Abstracts tagged "Lupus"

Abstract Number: 2912 • 2015 ACR/ARHP Annual Meeting
Concomitant Kidney Disease in Patients with Lupus Nephritis
Paul Hoover¹, Jose A. Gomez Puerta², Alexander Fine¹, Helmut Rennke³ and Karen H. Costenbader⁴, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Grupo de Inmunología e Inmunogenética, GICIG, Universidad de Antioquia, Medellín, Colombia, Medellín, Colombia, ³Pathology, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Immunology & Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: The most common and clinically and histologically best-characterized SLE kidney disease is lupus nephritis (LN). However, other forms of kidney disease can and do…
Abstract Number: 752 • 2015 ACR/ARHP Annual Meeting
A Strong Association Between Gout and Diuretic Use Among Lupus Patients
Eric Wise¹, Emily Lewis², Puja Khanna^2,3, Lili Zhao⁴ and W Joseph McCune⁵, ¹Rhuematology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI, ³Division of Rheumatology/Dept. of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, ⁴Department of Statistic, University of Michigan, Ann Arbor, MI, ⁵Int Med/ Rheum, University of Michigan, Ann Arbor, MI
Background/Purpose: Although gout has historically been thought to be a rare in patients with SLE, recent case series suggest that the incidence of gout in…
Abstract Number: 1085 • 2015 ACR/ARHP Annual Meeting
Levamisole Triggers Neutrophil Extracellular Trap Formation through Muscarinic Receptors in Patients with Drug-Induced Vasculitis
Peter C. Grayson¹, Carmelo Carmona-Rivera², Meryl Waldman³, Karran Phillips⁴, Venkataraman Subramaniam⁵, Paul Thompson⁶, Jonathan D. Graf⁷ and Mariana J. Kaplan¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, ³NIDDK, National Institutes of Health, Bethesda, MD, ⁴NIDA, National Institutes of Health, Baltimore, MD, ⁵Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ⁶Biochemistry and Molecular Pharmacology, University of Masshachussetts, Worcester, MA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Levamisole, an anti-helminth drug, has been implicated in cases of drug-induced autoimmunity in humans exposed to adulterated cocaine. Clinical manifestations of levamisole-induced autoimmunity include…
Abstract Number: 1820 • 2015 ACR/ARHP Annual Meeting
Prevalence and Risk-Factors for Asymptomatic Coronary-Artery Calcifications in Young Patients with Systemic Lupus Erythematosus
Juanita Romero-Diaz¹, Rocio Moran-Contla², Eric Kimura-Hayama³, Sergio Criales-Vera³, Carlos Núñez-Álvarez², Roberto Ivan Acosta-Hernandez⁴, Mario César Ocampo-Torres⁵ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ²Instituto Nacional de Cs Medicas y Nutricion Salvador Zubiran, Mexico city, Mexico, ³Radiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico, ⁴Society for Worldwide Med Exchange, North Bay Village, FL, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁶Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: Premature atherosclerosis is a major cause of morbidity and mortality in females with systemic lupus erythematosus (SLE), but little is known about the frequency,…
Abstract Number: 2922 • 2015 ACR/ARHP Annual Meeting
HLA-Specific Antibody Profile in Renal Transplant Patients with Systemic LUPUS Erythematosus
Diana Girnita¹, Paul Brailey² and Alin Girnita³, ¹Division of Immunology, Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, ²Transplant Immunology Division, University of Cincinnati Medical Center -Hoxworth Blood Center, cincinnati, OH, Oman, ³Transplant Immunology Division, University of Cincinnati Academic Health Center, Hoxworth Blood Center, Cincinnati, OH
Background/Purpose: End stage renal disease due to Systemic lupus erytematosus (SLE) is one of the autoimmune disorder leading to renal transplantation. In this single-center study…
Abstract Number: 14 • 2015 ACR/ARHP Annual Meeting
The SLE Susceptibility Gene Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 (NOD-like receptor family pyrin domain containing 3) Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex
Min Sun Shin¹, Youna Kang¹, Elizabeth Wahl¹, Lin Leng¹, Richard Bucala¹ and Insoo Kang², ¹Yale University School of Medicine, New Haven, CT, ²Rheumatology Section, Yale University School of Medicine, New Haven, CT
Background/Purpose: The pathologic hallmarks of systemic lupus erythematosus (SLE or lupus) are altered immune responses to nuclear autoantigens with autoantibody production and subsequent tissue injury.…
Abstract Number: 762 • 2015 ACR/ARHP Annual Meeting
The Interferon Signature Correlates with Longitudinal Disease Severity in Systemic Lupus Erythematosus, but Adds Little to Conventional Prognostic Indicators
Arundip Asaduzzaman¹, Babak Noamani², Denisse Bonilla³, Dafna Gladman⁴, Murray Urowitz^5,6, Paul R. Fortin⁷, Carolina Landolt-Marticorena⁸ and Joan E. Wither⁹, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Genetics and developmental biology, University Health Network, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵University of Toronto, Toronto, ON, Canada, ⁶Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁷Université Laval, CHU de Québec, Québec, QC, Canada, ⁸1E420/Div of Rheumatology, University Health Network, Toronto, ON, Canada, ⁹Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose: Type I interferon (IFN) is thought to play an important part in the pathophysiology of systemic lupus erythematosus (SLE), and cross-sectional data suggests an…
Abstract Number: 1106 • 2015 ACR/ARHP Annual Meeting
Efficacy of Abbv-105, a Selective and Irreversible Inhibitor of Bruton’s Tyrosine Kinase (BTK), in Multiple Models of Inflammation
Christian Goess¹, Candace Graff², Ting Ting Zhang², Gregory Preston², Richard McCarthy¹, Matthew Perham¹, Jacqueline Loud¹, Christopher M. Harris¹, Sara Murdock¹, Erik Sampson³, Michael Hoemann⁴, Michael Friedman⁴, Robert Talanian³, Jeremy Edmunds⁴ and Andrew Long¹, ¹Immunology Pharmacology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²DMPK, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ³AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁴Chemistry, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: Bruton’s Tyrosine Kinase (BTK) is a non-receptor tyrosine kinase required for intracellular signaling pathways downstream of several key immunoreceptors, including the B cell receptor,…
Abstract Number: 1825 • 2015 ACR/ARHP Annual Meeting
Osteoprotegerin Is Associated with Lupus and with Coronary Artery Calcification
Indu Poornima¹, Kelly J. Shields², Susan Manzi³, Rosalind Ramsey-Goldman⁴, Carrie Richardson⁵, Lewis Kuller⁶, George Kondos⁷, James Carr⁵, Craig Langman⁵, Heather Price⁵, Daniel Edmundowicz⁸ and Rachel Mackey⁹, ¹Division of Cardiology, Allegheny Health Network, Pittsburgh, PA, ²Rheumatology, Allegheny Singer Research Institute, Pittsburgh, PA, ³Rheumatology, Allegheny Health Network, Pittsburgh, PA, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern University, Evanston, IL, ⁶Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁷University of Illinois in Chicago, Chicago, IL, ⁸Cardiology, Temple University School of Medicine, Philadelphia, PA, ⁹Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: In the general population, we and others have reported that higher osteoprotegerin (OPG), a protein involved in bone remodeling, is associated with higher levels…
Abstract Number: 2926 • 2015 ACR/ARHP Annual Meeting
Cytochrome P450 Polymorphisms on Blood Hydroxychloroquine Levels in Patients with Systemic Lupus Erythematosus
Ji Yeon Lee¹, Min Kyung Chung², Ji Hun Kim², Jung Hee Koh³, Seung Min Jung⁴, Jennifer Lee², Seung-Ki Kwok⁵, Ji Hyeon Ju⁶, Kyung-Su Park⁷ and Sung-Hwan Park², ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, school of medicine, The catholic university of Korea, Seoul, South Korea, ⁵[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁷Division of Rheumatology, Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Hydroxychloroquine (HCQ) is a safe and effective treatment for systemic lupus erythematosus (SLE), and its blood concentration is known to be closely related to…
Abstract Number: 2671 • 2014 ACR/ARHP Annual Meeting
Impact of Glucocorticoid Dose on Maternal and Fetal Outcomes in Lupus Pregnancies
Dafhne Miranda¹, Miguel A. Saavedra², Eduardo Gomez³, Alberto Daniel Rocha Muñoz⁴, Jorge Gaspar Ramos⁵ and Luis Javier Jara⁶, ¹Rheumatology, Rheumatology Unit, Hospital de Especialidades. Centro Médico La Raza, IMSS, Distrito federal, Mexico, ²Rheumatology, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico, ³Institute for Research in Rheumatology and Musculoskeletal System, Guadalajara, Mexico, ⁴Institute for Research in Rheumatology and Musculoskeletal System, Guadalajara, Jalisco, Mexico, ⁵Rheumatology Unit, Hospital de Especialidades. Centro Médico La Raza, IMSS, Distrito federal, Mexico, ⁶Direction of Education and Research in health, Instituto Mexicano del Seguro Social, D.F., Mexico
Background/Purpose Lupus flares during pregnancy can be treated with short courses of low to moderate doses of glucocorticoids (GCs). GCs are associated with several maternal…
Abstract Number: 1311 • 2014 ACR/ARHP Annual Meeting
Lupus Nephritis in Mexican Children
María del Rocío Maldonado-Velázquez¹, Enrique Faugier¹, Fernando Garcia-Rodriguez², Paola Lara¹, Angel Flores¹, Javier Tomala-Haz¹ and Diego Salinas-Encinas¹, ¹Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico, ²Rheumatology, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
Background/PurposeIncidence and disease pattern of childhood-onset systemic lupus erythematosus (SLE) is reported to differ among ethnic groups. Lupus nephritis (LN) strongly affects the outcome in…
Abstract Number: 683 • 2014 ACR/ARHP Annual Meeting
Impact of Lupus on Work Productivity in Patients and Caregivers: Findings from a Cross-Sectional Online Survey in the United States
Sarah Al Sawah¹, R Paola Daly², Shonda Foster¹, April Naegeli¹, Katy Benjamin³, Helen Doll³, Greg Bond³, Olga Moshkovich³ and Graciela Alarcón⁴, ¹Eli Lilly and Company, Indianapolis, IN, ²Lupus Foundation of America, Inc., Washington, DC, ³ICON PRO, Bethesda, MD, ⁴University of Alabama Birmingham, Birmingham, AL
Background/Purpose Lupus imposes a substantial burden on patients’ work productivity1; however, little is known about its impact on the work productivity of those caring for…
Abstract Number: 2644 • 2014 ACR/ARHP Annual Meeting
Carotid Intima-Media Thickness and Plaque in Mexican Mestizos with Systemic Lupus Erythematosus: A Case-Control Study
Iris J. Colunga-Pedraza¹, Dionicio A. Galarza-Delgado¹, Alberto Cardenas-de La Garza¹, Ana L. Sanchez-Nuñez¹, Samantha L. Segarra-Linares¹, Rocío A. Carrillo-Palacios¹, David Vega-Morales¹, Fernando Góngora-Rivera² and Mario Alberto Garza-Elizondo¹, ¹Rheumatology, Hospital Universitario UANL, Monterrey, Mexico, ²Neurology., Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose Systemic lupus erythematosus (SLE) patients are at risk of premature cardiovascular disease (CVD). The specific reason of this situation is still debatable. Subclinical atherosclerosis…
Abstract Number: 1297 • 2014 ACR/ARHP Annual Meeting
Safety and Efficacy of Rituximab in Pediatric Lupus and Other Rheumatic Diseases
Ajay Tambralli¹, Timothy Beukelman², Randy Q. Cron² and Matthew L. Stoll², ¹Medicine, University of Rochester, Rochester, NY, ²Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rituximab (RTX) is a chimeric monoclonal antibody that specifically targets CD20 positive B cells and is used successfully for a variety of pediatric rheumatologic…

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