Abstracts tagged "Knee"

Abstract Number: 3255 • 2016 ACR/ARHP Annual Meeting
A Randomized Trial of Automated Telephone-Linked Communication to Improve Exercise Adherence for a Progressive Resistance Training Program in People with Knee Osteoarthritis
Kristin Baker¹, Aileen Ledingham¹, Carrie Brown², Kelly Pesanelli³, Faye Cochrane⁴, Robert Friedman⁵, Michael P. LaValley⁶, David T. Felson⁷ and Julie J. Keysor^1,8, ¹Physical Therapy, Boston University Sargent College, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Health Sciences, Boston University Sargent College, Boston, MA, ⁴ENACT, Boston University Sargent College, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶Biostatistics, Boston University School of Public Health, Boston, MA, ⁷Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁸Clinical Epidemiology Research and Training, Boston University School of Medicine, Boston, MA
Background/Purpose: In knee osteoarthritis (OA) strengthening exercise improves pain and physical function, however a marked decline in exercise adherence has limited the long term efficacy…
Abstract Number: 307 • 2016 ACR/ARHP Annual Meeting
Visualizing Different Patterns of Cartilage Change: A Two-Year Study of Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Grace H. Lo², Michael P. LaValley³, Ming Zhang¹, Jeffrey B. Driban⁴, Lori Lyn Price⁵, Eric Miller⁶, Charles Eaton⁷ and Timothy E. McAlindon⁸, ¹Tufts Medical Center, Boston, MA, ²Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ³Biostatistics, Boston University School of Public Health, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁶Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁷Brown University, Providence, RI, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Traditionally, regions of the knee that are assessed in clinical trials are selected based on anatomy or responsiveness to change. However, it is unclear…
Abstract Number: 2342 • 2016 ACR/ARHP Annual Meeting
Understanding Patient Barriers and Facilitators to Healthy Eating and Physical Activity before and after Knee Replacement
Christine Pellegrini¹, Gwendolyn Ledford¹, Rowland W. Chang² and Kenzie Cameron³, ¹Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³General Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Knee replacement typically results in reduced pain and improved physical function, yet post-operative physical activity levels often remain unchanged. Many patients also gain weight…
Abstract Number: 316 • 2016 ACR/ARHP Annual Meeting
Postural Stability Is Associated with Lower Pain, Lower Stiffness, and Higher Muscle Power Among Adults with Symptomatic Knee Osteoarthritis
Wei Liu¹, Augustine C. Lee², William F. Harvey², Lori Lyn Price³, Jeffrey B. Driban² and Chenchen Wang², ¹Osteopathic Rehabilitation and Biomechanics, 1Edward Via College of Osteopathic Medicine, Auburn, AL, USA, Auburn, AL, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Clinical Care Research, Tufts Medical Center, Boston, MA
Background/Purpose: Postural stability is an indicator of static standing balance and a critical component of physical function and fall prevention among those with knee OA.…
Abstract Number: 2343 • 2016 ACR/ARHP Annual Meeting
A Phase 2, Multi-Center, Randomized, Double-Blind, Active-Controlled, Parallel Group Study to Evaluate the Safety and Dose Effectiveness of Intradermal Injections of Purified Apis Mellifera Toxin to Improve Pain and Physical Function in Patients with Osteoarthritis of the Knee
Douglas R. Schumacher¹, Anna Jakubowska² and Christopher M.H. Kim³, ¹Radiant Research, Columbus, OH, ²Apimeds, Inc., Jungwongu, Seongnam, Gyeonggido, Korea, The Republic of, ³CHA University, Bundanggu, Seongnam, Gyeongghido, Korea, The Republic of
Background/Purpose: This Phase 2a/b trial evaluated the safety and dose effectiveness of honeybee toxin (purified Apis melliferatoxin) injections to improve pain and physical function in…
Abstract Number: 448 • 2016 ACR/ARHP Annual Meeting
Cross-Cultural and Construct Validity of the Animated Activity Questionnaire to Assess Activity Limitations in Patients with Hip and Knee Osteoarthritis in Different Languages
Wilfred Peter¹, Henrica de Vet², Maarten Boers³, Jaap Harlaar⁴, Leo D. Roorda⁵, Rudolf Poolman⁶, Vanessa Scholtes⁷, Martijn P.M. Steultjens⁸, Gordon Hendry⁹, Ewa M. Roos¹⁰, Francis Guillemin¹¹, Maria Grazia Benedetti¹², Lorenzo Cavazutti¹², Antonio Escobar Martinez¹³, Hanne Dagfinrud¹⁴ and Caroline Terwee¹⁵, ¹Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, Netherlands, ²EMGO Institute, VU Medical Centre, Amsterdam, Netherlands, ³Epidemiology & Biostatistics, VU Univ Medical Center F-wing, Amsterdam, Netherlands, ⁴Dep of Rehabilitation Medicine and MOVE research institute, VU University Medical Center, Amsterdam, Netherlands, ⁵Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁶Orthopedic department, Joint Reserach, OLVG, Amsterdam, Netherlands, ⁷Department of Orthopedics, Joint Research, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands, ⁸Rehabilitation Medicine, VU University Medical Center, Amsterdam, Netherlands, ⁹School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom, ¹⁰Inst Sports and Biomechanics, University of Southern Denmark, Odense, Denmark, ¹¹University of Lorraine, Nancy, France, ¹²Physical Medicine and Rehabilitation Unit, Istituto Ortopedico Rizzoli, Bologna, Italy, ¹³Health Service Research Network on Chronic Diseases (REDISSEC), Basurto University Hospital, Bilbao, Spain, ¹⁴Department of Rheumatology /National Advosory Unit for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ¹⁵Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Application of the AAQ in international studies requires good cross-cultural validity, i.e. minimal Differential Item Functioning (DIF) across countries. The aim of this study…
Abstract Number: 2344 • 2016 ACR/ARHP Annual Meeting
Inflammation and Glucose Homeostasis Are Associated with Specific Structural Features Among Adults without Knee Osteoarthritis
Alina Stout¹, Mary Barbe², Charles B. Eaton³, Mamta Amin⁴, Fatimah Al Eid¹, Lori Lyn Price⁵, Bing Lu⁶, Grace H. Lo⁷, Ming Zhang⁸, Timothy E. McAlindon⁹ and Jeffrey Driban⁸, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Temple University School of Medicine, Philadelphia, PA, ³Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁴Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁵Clinical Care Research, Tufts Medical Center, Boston, MA, ⁶Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁷Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁸Tufts Medical Center, Boston, MA, ⁹Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Adults with osteoarthritis (OA) have greater glucose concentrations and inflammation. It remains unclear if inflammation and glucose homeostasis are related to specific features of…
Abstract Number: 449 • 2016 ACR/ARHP Annual Meeting
the Animated Activity Questionnaire to Assess Activity Limitations in Patients with Hip and Knee Osteoarthritis: Reliability, Responsiveness, and Interpretation
Wilfred Peter¹, Henrica de Vet², Rudolf Poolman³, Vanessa Scholtes⁴, Dionne Timmermans⁵, Nina Klein Essink⁵ and Caroline Terwee⁶, ¹Amsterdam Rehabilitation Research Centre, Reade, centre for rehabilitation and rheumatology, Amsterdam, Netherlands, ²EMGO Institute, VU Medical Centre, Amsterdam, Netherlands, ³Orthopedic department, Joint Reserach, OLVG, Amsterdam, Netherlands, ⁴Department of Orthopedics, Joint Research, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands, ⁵Orthopedics, Joint Research, OLVG, Amsterdam, Netherlands, ⁶Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: A newly developed and (cross-cultural) validated measurement tool, the computerized Animated Activity Questionnaire (AAQ) for assessing activity limitations in hip and knee osteoarthritis (HKOA)…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
Abstract Number: 108 • 2016 ACR/ARHP Annual Meeting
Does Receiving Physical Therapy for Knee Osteoarthritis Impact Downstream Healthcare Utilization?
Allyn Bove¹, Christopher Bise¹, Ken Smith², Julie Fritz³, John Childs⁴, Gerard P. Brennan⁵, J. Haxby Abbott⁶ and G. Kelley Fitzgerald⁷, ¹Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ²Division of Internal Medicine; Institute for Clinical Research Education, University of Pittsburgh, Pittsburgh, PA, ³Department of Physical Therapy, University of Utah, Salt Lake City, UT, ⁴US Army-Baylor University, Schertz, TX, ⁵Rehabilitation Services, Intermountain Healthcare, Murray, UT, ⁶Centre for Musculoskeletal Outcomes Research, Department of Surgical Sciences, University of Otago, Dunedin, New Zealand, ⁷Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The clinical effectiveness of supervised exercise therapy for individuals with knee osteoarthritis (KOA) is well known. However, it is unclear whether participation in a…
Abstract Number: 1017 • 2016 ACR/ARHP Annual Meeting
Statistical Simulation Using Data from the Foundation for the National Institute of Health/Osteoarthritis Initiative Biomarkers Consortium to Evaluate the Clinical Utility of Prognostic Knee Osteoarthritis Biomarkers in Designing a Knee Osteoarthritis Clinical Trial
Sheng Feng¹, Zheng (Roger) Liu², Feng Hong¹, Jeroen Medema¹, Rajesh Kamath¹ and Marc C. Levesque¹, ¹AbbVie Bioresearch Center, Worcester, MA, ²AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: Development of disease-modifying osteoarthritis drugs (DMOADs) for knee osteoarthritis (OA) has been challenging, partially owing to lack of prognostic biomarkers. Our objective was to…
Abstract Number: 2354 • 2016 ACR/ARHP Annual Meeting
Pharmaceutical Grade Chondroitin Sulfate Improves Knee Osteoarthritis Symptoms More Than Placebo and As Much As Celecoxib: Results of the Chondroitin Vs Celecoxib Vs Placebo Trial (CONCEPT)
J-Y Reginster and CONCEPT Authors' Group, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: For the assessment of Symptomatic Slow Acting Drugs in Osteoarthritis (SYSADOAs), regulatory Agencies request the assessment of two co-primary endpoints: pain and function. They…
Abstract Number: 110 • 2016 ACR/ARHP Annual Meeting
Patient Decisions Related to Hip and Knee Arthroplasty and the Factors Influencing Them
W. Benjamin Nowell¹, Shilpa Venkatachalam¹, Erik Harden¹ and Thomas Concannon^2,3, ¹Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ²The RAND Corporation, Boston, MA, ³Tufts University School of Medicine, Boston, MA
Background/Purpose: Patient-engaged research can improve the safety and satisfaction outcomes of hip and knee arthroplasty (joint replacement surgery). Patients are able to identify the decisions…
Abstract Number: 1020 • 2016 ACR/ARHP Annual Meeting
Risk Factors Can Classify Individuals Who Develop Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Timothy E. McAlindon², Mamta Amin³, Lori Lyn Price⁴, Charles B. Eaton⁵, Julie Davis⁶, Bing Lu⁷, Grace H. Lo⁸, Jeffrey Duryea⁹ and Mary Barbe¹⁰, ¹Tufts Medical Center, Boston, MA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁶Rheumatology, Tufts Medical Center, Boston, MA, ⁷Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁸Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁹Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ¹⁰Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Accelerated knee osteoarthritis (KOA) is a painful disorder and associated with several risk factors: greater age, greater body mass index (BMI), static knee alignment,…
Abstract Number: 2356 • 2016 ACR/ARHP Annual Meeting
Comparison of Spa Therapy with or without Physical Rehabilitation for Knee Osteoarthritis: A Randomized Controlled Trial
Anne-Christine Rat^1,2, Damien Loeuille³, Emmanuel Spitz⁴, Alexandra Desvignes⁵, Michel Boulange⁶, Jean Paysant⁷, Francis Guillemin⁸ and Isabelle Chary-Valckenaere⁹, ¹Université de Lorraine, Apemac EA4360, Nancy, Nancy, France, ²Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France, ³Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ⁴Rheumatology Strasbourg, Strasbourg, France, ⁵rheumatology, Hopital Simone Veil, Eaubonne, Eaubonne, France, ⁶Hydrologie et Climatologie Médicale, CHRU Nancy, Nancy, France, ⁷Institut de rééducaption et réadapattion Louis Pierquin, Nancy, France, ⁸CHRU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ⁹CHRU Nancy, Nancy, France
Background/Purpose: To demonstrate the non-inferiority of “Active” compared to “Standard” spa therapy at 6 months in symptomatic knee osteoarthritis (KOA) care. Methods: Prospective, randomized, monocenter,…

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