Abstracts tagged "Lung Disease"

Abstract Number: 2998 • 2014 ACR/ARHP Annual Meeting
Screening for Interstitial Lung Disease in Systemic Sclerosis: Performance of High-Resolution Computed Tomography with Limited Number of Slices – a Prospective Study
Thomas Frauenfelder¹, Anna Winklehner¹, Thi Dan Linh Nguyen¹, Rucsandra Dobrota^2,3, Stephan Baumüller¹, Britta Maurer² and Oliver Distler², ¹Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ²Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Background/Purpose Early diagnosis of interstitial lung disease (ILD), currently the main cause of death in systemic sclerosis (SSc), is needed. The gold standard is high…
Abstract Number: 2922 • 2014 ACR/ARHP Annual Meeting
Association of Single Nucleotide Polymorphisms of PADI4 Gene with Susceptibility to Rheumatoid Arthritis-Related Lung Disease
Seong-Wook Kang¹, Seung-Taek Song¹, Song Soo Kim², Ji Young Kim¹, So Young Lee¹, Su-Jin Yoo³, In-Seol Yoo¹, Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Radiology, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose Rheumatoid arthritis (RA) causes a myriad of pulmonary complications, including bronchiolitis and bronchiectasis, pleuritis, and interstitial lung disease (ILD). Recently, several studies have shown…
Abstract Number: 2702 • 2014 ACR/ARHP Annual Meeting
Key Roles for Mir-155 and Mir-21 in Progressive Lung Fibrosis Associated with Systemic Sclerosis (SSc-ILD)
Romy Christmann¹, Percival D Sampaio-Barros², Claudia Borges³, Carlos Carvalho⁴, Ronaldo A Kairalla⁵, Edwin R. Parra⁶, Giuseppina Stifano⁷, Avi Spira⁸, Robert W. Simms⁹, Vera L. Capelozzi⁶ and Robert Lafyatis¹⁰, ¹Rheumatology, Arthritis Center/Rheumatology, Boston, MA, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, ⁴Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁵Division of Pulmonology - Heart Institute (InCor) - Medical School, University of Sao Paulo, Sao Paulo, Brazil, ⁶Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁷Rheumatology, Boston University Medical Center, Boston, MA, ⁸Boston University School of Medicine, Boston, MA, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰Arthritis Center, Boston University, Boston, MA
Background/Purpose We have already reported that macrophage activation, and up-regulation of TGF-beta- and interferon-regulated genes are involved in progressive SSc-ILD. Micro-rnas (miRNA) are a class…
Abstract Number: 1259 • 2014 ACR/ARHP Annual Meeting
A Multi-Center Study for Validation of a New Assay for Anti-Melanoma Differentiation-Associated Gene 5 (MDA5) Autoantibody
Shinji Sato¹, Akihiro Murakami², Akiko Kuwajima³, Kazuhiko Takehara⁴, Tsuneyo Mimori⁵, Atsushi Kawakami⁶, Michiaki Mishima⁷, Takafumi Suda⁸, Mariko Seishima⁹, Manabu Fujimoto¹⁰ and Masataka Kuwana¹¹, ¹Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, ²Medical & Biological Laboratories Co., Ltd, Nagaya, Japan, ³Medical & Biological Laboratories Co.,Ltd., Nagoya, Japan, ⁴Dermatology, Kanazawa University, Kanazawa, Japan, ⁵Dept of Rheum & Clinical Immunology, Kyoto Univ Grad Schl of Med, Kyoto, Japan, ⁶Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Kyoto, Japan, ⁸Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan, ⁹Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, ¹⁰Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose Anti-Melanoma Differentiation-Associated Gene 5 (MDA5) antibody is found specifically in patients with dermatomyositis (DM). This autoantibody is associated with clinically amyopathic DM (CADM) and…
Abstract Number: 755 • 2014 ACR/ARHP Annual Meeting
Increased Degradation of BMPR2 in a TGFβ Dependent Transgenic Mouse Model of Scleroderma with Susceptibility to Pulmonary Arterial Hypertension
Adrian J Gilbane¹, Emma C. Derrett-Smith², Andrew Pearce³, Christopher P Denton⁴ and Alan M. Holmes⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ³Respiratory Disease Area, Novartis, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose Scleroderma patients are susceptible to development of pulmonary arterial hypertension (PAH) that has similarities to some forms of heritable PAH. The basis for this…
Abstract Number: 732 • 2014 ACR/ARHP Annual Meeting
Predictors of Inpatient Mortality in Patients with Systemic Sclerosis: A Case Control Study
Shiv Tej Sehra¹, Chris T. Derk¹, Andrew Kelly² and Joshua Baker³, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Medicine, Pennsylvania Hospital, Philadelphia, PA, ³Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA
Background/Purpose There are few published studies on predictors of inpatient mortality in patients with systemic sclerosis (SSc). Knowledge of these predictors is important for early…
Abstract Number: 437 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Heat Shock Protein 90 Antibodies Identified in Bronchoalveolar Lavage Fluid Are a Marker of Lung-Specific Immune Responses
Lisa Harlow¹, Bernadette Gochuico², Ivan Rosas³, Tracy Doyle⁴, Juan Osorio⁴, Timothy Travers⁵, Carlos Camacho⁶, Chester V. Oddis⁷ and Dana P. Ascherman⁸, ¹Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ²Medical Genetics Branch, National Institutes of Health, Bethesda, MD, ³Medicine/Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁴Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁵Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁶Compuational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Background/Purpose . Previous work has demonstrated an association between serum anti-citrullinated HSP90 antibodies and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). To further investigate this potential…
Abstract Number: 413 • 2014 ACR/ARHP Annual Meeting
Association of Antinuclear Antibodies with Lung Disease, Malignancy and Joint Replacement in Rheumatoid Arthritis
Reshmi Raveendran¹, Bobby Kwanghoon Han², Quan-Zhen Li³ and Nancy J. Olsen¹, ¹Medicine, Penn State MS Hershey Medical Center, Hershey, PA, ²Rheumatology, Cooper Medical School of Rowan University, Camden, NJ, ³Immunology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose Antinuclear antibodies (ANAs) are present in a significant proportion of patients with rheumatoid arthritis (RA). Positivity for ANA in RA has been associated with…
Abstract Number: 236 • 2014 ACR/ARHP Annual Meeting
Risk Factors for Prevalent and Progressive Bone Deficits Among Adult Men and Women with Cystic Fibrosis
Joshua Baker¹, Putman Melissa², Karen Herlyn³, Angela S. Pizzo⁴, Allen Lapey⁵, Joel Finklestein² and Peter A. Merkel⁶, ¹Medicine/Rheumatology, Philadelphia VA Medical Center, Philadelphia, PA, ²Harvard University, Boston, MA, ³Department of Rheumatology, University Hospital Schleswig-Holstein, Lübeck, Germany, ⁴Mercy Hospital, Portland, ME, ⁵Cystic Fibrosis Center and Division of Pediatric Pulmonology, Massachusetts General Hospital, Boston, MA, ⁶University of Pennsylvania, Philadelphia, PA
Risk Factors for Prevalent and Progressive Bone Deficits Among Adult Men and Women with Cystic FibrosisBackground/Purpose Cystic Fibrosis (CF) is associated with an increased risk…
Abstract Number: 147 • 2014 ACR/ARHP Annual Meeting
US Lung Examination in SSc Patients: A Comparison of Two Different Scoring Systems
Andrea Delle Sedie¹, Cristina Lodato¹, Elisa Cioffi¹, Linda Carli², Stefano Bombardieri¹ and Lucrezia Riente¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²GenOMeC PhD, University of Siena, Siena, Italy
Background/Purpose Systemic sclerosis (SSc) is a disease characterized by a progressive fibrosis of the skin and internal organs, which can lead to death. Lung involvement…
Abstract Number: 2902 • 2013 ACR/ARHP Annual Meeting
Key Roles For Interferon and Macrophage Activation In Progressive Lung Fibrosis Associated With Systemic Sclerosis
Romy Christmann¹, Giuseppina Stifano², Claudia Borges³, Carlos Carvalho⁴, Ronaldo Kairalla⁴, Edwin R. Parra⁵, Avrum Spira⁶, Robert W. Simms¹, Percival Sampaio-Barros⁷, Vera L. Capelozzi⁵ and Robert Lafyatis¹, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, ⁴Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁵Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁶Computational Biomedicine, Boston University School of Medicine, Boston, MA, ⁷Rheumatology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Background/Purpose: Interstitial lung disease associate with Systemic Sclerosis(SSc-ILD) is one of the leading causes of mortality. We analyzed the gene expression of lung tissue in…
Abstract Number: 651 • 2013 ACR/ARHP Annual Meeting
Growth Differentation Factor-15, a Marker Of lung disease In Systemic Sclerosis, Is Involved In Fibrosis Development But Does Not Impair Fibrosis Development
Stijn Lambrecht¹, Vanessa Smith², Katelijne De wilde³, Julie Coudenys⁴, Filip De Keyser² and Dirk Elewaut⁵, ¹Dept of Rheumatology, Laboratory for Molecular Immunology and Inflammation, Ghent University, Ghent, Belgium, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Deptartment of Rheumatology, Ghent University, Ghent, Belgium, ⁴Dept of Rheumatology, Ghent University, Ghent, Belgium, ⁵Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose: It is generally known that members of the TGF-β superfamily are involved in the regulation of connective tissue biology in systemic sclerosis (SSc). Growth…
Abstract Number: 2685 • 2013 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase 3/4 Cross-Reactive Antibodies Are Associated With Radiographic Interstitial Lung Disease In Rheumatoid Arthritis, An Effect Potentiated By Smoking
Jon T. Giles¹, Erika Darrah², Sonye K. Danoff³, Cheilonda Johnson⁴, Felipe Andrade⁵, Antony Rosen² and Joan M. Bathon⁶, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ³Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, ⁴Medicine/Pulmonology, Johns Hopkins University, Baltimore, MD, ⁵Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Columbia University, New York, NY
Background/Purpose: Antibodies targeting citrullinated proteins (ACPA) are implicated in the pathogenesis of interstitial lung disease (ILD) in rheumatoid arthritis (RA). Citrullinated proteins and the enzymes…
Abstract Number: 423 • 2013 ACR/ARHP Annual Meeting
Serological Biomarkers For The Development Of Rheumatoid Arthritis Related Interstitial Lung Disease
Elena Nikiphorou¹, Esther Chan², Vadivelu Saravanan², Julie Dawson³, Navtej Sathi⁴, Felix Woodhead⁵, Mohamed Nisar⁶, Subhashini Arthanari⁶, Yasmeen Ahmad⁷, Adam Young⁸ and Clive Kelly², ¹Research Department of Epidemiology & Public Health, UCL and Rheumatology Department, St Albans City Hospital, ERAS, St Albans City Hospital & University College London (UCL), London, United Kingdom, ²Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom, ³Rheumatology, St Helens Hospital, St Helens, United Kingdom, ⁴Rheumatology, Wrightington Hospital, Wigan, United Kingdom, ⁵Respiratory, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, ⁶Rheumatology, Burton Hospital, Burton-on-Trent, United Kingdom, ⁷Department of Rheumatology, Peter Maddison Research Centre, Bangor, United Kingdom, ⁸Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom
Background/Purpose: Interstitial Lung Disease (ILD) is the commonest manifestation of lung disease in Rheumatoid Arthritis (RA) and the only complication reported to be increasing in…
Abstract Number: 2573 • 2013 ACR/ARHP Annual Meeting
The Role Of STAT-3 In The Development Of Pulmonary and Dermal Fibrosis
Mesias Pedroza¹, Sarah To¹, Anuh T. George¹, David J. Tweardy² and Sandeep K. Agarwal¹, ¹Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis is the accumulation of excessive extra-cellular matrix in tissues, leading to tissue damage. In systemic sclerosis, the trigger is postulated to be an…

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