Abstracts tagged "Lupus nephritis"

Abstract Number: 0624 • ACR Convergence 2024
Coexisting Tubulointerstitial Inflammation and Damage Is a Risk Factor for Chronic Kidney Disease in Patients with Lupus Nephritis
Dong-Jin Park¹, Hyemin Jeong², Sung-Eun Choi³, Ji-Hyoun Kang² and Shin-Seok Lee⁴, ¹Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Chonnam National University Hospital, Gwangju, South Korea, ³Chonnam National University Medical School & Hospital, Gwangju, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, KR, Gwangju, Republic of Korea
Background/Purpose: Conflicting studies have reported varying associations between tubulointerstitial inflammation (TII), tubulointerstitial damage (TID), and the long-term outcomes of lupus nephritis (LN), due to analyzing…
Abstract Number: 0670 • ACR Convergence 2024
A Randomized, Open-Label, Phase III Trial Comparing Efficacy and Safety of Intravenous Cyclophosphamide, Mycophenolate Mofetil, or Tacrolimus as Induction Therapy in Lupus Nephritis
Alekhya Amudalapalli, Ashlesha Shukla, Abhichandra Maddineni, Sandeep Nagar, Sudhish Gadde, Harish BV, Rashmi Ranjan Sahoo and Pradeepta Sekhar Patro, IMS and SUM Hospital, Bhubaneswar, India
Background/Purpose: The optimal treatment for lupus nephritis is challenging due to its heterogeneity and the lack of prognostic factors favoring one immunosuppressive drug over another.…
Abstract Number: 1523 • ACR Convergence 2024
Trend Analysis of Lupus Nephritis Flares, Mortality, and Disparities: 2016-2020
Husam El Sharu, East Carolina University, Greenville, NC
Background/Purpose: Introduction: In the past decade, the incidence of Lupus Nephritis (LN) flares linked to mortality has generally decreased, though an upward trend has emerged…
Abstract Number: 1812 • ACR Convergence 2024
Glycosylation Changes as Non-Invasive Biomarkers for Lupus Nephritis Detection and Prognosis
Aaron Angerstein¹, Richard Drake², Vishwajeeth Pasham², Bethany Wolf², Jim Oates² and Tammy Nowling², ¹Medical University of South Carolina, North Charleston, SC, ²Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease predominantly affecting women of childbearing age. Roughly 50% of SLE patients develop Lupus Nephritis (LN),…
Abstract Number: 2416 • ACR Convergence 2024
The Impact of Active Lupus Nephritis on Work Productivity in Patients from a Latin American Lupus Cohort
Romina Nieto¹, Rosana Quintana², Diana Carolina Fernández Ávila³, Rosa Serrano Morales⁴, Guillermina Harvey⁵, Lucia Hernandez⁶, Karen Roberts⁷, Luis Catoggio⁸, Gisela Subils⁹, Carla Gobbi¹⁰, Bordón Florencia Juliana¹¹, Pablo David Ibáñez Peña¹², Leonel Ariel Berbotto¹³, María C. Bertolaccini¹⁴, Diego O. Riseni¹⁵, María De Los Ángeles Gargiulo¹⁶, Cecilia Pisoni¹⁷, Joaquín Martínez Serventi¹⁸, Emilio Buschiazzo¹⁹, Vitalina De Souza Barbosa²⁰, ODIRLEI MONTICIELO²¹, Carolina Albanez de A. Da C. Andrade²², Francinne Machado Ribeiro²³, Eloisa Bonfa²⁴, Eduardo Borba²⁴, Emília Sato²⁵, Alexis Bondi Peralta²⁶, Silvana Donoso²⁷, Gustavo Aroca Martínez²⁸, Hellen Medina²⁸, Alex Echeverri²⁹, Sebastián Molina-Rios³⁰, Manuela Rubio³¹, Rafael López³², Mario Moreno³³, Olga Lidia Vera Lastra³⁴, Mario Pérez Cristóbal³⁵, Carlos Núñez-Álvarez³⁶, luis M Amezcua Guerra³⁷, Ignacio García-Valladares³⁸, Carlos Abud Mendoza³⁹, Dionicio Galarza-Delgado⁴⁰, Marcos Vázquez⁴¹, Astrid Paats⁴², Jorge N. Cieza Calderón⁴³, Ana Mabel Quiroz Alva⁴⁴, Roberto Muñoz Louis⁴⁵, Carina Pizzarossa⁴⁶, Adriana Carlomagno⁴⁷ RV Gamboa-Cardenas⁴⁸, Graciela Alarcon⁴⁹, Urbano Sbarigia⁵⁰, Federico Zazzetti⁵¹, Ashley Orillion⁵², Guillermo Pons-Estel¹ and Bernardo Pons-Estel¹, ¹Centro Regional de Enfermedades Autoinmunes y Reumaticas. GO-CREAR, Rosario, Santa Fe, Argentina, ²Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, ³Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, Rosario, Argentina, ⁴Sanatorio Parque. Centro de Enfermedades Autoinmunes y Reumaticas del Grupo Oroao., Rosario, Argentina, ⁵Escuela de Estadística, Facultad de Ciencias Económicas y Estadística, Universidad Nacional de Rosario, Rosario, Argentina, Rosario, Argentina, ⁶Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), ROSARIO, Santa Fe, Argentina, ⁷Sección Reumatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Sección Reumatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;, Buenos Aires, Argentina, ⁹Hospital Italiano de Córdoba, Córdoba, Argentina, Córdoba, Argentina, ¹⁰Hospital Córdoba, Ciudad de Córdoba, Argentina, Córdoba, Argentina, ¹¹Hospital Privado Universitario de Córdoba, Córdoba, Argentina, ¹²Hospital HIGA San Martín, La Plata, Argentina, La Plata, Argentina, ¹³Unidad de Enfermedades Autoinmunes, Hospital Escuela Eva Perón, Granadero Baigorria, Argentina, Granadero Baigorria, Argentina, ¹⁴Hospital Padilla, Tucumán, Argentina, Tucumán, Argentina, ¹⁵Hospital General de Agudos J.M. Ramos Mejía, Buenos Aires, Argentina, Buenos Aires, Argentina, ¹⁶Instituto de Investigaciones Médicas Alfredo Lanari, Buenos Aires, Argentina, Buenos Aires, Argentina, ¹⁷CEMIC, Buenos Aires, Argentina, ¹⁸Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina, CABA, Argentina, ¹⁹Hospital Señor del Milagro, Salta, Argentina, Salta, Argentina, ²⁰Hospital das Clínicas, Universidade Federal de Goias, Goias, Brazil, Goiânia, Brazil, ²¹HOSPITAL DE CLINICAS DE PORTO ALEGRE, PORTO ALEGRE, Rio Grande do Sul, Brazil, ²²Universidade Federal de Pernambuco, Pernambuco, Brazil, Pernambuco, Brazil, ²³Hospital Universitario Pedro Ernesto, UERJ, Rio De Janeiro, Brazil, Rio de Janeiro, Brazil, ²⁴Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, ²⁵Universidade Federal de Sao Paulo, São Paulo, SP, Brazil, ²⁶Hospital del Salvador, Santiago, Chile, ²⁷Clinical Laboratory Hospital Regional Libertador Bernardo O'Higgins, Rancagua, Chile, Rancagua, Chile, ²⁸Universidad Simón Bolivar, Barranquilla, Colombia, Barranquilla, Colombia, ²⁹Fundación Valle del Lili, Unidad de Reumatología, Colombia, Reumatología, Colombia, ³⁰Facultad de Medicina, Universidad Nacional de Colombia. Hospital Universitario Nacional, Bogotá, Colombia, ³¹Centro de Estudios de Reumatología & Dermatología SAS, Bogotá, Colombia, ³²Servicio de Reumatología. Hospital Luís Vernaza, Guayaquil, Ecuador, Guayaquil, Ecuador, ³³Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador, Guayaquil, Ecuador, ³⁴División de Investigación en Salud, Hospital de Especialidades Dr. Antonio Fraga Mouret, CMN La Raza, CDMX, Mexico, ³⁵Centro Médico Nacional Siglo XXI, CDMX, Mexico, IMMS, Mexico, ³⁶Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico, Mexico, Mexico, ³⁷Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez., México, Mexico, ³⁸Depto. de Inmunología y Reumatología, Hospital General de Occidente y Universidad de Guadalajara, Guadalajara, Mexico, Guadalajara, Mexico, ³⁹Hospital Central Dr. Ignacio Morones Prieto, SLP, México, SLP, Mexico, ⁴⁰UANL Hospital Universitario, Monterrey, Nuevo León, Mexico, ⁴¹Hospital de Clínicas I, Asunción, Paraguay, Asuncion del Paraguay, Paraguay, ⁴²Hospital de Clínicas I, Asunción, Paraguay, ⁴³Hospital Nacional Edgardo Rebagliatti Martins, Lima, Perú, Lima, Peru, ⁴⁴Hospital Cayetano Heredia, Lima, Perú, Lima, Peru, ⁴⁵Hospital Docente Padre Billini, Santo Domingo, República Dominicana, Santo Domingo, Dominican Republic, ⁴⁶Clínica Médica C, Hospital de Clínicas, UDELAR, Montevideo, Uruguay, ⁴⁷Grupo de Investigación de EAIS y Reumatológicas, Montevideo, Uruguay, ⁴⁸Universidad Científica del Sur, Lima, Lima, Peru, ⁴⁹The University of Alabama at Birmingham, Birmingham, AL, ⁵⁰Johnson & Johnson Innovative Medicine, Brussels, Belgium, ⁵¹Johnson & Johnson Innovative Medicine, Horsham, PA, PA, ⁵²Johnson & Johnson Innovative Medicine, Spring House, PA
Background/Purpose: The Latin American Group for the Study of Lupus (GLADEL) 2.0 is an observational prevalent and incident cohort of patients with systemic lupus erythematosus…
Abstract Number: 0636 • ACR Convergence 2024
Evaluation of Clinical, Histological and Biomarker Response After Induction Treatment of Lupus Nephritis (LN)
Danielle Egypto¹, Edgard Reis Neto², Guilherme Carlesso³, Luis Andrade⁴, Luiz Moura³, Debora Calderaro⁵ and Emília Sato⁶, and Emília Inoue Sato; Edgar Torres dos Reis Neto., ¹Federal University of Paraiba, JOÃO PESSOA, Paraiba, Brazil, ²Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal, São Paulo, SP, Brazil, ³Federal University of São Paulo, São Paulo, SP, Brazil, ⁴Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil, ⁵Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, ⁶Universidade Federal de Sao Paulo, São Paulo, SP, Brazil

Background/Purpose: LN occurrs in 50 to 75 percent of SLE patients and is associated with a significant morbimortality. LN presents distinct severity, with frequent flares…
Abstract Number: 0673 • ACR Convergence 2024
BCMA-CD19 Compound CAR-T (cCAR) Safely Provides a Complete Humoral Reset Eliminating All Autoantibodies Resulting in Long-term Medication-Free Complete Remission Among Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) Patients
Yong Yuan¹, Shanzhi He², Wenli Zhang³, Hongyu Zhang⁴, Vincent M DeStefano⁵, Masayuki Wada⁵, Kevin Pinz⁵, Greg Deener⁵, Yu Ma⁶, Min Wang², Fugui Li⁷, Ming Hong¹, Chanjuan Zou², Mingxia Wang², Ling Ding², Yingwen Liang⁸, Yupo Ma⁵ and Weija Wang⁹, ¹Department of Translational Medicine, Zhongshan people's Hospital, Zhongshan, China (People's Republic), ²Department of Rheumatoid Immunology, Zhongshan people's Hospital, Zhongshan, China (People's Republic), ³Department of Hematology, Peking University Shenzhen Hosptial, Shenzhen, China (People's Republic), ⁴Department of Hematology, Peking University Shenzhen Hospital, Shenzhen, China (People's Republic), ⁵iCell Gene Therapeutics, Inc., Stony Brook, NY, ⁶iCAR Bio Therapeutics Ltd, Zhongshan, China (People's Republic), ⁷Department of Translational Medicine. Zhongshan people's Hospital, Zhongshan, China (People's Republic), ⁸Department of Translational Medicine, Zhongshan's people Hospital, Zhongshan, China (People's Republic), ⁹Department of Translational Research, Zhongshan people's Hospital, Zhongshan, China (People's Republic)
Background/Purpose: Medication free complete remission (CR) has been elusive in SLE. An open label investigator-initiated trial (IIT) infused SLE/LN patients with a novel cCAR targeting…
Abstract Number: 1525 • ACR Convergence 2024
Early versus Late Lupus Nephritis: A Meta-analysis of Observational Studies
Alexandre Matar¹ and Omer Pamuk², ¹MetroHealth, Westlake, OH, ²University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disorder characterized by a broad range of clinical and immunological manifestations, one of which is…
Abstract Number: 1813 • ACR Convergence 2024
Elucidating the Molecular Correlates of Treatment Response in Lupus Nephritis via Imaging Mass Cytometry Proteomics and Machine Learning
Frank Sen Hee Tay¹, Anto Sam Crosslee Louis Sam Titus², Vinaika Maruvada², Sandy Lim¹, Jiacai Cho¹, Thomas Thamboo¹ and Chandra Mohan³, ¹National University Hospital, Singapore, Singapore, ²University of Houston, Houston, ³University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Despite the advances in the management…
Abstract Number: 2548 • ACR Convergence 2024
NADPH Oxidase in B Cells and Macrophages Protects Against Murine Lupus by Regulation of TLR7
Rachael Gordon¹, Haylee Cosgrove², Anthony Marinov³, Sebastien Gingras¹, Jeremy Tilstra², Allison Campbell⁴, Sheldon Bastacky¹, Andras Perl⁵, Kevin Nickerson¹ and Mark Shlomchik², ¹University of Pittsburgh, Pittsburgh, ²University of Pittsburgh, Pittsburgh, PA, ³University of Pittsburgh, Homestead, PA, ⁴Yale, New Haven, ⁵SUNY, Syracuse, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by loss of tolerance to nuclear antigens, immune activation, and organ damage. Loss of…
Abstract Number: 0002 • ACR Convergence 2024
Preclinical Evaluation of BCMA And/or CD19 Nanobody-based Single or Compound CAR-T Cells Targeting B and Plasma Cells Associated with Autoimmune Disorders
Byeong Hyeok Choi¹, Vincent M DeStefano², Masayuki Wada², Kevin G Pinz¹, Greg Deener², Nabil Hagag¹, Ahmed Abdel-Razek¹, Yu Ma³, Jing Luo³ and Yupo Ma², ¹iCell Gene Therapeutics Inc., Stony Brook, NY, ²iCell Gene Therapeutics, Inc., Stony Brook, NY, ³iCar Bio Therapeutics Ltd, Zhongshan City, Guangdong, China (People's Republic)
Background/Purpose: CD19 single and BCMA-CD19 compound chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable activity against autoimmune disorders, although relapses with CD19 CAR…
Abstract Number: 0638 • ACR Convergence 2024
Soluble TNF RII in Lupus Nephritis as a Biomarker of Disease Activity and Treatment Response
Ranjan Gupta¹, Sonam Rajput², Jayanth Kumar² and Dipendra K Mitra², ¹All India Institute of Medical Sciences, New Delhi, Delhi, India, ²All India Institute of Medical Sciences, New Delhi, New Delhi, India
Background/Purpose: Lupus Nephritis (LN) affects almost 60-70% patients of Systemic Lupus Erythematosus (SLE). Conventional markers of renal involvement i.e. proteinuria and renal biopsy have limitations…
Abstract Number: 0807 • ACR Convergence 2024
Evaluating Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus (SLE) and SLE Subgroups: Additional Risks Associated with Cardiovascular Events
Rashmi Dhital¹, Rebecca Baer², Kenneth Kalunian³ and Christina Chambers⁴, ¹UC San Diego, Brentwood, TN, ²UC San Diego, San Diego, ³University of California San Diego, La Jolla, CA, ⁴University of California, San Diego, La Jolla, CA
Background/Purpose: Systemic Lupus Erythematosus (SLE) presents substantial risks for both maternal cardiovascular events (CVEs) and adverse pregnancy outcomes, yet, the influence of maternal CVEs on…
Abstract Number: 1534 • ACR Convergence 2024
Use and Safety of Sodium-Glucose Cotransporter-2 Inhibitors Among Patients with Lupus Nephritis and Clinical Indications
April Jorge¹, Kila Panchot², Baijun Zhou², Aakash Patel¹ and Hyon K. Choi³, ¹Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital, Lexington, MA
Background/Purpose: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have nephroprotective and cardioprotective benefits and may have a role in lupus nephritis (LN) treatment. 2023 EULAR SLE treatment guidelines…
Abstract Number: 1841 • ACR Convergence 2024
Preclinical Evaluation of ALLO-329: Allogeneic CD19 CAR T Cells Expressing an Anti-Rejection CD70 CAR for the Treatment of Autoimmune Diseases
Kristen Zhang, Joanne Li, Duy Nguyen, Nguyen Tan, Hsin-Yuan Cheng, David Huang, Suhasni Gopalakrishnan, Zachary Roberts, Cesar Sommer and Elvin Lauron, Allogene Therapeutics, South San Francisco, CA
Background/Purpose: Autologous CD19 chimeric antigen receptor (CAR) T cell therapies have recently shown to be well tolerated and highly effective in patients with autoimmune diseases…

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