Abstracts tagged "Lupus"

Abstract Number: 920 • 2017 ACR/ARHP Annual Meeting
Area-Level Predictors of Medication Nonadherence Among U.S. Medicaid Beneficiaries with Lupus: A Multilevel Study
Candace H. Feldman¹, Karen H. Costenbader², Daniel H. Solomon³, S.V. Subramanian⁴ and Ichiro Kawachi⁵, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, ⁵Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA
Background/Purpose: Among lupus patients, adherence to hydroxychloroquine (HCQ), the backbone of therapy, remains suboptimal. Individual-level factors, including younger age, poverty, and black race, have been…
Abstract Number: 1643 • 2017 ACR/ARHP Annual Meeting
15 Year Comparative Analysis of Cardiovascular Events in Female Subjects with Lupus Versus Controls
Erika Joyce¹, Kristy Huysman², Linda Santelices², Michael Anderson², Amy H. Kao³, Jennifer Elliott⁴, Jennifer Mall², Amy Xiaoqin Tang⁵ and Susan Manzi², ¹Internal Medicine, Allegheny Health Network, Pittsburgh, PA, ²Medicine, Allegheny Health Network, Pittsburgh, PA, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁴Allegheny Health Network, Pittsburgh, PA, ⁵Lupus Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA
Background/Purpose: The multi-organ sequelae of systemic lupus erythematosus (SLE) may include nephritis, alveolar hemorrhage, and cardiovascular disease. Our long term follow up of female SLE…
Abstract Number: 2563 • 2017 ACR/ARHP Annual Meeting
SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice
Akiko Nagasu¹, Tomoyuki Mukai¹, Masanori Iseki², Hajime Nagasu³, Shunichi Fujita¹, Takafumi Mito¹, Shoko Kodama¹, Yumi Sasae⁴, Naoki Kashihara³, Katsuhiko Ishihara², Yasuyoshi Ueki⁵ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, ³Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Rheumatology, Kawasaki Medical School, Kurashiki Okayama, Japan, ⁵Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, leading to multiple organ dysfunction. SH3BP2 (Src homology domain 3…
Abstract Number: 233 • 2017 ACR/ARHP Annual Meeting
Engaging Community Stakeholders through a National Lupus Education Workshop
Karen Mancera Cuevas¹, Rosalind Ramsey-Goldman², Sheryl McCalla³, Patricia Canessa⁴ and Zineb Aouhab¹, ¹Rheumatology, Northwestern University, Chicago, IL, ²FSM, Northwestern University, Chicago, IL, ³American College of Rheumatology, Atlanta, GA, ⁴Illinois Public Health Association, Springfield, IL
Background/Purpose: The Popular Opinion Leader (POL) model based on health education theoretical foundations associated with Social Network Theory and Diffusion of Innovation was successfully piloted…
Abstract Number: 988 • 2017 ACR/ARHP Annual Meeting
Association of Ultraviolet-B Radiation and Risk of SLE Among Women in the Nurses’ Health Studies
Medha Barbhaiya¹, Jaime Hart^2,3, Susan Malspeis⁴, Sara K. Tedeschi⁵, David J. Kreps⁵, Trang VoPham⁶, Jeffrey A. Sparks⁷, Elizabeth Karlson⁵, Francine Laden^2,3,8 and Karen H. Costenbader⁵, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, ³Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, ⁷Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Ultraviolet-B radiation (UV-B) exposure may lead to worsened photosensitivity, rashes, and systemic flares among SLE patients. Although UV-B radiation damages keratinocytes and may result…
Abstract Number: 1662 • 2017 ACR/ARHP Annual Meeting
High Type I Interferon Activity Is Associated with Active Class Ⅲ/Ⅳ Lupus Nephritis in European-American Lupus Patients Independent of dsDNA Antibodies
Taro Iwamoto¹, Jessica M. Dorschner², Mark A. Jensen¹, Danielle Vsetecka², Shreyasee Amin³, Ashima Makol⁴, Floranne C. Ernste⁵, Thomas Osborn³, Kevin Moder³, Vaidehi Chowdhary⁶ and Timothy B. Niewold¹, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁶Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN
Background/Purpose: Lupus nephritis (LN) is one of the most severe types of organ involvement in systemic lupus erythematosus (SLE), despite the recent advances in immunosuppressive…
Abstract Number: 2577 • 2017 ACR/ARHP Annual Meeting
Segmented Filamentous Bacteria Colonization Exacerbate Lupus Nephritis in NZM2410 Mice and Causes an Expansion of Intestinal Group 3 Innate Lymphoid Cells
Giancarlo R. Valiente¹, Jeffrey Hampton², Takuma Wada³, Perry Blough³, William Willis⁴, Nicholas A. Young⁴, Lai-Chu Wu⁵ and Wael Jarjour⁶, ¹Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ³The Ohio State University, Columbus, OH, ⁴Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Title: Segmented Filamentous Bacteria Colonization Exacerbate Lupus Nephritis in NZM2410 Mice and Causes an Expansion of Intestinal Group 3 Innate Lymphoid Cells Background/Purpose: Innate Lymphoid…
Abstract Number: 98 • 2017 Pediatric Rheumatology Symposium
Contraceptive use, Counseling given and the Occurrence of Venous Thrombus Embolism in Adolescent Systemic Lupus Erythematosus
Martha Curry¹, Jennifer Kurkowski², Jane Geyer³, Julie Hakim³, Haleh Sangi⁴ and Marietta deGuzman⁵, ¹Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Division Pediatric and Adolescent Gynecology, Houston, TX, ³Baylor College of Medicine, Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁴Baylor College of Medicnine,Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁵Baylor College of Medicine, Division of Pediatric Rheumatology, Houston, TX
Background/Purpose: According to the Center for Disease Control, 46.8% of high school students surveyed in 2013 have been sexually active. Of those surveyed 34% had…
Abstract Number: 27 • 2017 Pediatric Rheumatology Symposium
Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythmatosus Patients
Shreya Goyal¹, Daniel Ashton^2,3, Kamlesh Kukreja^3,4, Michael C. Braun^5,6 and Scott E. Wenderfer^5,7, ¹Pediatrics, Baylor College of Medicine, Houston, TX, ²Interventional Radiology, Texas Children's Hospital, Houston, TX, ³Radiology, Baylor College of Medicine, Houston, TX, ⁴Interventional RAdiology, Texas Children's Hospital, Houston, TX, ⁵Texas Children's Hospital, Houston, TX, ⁶Pediatrics-Renal, Baylor College of Medicine, Houston, TX, ⁷Pediatrics-Renal, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Title: Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythematosus Patients Background/Purpose: There is very little data in the literature on…
Abstract Number: 35 • 2017 Pediatric Rheumatology Symposium
Kv1.3 Expression on Urinary Leukocytes in Lupus Nephritis: Potential for Targeted Immunotherapy
Anne Stevens¹, Andrew Hinkle², Megan Yuasa³, David Peckham⁴, Chelsea Olsen⁵, Craig Philips⁵, Shawn P. Iadonato⁴ and Peter Probst⁶, ¹University of Washington, Pediatrics, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Seattle Children’s Research Institute, Seattle, WA, ⁴Kineta Inc, Seattle, WA, ⁵KPI Therapeutics, Inc., Seattle, WA, ⁶Kineta, Inc, Seattle, WA
Background/Purpose: Lymphocyte activation depends upon a calcium signaling cascade that is regulated by voltage-gated potassium channels. Effector memory T cells (TEM), which are implicated in…
Abstract Number: 7 • 2017 Pediatric Rheumatology Symposium
Activation of Immature, Transitional B cells by Integrated BCR, TLR and TACI signals promotes systemic autoimmunity in high BAFF settings
Holly Jacobs, Samuel Du, Tanvi Arkatkar and Shaun Jackson, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: B cell activating factor of the TNF family (BAFF, also known as BLyS) promotes B cell survival and activation by binding distinct B cell…
Abstract Number: 26 • 2017 Pediatric Rheumatology Symposium
Gray Matter Volume Loss in Youth with SLE
Andrea Knight¹, Michelle Vickery², Arastoo Vossough³, Guray Erus⁴, Jimit Doshi⁵ and Susan Furth⁶, ¹Center for Pediatric Clinical Effectiveness & PolicyLab, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Section on Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁵Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁶Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neuropsychiatric SLE in children and adolescents presents diagnostic challenge due to limitations of conventional magnetic resonance imaging (MRI) to detect clinically relevant brain changes.…
Abstract Number: 1048 • 2016 ACR/ARHP Annual Meeting
Differences in Clinical Manifestations of SLE Across Four Racial/Ethnic Groups: The California Lupus Surveillance Project (CLSP)
Ernest Maningding¹, Jinoos Yazdany², Laura Trupin², Chris Tonner³, Charles G. Helmick⁴ and Maria Dall'Era⁵, ¹Internal Medicine, Santa Clara Valley Medical Center, San Jose, CA, ²Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ³Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴CDC, Atlanta, GA, ⁵Division of Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: The CLSP is a population-based registry of individuals with SLE residing in San Francisco County, California from 2007 – 2009. The registry has a…
Abstract Number: 1381 • 2016 ACR/ARHP Annual Meeting
Humoral Immune Response and Cytokine Profile after a Booster Dose with Tdap Vaccine in Juvenile Systemic Lupus Erythematosus and Controls
Octavio Peracchi¹, Aline Nicacio², Fernanda Spina³, Juliana Yamada³, Brunna Alvarenga³, Maria Isabel Pinto³ and Maria Teresa Terreri⁴, ¹Pediatric Rheumatology, Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, ²Pediatric Rheumatology Unit, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil, ³Federal University of Sao Paulo, Department of Pediatrics, Sao Paulo, Brazil, Sao Paulo, Brazil, ⁴Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil
Background/Purpose: Pertussis cases have increased worldwide and knowledge on immune response and cytokine profile after adult Tdap vaccine is scarce. This study evaluated the humoral…
Abstract Number: 2008 • 2016 ACR/ARHP Annual Meeting
Rapamycin Elicits Rapid and Lasting Improvement of Disease Activity through Blocking Pro-Inflammatory T Cell Lineage Specification in Patients with Active SLE
Zhi-Wei Lai¹, Ivan Marchena², Hajra Tily², Ricardo Garcia¹, Julie Yu², Lisa Francis², Maha Dawood², Ryan Kelly², Stephen Faraone², Paul E. Phillips³ and Andras Perl⁴, ¹Medicine, SUNY, Syracuse, NY, ²SUNY, Syracuse, NY, ³Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁴Department of Medicine, Upstate Medical University, Syracuse, NY
Background/Purpose: The rationale for this prospective, biomarker-driven, open-label clinical trial of rapamycin (ClinicalTrials.gov Identifier: NCT00779194) has been based on growing evidence for involvement of the…

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