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Abstracts tagged "lupus-like disease"

  • Abstract Number: 1732 • ACR Convergence 2022

    Novel Human Class II MHC Tetramers Detect Rare, Self-Reactive CD4+ T Cells Relevant to Mixed Connective Tissue Disease

    Shawn Mahmud, Thamotharampillai Dileepan, Bryce Binstadt and Marc Jenkins, University of Minnesota, Minneapolis, MN

    Background/Purpose: Nearly all patients with mixed connective tissue disease (MCTD) have IgG autoantibodies (autoAb) specific for U170k, a component of the U1-snNRP spliceosomal complex. A…
  • Abstract Number: PP14 • ACR Convergence 2022

    The Use of Social Support as Treatment

    Aleta McLean, Open Hand Atlanta, Atlanta, GA

    Background/Purpose: The months leading up to my diagnosis were frustrating. Initially my hair started falling out. I was told it was stress related. I was…
  • Abstract Number: 0662 • ACR Convergence 2022

    Partial Correlations Network Models Show Th1, Th2 and Th17 Responses to Be Interlinked in Dermal Pathogenesis of Cutaneous Lupus Erythematous

    Felix Chin1, Thomas Vazquez2, Josh Dan3, DeAnna Diaz4, Grant Sprow5, Jay Patel6, Nilesh Kodali7, Rui Feng8 and Victoria Werth9, 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2FIU Wertheim College of Medicine, Virginia Beach, VA, 3Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 4Philadelphia College of Medicine, Philadelphia, PA, 5Albert Einstein College of Medicine, Philadelphia, PA, 6Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PN, 7New Jersey Medical School, Coppell, TX, 8University of Pennsylvania, Philadelphia, 9University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Background/Purpose: The immunopathogenesis of cutaneous lupus erythematous (CLE) is highly diverse and involves activity of many different cell types and pathways. This heterogeneity is believed…
  • Abstract Number: 0667 • ACR Convergence 2022

    Correlation Matrices Visualize Differential Degree of Cell and Pathway Heterogeneity in Skin of Cutaneous Lupus Erythematosus Treatment Subgroups

    Felix Chin1, Thomas Vazquez2, Josh Dan3, DeAnna Diaz4, Grant Sprow5, Jay Patel6, Nilesh Kodali7, Rui Feng8 and Victoria Werth9, 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2FIU Wertheim College of Medicine, Virginia Beach, VA, 3Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 4Philadelphia College of Medicine, Philadelphia, PA, 5Albert Einstein College of Medicine, Philadelphia, PA, 6Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PN, 7New Jersey Medical School, Coppell, TX, 8University of Pennsylvania, Philadelphia, 9University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Background/Purpose: First-line treatment for cutaneous lupus erythematosus involves the use of antimalarials. Treatment response is highly variable with some patients responding well to hydroxychloroquine (HCQ),…
  • Abstract Number: 0795 • ACR Convergence 2022

    Post-Acute COVID-19 Sequalae (PACS) with New-onset Rheumatological Complications

    Neel Thanavala1, Kiho Son2, Nardien Sedhom2, Snehal Somalwar3, Zil Patel1, Rameen Jamil2, Carmen Venegas2, Ashutosh Thakar2, Agnes Yuen4, Melanie Kjarsgaard2, Susan Waserman2, Mylinh Duong2, Parameswaran Nair2, Christopher Carlsten4, Maggie Larche2, Terence Ho2, Sarah Svenningsen2, KONSTANTINOS TSELIOS5 and Manali Mukherjee2, 1The Research Institute of St. Joe's Hamilton, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3The Research Institute of St Joe's Hamilton, Hamilton, ON, Canada, 4University of British Columbia, Vancouver, BC, Canada, 5McMaster University, Population Health Research Institute, Hamilton, ON, Canada

    Background/Purpose: Post-Acute Sequalae of COVID-19 (PASC), prevalent in ~20-30% of convalescent COVID-19 patients is characterized by new/persistent symptoms after the initial recovery. Certain autoantibodies have…
  • Abstract Number: 1484 • ACR Convergence 2022

    Management of the Heightened Risk for Clinical Events from Atherosclerotic Cardiovascular Disease (ASCVD) in an Established Cohort of Lupus Erythematosus Patients

    Megan Zhao1, Kevin Williams2, Douglas Jacoby3, Rui Feng4 and Victoria Werth5, 1Perelman School of Medicine, Philadelphia, 2Temple University Hospital System, Philadelphia, 3University of Pennsylvania Health System, Philadelphia, 4University of Pennsylvania, Philadelphia, 5Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

    Background/Purpose: Lupus erythematosus (LE) patients are at heightened risk of clinical events, chiefly heart attacks and strokes, caused by ASCVD. To address this problem, we…
  • Abstract Number: 1689 • ACR Convergence 2022

    Oral Ginger Supplementation Counteracts NETosis in Autoimmune Mouse Models and in Healthy Humans

    Ramadan Ali1, Miela Zahavi2, Christine Rysenga1, Cyrus Sarosh3, Claire Hoy1, Kristen Demoruelle4 and Jason S Knight5, 1University of Michigan, Ann Arbor, MI, 2Universtiy of Michigan, Ann Arbor, MI, 3University of Michigan, Temperance, MI, 4University of Colorado Anschutz Medical Campus, Aurora, CO, 5University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: It has previously been reported that 6-gingerol, the most abundant phytochemical in ginger root, inhibits neutrophil phosphodiesterase activity and thereby counteracts neutrophil hyperactivity in…
  • Abstract Number: 1721 • ACR Convergence 2022

    Protective Effects of the Natural Antioxidant Taxifolin in Models of Lupus and Antiphospholipid Syndrome

    Christine Rysenga1, Linda May-Zhang2, Miela Zahavi3, Jason S Knight4 and Ramadan Ali1, 1University of Michigan, Ann Arbor, MI, 2Blue California, Rancho Santa Margarita, CA, 3Universtiy of Michigan, Ann Arbor, MI, 4University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: Taxifolin, also known as dihydroquercetin, is a bioactive flavonoid commonly found in apples, onions, French maritime bark, and milk thistle. Given its potent anti-inflammatory…
  • Abstract Number: 0537 • ACR Convergence 2021

    The Clinical, Oral Small Molecule IRAK4 Inhibitor, GS-5718, Improves Survival and Reduces Disease Pathologies by Modulating Multiple Inflammatory Endpoints in the Murine NZB/W Model of Spontaneous Lupus

    Adam Yadon1, Vanessa Gorney2, Angie Hammond3, Ethan Grant2 and Astrid Clarke3, 1Gilead Sciences, Inc., Seattle, WA, 2Gilead Sciences, Inc, Foster City, CA, 3Gilead Sciences, Inc, Seattle, WA

    Background/Purpose: Lupus is a heterogenous autoimmune disease characterized by loss of immune tolerance, production of nucleic acid:autoantibody immune complexes, immune cell hyperactivation, and increased proinflammatory…
  • Abstract Number: 0539 • ACR Convergence 2021

    Vgll3-transgenic Autoimmune Mice Display Features of Cutaneous Fibrosis

    Mehrnaz Gharaee-Kermani1, Allison Billi2, Marisa Hildebrandt2, Jacob Martens3, Rachael Wasikowski2, Joanne (Michelle) Kahlenberg1 and Johann Gudjonsson2, 1Internal Medicine - Division of Rheumatology and Department of Dermatology, University of Michigan, Ann Arbor, MI, 2Department of Dermatology, University of Michigan, Ann Arbor, MI, 3Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI

    Background/Purpose: Fibrosis is characterized by collagen deposition, fibro/myofibroblast accumulation, and extracellular matrix remodeling and can lead to disfiguring skin changes. In cutaneous lupus, scar formation…
  • Abstract Number: 0436 • ACR Convergence 2020

    The Addressing Lupus Pillars for Health Advancement (ALPHA) Project: Establishing Consensus and Prioritization of Global Community Recommendations to Address Major Challenges in Lupus Diagnosis, Care, Treatment and Research

    Karin Tse1, Sanjyot Sangodkar2, Kathleen Arntsen3, Sang-Cheol Bae4, Lauren Bloch2, Ian Bruce5, Erin Connolly-Strong6, Karen Costenbader7, Thomas Dörner8, Sydney Evans9, Timothy Franson2, Kenneth Getz10, Amy Kao11, Kenneth Kalunian12, Bradley Dickerson13, Susan Manzi14, Eric Morand15, Yaritza Peña10, Sandra Raymond16, Brad Rovin17, Laura Schanberg18, Joan Von Feldt19, Victoria Werth20, Angel Williams21, David Zook2 and Leslie Hanrahan16, 1Lupus Foundation of America, DC, WA, 2Faegre Drinker Consulting, Washington, DC, 3Lupus and Allied Diseases Association, Inc., Verona, NY, 4Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 5Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 6Mallinckrodt, Austin, TX, 7Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 8DRFZ and Charité University Hospitals, Berlin, Germany, 9Lupus Patient Representative, Riverdale, MD, 10Tufts Center for the Study of Drug Development, Boston, MA, 11EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 12University of California San Diego, La Jolla, CA, 13Aurinia Pharmaceuticals, Fort Washington, PA, 14Lupus Center of Excellence, Autoimmunity Institute, Allegheny Health Network, Pittsburgh, PA, 15Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 16Lupus Foundation of America, Washington, DC, 17The Ohio State University, Columbus, 18Duke University Medical Center, Durham, NC, 19GlaxoSmithKline, WILMINGTON, DE, 20University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 21Lupus Patient Representative, Richmond, VA

    Background/Purpose: The Addressing Lupus Pillars for Health Advancement (ALPHA) Project is a global consensus effort to identify, prioritize and address top barriers in lupus impacting…
  • Abstract Number: 0845 • ACR Convergence 2020

    Hematopoietic Specific Deficiency of Rho Kinase Attenuates Neutrophil NETosis and UVB-induced Skin Inflammation

    Minghui Li1, Xing Lyu1, Yubin Li2, James Liao3, Victoria Werth4 and Ming-Lin Liu1, 1University of Pennsylvania, philadelphia, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 3University of Chicago, Chicago, 4University of Pennsylvania and Corporal Michael J. Crescenz Veterans Administration Hospital, Philadelphia

    Background/Purpose: Neutrophils are the most abundant leukocytes and the first to be recruited to the site of photodamage after ultraviolet B (UVB) exposure. We have…
  • Abstract Number: 1449 • ACR Convergence 2020

    Altered Splicing in Leukocytes from Patients with Antiphospholipid Syndrome, Systemic Lupus Erythematosus and Antiphospholipid Syndrome with Lupus: Clinical Involvement

    Alejandra Maria Patiño-Trives1, Alejandro Ibáñez-Costa2, Carlos Pérez-Sánchez1, Laura Pérez-Sanchez3, Maria Luque-Tevar1, Iván Arias de la Rosa1, María-Carmen Abalos-Aguilera1, Desirée Ruiz-Vilchez4, Pedro Segui5, Mario Espinosa5, Nuria Barbarroja1, Eduardo Collantes4, Justo P. Castaño5, Raul M Luque5, María de los ángeles Aguirre-Zamorano5 and Chary Lopez-Pedrera1, 1Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, 2IMIBIC/University of Cordoba/Reina Sofia Hospital, Córdoba, 3Hospital Universitario Reina Sofía, Córdoba, Spain, 4Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, 5IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba

    Background/Purpose: To identify shared and differential changes in the splicing machinery of immune cells from antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and antiphospholipid syndrome…
  • Abstract Number: 1611 • ACR Convergence 2020

    Documentation of Pregnancy Counseling in SSA-Positive Patients of Childbearing Potential: A Cross-Sectional Study

    Heinrich-Karl Greenblatt1 and Elena Weinstein1, 1University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Systemic lupus erythematosus (SLE) and primary Sjogren's Syndrome (SS) are highly associated with anti-SSA (anti-Ro) seropositivity. Anti-SSA autoantibodies may cross the placenta, causing a…
  • Abstract Number: 1811 • ACR Convergence 2020

    Distinctive Molecular Signatures Among Monocytes from Childhood- and Adult-onset Systemic Lupus Erythematosus: Clinical Involvement and Relevance of Sustained Anti-dsDNA Positivity

    Alejandra Maria Patiño-Trives1, Concepción Aranda-Valera2, R Roldan3, Laura Pérez-Sanchez4, Carlos Pérez-Sánchez1, Maria Luque-Tevar1, Iván Arias de la Rosa1, María-Carmen Abalos-Aguilera1, Desirée Ruiz-Vilchez2, Pedro Segui5, Mario Espinosa5, Nuria Barbarroja1, Eduardo Collantes2, María de los ángeles Aguirre-Zamorano5 and Chary Lopez-Pedrera1, 1Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, 2Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, 3Hospital Universitario Reina Sofía, Cordoba, Spain, 4Hospital Universitario Reina Sofía, Córdoba, Spain, 5IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba

    Background/Purpose: By using integrative transcriptomic and protein analyses, this study aimed at identifying and characterize distinctive molecular signatures between childhood-onset (cSLE) and adult-onset Lupus (aSLE)…
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