Abstracts tagged "Lupus"

Abstract Number: 3161 • 2015 ACR/ARHP Annual Meeting
Rates of Hospitalization for Infection and Related Mortality By Race/Ethnicity and Sex Among Patients with End-Stage Renal Disease Due to Systemic Lupus Erythematosus
Candace H. Feldman¹, Francisco M. Marty², Wolfgang C. Winkelmayer³, Hongshu Guan⁴, Jessica M. Franklin⁵, Seoyoung C. Kim⁶, Daniel H. Solomon⁷ and Karen H. Costenbader^8,9, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Infectious Disease, Brigham and Women's Hospital, Boston, MA, ³Medicine-Nephrology, Baylor College of Medicine, Houston, TX, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ⁶Medicine, Division of Rheumatology, Division of Pharmacoepidemiology, Brigham & Women's Hospital, Boston, MA, ⁷Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, ⁸Rheumatology, Brigham & Women's Hospital, Boston, MA, ⁹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Infections are a significant cause of morbidity and mortality in SLE patients. Recent studies show that lupus nephritis patients have more than two-fold higher…
Abstract Number: 393 • 2015 ACR/ARHP Annual Meeting
From Childhood to Adulthood: Identifying Latent Classes of Disease Activity Trajectories in Childhood-Onset Systemic Lupus Erythematosus Patients
Lily Siok Hoon Lim¹, Eleanor Pullenayegum², Lillian Lim³, Dafna Gladman⁴, Brian Feldman⁵ and Earl Silverman⁶, ¹Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ²Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada, ³Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Background/Purpose: Although SLE patients are thought to follow different patterns of disease courses, no information is available about the longitudinal disease activity or the number…
Abstract Number: 799 • 2015 ACR/ARHP Annual Meeting
Transcriptional Profiling of Cutaneous Lupus Reveals Pronounced Changes in Keratinocyte and Myeloid Lineage Expressed Genes and Demonstrates Uniquely Regulated Interferon Pathways Between Rash Subtypes
Celine C. Berthier¹, Jasmine Stannard², Emily Myers³, William Swindell⁴, Lori Lowe⁴, Tamra J. Reed⁵, Johann Gudjonsson⁴ and J. Michelle Kahlenberg⁶, ¹Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ²Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Rheumatology, Georgetown University, Washington, DC, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus rashes can be substantial, disfiguring, and often refractory to usual lupus therapies. Phenotypic presentation and risk of systemic lupus manifestations differs by…
Abstract Number: 1752 • 2015 ACR/ARHP Annual Meeting
Characterization of Epitopes Identified with Cerebral Vasculature Injury
Melissa Butts¹, Jess Edison¹, Christopher Tracy¹, Brian Stout¹, Huazhen Chen² and Chantal Moratz², ¹Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ²Medicine, Uniformed Services University School of Health Sciences, Bethesda, MD
Background/Purpose: There is an association between natural antibodies, such as anti-phospholipid antibodies, and vasculature injury in stroke and in SLE models of systemic ischemic damage. …
Abstract Number: 2080 • 2015 ACR/ARHP Annual Meeting
Teaching Fellows in Lupus: Rheumatology Fellows Are Successful Educators in Improving Lupus Recognition By Frontline Healthcare Providers
Amy Caron¹, S. Sam Lim², Lexi Rene³, Diane Gross⁴, Maria Dall'Era⁵, Rosalind Ramsey-Goldman⁶ and Amanda Sammut⁷, ¹Lupus Research Institute, New York City, NY, ²Emory University School of Medicine, Atlanta, GA, ³Rollins School of Public Health, Emory University, Atlanta, GA, ⁴S.L.E. Lupus Foundation/Lupus Research Institute, New York, NY, ⁵University of California San Francisco School of Medicine, San Francisco, CA, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Columbia University Medical Center and Harlem Hospital Center, New York, NY
Background/Purpose: The heterogeneity and non-specific features of lupus may delay diagnosis. This delay can lead to accrual of organ damage and an increased risk of…
Abstract Number: 3222 • 2015 ACR/ARHP Annual Meeting
Repeated Administration of Dapirolizumab Pegol (DZP) Appears Safe and Well Tolerated in Patients with Systemic Lupus Erythematosus (SLE) and Is Accompanied By an Improvement in Disease Activity: Results from a Phase 1 Study
Chris Chamberlain¹, Murray Urowitz^2,3, Julie Soranson¹, Mark Watling¹, Peter Colman¹, Olivier Harari¹, Thomas Dorner⁴ and Falk Hiepe⁴, ¹UCB Pharma, Slough, United Kingdom, ²University of Toronto, Toronto, ON, Canada, ³Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Charité – Universitätsmedizin, Berlin, Germany
Background/Purpose: CD40 ligand (CD40L) regulates interactions between T cells, B cells, and antigen presenting cells. Considerable evidence suggests CD40L blockade might provide an effective treatment…
Abstract Number: 397 • 2015 ACR/ARHP Annual Meeting
Longitudinal Observation of Psychological Factors and Health-Related Quality of Life in Childhood-Onset Lupus
Catherine Donnelly¹, Jordan T. Jones², Ji Li³, Natoshia Cunningham⁴, Susmita Kashikar-Zuck⁵ and Hermine I. Brunner², ¹Internal Medicine, University of Cincinnati, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Pediatrics, Peking Union Medical College Hospital, Beijing, China, ⁴Behavioral Medicine & Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Childhood-onset Lupus (cSLE) is associated with decreased Health-related Quality of Life (HRQoL), and disease activity measures are often unrelated to overall perception of health. The…
Abstract Number: 804 • 2015 ACR/ARHP Annual Meeting
Prolactin Induces Interferon Regulatory Factor 1 Activation and Histone H4 Hyperacetylation in Primary Monocytes Comparable to Changes Seen in Monocytes from Systemic Lupus Erythematosus Patients
Yiu Tak Leung¹, Kathleen E. Sullivan², Kelly Maurer³, Li Song⁴ and Lihua Shi³, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: : Epigenetic changes have been described in systemic lupus erythematosus (SLE) and offer a potential explanation for the chronicity of disease. We previously found…
Abstract Number: 1755 • 2015 ACR/ARHP Annual Meeting
The Lymphotoxin/Megakaryoblastic Leukemia 1/Actin Axis As a Master Regulator of TLR Signaling in Lupus
John D. Mountz¹, Jun Li², Jennie Hamilton³, PingAr Yang⁴, Qi Wu⁵, Bao Luo⁶, Yanna Ding³, Hao Li⁶, David Crossman⁷, Erik Malarkey⁸, Yong Zhou², Yang-Xin Fu⁹ and Hui-Chen Hsu⁵, ¹Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL, ²Medicine, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁸Cell, Development, and Integrated Biology, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Pathology, The University of Chicago, Chicago, IL
Background/Purpose: Marginal zone macrophages (MZMs) of the spleen are essential for rapid and tolerogenic clearance of apoptotic cells (ACs). MZMs are decreased in two…
Abstract Number: 2081 • 2015 ACR/ARHP Annual Meeting
The SLE Workshop: An Evaluation of a Long-Standing Hospital-Based Psychoeducational Program
Melissa T. Flores¹, Roberta Horton¹, Jillian A. Rose¹, Stephen A. Paget² and Michael Lockshin³, ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Division of Rheumatology, Hospital for Special Surgery, New York, NY, ³Barbara Volcker Center for Women & Rheumatic Disease, Hospital for Special Surgery, New York, NY
Background/Purpose: An evaluation was conducted of a monthly hospital-based psychoeducational support group, ongoing since 1985, for people with lupus. Each 2-hour session begins with a…
Abstract Number: 1876 • 2014 ACR/ARHP Annual Meeting
Influence of Alcohol Consumption on the Risk of SLE Among Women in the Nurses’ Health Studies
Medha Barbhaiya, Bing Lu, Shun-Chiao Chang, Jeffrey A. Sparks, Elizabeth W. Karlson and Karen H. Costenbader, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Prior case-control studies have reported an inverse association between moderate alcohol consumption and the development of SLE. However, case-control studies may be prone to…
Abstract Number: 856 • 2014 ACR/ARHP Annual Meeting
A Pathogenic Role for the Gut Microbiota in Murine Antiphospholipid Syndrome and Lupus
Silvio M. Vieira¹, Andrew Yu¹, Michael Hiltesperger¹, Odelya E. Pagovich¹, Eleni Tiniakou¹, William Ruff², John Sterpka¹ and Martin Kriegel^2,3, ¹Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, New Haven, CT, ³Medicine, Section of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: The etiology of lupus-associated antiphospholipid syndrome (APS) is unknown but microbial triggers have been implicated in transient antiphospholipid antibody production in both mice and…
Abstract Number: 645 • 2014 ACR/ARHP Annual Meeting
The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes CD4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus
Laurence Morel¹, Yiming Yin², Seung-Chul Choi², Eric S. Sobel³ and Byron Croker², ¹Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL, ²University of Florida, Gainesville, FL, ³Medicine/Div of Rheumatology, University of Florida, Gainesville, FL
Background/Purpose: Autoreactive CD4 T cells are key effectors in Systemic Lupus Erythematosus (SLE). Cell metabolism is an important checkpoint for T cell activationand differentiation. Both…
Abstract Number: 1827 • 2014 ACR/ARHP Annual Meeting
Anti-Ro and Anti-La Antibodies in the General Pregnant Population
Evelyn V. Rozenblyum¹, Sharon Sukhdeo², Edgar Jaeggi³, Lisa Hornberger⁴, Philip Wyatt⁵, Carl A. Laskin⁶ and Earl D. Silverman⁷, ¹Pediatrics, University of Toronto, Toronto, ON, Canada, ²Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ³Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁴Pediatric Cardiology , Tel: 780-407-3355; Fax: 780-407-3954;, Stollery Children's Hospital, Edmonton, ON, Canada, ⁵Department of Genetics, North York General Hospital, Toronto, ON, Canada, ⁶University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose Neonatal lupus erythematosus (NLE) is a passively transferred autoimmune disease that occurs in babies born to pregnant women with anti-Ro and anti-La antibodies. The…
Abstract Number: 704 • 2014 ACR/ARHP Annual Meeting
Utility and Associated Risk of Pulmonary Embolism CT Scans in the Michigan Lupus Cohort
Ruba Kado¹, Emily Siegwald², Emily Lewis², Mitch Goodsitt³, Emmanuel Christodoulou³, Ella Kazerooni³ and W. Joseph McCune⁴, ¹Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI, ³Radiology, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine/Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Ionizing radiation from CT scanning can increase cancer risk. Lupus patients are frequently evaluated for chest pain and may have multiple pulmonary embolism CT…

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