ACR Meeting Abstracts

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Abstracts tagged "longitudinal studies"

  • Abstract Number: 1110 • 2012 ACR/ARHP Annual Meeting

    Radiologic Progression in Hand Osteoarthritis (OA) Over 2.6 Years – Data From the Sekoia Trial

    Emmanuel Maheu1, Christian Cadet2 and Francis Berenbaum1, 1Rheumatology, AP-HP, St Antoine Hospital, Paris, France, 2Rheumatology, Paris, France

    Background/Purpose: Hand OA is a frequent polyarticular disease. Few is known with respect to its radiological progression over time, which in addition is difficult to…
  • Abstract Number: 1032 • 2012 ACR/ARHP Annual Meeting

    Medial Meniscal Root Tears and the Association with Meniscal Extrusion, Prevalent Cartilage Damage and Longitudinal Cartilage Loss: The MOST Study

    Mohamed Jarraya1, David T. Felson2, Daichi Hayashi1, Frank Roemer3, Yuqing Zhang4, Jingbo Niu5, Michel Crema6, Martin Englund7, John A. Lynch8, Michael C. Nevitt9, James Torner10, C.E. Lewis11 and Ali Guermazi6, 1Department of Radiology, Boston University, Boston, MA, 2Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, 3Radiology, Klinikum Augsburg, Augsburg, Germany, 4Clinical Epidemiology Unit, Boston University, Boston, MA, 5Boston University, Boston, MA, 6Radiology, Boston University, Boston, MA, 7Department of Orthopedics, Lund University, Lund, Sweden, 8Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, 9Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, 10Epidemiology, University of Iowa, Iowa City, IA, 11University of Alabama at Birmingham, Birmingham City, AL

    Background/Purpose: The meniscal root is a ligamentous structure that anchors the posterior horn of the meniscus to the tibial plateau. The association of isolated meniscal…
  • Abstract Number: 816 • 2012 ACR/ARHP Annual Meeting

    Glomerular Filtration Rate, Chronic Kidney Disease and Incidence of Physician Diagnosed Gout

    Eswar Krishnan, Medicine, Standford University, Palo Alto, CA

    Background/Purpose: The kidney is the major organ of urate excretion in humans. Yet, there are few studies that assess whether reduced glomerular filtration and/or kidney…
  • Abstract Number: 653 • 2012 ACR/ARHP Annual Meeting

    Longitudinal Analysis of Plasma Factors and Disease Activity Identifies Von Willebrand Factor As A Biomarker of Lupus Flare

    Mikhail Olferiev1, Kyriakos A. Kirou1, Elena Gkrouzman1, Dorthe Lundsgaard2, Klaus S. Frederiksen3, Jan Fleckner4 and Mary K. Crow5, 1Hospital for Special Surgery, New York, NY, 2Inflammation Science, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark, 3Novo Nordisk A/S, Søborg, Denmark, 4NovoNordisk, Copenhagen, Denmark, 5Department of Medicine, Hospital for Special Surgery, New York, NY

    Background/Purpose: Lupus, a chronic autoimmune disease, is characterized by a variable clinical course, with periods of active disease termed flares. The severity of flares can…
  • Abstract Number: 2514 • 2012 ACR/ARHP Annual Meeting

    Racial/Ethnic Trends in Incidence and Prevalence of Rheumatoid Arthritis in a Large Multi-Ethnic Managed Care Population

    Aniket A. Kawatkar1, Cecilia Portugal1, Li-Hao Chu2 and Rajan Iyer3, 1Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 2Department of Research and Evaluation,, Kaiser Permanente Southern California, Pasadena, 3Department of Research and Evaluation,, Kaiser Permanente Southern California, Pasadena, CA

    Background/Purpose: As epidemiologic studies throughout the world have shown significant variations, we sought to characterize racial differences in longitudinal epidemiologic trends of adult rheumatoid arthritis…
  • Abstract Number: 448 • 2012 ACR/ARHP Annual Meeting

    Sustained and Cumulated Response Over Time in Rheumatoid Arthritis Patients Treated with Rituximab After Initial Failure of Anti Tumor Necrosis Factor Agents

    Ioan Ancuta1, Catalin Codreanu2, Ruxandra Ionescu3, Magda Parvu4 and Mihai Bojinca5, 1Internal Medicine, Cantacuzino Hospital, Bucharest, Romania, 2Rheumatology, “Dr. I. Stoia” Center for Rheumatic Diseases, Bucharest, Romania, 3Clinic Hospital "Sf. Maria", Bucharest, Romania, 4Internal Medicine, “N.Gh. Lupu” Clinical Hospital, Bucharest, Romania, 5Internal Medicine, “Dr. I. Cantacuzino” Hospital, Bucharest, Romania

    Background/Purpose: Although anti-TNF therapies moved forward the treatment of rheumatoid arthritis (RA), failure of the first anti-TNF medication is not uncommon. Many times modifying dosage/frequency…
  • Abstract Number: 2490 • 2012 ACR/ARHP Annual Meeting

    Herpes Zoster and Tofacitinib Therapy in Patients with Rheumatoid Arthritis

    K. L. Winthrop1, H. Valdez2, E. Mortensen3, R. Chew4, S. Krishnaswami5, T. Kawabata5 and R. Riese4, 1Division of Infectious Diseases, Oregon Health and Science University, Portland, OR, 2Pfizer Inc., New York, NY, 3Global Medical Affairs, Pfizer Inc., Collegeville, PA, 4Pfizer Inc., Groton, CT, 5Pfizer Inc, Groton, CT

    Background/Purpose: Patients (pts) with RA are at increased risk for herpes zoster (HZ) i.e. ‘shingles'. Tofacitinib, a novel oral Janus kinase inhibitor investigated as a…
  • Abstract Number: 449 • 2012 ACR/ARHP Annual Meeting

    Rituximab After First Anti Tumor Necrosis Factor Failure Is More Efficient with High Impact in Reducing Time and Costs to Achieve Superior Rates of Low Disease Activity and Remission

    Ioan Ancuta1, Catalin Codreanu2, Ruxandra Ionescu3, Magda Parvu4 and Mihai Bojinca1, 1Internal Medicine, “Dr. I. Cantacuzino” Hospital, Bucharest, Romania, 2Rheumatology, “Dr. I. Stoia” Center for Rheumatic Diseases, Bucharest, Romania, 3Internal Medicine, Clinic Hospital Sf. Maria, Bucharest, Romania, 4Internal Medicine, “N.Gh. Lupu” Clinical Hospital, Bucharest, Romania

    Background/Purpose: Significant steps were done in creating new medications for treatment of rheumatoid arthritis (RA). As RA seriously affects the patients’ quality of life, the…
  • Abstract Number: 2469 • 2012 ACR/ARHP Annual Meeting

    A Virtual Knee Joint Replacement Clinical Endpoint Based On Longitudinal Trends and Thresholds in Koos Knee Pain and Function in Osteoarthritis Initiative Participants

    Robert M. Boudreau1, David J. Hunter2, Zhijie Wang3, Frank Roemer4, Felix Eckstein5, Michael J. Hannon3, Ali Guermazi6 and C. Kent Kwoh7, 1Epidemiology, University of Pittsburgh, Pittsburgh, PA, 2Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 3Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Radiology, Boston University School of Medicine, Boston, MA, 5Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, 6Boston University, Boston, MA, 7School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes, but has limitations as an endpoint in OA intervention trials. A definition…
  • Abstract Number: 390 • 2012 ACR/ARHP Annual Meeting

    Performance of Criteria for Remission in a Long-Term Observational Study of Patients with Early Rheumatoid Arthritis

    Bjorn Svensson1, Maria LE Andersson2, Sidona-Valentina Bala3, Kristina Forslind4 and Ingiäld Hafström5, 1Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden, 2R&D Center, Spenshult Hospital, Oskarström, Sweden, 3Department of Health Sciences,, Lund University, Lund, Sweden, 4Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden, 5Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Remission is widely accepted as the goal of treatment in RA and has to be sustained to keep joint damage at a minimum (Smolen…
  • Abstract Number: 2158 • 2012 ACR/ARHP Annual Meeting

    Baseline Folate Related Biomarkers in Serum and erythrocytes Are Not Associated with Methotrexate Response and Adverse Events in Rheumatoid Arthritis

    Maurits C.F.J. De Rotte1, Saskia M.F. Pluijm2, Maja Bulatovic3, Johanna M.W. Hazes4 and Robert De Jonge1, 1Clinical Chemistry, Erasmus Medical Center, Rotterdam, Netherlands, 2Public Health, Erasmus Medical center, Rotterdam, Netherlands, 3Department of Paediatric Immunology, University Medical Centre Utrecht, Netherlands, 4Rheumatology, Erasmus MC, Rotterdam, Netherlands

    Background/Purpose: Methotrexate (MTX) is the most commonly used drug in rheumatoid arthritis (RA). 30% of patients fail to respond to the drug or suffer from…
  • Abstract Number: 232 • 2012 ACR/ARHP Annual Meeting

    The Natural History of Sporadic Inclusion Body Myositis – an Observational Longitudinal Study

    Pedro Machado1, Andrea Cortese1, Jasper Morrow1, Liz Dewar1, Andy Hiscock1, Adrian Miller1, Stefen Brady2, David Hilton-Jones2, Matt Parton1 and Michael G. Hanna1, 1MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom, 2Oxford Muscle and Nerve Centre, John Radcliffe Hospital, Oxford, United Kingdom

    Background/Purpose: Our aim was to assess prospectively the clinical features and functional impact of inclusion body myositis (IBM), to identify reliable outcome measures for future…
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