Abstracts tagged "Lupus"

Abstract Number: 1294 • 2017 ACR/ARHP Annual Meeting
Time to Pregnancy in Women with Systemic Lupus Erythematosus
Meriem El bakali¹, Sasha Bernatsky², Christian A. Pineau³ and Evelyne Vinet⁴, ¹Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³McGill University Health Centre, Montreal, QC, Canada, ⁴Divisions of Rheymatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Women diagnosed with systemic lupus erythematosus (SLE) during the reproductive period have fewer children than unaffected women. Multiple disease-related factors might influence family size…
Abstract Number: 1839 • 2017 ACR/ARHP Annual Meeting
Development and Validation of a Novel Evidence-Based Lupus Multivariable Outcome Score for Clinical Trials
Michal Abrahamowicz¹, John M. Esdaile², Rosalind Ramsey-Goldman³, Lee S. Simon⁴, Vibeke Strand⁵ and Peter E. Lipsky⁶, ¹Departmernt of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³FSM, Northwestern University, Chicago, IL, ⁴SDG LLC Consulting, West Newton, MA, ⁵Stanford University, Palo Alto, CA, ⁶AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Randomized controlled trials (RCTs) of new SLE treatments are hampered by the lack of effective outcome measures that are responsive to change and clinically…
Abstract Number: 2636 • 2017 ACR/ARHP Annual Meeting
EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion through Junctional Adhesion Molecule-a in Lupus Patients
Pei-Suen Tsou¹, Patrick Coit¹, Nathan Kilian² and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: EZH2 is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and modulates DNA methylation patterns. We have previously suggested that EZH2…
Abstract Number: 678 • 2017 ACR/ARHP Annual Meeting
Systemic Hypertension Is Associated with Presence of Vascular Injury on Lupus Nephritis Renal Biopsies: A Retrospective Cohort Study
Cianna Leatherwood, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Vascular injury in lupus nephritis is often described on renal biopsy, but its clinical correlates are not well understood. Recent evidence suggests it may…
Abstract Number: 1296 • 2017 ACR/ARHP Annual Meeting
Hydroxychloroquine Level Decreases throughout Pregnancy: Implications for Maternal and Neonatal Outcomes
Stephen Balevic¹, Michael Cohen-Wolkowiez², Amanda M. Eudy³, Laura E. Schanberg⁴ and Megan E. B. Clowse⁵, ¹Rheumatology, Adult and Pediatric, Duke University Medical Center, Durham, NC, ²Pharmacometrics Center, Duke Clinical Research Institute, Durham, NC, ³Duke University Medical Center, Chapel Hill, NC, ⁴Pediatrics, Duke University Medical Center, Durham, NC, ⁵Duke University Medical Center, Durham, NC
Background/Purpose: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Prior data suggests that hydroxychloroquine (HCQ) can reduce disease activity and…
Abstract Number: 1861 • 2017 ACR/ARHP Annual Meeting
Evaluation of a Longstanding Telephone Peer Counseling Service on People with Systemic Lupus Erythematosus and Their Loved Ones
Priscilla Toral¹, Melissa T. Flores¹, Roberta Horton¹ and Jillian Rose², ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Studies show telephone peer support has been used to address a range of health concerns in people living with chronic illness. A phone evaluation…
Abstract Number: 2655 • 2017 ACR/ARHP Annual Meeting
Contribution of Monocytes to Circulating microRNAs Related to Cardiovascular Disease in Systemic Lupus Erythematosus. Effects of In Vivo Treatment with Rituximab
Carlos Perez-Sanchez¹, Irene Cecchi², Massimo Radin³, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon⁴, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera⁴, Ivan Arias de la Rosa⁴, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁵, Savino Sciascia⁶ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: Despite emerging data on disease-specific associations for various blood- and plasma-derived miRNAs, consensus is lacking as to whether a cellular, extracellular, or a mixed…
Abstract Number: 98 • 2017 Pediatric Rheumatology Symposium
Contraceptive use, Counseling given and the Occurrence of Venous Thrombus Embolism in Adolescent Systemic Lupus Erythematosus
Martha Curry¹, Jennifer Kurkowski², Jane Geyer³, Julie Hakim³, Haleh Sangi⁴ and Marietta deGuzman⁵, ¹Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Division Pediatric and Adolescent Gynecology, Houston, TX, ³Baylor College of Medicine, Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁴Baylor College of Medicnine,Division of Pediatric and Adolescent Gynecology, Houston, TX, ⁵Baylor College of Medicine, Division of Pediatric Rheumatology, Houston, TX
Background/Purpose: According to the Center for Disease Control, 46.8% of high school students surveyed in 2013 have been sexually active. Of those surveyed 34% had…
Abstract Number: 27 • 2017 Pediatric Rheumatology Symposium
Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythmatosus Patients
Shreya Goyal¹, Daniel Ashton^2,3, Kamlesh Kukreja^3,4, Michael C. Braun^5,6 and Scott E. Wenderfer^5,7, ¹Pediatrics, Baylor College of Medicine, Houston, TX, ²Interventional Radiology, Texas Children's Hospital, Houston, TX, ³Radiology, Baylor College of Medicine, Houston, TX, ⁴Interventional RAdiology, Texas Children's Hospital, Houston, TX, ⁵Texas Children's Hospital, Houston, TX, ⁶Pediatrics-Renal, Baylor College of Medicine, Houston, TX, ⁷Pediatrics-Renal, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Title: Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythematosus Patients Background/Purpose: There is very little data in the literature on…
Abstract Number: 35 • 2017 Pediatric Rheumatology Symposium
Kv1.3 Expression on Urinary Leukocytes in Lupus Nephritis: Potential for Targeted Immunotherapy
Anne Stevens¹, Andrew Hinkle², Megan Yuasa³, David Peckham⁴, Chelsea Olsen⁵, Craig Philips⁵, Shawn P. Iadonato⁴ and Peter Probst⁶, ¹University of Washington, Pediatrics, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Seattle Children’s Research Institute, Seattle, WA, ⁴Kineta Inc, Seattle, WA, ⁵KPI Therapeutics, Inc., Seattle, WA, ⁶Kineta, Inc, Seattle, WA
Background/Purpose: Lymphocyte activation depends upon a calcium signaling cascade that is regulated by voltage-gated potassium channels. Effector memory T cells (TEM), which are implicated in…
Abstract Number: 7 • 2017 Pediatric Rheumatology Symposium
Activation of Immature, Transitional B cells by Integrated BCR, TLR and TACI signals promotes systemic autoimmunity in high BAFF settings
Holly Jacobs, Samuel Du, Tanvi Arkatkar and Shaun Jackson, Seattle Children's Research Institute, Seattle, WA
Background/Purpose: B cell activating factor of the TNF family (BAFF, also known as BLyS) promotes B cell survival and activation by binding distinct B cell…
Abstract Number: 26 • 2017 Pediatric Rheumatology Symposium
Gray Matter Volume Loss in Youth with SLE
Andrea Knight¹, Michelle Vickery², Arastoo Vossough³, Guray Erus⁴, Jimit Doshi⁵ and Susan Furth⁶, ¹Center for Pediatric Clinical Effectiveness & PolicyLab, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Section on Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁵Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁶Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neuropsychiatric SLE in children and adolescents presents diagnostic challenge due to limitations of conventional magnetic resonance imaging (MRI) to detect clinically relevant brain changes.…
Abstract Number: 1168 • 2016 ACR/ARHP Annual Meeting
The Epidemiology of Individuals Not Fully Meeting Classification Criteria for Systemic Lupus Erythematosus (SLE): The Georgia Lupus Registry
Puja Saxena¹, Gaobin Bao², Cristina Drenkard³ and S. Sam Lim², ¹Rheumatology, Emory University School of Medicine, Atlanta, GA, ²Medicine, Emory University School of Medicine, Atlanta, GA, ³Emory University School of Medicine, Atlanta, GA
Background/Purpose: Identifying individuals as early as possible in the development of an autoimmune disease may lead to important opportunities. This study utilizes an established population-based…
Abstract Number: 1799 • 2016 ACR/ARHP Annual Meeting
Smoking, Antiphospholipid Antibodies and Thrombosis in SLE
Michelle Petri¹, George Stojan² and Wei Fu³, ¹Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Anticardiolipin Ever smoking 411 (48.1%) Past smoking 246 (49.8%) Current smoking 165 (46.6%) Never smoking 721 (48.9%) P Value (Ever vs. Never) 0.6943…
Abstract Number: 2821 • 2016 ACR/ARHP Annual Meeting
Is Hyperuricemia an Independent Risk Factor for Arterial Thrombosis in Systemic Lupus Erythematosus?
Chi Chiu Mok¹, Ling Yin Ho², Chi Hung To³ and Kar Li Chan¹, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong, ³Medicine, Pok Oi Hospital, Hong Kong, Hong Kong
Background/Purpose: To evaluate whether hyperuricemia is independently associated with cardiovascular events in a cross-sectional study of Chinese patients with SLE. Methods: Consecutive patients who fulfilled…

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