Abstracts tagged "lupus nephritis and systemic lupus erythematosus (SLE)"

Abstract Number: 755 • 2015 ACR/ARHP Annual Meeting
Validating the RAIL Algorithm in Adult Lupus Nephritis Patients
Gaurav Gulati¹, Khalid Abulaban², Jun Ying³, Xiaolan Zhang⁴, Huijuan Song⁵, Qing Ma⁶, Christopher Haffner⁶, Kasha Wiley⁷, Michael Bennett⁸, Brad H. Rovin⁵ and Hermine I. Brunner⁹, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴Ohio State University, Columbus, OH, ⁵Ohio State University Medical Center, Columbus, OH, ⁶Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Division of Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁹Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Lupus Nephritis (LN) significantly contributes to morbidity and mortality among Systemic Lupus Erythematosus (SLE) patients. We have established the Renal Activity Index for Lupus…
Abstract Number: 1071 • 2015 ACR/ARHP Annual Meeting
Single-Cell RNA Sequencing of Human Podocytes, Endothelial Cells, and Tubular Cells Identifies Markers and Gene Profiles Differentiating Class IV and Class V Renal Disease in Lupus Nephritis
Evan Der¹, Kemal Akat², Robert Clancy³, Beatrice Goilav⁴, Anna R. Broder⁵, H. Michael Belmont⁶, Peter M. Izmirly⁷, Nicole Jordan⁸, Tao Wang⁹, James Pullman¹⁰, Daniel Schwartz¹⁰, Ming Wu¹¹, Thomas Tuschl², Jill P. Buyon³ and Chaim Putterman¹², ¹Albert Einstein College of Medicine, Bronx, NY, ²Rockefeller University, New York, NY, ³Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁵Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ⁶Hosp for Joint Disease, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY, ⁸Montefiore Medical Center, New York, NY, ⁹Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, ¹⁰Pathology, Albert Einstein College of Medicine, Bronx, NY, ¹¹Pathology, New York University School of Medicine, New York, NY, ¹²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Currently, classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Transcriptome analysis may accurately differentiate types of renal involvement,…
Abstract Number: 1845 • 2015 ACR/ARHP Annual Meeting
HMGB1 Early Marker in Lupus Nephritis
Aisha Badawy¹, Randa Salam², Hanan Fouad³, Amira Bassam⁴ and Sahar Lashen⁵, ¹Internal medicine cairo university, professor of internal medicine and rheumatology, cairo, Egypt, ²Internal medicine cairo university, Assistant professor internal medicine, cairo, Egypt, ³medical biochemistry cairo university, Professor of medical biochemistry, cairo, Egypt, ⁴pathology Cairo university, Lecturer of Pathology Cairo university, cairo, Egypt, ⁵Internal medicine, assistant lecturer of internal medicine cairo university, cairo, Egypt
Background/Purpose: Systemic Lupus Erythematosis is a systemic autoimmune disease characterised by involvement of multiple organ systems Lupus nephritis (LN) is a severe and frequent manifestation…
Abstract Number: 1847 • 2015 ACR/ARHP Annual Meeting
Serum Ferritin and Insulin-like Growth Factor-Binding Protein 2 As Biomarkers of Clinical and Histopathological Treatment Response in Lupus Nephritis
Ioannis Parodis¹, Huihua Ding², Agneta Zickert¹, Chandra Mohan² and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of Systemic Lupus Erythematosus (SLE). Renal biopsy is gold standard for evaluation of renal activity and damage…
Abstract Number: 1849 • 2015 ACR/ARHP Annual Meeting
Serum Axl and Tumor Necrosis Factor Receptor II Portend Long-Term Renal Outcome in Lupus Nephritis
Ioannis Parodis¹, Huihua Ding², Agneta Zickert¹, Chandra Mohan² and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of Systemic Lupus Erythematosus (SLE). Renal biopsy is gold standard for evaluation of renal activity and damage.…
Abstract Number: 1850 • 2015 ACR/ARHP Annual Meeting
Increased Levels of Immunoglobulin Binding Protein 1 Are Associated with Disease Activity Including Renal Damage in Patients with Systemic Lupus Erythematosus
Eun-Ju Lee^1,2, Seokchan Hong³, Doo-Ho Lim¹, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Asan Institute for Life Science, Asan Medical Center, Seoul, South Korea, ³Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: Systemic lupus erythematous (SLE) is a multisystem autoimmune inflammatory disease. Lupus nephritis (LN) is one of the most serious complications in patients with SLE.…
Abstract Number: 2692 • 2014 ACR/ARHP Annual Meeting
Up-Regulated Expression of CXCR4 on Circulating B Cells in Patients with Systemic Lupus Erythematosus
Hironari Hanaoka¹, Yuka Okazaki¹, Akinori Hashiguchi², Hidekata Yasuoka³, Tsutomu Takeuchi¹ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Pathology, Keio University School of Medicine, Tokyo, Japan, ³Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose It is increasingly appreciated that circulating B cells are functionally altered and are involved in pathogenic process in patients with systemic lupus erythematosus (SLE).…
Abstract Number: 2089 • 2014 ACR/ARHP Annual Meeting
The APOL1 Gene Is Not Associated with Lupus Nephritis in Individuals with Enriched Amerindian Ancestry
Julio Molineros¹, Hannah Ainsworth², Robert Kimberly³, Michelle Petri⁴, Rosalind Ramsey-Goldman⁵, Luis M. Vilá⁶, John D. Reveille^7,8, Elizabeth E. Brown⁹, Swapan Nath¹, Carl D. Langfeld¹⁰, Bernardo Pons-Estel on behalf of GENLES¹¹, Graciela S. Alarcon¹² and Marta E. Alarcon Riquelme¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Wake Forest, Winston-Salem, NC, ³University of Alabama, Birmingham, AL, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheumatology, Northwestern University and Feinberg School of Medicine, Chicago, IL, ⁶Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ⁷Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁸Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰Department of Biostatistics, Wake Forest University Health Sciences, Winston-Salem, NC, ¹¹Sanatorio Parque, Rosario, Argentina, ¹²Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
The APOL1 Gene is not Associated with Lupus Nephritis in Individuals with Enriched Amerindian AncestryBackground/Purpose: The APOL1 gene coding variants G1 and G2 have been…
Abstract Number: 1671 • 2014 ACR/ARHP Annual Meeting
Renal Relapses Are Common in Lupus Nephritis
Angela Pakozdi¹, Ravindra Rajakariar², Michael Sheaff³ and Dev Pyne¹, ¹Rheumatology, Barts Health NHS Trust, London, United Kingdom, ²Renal Medicine, Barts Health NHS Trust, London, United Kingdom, ³Histopathology, Barts Health NHS Trust, London, United Kingdom
Background/Purpose Renal relapses are part of the natural history of lupus nephritis (LN) and represent a significant challenge not only because they are associated with…
Abstract Number: 1661 • 2014 ACR/ARHP Annual Meeting
Are Repeat Renal Biopsies Important in Managing Lupus Nephritis Flares?
Angela Pakozdi¹, Ravindra Rajakariar², Michael Sheaff³ and Dev Pyne¹, ¹Rheumatology, Barts Health NHS Trust, London, United Kingdom, ²Renal Medicine, Barts Health NHS Trust, London, United Kingdom, ³Histopathology, Barts Health NHS Trust, London, United Kingdom
Background/Purpose Lupus nephritis (LN) is the major cause of morbidity and mortality in patients with systemic lupus erythematosus. The role of repeat kidney biopsies (RB)…
Abstract Number: 1610 • 2014 ACR/ARHP Annual Meeting
New Autoantigens Associated with Lupus Nephritis
Sachiko Onishi¹, Yuki Tanaka², Tatsuhiko Miyazaki³, Jun Ishizaki¹, Takuya Matsumoto¹, Endy Adnan¹, Hitoshi Yamasaki⁴, Koichiro Suemori¹, Takafumi Okura⁵, Masaki Yasukawa¹ and Hitoshi Hasegawa⁶, ¹Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan, ²Integrated Center for Sciences, Ehime University, Toon, Japan, ³Division of Pathology, Gifu University Hospital, Gifu, Japan, ⁴Department of Hematology, Clinical Immunology, and Infectious Disease, Ehime University Graduate School of Medicine, Toon, Japan, ⁵Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Japan, ⁶Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan
[Background/Purpose ] Systemic lupus erythematosus (SLE) is characterized by the production of a variety of autoantibodies and is considered a prototype immune complex disease. Anti-dsDNA…
Abstract Number: 1606 • 2014 ACR/ARHP Annual Meeting
Profiling a Broad Range of Autoantibodies in Healthy and Systemic Lupus Erythematosis Revealed Autoantibody Patterns Associated with Autoantibody Transition and Disease Activity
Quan-Zhen Li Li¹, Edward Wakeland², Prithvi Raj³, Honglin Zhu², Xiaoxia Zuo⁴, Mei Yan⁵ and Indu Raman⁶, ¹Immunology and internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Immunology, University of Texas Southwestern Medical Center, Dallas, TX, ³Immunology, University of Texas Southwestern Medical Center, dallas, TX, ⁴Rheumatology, Xiangya Hospital of Hunan Medical Univ, Changsha, China, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Autoantibodies targeting to nuclear antigens are serological hallmarks of SLE, however, the processing of autoantibody production during the transition from normal to autoimmunity and…
Abstract Number: 1306 • 2014 ACR/ARHP Annual Meeting
Outcome of Lupus Nephritis in Children Less Than 12 Years Old from North-India
Anju Gupta, Bonnie Abujam, Deepti Suri, Amit Rawat and Surjit Singh, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Background/Purpose Studies on lupus nephritis in young children below 12 years of age from developing countries are limited. This study looks at long-term outcome in…
Abstract Number: 959 • 2014 ACR/ARHP Annual Meeting
Discoid Lupus Onset and Decrease Risk of Renal Disease in Patients with Systemic Lupus Erythematosus: Data from a Large Latin American Cohort
Guillermo J. Pons-Estel¹, Gaobin Bao², Bernado Pons-Estel³, Daniel Wojdyla⁴, Veronica Saurit^5,6, Alejandro J. Alvarellos⁷, Francisco Caeiro⁸, Emilia I. Sato⁹, Enrique R. Soriano¹⁰, Lilian Tereza Costallat¹¹, Oscar Neira¹², Antonio A. Iglesias-Gamarra¹³, Gil Reyes Llerena¹⁴, Mario Cardiel¹⁵, Eduardo M. Acevedo-Vásquez¹⁶, Rosa Chacon¹⁷ and Cristina M. Drenkard¹⁸, ¹Servicio de Enfermedades Autoinmunes, Department of Autoimmune Diseases, Institut Clìnic de Medicina i Dermatologia, Hospital Clìnic, Barcelona, Spain, ²Medicine, Emory University, Atlanta, GA, ³Hospital Provincial de Rosario, Rosario, Argentina, ⁴Universidad Nacional de Rosario, Argentina, Rosario, Argentina, ⁵Rheumatology, Hospital Privado Córdoba, Cordoba, Argentina, ⁶Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina, ⁷Reumatología, Hospital Privado Córdoba, Córdoba, Argentina, ⁸Naciones Unidas 346, Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ⁹Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ¹⁰Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ¹¹RUA EZEQUIEL MAGALHAES,26, Unicamp, Campinas, Brazil, ¹²Rheumatology Section, Univ of Chile Hosp Salvador, Santiago, Chile, ¹³Facultad de Medicina- Departamento de Medicina-Unidad de Reumatología, Professor-Universidad Nacional de Colombia, Bogota, Colombia, ¹⁴Servicio Nacional de Reumatología, Centro de Investigaciones Médico Quirúrgicas (CIMEQ), La Habana, Cuba, ¹⁵Unidad de Investigación ‘Dr. Mario Alvizouri Muñoz’, Secretaría de Salud de Michoacán, Morelia, Mexico, ¹⁶Rheumatology, Hospital Nacional “Guillermo Almenara Irigoyen”, Lima, Peru, ¹⁷Servicio de Reumatología, Hospital Universitario, Centro Nacional de Enfermedades Reumáticas and Hospital de Clínicas Caracas, Caracas, Venezuela, ¹⁸Medicine, Div Rheumatology, Emory University, Atlanta, GA
Background/Purpose .Early data derived from small selected samples suggest that discoid lupus erythematosus (DLE) is negatively associated with renal involvement in patients with SLE. Recent…
Abstract Number: 640 • 2014 ACR/ARHP Annual Meeting
A Peptide Mimic Inhibits the Cross Reaction of Anti-DNA Antibodies with Glomerular Antigens
Yumin Xia¹, Ertan Eryilmaz², Rahul Pawar¹, David Cowburn² and Chaim Putterman³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, ³The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high titers of multiple autoantibodies. Of those, anti-DNA antibodies play a key role in…

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