare Supplemental Claims Analysis
Shonda A Foster¹, Emily Durden², Brett Maiese², Sarah Al Sawah¹ and Kathleen Solotkin¹, ¹Eli Lilly and Company, Indianapolis, IN, ²Truven Health Analytics, Bethesda, MD
Background/Purpose: Currently, there is not a standard treatment algorithm for the management of Systemic Lupus Erythematosus (SLE); however, there are medications that may be considered…
Abstract Number: 870 • 2014 ACR/ARHP Annual Meeting
IRF1 Influences on Histone H4 Acetylation in Systemic Lupus Erythematosus
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song², Zhe Zhang³, Michelle Petri⁴ and Kathleen E. Sullivan², ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is the classical systemic autoimmune disease. Epigenetic processes, such as posttranslational histone modifications, can regulate gene expression without altering the…
Abstract Number: 663 • 2014 ACR/ARHP Annual Meeting
STAT3 Inhibition Delays the Onset of Lupus Nephritis in MRL/Lpr Mice
Linsday Edwards¹ and Vasileios C. Kyttaris², ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose The transcription factor Signal transducer and activator of transcription (STAT) 3 is overexpressed and aberrantly activated in patients with SLE as well as lupus-prone…
Abstract Number: 2172 • 2014 ACR/ARHP Annual Meeting
PTPN22 Promotes TLR-Induced Amelioration of Arthritis
David Ewart¹, Erik J. Peterson¹ and Yaya Wang², ¹University of Minnesota, Minneapolis, MN, ²Center for Immunology, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) synovial fluid exhibits high levels of type 1 interferons (IFN). Type 1 IFN may exert potent anti-inflammatory effects, since a TLR3…
Abstract Number: 864 • 2014 ACR/ARHP Annual Meeting
Association of Coronary Artery Calcification with Brown and White Pericardial Adipose Tissue in SLE
Kelly J. Shields, Medicine, Lupus Center of Excellence / Allegheny Health Network, Pittsburgh, PA
Background/Purpose Women with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD). We have shown that clinically CVD-free women with SLE have…

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