Abstracts tagged "longitudinal studies"

Abstract Number: 2161 • 2012 ACR/ARHP Annual Meeting
Methotrexate Polyglutamate Concentrations in Erythrocytes Are a Potential Tool for Therapeutic Drug Monitoring of Methotrexate Response in Rheumatoid Arthritis
Maurits C.F.J. De Rotte¹, Ethan den Boer², Maja Bulatovic³, Saskia M.F. Pluijm⁴, Johanna M.W. Hazes⁵ and Robert De Jonge¹, ¹Clinical Chemistry, Erasmus Medical Center, Rotterdam, Netherlands, ²Clinical Chemistry, Erasmus University Hospital, Rotterdam, Netherlands, ³Department of Paediatric Immunology, University Medical Centre Utrecht, Netherlands, ⁴Public Health, Erasmus Medical center, Rotterdam, Netherlands, ⁵Rheumatology, Erasmus MC, Rotterdam, Netherlands
Background/Purpose: Methotrexate (MTX) is the most commonly used drug in rheumatoid arthritis (RA). 30% of patients fail to respond to the drug or suffer from…
Abstract Number: 2134 • 2012 ACR/ARHP Annual Meeting
The Changed Prognosis of Patients with Early Rheumatoid Arthritis
Karin Britsemmer¹ and Dirkjan van Schaardenburg², ¹Rheumatology, Jan van Breemen Research Institute / Reade, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
The Changed Prognosis of Patients with Early Rheumatoid Arthritis Background/Purpose: The treatment of rheumatoid arthritis (RA) has changed greatly during the past fifteen to twenty…
Abstract Number: 2068 • 2012 ACR/ARHP Annual Meeting
Is There a Difference in Rheumatology Patient Reported Outcomes When Measured At Home Versus the Clinic Setting?
C.J. Inman¹, Frederick Wolfe² and Kaleb Michaud³, ¹Pediatric Administration, University of Utah, Salt Lake City, UT, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Registries have become a common tool for collecting patient-centered outcome measures. Clinical effectiveness research may be improved if data from multiple registries could be…
Abstract Number: 1587 • 2012 ACR/ARHP Annual Meeting
Despite Low Disease Activity Patients with Poly- and Dermatomyositis Perceive Activity Limitation, Reduced Grip Force and Quality of Life Longitudinally
Malin Regardt¹, Marie-Louise Schult², Ingrid E. Lundberg³ and Elisabet MB Welin Henriksson⁴, ¹Department of Occupational Therapy, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet., Stockholm, Sweden, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Medicine, Karolinska Institutet Rheum, Stockholm, Sweden
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are characterized by proximal muscle weakness. A recent study has shown that patients with PM and DM have reduced…
Abstract Number: 1278 • 2012 ACR/ARHP Annual Meeting
Tuberculosis and Tofacitinib Therapy in Patients with Rheumatoid Arthritis
Kevin L. Winthrop¹, S.-H. Park², A. Gul³, M. Cardiel⁴, JJ Gomez-Reino⁵, D. Ponce de Leon⁶, R. Riese⁷, R. Chew⁷, T. Kawabata⁷, E. Mortensen⁶ and H. Valdez⁸, ¹Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ²The Catholic University of Korea, Seoul, South Korea, ³Istanbul University, Istanbul, Turkey, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ⁶Pfizer Inc., Collegeville, PA, ⁷Pfizer Inc., Groton, CT, ⁸Pfizer Inc., New York, NY
Background/Purpose: Biologic therapies that block tumor necrosis factor-alpha (TNF) increase the risk of tuberculosis (TB), and screening for latent tuberculosis infection (LTBI) before their initiation…
Abstract Number: 1282 • 2012 ACR/ARHP Annual Meeting
Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy up to 48 Months
Jurgen Wollenhaupt¹, Joel C. Silverfield², Eun Bong Lee³, Susan P. Wood⁴, Koshika Soma⁵, Lisy Wang⁴, Hiroyuki Nakamura⁶, Yoshihiro Komuro⁶, Chudi I. Nduaka⁴, David Gruben⁴, Birgitta Benda⁷, Samuel H. Zwillich⁵, Richard Riese⁴ and John D. Bradley⁴, ¹Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ²Healthpoint Medical Group, Tampa, FL, ³Seoul National University, Seoul, South Korea, ⁴Pfizer Inc., Groton, CT, ⁵Pfizer Inc, Groton, CT, ⁶Pfizer Japan Inc., Tokyo, Japan, ⁷Pfizer Inc., Collegeville, PA
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy in RA. Here we report the safety…
Abstract Number: 1125 • 2012 ACR/ARHP Annual Meeting
Three Trajectories of Activity Limitations in Early Symptomatic Knee Osteoarthritis: A 5-Year Follow-up Study
Jasmijn F. M. Holla¹, Marike van der Leeden¹, Leo D. Roorda², Martijn W. Heymans³, Sita M.A. Bierma-Zeinstra⁴, Maarten Boers⁵, Willem F. Lems⁶, Martijn P.M. Steultjens⁷ and Joost Dekker⁸, ¹Amsterdam Rehabilitation Research Center, Reade, Amsterdam, Netherlands, ²Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, ³Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁴Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ⁵Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁶Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁷Institute for Applied Health Research and School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, ⁸Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Knee osteoarthritis (OA) is one of the leading causes of activity limitations among older adults. The course of activity limitations is highly variable; some…
Abstract Number: 1126 • 2012 ACR/ARHP Annual Meeting
Comparison between Osteoartritis Initiative and CHECK study (Cohort Hip & Cohort Knee); Development of pain and function during 4 years follow-up
Janet Wesseling¹, Sita M.A. Bierma-Zeinstra², Margreet Kloppenburg³, Johannes WJ Bijlsma⁴ and CHECK steering group⁵, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ³Department Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands, Leiden, Netherlands, ⁴Dept of Rheumatology & Immun, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Dept of Rheumatology & Immun, University Medical Center Utrecht, Utrecht
Background/Purpose: Pain and disability related to osteoarthritis (OA) may generally be considered to be chronic, but it is known that its course can be very…
Abstract Number: 1110 • 2012 ACR/ARHP Annual Meeting
Radiologic Progression in Hand Osteoarthritis (OA) Over 2.6 Years – Data From the Sekoia Trial
Emmanuel Maheu¹, Christian Cadet² and Francis Berenbaum¹, ¹Rheumatology, AP-HP, St Antoine Hospital, Paris, France, ²Rheumatology, Paris, France
Background/Purpose: Hand OA is a frequent polyarticular disease. Few is known with respect to its radiological progression over time, which in addition is difficult to…
Abstract Number: 1032 • 2012 ACR/ARHP Annual Meeting
Medial Meniscal Root Tears and the Association with Meniscal Extrusion, Prevalent Cartilage Damage and Longitudinal Cartilage Loss: The MOST Study
Mohamed Jarraya¹, David T. Felson², Daichi Hayashi¹, Frank Roemer³, Yuqing Zhang⁴, Jingbo Niu⁵, Michel Crema⁶, Martin Englund⁷, John A. Lynch⁸, Michael C. Nevitt⁹, James Torner¹⁰, C.E. Lewis¹¹ and Ali Guermazi⁶, ¹Department of Radiology, Boston University, Boston, MA, ²Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, ³Radiology, Klinikum Augsburg, Augsburg, Germany, ⁴Clinical Epidemiology Unit, Boston University, Boston, MA, ⁵Boston University, Boston, MA, ⁶Radiology, Boston University, Boston, MA, ⁷Department of Orthopedics, Lund University, Lund, Sweden, ⁸Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁹Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ¹⁰Epidemiology, University of Iowa, Iowa City, IA, ¹¹University of Alabama at Birmingham, Birmingham City, AL
Background/Purpose: The meniscal root is a ligamentous structure that anchors the posterior horn of the meniscus to the tibial plateau. The association of isolated meniscal…
Abstract Number: 816 • 2012 ACR/ARHP Annual Meeting
Glomerular Filtration Rate, Chronic Kidney Disease and Incidence of Physician Diagnosed Gout
Eswar Krishnan, Medicine, Standford University, Palo Alto, CA
Background/Purpose: The kidney is the major organ of urate excretion in humans. Yet, there are few studies that assess whether reduced glomerular filtration and/or kidney…
Abstract Number: 653 • 2012 ACR/ARHP Annual Meeting
Longitudinal Analysis of Plasma Factors and Disease Activity Identifies Von Willebrand Factor As A Biomarker of Lupus Flare
Mikhail Olferiev¹, Kyriakos A. Kirou¹, Elena Gkrouzman¹, Dorthe Lundsgaard², Klaus S. Frederiksen³, Jan Fleckner⁴ and Mary K. Crow⁵, ¹Hospital for Special Surgery, New York, NY, ²Inflammation Science, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark, ³Novo Nordisk A/S, Søborg, Denmark, ⁴NovoNordisk, Copenhagen, Denmark, ⁵Department of Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Lupus, a chronic autoimmune disease, is characterized by a variable clinical course, with periods of active disease termed flares. The severity of flares can…

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