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Abstracts tagged "Langerhans cell"

  • Abstract Number: 1487 • ACR Convergence 2021

    Type I Interferon Modulates Langerhans Cell ADAM17 in Lupus to Contribute to Photosensitivity

    Thomas Li1, Keila Veiga2, Noa Schwartz3, Jose Lora4, Yong Liu4, Ali Jabbari5, William Shipman1, Mehdi Rashighi6, James Krueger7, Niroshana Anandasabapathy4, David Oliver8, Yurii Chinenov8, Carl Blobel1 and Theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2New York Medical College, Hawthorne, NY, 3Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, 4Weill Cornell Medicine, New York, NY, 5University of Iowa, Iowa City, IA, 6University of Massachusetts Medical School, Worcester, MA, 7Rockefeller University, New York, NY, 8David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: Photosensitivity is a common feature in the autoimmune disease lupus erythematosus (LE) where patients develop inflammatory skin lesions in response to ultraviolet radiation (UVR).…
  • Abstract Number: 168 • Pediatric Rheumatology Symposium 2020

    Examining the Role of IFN-I and Langerhans Cell ADAM17 in Lupus Photosensitivity

    Keila Veiga1, Noa Schwartz 2, William Shipman 1, Marvin Sandoval 3, Thomas Li 1, Yurii Chinenov 1, David Oliver 1, Ali Jabbari 4, James Krueger 5, Sarah Taber 1, Niroshana Anandasabapathy 6 and Theresa Lu 1, 1Hospital for Special Surgery, New York, 2Albert Einstein College of Medicine/Montefiore Medical Center, New York, 3Weill Cornell Graduate School of Medical Sciences, New York, 4University of Iowa, Iowa City, 5Rockefeller Center, New York, 6Weill Cornell Medicine, New York

    Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus.  Lesions can be disfiguring and have a negative impact on quality of…

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