Abstracts tagged "Lupus"

Abstract Number: 1586 • 2017 ACR/ARHP Annual Meeting
Resistant Hypertension Is Associated with Inflammation, Renal Function, and Increased Mortality in Patients with Systemic Lupus Erythematosus
Jocelyn Gandelman¹, Megan Shuey², April Barnado³, Li Wang⁴, C. Michael Stein³ and Cecilia P. Chung³, ¹Vanderbilt University School of Medicine, Nashville, TN, ²Department of Pharmacology, Vanderbilt University, Nashville, TN, ³Medicine, Vanderbilt University Medical Center, Nashville, TN, ⁴Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Resistant hypertension (RHTN) is defined as blood pressure that remains >140/90 mm Hg despite concurrent use of three different antihypertensive drugs. RHTN has an…
Abstract Number: 1953 • 2017 ACR/ARHP Annual Meeting
Dietary Quality and Risk of SLE in the Nurses’ Health Studies
Medha Barbhaiya¹, Bing Lu¹, Sara K. Tedeschi², Susan Malspeis³, Jeffrey A. Sparks⁴, Walter C. Willett^5,6, Elizabeth Karlson⁷ and Karen H. Costenbader⁷, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy,, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Nutrition, Harvard School of Public Health, Boston, MA, ⁷Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Prior studies suggest that high intake of antioxidants, fish, olive oil, and nuts may decrease risk of chronic inflammatory diseases and reduce inflammatory biomarkers.…
Abstract Number: 2810 • 2017 ACR/ARHP Annual Meeting
The Impact of Psychiatric Comorbidity on Health Care Utilization for Youth with Systemic Lupus Erythematosus
Andrea M. Knight^1,2, Alaina M. Davis³, Marisa S. Klein-Gitelman⁴, Zuleyha Cidav⁵ and David Mandell⁶, ¹Division of Rheumatology, Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³Pediatric Rheumatology, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Pediatric Rheumatology, Nashville, TN, ⁴Division of Pediatric Rheumatology/PDD PTD, Lurie Children's Hospital of Chicago/Northwestern University, Chicago, IL, ⁵Perelman School of Medicine, Center for Mental Health Policy and Services Research, University of Pennsylvania, Philadelphia, PA, ⁶Psychiatry and Pediatrics, Center for Mental Health Policy and Services Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Youth with systemic lupus erythematosus (SLE) have high health care utilization, which may be exacerbated by psychiatric disorders, a common comorbidity in this group.…
Abstract Number: 832 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis Reveals Heterogeneity of Type I IFN Gene Expression in Developing Autoreactive B Cells
Jennie Hamilton¹, PingAr Yang², Qi Wu³, Bao Luo⁴, Shanrun Liu⁵, Jun Li⁶, Mark Walter⁷, Eleanor Fish⁸, Hui-Chen Hsu³ and John D. Mountz⁹, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁸University Health Network & Department of Immunology, University of Toronto, Toronto General Research Institute, Toronto, ON, Canada, ⁹University of Alabama at Birmingham, Department of Medicine, Birmingham, AL
Background/Purpose: B cell development involves passage through a formative transitional B cell stage in the spleen. In SLE, self-nucleic acid reactive B cells fail to…
Abstract Number: 1596 • 2017 ACR/ARHP Annual Meeting
Effect of the Metabolic Syndrome on Organ Damage, Renal Function and Mortality in Patients with Systemic Lupus Erythematosus: A Longitudinal Analysis
Chi Chiu Mok¹, Sau Mei Tse¹ and Ling Yin Ho², ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong
Background/Purpose: To study the effect of the metabolic syndrome (MetS) on organ damage, renal function and mortality in patients with SLE. Methods: Consecutive patients who…
Abstract Number: 2033 • 2017 ACR/ARHP Annual Meeting
Low Health Literacy Does Not Impact Adherence to Hydroxychloroquine in Patients with Systemic Lupus
Alexandra Perel-Winkler¹, Kayla Neville², Samantha Nguyen¹, Miya Okado¹, James Miceli¹, Jon T. Giles³ and Anca Askanase¹, ¹Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Columbia University College of Physicians & Surgeons, New York, NY, ³Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Low health literacy has been associated with poor health outcomes and increased hospital admissions. Adherence to medication has been shown to significantly impact mortality, morbidity,…
Abstract Number: 2813 • 2017 ACR/ARHP Annual Meeting
Interferon-Induced APOL1 over-Expression Causes Autophagic Dysfunction and Mitochondrial Stress in Risk Variant-Carrying Endothelial Cells
Ashira Blazer¹, Sara Rasmussen², Androo Markham³, Shilpi Mehta-Lee⁴, Jill P. Buyon⁴ and Robert M. Clancy², ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, New York, NY
Background/Purpose: In SLE Apolipoprotein L1 (APOL1) risk variants (RV) associate with cardiovascular and end stage renal disease. APOL1 induction initially promotes cellular maintenance through autophagy;…
Abstract Number: 7 • 2017 Pediatric Rheumatology Symposium
Activation of Immature, Transitional B cells by Integrated BCR, TLR and TACI signals promotes systemic autoimmunity in high BAFF settings
Holly Jacobs, Samuel Du, Tanvi Arkatkar and Shaun Jackson, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: B cell activating factor of the TNF family (BAFF, also known as BLyS) promotes B cell survival and activation by binding distinct B cell…
Abstract Number: 26 • 2017 Pediatric Rheumatology Symposium
Gray Matter Volume Loss in Youth with SLE
Andrea Knight¹, Michelle Vickery², Arastoo Vossough³, Guray Erus⁴, Jimit Doshi⁵ and Susan Furth⁶, ¹Center for Pediatric Clinical Effectiveness & PolicyLab, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Section on Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁵Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁶Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neuropsychiatric SLE in children and adolescents presents diagnostic challenge due to limitations of conventional magnetic resonance imaging (MRI) to detect clinically relevant brain changes.…
Abstract Number: 98 • 2017 Pediatric Rheumatology Symposium
Contraceptive use, Counseling given and the Occurrence of Venous Thrombus Embolism in Adolescent Systemic Lupus Erythematosus
Martha Curry¹, Jennifer Kurkowski², Jane Geyer³, Julie Hakim³, Haleh Sangi⁴ and Marietta deGuzman⁵, ¹Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Division Pediatric and Adolescent Gynecology, Houston, TX, ³Baylor College of Medicine, Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁴Baylor College of Medicnine,Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁵Baylor College of Medicine, Division of Pediatric Rheumatology, Houston, TX
Background/Purpose: According to the Center for Disease Control, 46.8% of high school students surveyed in 2013 have been sexually active. Of those surveyed 34% had…
Abstract Number: 27 • 2017 Pediatric Rheumatology Symposium
Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythmatosus Patients
Shreya Goyal¹, Daniel Ashton^2,3, Kamlesh Kukreja^3,4, Michael C. Braun^5,6 and Scott E. Wenderfer^5,7, ¹Pediatrics, Baylor College of Medicine, Houston, TX, ²Interventional Radiology, Texas Children's Hospital, Houston, TX, ³Radiology, Baylor College of Medicine, Houston, TX, ⁴Interventional RAdiology, Texas Children's Hospital, Houston, TX, ⁵Texas Children's Hospital, Houston, TX, ⁶Pediatrics-Renal, Baylor College of Medicine, Houston, TX, ⁷Pediatrics-Renal, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Title: Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythematosus Patients Background/Purpose: There is very little data in the literature on…
Abstract Number: 35 • 2017 Pediatric Rheumatology Symposium
Kv1.3 Expression on Urinary Leukocytes in Lupus Nephritis: Potential for Targeted Immunotherapy
Anne Stevens¹, Andrew Hinkle², Megan Yuasa³, David Peckham⁴, Chelsea Olsen⁵, Craig Philips⁵, Shawn P. Iadonato⁴ and Peter Probst⁶, ¹University of Washington, Pediatrics, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Seattle Children’s Research Institute, Seattle, WA, ⁴Kineta Inc, Seattle, WA, ⁵KPI Therapeutics, Inc., Seattle, WA, ⁶Kineta, Inc, Seattle, WA
Background/Purpose: Lymphocyte activation depends upon a calcium signaling cascade that is regulated by voltage-gated potassium channels. Effector memory T cells (TEM), which are implicated in…
Abstract Number: 123 • 2016 ACR/ARHP Annual Meeting
A Panel of Urinary Biomarkers to Assess Renal Involvement in Latin American Patients with Systemic Lupus Erythematosus
José A. Gómez-Puerta^1,2, Blanca L Ortiz Reyes¹, Tomás Urrego¹, Adriana L Vanegas^2,3, Carlos Horacio Muñoz^3,4, Mauricio Restrepo², Wilmer Rojas-Zuleta², Sofia Arteaga², Luis Alonso Gonzalez⁴ and Gloria Vásquez^1,4, ¹Grupo de Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia, ²Rheumatology Unit, Universidad de Antioquia, Medellín, Colombia, ³Hospital Universitario de San Vicente Fundación, Medellín, Colombia, ⁴Rheumatology Unit, Universidad de Antioquia, Medellin, Colombia
Background/Purpose: Some previous studies in Caucasian, Asian, and African-american patients have shown promising results for several urinary biomarkers in patients with lupus nephritis (LN). However,…
Abstract Number: 1174 • 2016 ACR/ARHP Annual Meeting
Perceived Stress and Reported Cognitive Symptoms Among Patients with Systemic Lupus Erythematosus
Laura Plantinga¹, Cristina Drenkard², C. Barrett Bowling¹ and S. Sam Lim³, ¹Department of Medicine, Emory University, Atlanta, GA, ²Department of Medicine, Emory University School of Medicine, Atlanta, GA, ³Medicine, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Higher stress is associated with lower cognitive functioning in many populations. We examined associations of perceived stress with cognitive symptoms among adults with systemic…
Abstract Number: 1834 • 2016 ACR/ARHP Annual Meeting
Commensal Ro60 Autoantigen Ortholog Cross-Reactivity in Human Lupus and Gnotobiotic Models
Teri Greiling¹, Carina Dehner², Stephen Renfroe³, Xinguo Chen⁴, Kevin Hughes⁴, Silvio M. Vieira³, William Ruff³, Marco Boccitto⁴, Andrew Goodman⁵, Sandra L. Wolin⁴ and Martin Kriegel^3,6, ¹Dermatology and Immunobiology, Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, new haven, CT, ³Immunobiology, Yale School of Medicine, New Haven, CT, ⁴Cell Biology, Yale School of Medicine, New Haven, CT, ⁵Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, ⁶Medicine/Division of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: The earliest autoantibodies in lupus are directed against the autoantigen Ro60, an RNA binding protein with orthologs that we identified in a subset of…

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