ACR Meeting Abstracts

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Abstracts tagged "longitudinal studies"

  • Abstract Number: 392 • 2013 ACR/ARHP Annual Meeting

    Prevalence Of Cardiovascular Risk Factors and Cardiovascular Disease In Rheumatoid Arthritis Patients Across International Regions: A Comparison Of The Corrona International and Corrona United States Registries

    Dimitrios A. Pappas1, Kathy Lampl2, Joel M. Kremer3, Sebastião C. Radominski4, Janos Gal5, Fredrik Nyberg6, Anand N. Malaviya7, Aimée Whitworth8, Oscar Luis Rillo9, Allan Gibofsky10, Tatiana Popkova11, Meilien Ho12, Ieda Laurindo13, George W. Reed8, Eduardo Mario Kerzberg14, Laura Horne15, Roman Záhora16, Katherine C. Saunders17, Bernado Pons-Estel18, Alina U. Onofrei19 and Jeffrey D. Greenberg20, 1Columbia University, New York, NY, 2AstraZeneca R&D Wilmington, Wilmington, DE, 3Center for Rheumatology, Albany Medical College, Albany, NY, 4Universidade Federal do Paraná, Curitiba, Brazil, 5Rheumatology, County Hospital, Kecskemet, Hungary, 6AstraZeneca R&D, Mölndal, Sweden, 7Rheumatology, Consultant Rheumatologist, ISIC Superspeciality Hospital, New Delhi-11007-, India, 8CORRONA, Inc., Southborough, MA, 9Hospital Tornú, Capital Federal, Argentina, 10Medicine and Public Health, Hospital for Special Surgery, New York, NY, 11Research Institute of Rheumatology -Russian Academy of Medical Science, Moscow, Russia, 12AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, 13Rheumatology, Universidade de São Paulo, São Paulo, Brazil, 14Rheumatology, J. M. Ramos Mejía Hospital, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina, 15AstraZeneca, Wilmington, DE, 16Revmatologická ambulance, Terezin, Czech Republic, 17Corrona, LLC., Southborough, MA, 18Hospital Provincial de Rosario, Rosario, Argentina, 19University of Massachusetts Medical School, Worcester, MA, 20Rheumatology, NYU Hospital for Joint Diseases, New York, NY

    Background/Purpose: Cardiovascular disease (CVD) is a major comorbidity in patients (pts) with rheumatoid arthritis (RA). We explored variations in the prevalence of cardiovascular (CV) risk…
  • Abstract Number: 290 • 2013 ACR/ARHP Annual Meeting

    Children With JIA Show Distinct Patterns Of Improvement In Their Health-Related Quality Of Life During The First Year On Treatment: Growth Mixture Modeling Of a Prospective Cohort Of Newly Diagnosed Patients

    Bin Huang1, Chen Chen2, Stacey Niehaus3, Hermine Brunner4, Rina Mina5 and Michael Seid6, 1Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center/University of Cincinnati School of Medicine, Cincinnati, OH, 2Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Cincinnati Children's Hospital Medical Center/University of Cincinnati School of Medicine, Cincinnati, OH, 5Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Pulmonary, Cincinnati Children's Hospital Medical Center/University of Cincinnati School of Medicine, Cincinnati, OH

    Background/Purpose: Health-related quality of life (HRQOL) is a key outcome in clinical care and research for children with JIA.  Despite excellent clinical control and the…
  • Abstract Number: 251 • 2013 ACR/ARHP Annual Meeting

    Physical Activity Is Associated With Reduced Incident Disability: Evidence From The Osteoarthritis Initiative

    Dorothy D. Dunlop1, Jing Song1, Pamela A. Semanik2, Leena Sharma2, Joan M. Bathon3, Charles Eaton4, Marc C. Hochberg5, Rebecca D. Jackson6, C. Kent Kwoh7, W, Jerry Mysiw6, Michael C. Nevitt8 and Rowland W. Chang1, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Columbia University, New York, NY, 4Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, 5Medicine, University of Maryland School of Medicine, Baltimore, MD, 6Ohio State University, Columbus, OH, 7School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA

     Background/Purpose: Over 56 million people in the U.S. are classified as disabled.  Physical activity is a low cost, broadly applicable approach to improve cardiovascular fitness,…
  • Abstract Number: 2763 • 2013 ACR/ARHP Annual Meeting

    Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis

    Inmaculada del Rincon1, Roy W. Haas2, Jose Felix Restrepo3, Daniel F. Battafarano4, Daniel H. O'Leary5, Emily Molina1 and Agustin Escalante6, 1Rheumatology, University of Texas Health Science Center, San Antonio, TX, 2Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, 3Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 4Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, 5Radiology, Tufts University-Boston Campus, Boston, MA, 6Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: Patients with rheumatoid arthritis (RA) have higher mortality than do persons of the same age and sex without RA. This is due in part…
  • Abstract Number: 2752 • 2013 ACR/ARHP Annual Meeting

    Good, Moderate and Poor Outcome Trajectories Of Pain Severity In Early Symptomatic Knee Osteoarthritis; 5 Year Follow-Up Of Check study

    Janet Wesseling1, Alex N. Bastick2, Sita M.A. Bierma-Zeinstra3 and Johannes W.J. Bijlsma4, 1Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, 3Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Knee pain is often the first sign of knee OA (osteoarthritis) and it is known that its course can be very different between patients over…
  • Abstract Number: 2328 • 2013 ACR/ARHP Annual Meeting

    Tofacitinib, An Oral Janus Kinase Inhibitor, In The Treatment Of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy Up To 5 Years

    Jürgen Wollenhaupt1, Joel Silverfield2, Eun Bong Lee3, Susan P. Wood4, Ketti K. Terry4, Hiroyuki Nakamura5, Yukako Ohno5, David Gruben4, Birgitta Benda6, Lisy Wang4 and Richard Riese4, 1Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 2Healthpoint Medical Group, Tampa, FL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc, Groton, CT, 5Pfizer Japan Inc, Tokyo, Japan, 6Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is a novel, oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). Here we report tofacitinib safety, tolerability, and durability of response…
  • Abstract Number: 1942 • 2013 ACR/ARHP Annual Meeting

    Ultrasound Shows Tenosynovitis to be Frequently Present  as Well As Sensitive to Change in RA Patients On Biologic Medication

    Hilde B. Hammer, Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Ultrasound (US) (grey scale (GS) and power Doppler (PD)) is a sensitive tool for examination of tenosynovitis in patients with rheumatoid arthritis (RA). The…
  • Abstract Number: 1278 • 2012 ACR/ARHP Annual Meeting

    Tuberculosis and Tofacitinib Therapy in Patients with Rheumatoid Arthritis

    Kevin L. Winthrop1, S.-H. Park2, A. Gul3, M. Cardiel4, JJ Gomez-Reino5, D. Ponce de Leon6, R. Riese7, R. Chew7, T. Kawabata7, E. Mortensen6 and H. Valdez8, 1Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, 2The Catholic University of Korea, Seoul, South Korea, 3Istanbul University, Istanbul, Turkey, 4Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, 5Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 6Pfizer Inc., Collegeville, PA, 7Pfizer Inc., Groton, CT, 8Pfizer Inc., New York, NY

    Background/Purpose: Biologic therapies that block tumor necrosis factor-alpha (TNF) increase the risk of tuberculosis (TB), and screening for latent tuberculosis infection (LTBI) before their initiation…
  • Abstract Number: 1282 • 2012 ACR/ARHP Annual Meeting

    Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy up to 48 Months

    Jurgen Wollenhaupt1, Joel C. Silverfield2, Eun Bong Lee3, Susan P. Wood4, Koshika Soma5, Lisy Wang4, Hiroyuki Nakamura6, Yoshihiro Komuro6, Chudi I. Nduaka4, David Gruben4, Birgitta Benda7, Samuel H. Zwillich5, Richard Riese4 and John D. Bradley4, 1Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 2Healthpoint Medical Group, Tampa, FL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc., Groton, CT, 5Pfizer Inc, Groton, CT, 6Pfizer Japan Inc., Tokyo, Japan, 7Pfizer Inc., Collegeville, PA

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy in RA. Here we report the safety…
  • Abstract Number: 1125 • 2012 ACR/ARHP Annual Meeting

    Three Trajectories of Activity Limitations in Early Symptomatic Knee Osteoarthritis: A 5-Year Follow-up Study

    Jasmijn F. M. Holla1, Marike van der Leeden1, Leo D. Roorda2, Martijn W. Heymans3, Sita M.A. Bierma-Zeinstra4, Maarten Boers5, Willem F. Lems6, Martijn P.M. Steultjens7 and Joost Dekker8, 1Amsterdam Rehabilitation Research Center, Reade, Amsterdam, Netherlands, 2Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, 3Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 4Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, 5Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 6Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 7Institute for Applied Health Research and School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, 8Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Knee osteoarthritis (OA) is one of the leading causes of activity limitations among older adults. The course of activity limitations is highly variable; some…
  • Abstract Number: 1126 • 2012 ACR/ARHP Annual Meeting

    Comparison between Osteoartritis Initiative and CHECK study (Cohort Hip & Cohort Knee); Development of pain and function during 4 years follow-up

    Janet Wesseling1, Sita M.A. Bierma-Zeinstra2, Margreet Kloppenburg3, Johannes WJ Bijlsma4 and CHECK steering group5, 1Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, 3Department Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands, Leiden, Netherlands, 4Dept of Rheumatology & Immun, University Medical Center Utrecht, Utrecht, Netherlands, 5Dept of Rheumatology & Immun, University Medical Center Utrecht, Utrecht

    Background/Purpose:  Pain and disability related to osteoarthritis (OA) may generally be considered to be chronic, but it is known that its course can be very…
  • Abstract Number: 1110 • 2012 ACR/ARHP Annual Meeting

    Radiologic Progression in Hand Osteoarthritis (OA) Over 2.6 Years – Data From the Sekoia Trial

    Emmanuel Maheu1, Christian Cadet2 and Francis Berenbaum1, 1Rheumatology, AP-HP, St Antoine Hospital, Paris, France, 2Rheumatology, Paris, France

    Background/Purpose: Hand OA is a frequent polyarticular disease. Few is known with respect to its radiological progression over time, which in addition is difficult to…
  • Abstract Number: 1032 • 2012 ACR/ARHP Annual Meeting

    Medial Meniscal Root Tears and the Association with Meniscal Extrusion, Prevalent Cartilage Damage and Longitudinal Cartilage Loss: The MOST Study

    Mohamed Jarraya1, David T. Felson2, Daichi Hayashi1, Frank Roemer3, Yuqing Zhang4, Jingbo Niu5, Michel Crema6, Martin Englund7, John A. Lynch8, Michael C. Nevitt9, James Torner10, C.E. Lewis11 and Ali Guermazi6, 1Department of Radiology, Boston University, Boston, MA, 2Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, 3Radiology, Klinikum Augsburg, Augsburg, Germany, 4Clinical Epidemiology Unit, Boston University, Boston, MA, 5Boston University, Boston, MA, 6Radiology, Boston University, Boston, MA, 7Department of Orthopedics, Lund University, Lund, Sweden, 8Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, 9Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, 10Epidemiology, University of Iowa, Iowa City, IA, 11University of Alabama at Birmingham, Birmingham City, AL

    Background/Purpose: The meniscal root is a ligamentous structure that anchors the posterior horn of the meniscus to the tibial plateau. The association of isolated meniscal…
  • Abstract Number: 816 • 2012 ACR/ARHP Annual Meeting

    Glomerular Filtration Rate, Chronic Kidney Disease and Incidence of Physician Diagnosed Gout

    Eswar Krishnan, Medicine, Standford University, Palo Alto, CA

    Background/Purpose: The kidney is the major organ of urate excretion in humans. Yet, there are few studies that assess whether reduced glomerular filtration and/or kidney…
  • Abstract Number: 653 • 2012 ACR/ARHP Annual Meeting

    Longitudinal Analysis of Plasma Factors and Disease Activity Identifies Von Willebrand Factor As A Biomarker of Lupus Flare

    Mikhail Olferiev1, Kyriakos A. Kirou1, Elena Gkrouzman1, Dorthe Lundsgaard2, Klaus S. Frederiksen3, Jan Fleckner4 and Mary K. Crow5, 1Hospital for Special Surgery, New York, NY, 2Inflammation Science, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark, 3Novo Nordisk A/S, Søborg, Denmark, 4NovoNordisk, Copenhagen, Denmark, 5Department of Medicine, Hospital for Special Surgery, New York, NY

    Background/Purpose: Lupus, a chronic autoimmune disease, is characterized by a variable clinical course, with periods of active disease termed flares. The severity of flares can…
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