Abstracts tagged "Lupus"

Abstract Number: 1643 • 2017 ACR/ARHP Annual Meeting
15 Year Comparative Analysis of Cardiovascular Events in Female Subjects with Lupus Versus Controls
Erika Joyce¹, Kristy Huysman², Linda Santelices², Michael Anderson², Amy H. Kao³, Jennifer Elliott⁴, Jennifer Mall², Amy Xiaoqin Tang⁵ and Susan Manzi², ¹Internal Medicine, Allegheny Health Network, Pittsburgh, PA, ²Medicine, Allegheny Health Network, Pittsburgh, PA, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁴Allegheny Health Network, Pittsburgh, PA, ⁵Lupus Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA
Background/Purpose: The multi-organ sequelae of systemic lupus erythematosus (SLE) may include nephritis, alveolar hemorrhage, and cardiovascular disease. Our long term follow up of female SLE…
Abstract Number: 2563 • 2017 ACR/ARHP Annual Meeting
SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice
Akiko Nagasu¹, Tomoyuki Mukai¹, Masanori Iseki², Hajime Nagasu³, Shunichi Fujita¹, Takafumi Mito¹, Shoko Kodama¹, Yumi Sasae⁴, Naoki Kashihara³, Katsuhiko Ishihara², Yasuyoshi Ueki⁵ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, ³Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Rheumatology, Kawasaki Medical School, Kurashiki Okayama, Japan, ⁵Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, leading to multiple organ dysfunction. SH3BP2 (Src homology domain 3…
Abstract Number: 233 • 2017 ACR/ARHP Annual Meeting
Engaging Community Stakeholders through a National Lupus Education Workshop
Karen Mancera Cuevas¹, Rosalind Ramsey-Goldman², Sheryl McCalla³, Patricia Canessa⁴ and Zineb Aouhab¹, ¹Rheumatology, Northwestern University, Chicago, IL, ²FSM, Northwestern University, Chicago, IL, ³American College of Rheumatology, Atlanta, GA, ⁴Illinois Public Health Association, Springfield, IL
Background/Purpose: The Popular Opinion Leader (POL) model based on health education theoretical foundations associated with Social Network Theory and Diffusion of Innovation was successfully piloted…
Abstract Number: 988 • 2017 ACR/ARHP Annual Meeting
Association of Ultraviolet-B Radiation and Risk of SLE Among Women in the Nurses’ Health Studies
Medha Barbhaiya¹, Jaime Hart^2,3, Susan Malspeis⁴, Sara K. Tedeschi⁵, David J. Kreps⁵, Trang VoPham⁶, Jeffrey A. Sparks⁷, Elizabeth Karlson⁵, Francine Laden^2,3,8 and Karen H. Costenbader⁵, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, ³Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, ⁷Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Ultraviolet-B radiation (UV-B) exposure may lead to worsened photosensitivity, rashes, and systemic flares among SLE patients. Although UV-B radiation damages keratinocytes and may result…
Abstract Number: 1662 • 2017 ACR/ARHP Annual Meeting
High Type I Interferon Activity Is Associated with Active Class Ⅲ/Ⅳ Lupus Nephritis in European-American Lupus Patients Independent of dsDNA Antibodies
Taro Iwamoto¹, Jessica M. Dorschner², Mark A. Jensen¹, Danielle Vsetecka², Shreyasee Amin³, Ashima Makol⁴, Floranne C. Ernste⁵, Thomas Osborn³, Kevin Moder³, Vaidehi Chowdhary⁶ and Timothy B. Niewold¹, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁶Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN
Background/Purpose: Lupus nephritis (LN) is one of the most severe types of organ involvement in systemic lupus erythematosus (SLE), despite the recent advances in immunosuppressive…
Abstract Number: 2577 • 2017 ACR/ARHP Annual Meeting
Segmented Filamentous Bacteria Colonization Exacerbate Lupus Nephritis in NZM2410 Mice and Causes an Expansion of Intestinal Group 3 Innate Lymphoid Cells
Giancarlo R. Valiente¹, Jeffrey Hampton², Takuma Wada³, Perry Blough³, William Willis⁴, Nicholas A. Young⁴, Lai-Chu Wu⁵ and Wael Jarjour⁶, ¹Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ³The Ohio State University, Columbus, OH, ⁴Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Title: Segmented Filamentous Bacteria Colonization Exacerbate Lupus Nephritis in NZM2410 Mice and Causes an Expansion of Intestinal Group 3 Innate Lymphoid Cells Background/Purpose: Innate Lymphoid…
Abstract Number: 296 • 2017 ACR/ARHP Annual Meeting
A Module of Genes Describing Low Density Granulocytes Can be Identified and Followed in the Periphery of Lupus Patients
Brian Keggereis¹, Michelle Catalina², Nick Geraci¹, Sarah Heuer², Prathyusha Bachali², Sushma Madamanchi², Peter E. Lipsky² and Amrie Grammer², ¹AMPELBioSolutions and RILITE Research Institute, Charlottesville, VA, ²AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA
Background/Purpose: Lupus is an autoimmune disease characterized by a type I interferon signature thought to be initiated by granulocyte NETosis. The granulocyte population in the…
Abstract Number: 1003 • 2017 ACR/ARHP Annual Meeting
Hair Treatments and the Risk of Systemic Lupus Erythematosus: the Michigan Lupus Epidemiology & Surveillance (MILES) Program
Emily C. Somers¹, Christina Mrukowicz², Wendy Marder¹, W. Joseph McCune³, Afton L. Hassett⁴, Suzanna Zick⁵, Siobán Harlow⁶ and Caroline Gordon⁷, ¹Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ⁴Rheumatology, Emory University, Atlanta, GA, ⁵Department of Family Medicine, University of Michigan, Ann Arbor, MI, ⁶Epidemiology Department- School of Public Health, Obstetrics and Gynecology- Medical School, University of Michigan, Ann Arbor, MI, ⁷School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Hair dye exposure has been reported as a risk factor for systemic lupus erythematosus (SLE) and connective tissue diseases, though conflicting results exist. We…
Abstract Number: 1667 • 2017 ACR/ARHP Annual Meeting
Increased Levels of BAFF in SLE Patients Correlates with Neutrophil Activation and Autoantibody Production
Andrew Vasconcellos¹, John Marken¹, Ting Wang^1,2, Christian Lood³ and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, ³Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: Neutrophil (PMN) activation and neutrophil extracellular trap (NET) formation are implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE), particularly in the acceleration of…
Abstract Number: 2590 • 2017 ACR/ARHP Annual Meeting
Subcutaneous Belimumab Plus Standard of Care Demonstrated Improvement in Multiple Organ Domains Versus Placebo Plus Standard of Care in Patients with Active Systemic Lupus Erythematosus (SLE)
Andrea Doria¹, Bonnie Pobiner², William Eastman³, Milena Kurtinecz⁴, Anne Hammer², James Groark⁵ and Damon Bass⁵, ¹Division of Rheumatology, University of Padova, Padova, Italy, ²GSK Research Triangle Park, Research Triangle Park, NC, ³GSK, Research Triangle Park, NC, ⁴GSK, Philadelphia, PA, ⁵GSK Collegeville, Collegeville, PA
Background/Purpose : Organ manifestation domain score improvement was assessed with subcutaneous (SC) belimumab (BEL) plus standard SLE care (SoC) in active, autoantibody-positive SLE. Methods: BLISS-SC…
Abstract Number: 300 • 2017 ACR/ARHP Annual Meeting
The DNA-Binding Protein ARID3a Is Associated with Interferon Alpha Production in Lupus Patient Plasmacytoid Dendritic Cells and Neutrophils
Michelle Ratliff¹, Joshua Garton^1,2, Indra Adrianto³, Ambra Pastori⁴, Courtney Montgomery⁵, Patrick Gaffney⁴, Judith A. James^3,6 and Carol Webb^1,7,8, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Chemistry, University of Oklahoma, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: We previously demonstrated over-expression of the DNA-binding protein ARID3a in peripheral blood B lymphocytes from patients with systemic lupus erythematosus (SLE) compared to healthy…
Abstract Number: 1026 • 2017 ACR/ARHP Annual Meeting
Gene Expression Analysis Reveals Common Pathways of Tissue Pathogenesis in Lupus Organ Involvement
Amrie Grammer¹, Sarah Heuer¹, Robert Robl¹, Adam Labonte¹, Prathyusha Bachali¹, Sushma Madamanchi¹ and Peter E. Lipsky², ¹AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, ²AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Lupus is a prototypic autoimmune disease characterized by B cell hyperactivity, autoantibody formation and resultant tissue damage. The mechanisms underlying tissue pathology in lupus…
Abstract Number: 1669 • 2017 ACR/ARHP Annual Meeting
Anti-Mitochondria DNA Antibody As an Improved Biomarker for Systemic Lupus Erythematosus
Yangsheng Yu¹, Kalika Mahato¹, Suyang Xu¹, Jenna Mu¹, Amanda Zhang¹, James R. O'Dell², Lynell W. Klassen², Michelene Hearth-Holmes³ and Kaihong Su¹, ¹Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ²Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine/Rheumatology Division, Univ. of Nebraska Medical Center, Omaha, NE
Background/Purpose: Anti-dsDNA antibodies are highly specific for systemic lupus erythematosus (SLE) and often associate with lupus nephritis. Extracellular nucleosome DNA released from apoptotic or necrotic…
Abstract Number: 2595 • 2017 ACR/ARHP Annual Meeting
The Role of Hydroxychloroquine in the Treatment of Undifferentiated Connective Tissue Disease
Hayley Epstein¹, Diana P. Pena², Bianca Di Cocco¹, Teja Kapoor³ and Anca Askanase⁴, ¹Rheumatology, CUMC, New York, NY, ²Rheumatology, Universidad Militar Nueva Granada, Bogotá, Colombia, ³Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁴Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: To evaluate the change in ANA titers as a proxy for progression in patients with undifferentiated connective tissue disease (UCTD) treated with hydroxychloroquine (HCQ)…
Abstract Number: 354 • 2017 ACR/ARHP Annual Meeting
Multidomain Functional Assessment in a Cohort of Patients with Systemic Lupus Erythematosus: A Pilot Study
Laura Plantinga¹, Benjamin Tift², C. Barrett Bowling³, Charmayne M. Dunlop-Thomas⁴, S. Sam Lim⁵ and Cristina Drenkard⁵, ¹Department of Medicine, Emory University School of Medicine, Atlanta, GA, ²Edward Via College of Osteopathic Medicine, Spartanburg, SC, ³Durham Veterans Affairs Medical Center, Durham, NC, ⁴Emory University School of Medicine, Atlanta, GA, ⁵Division of Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, complex disease with multiple comorbid conditions and non-disease-specific manifestations. Consequently, the impact of SLE on both physical…

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