ACR Meeting Abstracts

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Abstracts tagged "Lupus nephritis"

  • Abstract Number: 1458 • ACR Convergence 2023

    Activated Naïve DNA-Reactive B Cells in Lupus Nephritis Patients Are Increased and Associated with Disease Activity

    Kittikorn Wangriatisak1, Francesca Faustini2, Charlotte de Vries3, Ravi Kumar Sharma4, Caroline Grönwall5, Prapaporn Pisitkun6, Patchanee Chootong7, Vivianne Malmström5 and Iva Gunnarsson8, 1Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Thailand ; Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 2Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Sweden; Medicine Unit Dermatology, Gastroenterology, Rheumatology; unit of Rheumatology, Karolinska University Hospital Solna, Stockholm, Sweden, 3Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 4Division of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Karolinska Institutet, Stockholm, Sweden, 6Division of Allergy Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bankok, Thailand, 7Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand, 8Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Sweden; Medicine Unit Dermatology, Gastroenterology, Rheumatology; unit of Rheumatology, Karolinska University Hospital Solna, Sweden, Stockholm, Sweden

    Background/Purpose: Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), which is characterized by abnormal B-cell activation and their…
  • Abstract Number: 1579 • ACR Convergence 2023

    Sodium-Glucose Co-transporter-2 Inhibitors and the Risk of Cardiac and Renal Outcomes in Systemic Lupus Erythematosus

    April Jorge1, Baijun Zhou1, Natalie McCormick1, Chio Yokose1, Yuqing Zhang2 and Hyon K. Choi3, 1Massachusetts General Hospital, Boston, MA, 2Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 3Massachusetts General Hospital and Harvard Medical School, Lexington, MA

    Background/Purpose: Sodium-glucose cotransporter-2 inhibitors (SGLT2) have benefits on kidney and cardiovascular (CV) outcomes that are largely independent of glycemic control. These benefits have been demonstrated…
  • Abstract Number: 2297 • ACR Convergence 2023

    Interferon-α as a Biomarker to Predict Flares in Lupus Nephritis

    Laura Patricia Whittall Garcia1, Dafna Gladman2, Murray Urowitz3, Zahi Touma4 and Joan Wither1, 1University Health Network, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute; University of Toronto Lupus Clinic; Division of Rheumatology, Toronto, ON, Canada, 4University of Toronto, Toronto, ON, Canada

    Background/Purpose: Type I Interferons (IFN-I) play a role in SLE and Lupus Nephritis (LN) pathogenesis. We have recently shown that IFN-I gene expression predicts the…
  • Abstract Number: 0577 • ACR Convergence 2023

    Analysis of Intracytoplasmic Toll – Like Receptors (TLRs) and MyD88 Expression in B Cell Subsets in Patients with Lupus Nephritis

    Michelle Patricia Loeza-Uribe1, Michelle Nicolle Espinoza-Carranza1, Yatzil Reyna-Juárez1, Beatriz Alcalá-Carmona1, Nancy Raquel Mejía-Domínguez2, Guillermo Juárez-Vega2, José Luis Maravillas-Montero2, Karina Santana-de Anda1, José Jiram Torres-Ruiz1 and Diana Gómez-Martín1, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Mexico

    Background/Purpose: Intrinsic signaling of intracytoplasmic TLRs (7 and 9) and MyD88 in B cells (BC) plays an important role in the development and pathogenesis of…
  • Abstract Number: 0899 • ACR Convergence 2023

    Complement Factor I (CFI) Gene Expression by Kidney Tubular Cells Is Increased in Lupus Nephritis Patients with Interstitial Fibrosis and Tubular Atrophy

    Shudan Wang1, John Greally2, Masako Suzuki3, Jee-Young Moon2, Tao Wang2, Yvonne M Saenger2, Brad Rovin4 and J. Michelle Kahlenberg5, 1Albert Einstein College of Medicine / Montefiore Medical Center, New York, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Texas A&M University, College Station, TX, 4Ohio State University, Columbus, OH, 5University of Michigan, Ann Arbor, MI

    Background/Purpose: Tubulointerstitial injury is a strong predictor of progression to kidney failure in lupus nephritis (LN). Prior animal studies suggest intrarenal complement activation has an…
  • Abstract Number: 1464 • ACR Convergence 2023

    Lupus Flares More Common in Patients on Dialysis Compared to After Renal Transplant: A Systematic Review and Meta-analysis

    Omer Pamuk1, Ansaam Daoud2, Loai Dweik3, Niraj Desai4 and sarfaraz Hasni5, 1University Hospitals Cleveland Medical Center, Cleveland, OH, 2University Hospitals, Case Western Reserve University, Akron, OH, 3Cleveland Clinic Akron General, Akron, OH, 4Case Western Reserve University / University Hospitals Cleveland Medical Center, Cleveland, OH, 5Lupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: End-stage renal disease (ESRD) may develop in up to 20% of patients with lupus nephritis (LN). The SLE disease activity generally declines after the…
  • Abstract Number: 1585 • ACR Convergence 2023

    Defining Neutrophil-Mediated Renal Damage Triggered by Ultraviolet (UV) Skin Exposure

    Angelique Cortez1, Lindsay Mendyka2, Fred Kolling3, Michael Whitfield1 and Sladjana Skopelja-Gardner4, 1Dartmouth College, Hanover, NH, 2Dartmouth Hitchcock, Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4Dartmouth-Hitchcock, Lebanon, NH

    Background/Purpose: Lupus (SLE) is one of the leading causes of death in young women in the United States. Roughly ~80% of SLE patients experience sensitivity…
  • Abstract Number: 2310 • ACR Convergence 2023

    Machine Learning Approaches for Prediction of Renal Flares in Systemic Lupus Erythematosus: Knowledge-Driven Models Outperformed Data-Driven Models

    Nursen Cetrez1, Julius Lindblom1, Raffaele Da Mutten2, Dionysis Nikolopoulos2 and Ioannis Parodis1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden

    Background/Purpose: Renal flares in patients with SLE result in significant nephron loss. Thus, identification of reliable early signals of impending renal flares is anticipated to…
  • Abstract Number: 0578 • ACR Convergence 2023

    Prospective Observational Study of Microvascular C5b-9 Deposition in Non-lesional Skin in Systemic Lupus Erythematosus Patients and Its Correlation with Active Lupus Nephritis

    Meghan Anderson1, Cynthia Magro2 and H Michael Belmont3, 1New York University, New York, NY, 2Weill Cornell Medicine, New York, NY, 3NYU School of Medicine, New York, NY

    Background/Purpose: Tissue damage in LN is mediated by immune complex activation of the classic complement pathway (PMID 23929771). In a study of LN, renal C5b-9…
  • Abstract Number: 0908 • ACR Convergence 2023

    Association of Biologic Sex with Glycosphingolipids and the N-glycome in Lupus Nephritis and Renal Mesangial Cell Function

    Tammy Nowling, bethany wolf, Calvin Blaschke, Richard Drake, Sandra Sanchez, Mariia Stefanenko, Mykhailo Fedoriuk, Oleg Palygin, Hongxia Bai and Jessalyn Rodgers, Medical University of South Carolina, Charleston, SC

    Background/Purpose: SLE primarily afflicts women and many SLE patients develop nephritis, a serious complication of lupus. Identification of biomarkers and the pathogenic mechanisms underlying LN…
  • Abstract Number: 1471 • ACR Convergence 2023

    A Comparative Study of Lupus Nephritis Class II and IgA Nephropathy: Renal Disease Other Than Lupus Nephritis in Systemic Lupus Erythematosus Patients

    Eun song Kang1 and Seokchan Hong2, 1Korea University Ansan Hospital, Seoul, South Korea, 2Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Background/Purpose: Lupus nephritis (LN) is one of major organ involvement of SLE and renal biopsy is commonly performed in SLE patients suspected of having LN…
  • Abstract Number: 1598 • ACR Convergence 2023

    Single-cell Spatial Proteomics Identifies Intraglomerular Myeloid Cells in Membranous Lupus Nephritis

    Chen-Yu Lee1, Caleb Marlin2, Xiaoping Yang1, Tayte Stephens2, Alessandra Ida Celia3, Jeff Hodgin4, Peter Izmirly5, H Michael Belmont6, Jill Buyon7, Chaim Putterman8, Judith James2, the Accelerating Medicines Partnership in RA/SLE9, Michelle Petri10, Joel Guthridge2, Avi Rosenberg11 and Andrea Fava1, 1Johns Hopkins University, Baltimore, MD, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3John Hopkins University of Medicine, Rome, Italy, 4University of Michigan, Ann Arbor, MI, 5New York University School of Medicine, New York, NY, 6NYU School of Medicine, New York, NY, 7NYU Grossman School of Medicine, New York, NY, 8Albert Einstein College of Medicine, Bronx, NY, 9Multiple, Multiple, 10Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 11Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) leads to end-stage kidney disease (ESKD) in more than 20% of patients despite optimal treatment. Up to 30% of LN patients…
  • Abstract Number: 2314 • ACR Convergence 2023

    Comparison of Disease Severity and Outcomes in Adolescent-Onset and Young Adult-Onset Systemic Lupus Erythematosus

    Emma Materne1, Baijun Zhou1, Hyon K. Choi2, Yuqing Zhang3 and April Jorge1, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital and Harvard Medical School, Lexington, MA, 3Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA

    Background/Purpose: Adolescent-onset SLE is associated with more severe disease than adult-onset SLE, but young adults may also experience adverse outcomes. We sought to compare disease…
  • Abstract Number: 0593 • ACR Convergence 2023

    Lupus Nephritis of the Spanish National Registry of Belimumab in Patients with Systemic Lupus Erythematosus

    María laiño1, Monica Enguita2, Pablo Navarro3, Javier Loricera4, Angel Garcia-Aparicio5, Carmen Lasa6, Vanesa Calvo Río7, Adela Gallego8, Clara Moriano Morales9, Javier Narvaez10, MARIA IRENE CARRION BARBERA11, Jordi Camins-Fàbregas12, Joaquin Maria Belzunegui Otano13, Ana Urruticoechea14, Leticia del Olmo Perez15, Santos Castañeda16, Patricia Quiroga16, Ivette Casafont-Sole17, Juan Ramon De Dios Jimenez De Aber18, Marta López19, Judit Font Urgelles20, Rafaela Ortega Castro21, Marta Garijo Bufort22, Jorge Juan Fragio23, Ignacio Vázquez24, Mamen Ortega25, Aaron Fariñas26, Cilia Peralta27, Juan María Blanco28, Sergi Heredia Martin29, Maria Valvanera Pinillos30, Eztizen Labrador-Sánchez31, Piter Jose Cossio Jimenez32, Carlos Vazquez Galeano33 and Vicente Aldasoro1, 1Hospital Universitario de Navarra, Pamplona, Spain, 2Navarrabiomed-Unidad de Metodología, Pamplona, Spain, 3Rheumatology, Hospial Universitario Puerta de Hierro, Majadahonda, Spain, 4Hospital Universitario Marqués de Valdecilla, Santander, Spain, 5Hospital Universitario de Toledo, Toledo, Spain, 6Hospital Universitario Marqués de Valdecilla, IDIVAL., La Cavada, Spain, 7Valdecilla Hospital, Santander, Spain, 8Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 9Rheumatology, Hospital Universitario de León, León, Spain, 10Hospital Universitario de Bellvitge, Barcelona, Spain, 11Hospital del Mar/Parc de Salut Mar-IMIM, Barcelona, Spain, 12Hospital General de Granollers, Granollers, Spain, 13University Hospital Donostia, Donostia-San Sebasti, Spain, 14Hospital Can Misses, Ibiza, Spain, 15Hospital Nuestra Señora del Prado, Talavera de la Reina, Spain, 16Hospital Universitario de la Princesa, Madrid, Spain, 17Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 18Hospital de Araba, Alava, Spain, 19Hospital Universitario Arava, Pamplona, Spain, 20Hospital Universitario German Trias i Pujol,, Badalona, Spain, 21Hospital Reina Sofía, Cordoba, Spain, 22Hospital de Sagunto, Valencia, Spain, 23Hospital General Universitario Valencia, Valencia, Spain, 24H. U. Dr. Peset, Valencia, Spain, 25Hospital Universitario de Getafe, Getafe, Spain, 26Complejo Asistencial Universitario de Palencia, Palencia, Spain, 27Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 28Hospital Universitario de Basurto, Bilbao, Spain, 29Complex Hospitalari Moisès Broggi, Barcelona, Spain, 30Hospital Universitario San Pedro, Logroño, Spain, 31Hospital Universitario San Pedro, Laguardia, Spain, 32HOSPITAL REINA SOFIA, Tudela, Spain, 33ZARAGOZA, Madrid, Spain

    Background/Purpose: Belimumab (BLM) is a B-cell stimulating factor (BlyS) monoclonal antibody, approved in 2022 for the treatment of lupus nephritis (NL) and since 2011 for…
  • Abstract Number: 0911 • ACR Convergence 2023

    Spatial Transcriptomics Reveals Normal-density and Low-density Neutrophils Are More Prevalent Than Macrophages in Lupus Nephritis Glomeruli, and Urine DNA Methylation Analyses Capture Both Myeloid Populations

    Sladjana Skopelja-Gardner1, Joshua Skydel2, Alecia Roy3, Brenna Kerin3, James Whitley3, Fred Kolling4, Noelle Kosarek4, Michelle Petri5, Andrea Fava6, Lucas Salas7 and Christopher Burns3, 1Department of Medicine, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth-Hitchcock Medical Center, Lebanon, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 7Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Despite compelling evidence that normal-density (NDN) and low-density neutrophils (LDN) are activated in the blood of lupus patients, their role in lupus nephritis (LN)…
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