Abstracts tagged "Lupus"

Abstract Number: 208 • 2015 ACR/ARHP Annual Meeting
Neutrophil-Mediated Mechanisms of Drug-Induced Autoimmunity
Jorge Irizarry-Caro¹, Carmelo Carmona-Rivera¹, Elaine Novakovich¹, Venkataraman Subramaniam², Paul Thompson³, Mariana J. Kaplan⁴ and Peter C. Grayson⁵, ¹National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ³University of Massachusetts, Worcester, MA, ⁴Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Certain medications are known to induce autoimmune disease in humans, triggering clinical features and autoantibody profiles that mirror idiopathic systemic lupus erythematosus (SLE) and/or…
Abstract Number: 776 • 2015 ACR/ARHP Annual Meeting
Sensitivity of Antinuclear Antibody By Immunofluorescence Testing for Detection of Anti-Ro/SSA Antibodies
Ivan Alcantara-Arreola¹, Nina Tello-Winniczuk² and Alejandro Diaz-Borjon³, ¹Hospital Angeles Lomas, Huixquilucan, Mexico, ²Division of Internal Medicine / Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico, ³Med/Div of Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico
Background/Purpose: A positive ANA test is a diagnostic criterion for several rheumatic diseases, although it may appear in other autoimmune disorders and healthy individuals. An…
Abstract Number: 1199 • 2015 ACR/ARHP Annual Meeting
The Charla De Lupus (Lupus Chat)® Program: An Evaluation of a Lupus Support Program for Teens, Young Adults and Parents
Melissa T. Flores¹, Jillian A. Rose¹, Roberta Horton¹, Dariana M. Pichardo¹, Lillian Mendez¹ and Lisa F. Imundo², ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: Research shows that chronic illnesses such as lupus have a multi-level impact on the entire family; it can be challenging for both patients &…
Abstract Number: 1864 • 2015 ACR/ARHP Annual Meeting
H3K4me3 Peak Shape Dictates Transcription and Regulates Differential Expression in SLE
Kathleen E. Sullivan¹, Lihua Shi², Li Song³, Michelle Petri⁴ and Zhe Zhang⁵, ¹Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁵Bioinformatics, Children's Hospital of Philadelphia, Bioinformatics, Philadelphia, PA
Background/Purpose: H3K4me3 is a post-translational modification of histone H3 associated typically with gene activation. We had previously characterized changes in H3K4me3 associated with SLE in…
Abstract Number: 3023 • 2015 ACR/ARHP Annual Meeting
Decreased Intracellular Calcium Flux in Follicular Helper T Cells after T Cell Receptor Stimulation
Abhinav Seth¹, Edward I. Herman², Jason S. Weinstein¹, Jin Young Choi³ and Joseph E. Craft⁴, ¹Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ⁴Dept of Internal Med/Rheum, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells are a specialized subset of CD4+ helper T cells that are required for B cell maturation in germinal centers…
Abstract Number: 385 • 2015 ACR/ARHP Annual Meeting
Urinary Cell-Free Microrna’s As Biomarkers of Lupus Nephritis in Children
Khalid Abulaban¹, Ndate Fall², Jun Ying³, Kasha Wiley⁴, Ravi Nunna³, Prasad Devarajan⁵, Alexei A. Grom⁴, Michael Bennett⁶, Stacy P. Ardoin⁷ and Hermine I. Brunner⁸, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Dept of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁶Division of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁷Pediatric & Adult Rheumatology, Ohio State University, Columbus, OH, ⁸Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: MicroRNAs (miRNAs) are single-stranded RNAs involved in the regulation of host genome expression at the post-transcriptional level. The objective of this study was to…
Abstract Number: 777 • 2015 ACR/ARHP Annual Meeting
SLE-KeyTM Rule-out Test to Assess Lupus in Anti-Nuclear Antibody Positive Subjects Using the Immunarray iCHIP®
D. Scott Batty¹, I.R. Cohen², Chaim Putterman³, Nicole Jordan⁴, Keren Jakobi⁵, Rachel Sorek⁵, Yakov Blumenstein⁵, Pennina Safer⁵ and David Pisetsky⁶, ¹ImmunArray Inc., Richmond, VA, ²Weizmann Institute of Science, Rehovot, Israel, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel, ⁶Duke University Medical Center and Durham VAMC, Durham, NC
Background/Purpose: SLE is associated with a broad spectrum of autoantibodies, but currently there is no single serologic test to diagnose SLE definitively. Diagnosis is thus…
Abstract Number: 1236 • 2015 ACR/ARHP Annual Meeting
Google-Driven Search for Autoimmune Big Data Links Air Pollution and Younger Age at Diagnosis of Systemic Lupus Erythematosus: Geoepidemiological Analysis of 171,000 Adult Patients
Manuel Ramos-Casals¹, Pilar Brito-Zerón¹, Belchin Kostov², Soledad Retamozo¹, Antoni Sisó-Almirall², Xavier Bosh³, David Buss⁴, Courtney Grant⁵, Daphne Superville⁶, Antoni Trilla⁷, Yehuda Shoenfeld⁸, John H. Stone⁹ and Munther Khamashta¹⁰, ¹Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ²Primary Care Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Primary Care Centre Les Corts, CAPSBE, Barcelona, Spain, ³Department of Internal Medicine, ICMiD, Hospital Clínic, Barcelona, Spain, ⁴Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, ⁵University of Glasgow, Glasgow, United Kingdom, ⁶Massachusetts Institute of Technology (MIT), Cambridge, MA, ⁷Preventive Medicine and Epidemiology Unit, Hospital Clínic-Universitat de Barcelona-Barcelona Centre for International Health Research, Barcelona, Spain, ⁸Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, ⁹Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹⁰Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Systemic autoimmune diseases (SAD) are characterized by a wide spectrum of demographic patterns with respect to the age at diagnosis, gender distribution and ethnic differences.…
Abstract Number: 1871 • 2015 ACR/ARHP Annual Meeting
Familial Aggregation of Rheumatoid Arthritis, Sjögren’s Syndrome, and Systemic Sclerosis Were Detected in Systemic Lupus Erythematous Families
Rufei Lu¹, Hua Chen¹, Krista Bean¹, Teresa Aberle¹, Joel Guthridge¹ and Judith James^1,2, ¹Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Medicine & Pathology, Univ. of Oklahoma, Okla, OK
Background/Purpose: Many systemic autoimmune diseases share heritable and non-heritable risks, as well as some clinical manifestations. A recent meta-analysis based upon genome-wide genetic studies contrasting…
Abstract Number: 3082 • 2015 ACR/ARHP Annual Meeting
Nanogel Based Delivery of an Inhibitor of Calcium/ Calmodulin- Dependent Protein Kinase 4 Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice
Kotaro Otomo¹, Tomohiro Koga², Nobuya Yoshida³, Masayuki Mizui⁴, Christina Kriegel⁵, Tarek Fahmy⁶ and George C. Tsokos³, ¹Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Department of Biomedical Engineering, Yale University, New Heaven, CT, ⁶Biomedical and Chemical Engineering, Yale University, New Heaven, CT
Background/Purpose: Treatment of autoimmune diseases is still based on the use of general immunosuppressive drugs which invariably cause severe side effects. This fact has compelled…
Abstract Number: 391 • 2015 ACR/ARHP Annual Meeting
Current Provider Practices and Perceived Barriers for Mental Health Care of Adolescents with SLE
Andrea Knight^1,2,3, Michelle Vickery², Eyal Muscal⁴, Alaina Davis⁵, Julia Harris⁶, Arzu Soybilgic⁷, Karen Onel⁸, Laura E. Schanberg⁹, Tamar Rubinstein¹⁰, Beth S. Gottlieb¹¹, Tracey Wright¹², Emily von Scheven¹³ and for the CARRA Investigators, ¹Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Pediatric Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁵Pediatric Rheumatology, Vanderbilt University School of Medicine, Monroe Carell Junior Children's Hospital, Nashville, TN, ⁶Pediatric Rheumatology, Children’s Mercy Kansas City, Kansas City, MO, ⁷Pediatric Rheumatology, University of Illinois College of Medicine, Chicago, IL, ⁸Pediatric Rheumatology, Univ of Chicago, Chicago, IL, ⁹Dept of Pediatrics, Duke University Medical Center, Durham, NC, ¹⁰Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ¹¹Pediatric Rheumatology, The Steven and Alexandra Cohen Children's Medical Center of New York, The Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, ¹²Pediatrics/Rheumatology, UT Southwestern Medical Center, Dallas, TX, ¹³Dept of Pediatric Rheumatology, Univ of California San Francisco, San Francisco, CA
Background/Purpose: Depression and anxiety are common in adolescents with SLE. Barriers to mental health intervention in pediatric rheumatology care are unclear. We aimed to determine…
Abstract Number: 779 • 2015 ACR/ARHP Annual Meeting
Mapping Perceptions of Medication Decision Making Facilitators: The Importance of Patient Context
Haiyan Qu¹, Jinoos Yazdany², W. Winn Chatham³, Ricahrd Shewchuk⁴ and Jasvinder A. Singh¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of California, San Francisco, San Francisco, CA, ³Medicine/Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴University fo Alabama at Birmingham, Birmingham, AL
Background/Purpose: Our objective was to derive a cognitive map of how stakeholders perceive patient-identified facilitators to establish a theoretical framework for the purpose of developing…
Abstract Number: 1245 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Lupus Nephritis Shows Enrichment in Genes Involved in Regulation of TH2 Differentiation and Renal Development
Renuka Nayak¹, Sharon A. Chung², Joanne Nitiham³ and Lindsey A. Criswell³, ¹Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ²Russell/Englemen Rheumatology Research Center, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Genetic and epigenetic factors contribute to the progression of systemic lupus erythematosus (SLE). We have the ability to identify these factors and their influence…
Abstract Number: 1934 • 2015 ACR/ARHP Annual Meeting
Autophagy Pathway As a Target of Therapeutic P140 Peptide Used in Lupus
Maud Wilhelm¹, Fengjuan Wang², Nicolas Schall², Michael Faludi³, Jean Francois Kleinmann⁴, Emil P. Nashi⁵, Thierry Martin⁶, Jean Sibilia⁷, Jean-Louis Pasquali⁸, Daniel Wallace⁹ and Sylviane Muller¹⁰, ¹Immunopathologie & Chimie Thérapeutique, CNRS, Strasbourg, France, ²CNRS, Strasbourg, France, ³761 Graham, McGill University, Mont-Royal, QC, Canada, ⁴Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁵Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁶Cnrs UPR9021, IBMC, Strasbourg, France, ⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁸Strasbourg University, Hospital, CNRS UPR 3572, Strasbourg, France, ⁹Cedars-Sinai/UCLA, Los Angeles, CA, ¹⁰CNRS Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
Background/Purpose: P140 is a 21-mer peptide (sequence 131-151, phosphorylated at position 140) that is derived from the spliceosomal protein U1-70K. In a multicenter, randomized, placebo-controlled…
Abstract Number: 3160 • 2015 ACR/ARHP Annual Meeting
Comparative Rates of Serious Infections and All-Cause Mortality Among Systemic Lupus Erythematosus Patients Receiving Mycophenolate Mofetil Versus Azathioprine
Candace H. Feldman¹, Francisco M. Marty², Wolfgang C. Winkelmayer³, Hongshu Guan⁴, Jessica M. Franklin⁵, Daniel H. Solomon¹, Seoyoung C. Kim⁶ and Karen H. Costenbader⁷, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Infectious Disease, Brigham and Women's Hospital, Boston, MA, ³Medicine-Nephrology, Baylor College of Medicine, Houston, TX, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ⁶Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at high risk of infections partly from use of immunosuppressives (IS). Clinical trials are powered to detect…

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