Abstracts tagged "large vessel vasculitis"

Abstract Number: 1845 • 2017 ACR/ARHP Annual Meeting
Comparison of Magnetic Resonance Angiography (MRA) and 18f-Fluorodeoxyglucose Positron Emission Tomography (PET) in Large Vessel Vasculitis
Kaitlin A. Quinn^1,2, Ashkan Malayeri³, Mark Ahlman³, Armin Bagheri⁴, Robert Evers⁵, Ali Cahid Civelek³, Elaine Novakovich⁶ and Peter C. Grayson⁷, ¹Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ²NIAMS/NIH, Bethesda, MD, ³Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, ⁴Vasculitis Translational Research Program, NIAMS, NIH, Bethesda, MD, ⁵NIH, Bethesda, MD, ⁶Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, ⁷National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD
Background/Purpose: Magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography (PET) may provide unique or redundant information in large vessel vasculitis (LVV). The study objective…
Abstract Number: 2737 • 2017 ACR/ARHP Annual Meeting
Pulmonary Manifestations of Primary Systemic Vasculitides
Jean-Paul Makhzoum¹, Raashid Luqmani², Richard A. Watts³, Anthea Craven⁴, Peter A. Merkel⁵ and Christian Pagnoux⁶, ¹Rheumatology, Vasculitis Clinic, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ²Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ³Rheumatology Department, The Ipswich Hospital, Ipswich, Great Britain, ⁴Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Oxford University Hospitals, Oxford, United Kingdom, ⁵Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁶Rheumatology-Vasculitis clinic, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Pulmonary involvement in systemic primary vasculitides is diverse and occurs with variable incidence depending on the type of vasculitis. This study aimed to describe…
Abstract Number: 3197 • 2016 ACR/ARHP Annual Meeting
Ultrasound Definitions for Cranial and Large Vessel Giant Cell Arteritis: Results of a Reliability Exercise on Images and Videos of the Omeract Ultrasound Large Vessel Vasculitis Task Force
Stavros Chrysidis¹, Christina Duftner², Christian Dejaco³, Cristina Ponte⁴, Annamaria Iagnocco⁵, Bhaskar Dasgupta⁶, Maria Antonietta D'Agostino⁷, Eugenio De Miguel⁸, Ulrich Fredberg⁹, Wolfgang Hartung¹⁰, Alojzija Hocevar¹¹, Tanaz A. Kermani¹², Matthew J. Koster¹³, Tove Lorenzen¹⁴, Pierluigi Macchioni¹⁵, Marcin Milchert¹⁶, Naina Rastalsky¹⁷, Chetan Mukhtyar¹⁸, Valentin S. Schaefer¹⁹, Kenneth J. Warrington²⁰, Lene Terslev²¹, George A. W. Bruyn²², Petra Hanova²³, Uffe Møller Døhn²⁴, Esperanza Naredo²⁵, Carlo Alberto Scirè²⁶, Greta Carrara²⁷, Sofia Ramiro²⁸, Andreas P Diamantopoulos²⁹ and Wolfgang A. Schmidt¹⁹, ¹Department of Rheumatology, Hospital of Southwest Denmark, Esbjerg, Denmark, ²Medical University Innsbruck, Innsbruck, Austria, ³Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁴Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, ⁵Sapienza Università Di Roma,, Roma, Italy, ⁶Rheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, ⁷Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁸Hospital Universitario La Paz, Madrid, Spain, ⁹Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark, ¹⁰Department of Rheumatology/Clinical Immunology, Asklepios Medical Center, 93077 Bad Abbach, Germany, ¹¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹²Rheumatology, University of California Los Angeles, Santa Monica, CA, ¹³Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, ¹⁴Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, ¹⁵Arcispedale Santa Maria Nuova, Reggio Emilia,, Reggio Emilia, Italy, ¹⁶Pomeranian Medical University, Szczecin,, Szczecin, Poland, ¹⁷St. Elizabeth's Medical Center, Boston, MA, Boston, MA, ¹⁸Norfolk and Norwich University Hospital, Norwich, United Kingdom, ¹⁹Immanuel Krankenhaus Berlin, Med Ctr for Rheumatology Berlin-Buch, Berlin, Germany, ²⁰Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ²²Rheumatology, MC Groep, Loenga, Netherlands, ²³Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²⁴Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Glostrup, Denmark, ²⁵Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain, ²⁶Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, ²⁷Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy, ²⁸Leiden University Medical Center, Leiden, Netherlands, ²⁹Rheumatology, Haugesund Sanitetsforenings Revmatismesykehus, Haugesund, Norway
Background/Purpose: By a Delphi process, the OMERACT Ultrasound (US) large vessel vasculitis task force has recently defined the US appearance of normal temporal arteries…
Abstract Number: 862 • 2016 ACR/ARHP Annual Meeting
Utility of 18f FDG Positron Emission Tomography (PET) As a Diagnostic Test and Marker of Disease Activity in Large Vessel Vasculitis
Sara Alehashemi¹, Mark Ahlman², Ali Cahid Civelek², Elaine Novakovich³, Ashkan Malayeri², Peter A. Merkel⁴, Thomas Cupps⁵, David Bluemke² and Peter C. Grayson³, ¹Rheumatology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA, ⁵Rheumatology, Georgetown University, Bethesda, MD
Background/Purpose: FDG-PET may have a role in diagnosing and monitoring disease activity in large vessel vasculitis (LVV). Studies that assess the diagnostic accuracy of PET…
Abstract Number: 880 • 2016 ACR/ARHP Annual Meeting
Pilot Study of Microbubble Contrast-Enhanced Vascular Ultrasonography: A Novel Method of Detecting Large Vessel Vasculitis?
Kimberly P. Liang¹, Douglas P. Landsittel², Bernadette B. Sendon³, Donald M. Jones⁴, Suresh R. Mulukutla⁵, Steven E. Reis⁶, Ali Hakim Shoushtari⁷ and Larry W. Moreland⁸, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology & Clinical Immunology, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ⁵Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, ⁶Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, ⁷Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, ⁸Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: A key unmet need in the monitoring of disease activity in large vessel vasculitides (LVV), i.e., giant cell arteritis (GCA) and Takayasu arteritis…
Abstract Number: 2980 • 2016 ACR/ARHP Annual Meeting
Inflammation As an Under-Recognized Cause of Ascending Aortic Aneurysms: A Single-Center Clinical and Pathological Study of 53 Cases over 6 Years
Tariq Al-Araimi¹ and Arthur Bookman², ¹Department of Medicine, Toronto, ON, Canada, ²Division of Rheumatology, University Health Network, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada
Background/Purpose: This study is aimed at estimating the prevalence of inflammatory ascending aneurysms, describing clinical and histopathological findings, and assessing whether appropriate follow-up was arranged…
Abstract Number: 3182 • 2016 ACR/ARHP Annual Meeting
Attenuation of Fluorine-18-Fluorodeoxyglucose Uptake in Large Vessel Giant Cell Arteritis after Short-Term High-Dose Steroid Treatment – a Diagnostic Window of Opportunity
Berit Dalsgaard Nielsen¹, Ib Tønder Hansen², Kresten Krarup Keller³, Philip Therkildsen⁴, Ellen-Margrethe Hauge³ and Lars Christian Gormsen⁵, ¹Rheumatology, Department of Rheumatology, Aarhus University Hospital, Århus C, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus C, Denmark, ⁵Nuclear Medicine and PET Center, Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Århus C, Denmark
Background/Purpose: Fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT is, due to its excellent diagnostic accuracy[1], increasingly used to diagnose large vessel GCA (LV-GCA). However, PET/CT is not always readily…
Abstract Number: 864 • 2015 ACR/ARHP Annual Meeting
Anticytokine Autoantibody Profiling in Five Types of Systemic Vasculitis
Sarthak Gupta^1,2, Seema K. Patel², Mary Blake², Massimo G. Gadina², Wanxia L. Tsai², Simon Carette³, David Cuthbertson⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁵, Carol A. McAlear⁸, Larry W. Moreland⁹, Paul A. Monach¹⁰, Christian Pagnoux³, Philip Seo¹¹, Ulrich Specks¹², Antoine G. Sreih¹³, Steven R. Ytterberg¹⁴, Sarah K. Browne^1,15, Steven M. Holland¹, Mariana J. Kaplan², Peter A. Merkel¹⁶, Peter C. Grayson² and Vasculitis Clinical Research Consortium, ¹Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁴Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵Rheumatology, Cleveland Clinic, Cleveland, OH, ⁶Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, ⁷Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Rheumatology, Boston University School of Medicine, Boston, MA, ¹¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹²Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹³Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁴Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁵Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, ¹⁶Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Anticytokine autoantibodies (ACAs) are pathogenic in many hematologic, pulmonary and infectious diseases. Evaluation in autoimmune diseases, including systemic lupus erythematosus (SLE), shows that ACAs…
Abstract Number: 1954 • 2015 ACR/ARHP Annual Meeting
How Can We Use Ultrasound in the Diagnosis and Management of Patients with Giant Cell Arteritis?
Cristina Ponte^1,2, Sophie Vaggers¹, Jan Sznajd¹, Lorraine O'Neill¹, Jennifer Piper³, Jessica Gunn¹, Kulveer Mankia¹ and Raashid Luqmani¹, ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: Giant cell arteritis (GCA), the most common primary vasculitis, can cause irreversible blindness in 20-30% of untreated cases, but glucocorticoid therapy leads to significant…
Abstract Number: 1959 • 2015 ACR/ARHP Annual Meeting
Color Doppler Ultrasonography Appears to Perform Better Than Magnetic Resonance Angiography in the Diagnostics of Patients with Systemic Large Vessel Vasculitis
Andreas P Diamantopoulos^1,2, Julia Geiger³, Frode Lohne⁴, Geirmund Myklebust⁵ and Wolfgang A. Schmidt⁶, ¹Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ²Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, ³Department of Radiology, University Children's Hospital, Zurich, Switzerland, ⁴Radiology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁵Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, ⁶Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany
Background/Purpose: Color Doppler ultrasound (CDUS) and Magnetic resonance angiography (MRA) has been extensively used in the diagnostics of large vessel vasculitis (LVV) [giant cell arteritis…
Abstract Number: 1960 • 2015 ACR/ARHP Annual Meeting
a Structured and Extensive Training Program on Vascular Ultrasound, Results in an Excellent Agreement Between Ultrasound and Temporal Artery Biopsy in the Diagnosis of Giant Cell Arteritis
Stavros Chrysidis¹, Ulrich Fredberg², Uffe Møller Døhn³, Tove Lorenzen⁴, Lene Terslev⁵, Knud Larsen⁶ and Andreas P Diamantopoulos⁷, ¹Department of Rheumatology, Hospital of Southwest Denmark, Esbjerg, Denmark, ²Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, Silkeborg, Denmark, ³Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Glostrup, Denmark, ⁴Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, ⁵Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ⁶otolaryngology, Southwest hospital, Esbjerg, Denmark, ⁷Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway
Background/Purpose: There is an increased use of vascular ultrasound (US) for diagnosing giant cell arteritis (GCA). Consequently, extensive and structured training of ultrasonographers performing vascular…
Abstract Number: 1961 • 2015 ACR/ARHP Annual Meeting
Interobserver Agreement on Ultrasonographic and Magnetic Resonance Angiography Findings in Patients with Large Vessel Vasculitis
Andreas P Diamantopoulos^1,2, Julia Geiger³, Frode Lohne⁴, Geirmund Myklebust⁵ and Wolfgang A. Schmidt⁶, ¹Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, ²Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ³Department of Radiology, University Children's Hospital, Zurich, Switzerland, ⁴Radiology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁵Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, ⁶Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany
Background/Purpose: Ultrasound and Magnetic resonance angiography (MRA) yields a high sensitivity and specificity regarding the diagnosis of cranial giant cell arteritis (GCA). Ultrasound and MRA…
Abstract Number: 1990 • 2015 ACR/ARHP Annual Meeting
Corticosteroid Use in Idiopathic Aortitis: A Systematic Review
Nancy Maltez¹ and Nataliya Milman², ¹Internal Medicine, University of Ottawa, Ottawa, ON, Canada, ²Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada
Background/Purpose: Idiopathic aortitis (IA) is a poorly defined entity with no specific pathological or clinical criteria for its classification or diagnosis, except for the presence…
Abstract Number: 1991 • 2015 ACR/ARHP Annual Meeting
Large Vessel Involvement By IgG4-Related Disease
Cory Perugino¹, Zachary Wallace¹ and John H. Stone², ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition of uncertain etiology. Reports have described inflammatory aortitis and peri-aortitis in the setting of retroperitoneal fibrosis…
Abstract Number: 3058 • 2015 ACR/ARHP Annual Meeting
NMR-Based Metabolomics Provides New Insights into the Inflammatory Processes in Takayasu Arteritis
Ramnath Misra¹, Anupam Guleria², Durga Prasanna Misra¹, Avadesh Pratap³, Durgesh Dubey⁴, Atul Rawat⁴, Smriti Chaurasia³, C L Khetrapal⁴, Dinesh Kumar⁴ and Paul Bacon⁵, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Centre of Biomedical Research, Lucknow, India, ³S.G.P.G.I.M.S, Department of Clinical Immunology, Lucknow, India, ⁴Centre for Biomedical Research, Lucknow, India, ⁵Rheumatology, Birmingham Universit, Birmingham, United Kingdom
Background/Purpose: Takayasu Arteritis (TA), a large vessel disease of unknown aetiology, is the orphan of the inflammatory vasculitides with no evidence base for therapy. It…

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