ACR Meeting Abstracts

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Abstracts tagged "longitudinal studies"

  • Abstract Number: 712 • 2015 ACR/ARHP Annual Meeting

    Factors Associated with Anti-TNF Treatment in a Longitudinally Followed Ankylosing Spondylitis (AS) Cohort

    Mary Gibson1, MinJae Lee2, Michael M. Ward3, Lianne S. Gensler4, Matthew A. Brown5, Shervin Assassi6, Colton Pence1, Laura A. Diekman7, Mohammad H. Rahbar8, Michael H. Weisman9 and John D. Reveille1, 1Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 2Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, 3NIH/NIAMS, Bethesda, MD, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5The University of Queensland Diamantina Institute, Brisbane, Australia, 6Rheumatology, University of Texas Medical School at Houston, Houston, TX, 7Rheumatology, University of Texas Medical School, Houston, TX, 8The University of Texas Health Science Center at Houston, Houston, TX, 9Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: TNF-α inhibitor therapy is recommended by ASAS/EULAR guidelines for ankylosing spondylitis (AS) patients with moderate-to-high disease activity despite inadequate response to NSAIDs  in addition…
  • Abstract Number: 716 • 2015 ACR/ARHP Annual Meeting

    Urinary Proteomics Identifies Three Novel Biomarkers for Lupus Nephritis Activity: Retinol Binding Protein, Alpha-1-Antichymotrysin and Haptoglobin

    Amita Aggarwal1, Sudhir sinha2, Ranjan Gupta3, Liza Rajasekhar4, Akhilesh Yadav3, Ramnath Misra1 and Virsingh Negi5, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Department of Biochemistry, CSIR-central drug research institute, Lucknow, India, 3Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 4Department of Rheumatology, Nizam Institute of Medical Sciences, Hyderabad, India, 5Department of Clinical Immunology, JIPMER, Puducherry, India

    Background/Purpose: Urinary biomarkers have a potential for identification, follow-up and assessment of response to treatment in patients with lupus nephritis. Urinary proteomics can help in…
  • Abstract Number: 849 • 2015 ACR/ARHP Annual Meeting

    A Computational Tool for Individualized Prognosis of Percent of Predicted Forced Vital Capacity Trajectories in Systemic Sclerosis

    Peter Schulam1, Colin Ligon2, Robert Wise3, Laura K. Hummers4, Fredrick M. Wigley5 and Suchi Saria1,6, 1Department of Computer Science, Johns Hopkins University, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, 6Departments of Biostatistics, and Health Policy and Management, Bloomberg School of Public Health, Baltimore, MD

    Background/Purpose: Interstitial lung disease (ILD) is a common cause of mortality in systemic sclerosis (Ssc). Decreased forced vital capacity (FVC) in Ssc-ILD is associated with…
  • Abstract Number: 1645 • 2015 ACR/ARHP Annual Meeting

    Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Clinical and Radiographic Efficacy in Open-Label, Long-Term Extension Studies over 7 Years

    Jürgen Wollenhaupt1, Joel Silverfield2, Eun Bong Lee3, Ketti Terry4, Kenneth Kwok5, Irina Lazariciu6, Chudy Nduaka7, Carol A. Connell4, Ryan DeMasi5 and Lisy Wang4, 1Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 2Healthpoint Medical Group, Tampa, FL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc, Groton, CT, 5Pfizer Inc, New York, NY, 6Quintiles, Saint-Laurent, QC, Canada, 7Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report tofacitinib safety, tolerability, and clinical response over 84 months…
  • Abstract Number: 1708 • 2015 ACR/ARHP Annual Meeting

    Predictors of Depression Severity in Ankylosing Spondylitis

    Mark Hwang1, MinJae Lee2, Michael M. Ward3, Lianne S. Gensler4, Matthew A. Brown5, Shervin Assassi6, Laura A. Diekman7, Mohammad H. Rahbar8, Michael H. Weisman9 and John D. Reveille10, 1Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, 2Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, 3NIH/NIAMS, Bethesda, MD, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5The University of Queensland Diamantina Institute, Brisbane, Australia, 6Rheumatology, University of Texas Medical School at Houston, Houston, TX, 7Rheumatology, University of Texas Medical School, Houston, TX, 8The University of Texas Health Science Center at Houston, Houston, TX, 9Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 10Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: Depression is a known comorbidity of ankylosing spondylitis (AS) with over one-third of AS patients affected and increased depression-rate ratio compared to the general…
  • Abstract Number: 2071 • 2015 ACR/ARHP Annual Meeting

    Urinary Osteoprotegerin As Biomarker of Lupus Nephritis Disease Activity: Cross Sectional and Longitudinal Study

    Ranjan Gupta1, Amita Aggarwal2, Sudhir sinha3, Liza Rajasekhar4, Akhilesh Yadav1, Priyanka Gaur1, Ramnath Misra2 and Virsingh Negi5, 1Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 3Department of Biochemistry, CSIR-central drug research institute, Lucknow, India, 4Department of Rheumatology, Nizam Institute of Medical Sciences, Hyderabad, India, 5Department of Clinical Immunology, JIPMER, Puducherry, India

    Background/Purpose: Urinary biomarkers may help in identification, treatment and assessment of response to therapy in patients with lupus nephritis (LN). Osteoprotegerin (OPG) is produced by…
  • Abstract Number: 2693 • 2015 ACR/ARHP Annual Meeting

    Comparing Eight Year Clinical and Radiographic Outcome in Two Cohorts of Patients with Rheumatoid Arthritis

    Maria LE Andersson1, Kristina Forslind2 and Ingiäld Hafström3, 1R&D Centre Spenshult,Halmstad, Halmstad, Sweden, 2Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden, 3Rheumatology Dept, Karoliska Institute, Stockholm, Sweden

    Background/Purpose: To compare patient and disease characteristics over the first 8 years of disease in a large inception cohort of early RA patients included 1992…
  • Abstract Number: 3068 • 2015 ACR/ARHP Annual Meeting

    Damage Assessment in Takayasu’s Arteritis

    Antoine G. Sreih1, Tanaz A. Kermani2, David Cuthbertson3, Simon Carette4, Gary S. Hoffman5, Nader A. Khalidi6, Curry L. Koening7, Carol A. Langford5, Carol McAlear8, Paul A. Monach9, Larry W. Moreland10, Christian Pagnoux11, Philip Seo12, Kenneth J. Warrington13, Steven R. Ytterberg14 and Peter A. Merkel8, 1Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Rheumatology, University of California Los Angeles, Santa Monica, CA, 3Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 4Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Rheumatology, Cleveland Clinic, Cleveland, OH, 6McMaster University, Hamilton, ON, Canada, 7Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, 8Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 9Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, 10Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 11Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 12Division of Rheumatology, Johns Hopkins, Baltimore, MD, 13Rheumatology, Mayo Clinic, Rochester, MN, 14Rheumatology Division, Mayo Clinic, Rochester, MN

       Background/Purpose: This study aimed to describe disease-related damage in Takayasu's arteritis (TAK) and evaluate damage assessment tools using data from a large longitudinal cohort. …
  • Abstract Number: 3146 • 2015 ACR/ARHP Annual Meeting

    Health Related Quality of Life in Adults with JIA – a 30 Year Longitudinal Study

    Anita Tollisen1,2,3, Anne Marit Selvaag1, Hanne A. Aulie1, Anners Lerdal4,5 and Berit Flato1,2, 1Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 2Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 3Department of Medicine, Lovisenberg Diakonale Hospital, Oslo, Oslo, Norway, 4Faculty of Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway, 5Lovisenberg Diakonale Hospital, Oslo, Oslo, Norway

    Background/Purpose: Improvement of health-related quality of life (HRQOL) is a central aim in treatment of patients with JIA. The primary aim of the study is…
  • Abstract Number: 31 • 2015 ACR/ARHP Annual Meeting

    Risk of Chronic Obstructive Pulmonary Disease in Rheumatoid Arthritis: A Population Based Cohort Study

    Katherine McGuire1, J Antonio Avina-Zubieta2, Eric C. Sayre1, JM Esdaile3 and Diane Lacaille4, 1Arthritis Research Canada, Richmond, BC, Canada, 2Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, 3Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, 4Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: A link between chronic obstructive pulmonary disease (COPD) and inflammation has been established in a number of studies. This raises the question of whether…
  • Abstract Number: 392 • 2015 ACR/ARHP Annual Meeting

    From Childhood to Adulthood: Longitudinal Trajectory of Damage in Patients with Childhood-Onset Systemic Lupus Erythematosus (cSLE)

    Lily Siok Hoon Lim1,2,3,4, Eleanor Pullenayegum5, Lillian Lim6, Dafna Gladman7, Brian Feldman8 and Earl Silverman9, 1Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada, 2Rheumatology, SickKids, Toronto, ON, Canada, 3Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, 4Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada, 5Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 6Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, 7Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 9Division of Rheumatology, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada

    Background/Purpose: Outcomes of patients with cSLE over time and into adulthood are poorly understood. There has been no information about the longitudinal trajectory of organ…
  • Abstract Number: 2654 • 2014 ACR/ARHP Annual Meeting

    Cognitive Function in Systemic Lupus Erythematosus Patients with Past History of Neuropsychiatric Manifestations : A Longitudinal Study

    Yang Gao1, Yi Lo1, Jacky Wan2, Esther YY Lau2 and Mo Yin Mok1, 1Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong, 2Department of Psychology, University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE) and its associations with neuropsychiatric involvement (NPSLE) and psychiatric factors have been…
  • Abstract Number: 2494 • 2014 ACR/ARHP Annual Meeting

    Persistence on Single Disease Modifying Anti-Rheumatic Drug Therapy in US Veterans with Rheumatoid Arthritis Is Extremely Rare

    Jonathan Kruger1, Michael Morgan1, Andreas Reimold2, Ted R. Mikuls3, Gail Kerr4 and Grant W. Cannon5, 1Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 2Rheumatology, Dallas VA and Univ of TX Southwestern Med Ct, Dallas, TX, 3Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4Rheumatology, Washington DC VA and Georgetown and Howard University, Washington, DC, 5Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT

    Background/Purpose:             Few rheumatoid arthritis (RA) patients are managed successfully with a single disease modifying anti-rheumatic drug (DMARD).  This investigation determined the prevalence and clinical…
  • Abstract Number: 2398 • 2014 ACR/ARHP Annual Meeting

    Continued Participation in a 10-Year Tight Control Treat-to-Target Study in Rheumatoid Arthritis: Why Keep Patients Doing Their BeSt?

    I.M. Markusse1, L. Dirven2, T.H.E. Molenaar3, N. Riyazi4, P.B.J. de Sonnaville5, P.J.S.M. Kerstens6, W.F. Lems7, T.W.J. Huizinga2 and C.F. Allaart2, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Dept of Rheumatology, Groene Hart Hospital, Gouda, Netherlands, 4Rheumatology, Haga Hospital, The Hague, Netherlands, 5Rheumatology, Admiraal de Ruyter Ziekenhuis, Goes, Netherlands, 6Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 7Rheumatology, VU Medical Center, Amsterdam, Netherlands

    Background/Purpose: To identify risk factors for premature study termination and patients’ motives for adherence to a long term follow-up clinical trial in rheumatoid arthritis (RA).…
  • Abstract Number: 2248 • 2014 ACR/ARHP Annual Meeting

    Clinical Outcomes, Neuropathic Pain and Patient Satisfaction over a 15 Year Period Following Primary Tka: A Repeat-Cross-Sectional Analysis

    Anne Lübbeke1, Matthieu Zingg2, Daniel Fritschy1, Pierre Hoffmeyer1 and Hermes Miozzari2, 1Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, 2Orthopaedics, Geneva University Hospitals, Geneva, Switzerland

    Background/Purpose Studies evaluating patient-reported long term outcomes (>10 years) after primary TKA are lacking. Moreover, variability in patient satisfaction after TKA has been reported for…
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