Abstracts tagged "Knee osteoarthritis"

Abstract Number: 0729 • ACR Convergence 2021
A Multicenter, Observational, Extension Study Evaluating the Safety, Tolerability, and Efficacy of a Single Lorecivivint Injection in Knee OA Subjects
Ismail Simsek¹, Christopher Swearingen¹, Heli Ghandehari¹, Sarah Kennedy², Jeyanesh Tambiah¹, Yusuf Yazici³ and Nebojsa Skrepnik⁴, ¹Biosplice Therapeutics, Inc., San Diego, CA, ²Biosplice Therapeutics, Inc, San Diego, CA, ³New York University School of Medicine, La Jolla, CA, ⁴Tucson Orthopaedic Institute, Tucson
Background/Purpose: Lorecivivint (LOR), a novel intra-articular (IA) CLK/DYRK inhibitor that modulates Wnt and inflammatory pathways, is in development as a knee osteoarthritis (OA) treatment. To…
Abstract Number: 0730 • ACR Convergence 2021
Safety, Tolerability, and Pharmacokinetics of an Intra-articular Corticosteroid Injection Administered 7 Days Before or After Intra-articular Lorecivivint Injection into the Same Knee of Healthy Volunteers: An Open-Label, Parallel-Arm Study
Amy Halseth¹, Nancy Lane², Sarah Kennedy³, Christopher Swearingen¹, Victor Lopez¹, Ismail Simsek¹, Mark Fineman¹ and Yusuf Yazici⁴, ¹Biosplice Therapeutics, Inc., San Diego, CA, ²University of California Davis, Hillsborough, CA, ³Biosplice Therapeutics, Inc, San Diego, CA, ⁴New York University School of Medicine, La Jolla, CA
Background/Purpose: Knee osteoarthritis (OA) is a painful condition leading to joint damage and impaired function. Intra-articular (IA) corticosteroid injections are frequently prescribed to treat pain.…
Abstract Number: 911 • 2019 ACR/ARP Annual Meeting
Perfusion in Bone Marrow Lesions Assessed on Dynamic Contrast-enhanced MRI and Its Association with Pain in Knee Osteoarthritis: A Cross-sectional Study
Cecilie Daugaard¹, Robert Riis ², Elisabeth Bandak ³, Janus Nybing ⁴, Stine Hangaard ³, Henrik Gudbergsen ³, Marius Henriksen ³, Henning Bliddal ³ and Mikael Boesen ⁴, ¹The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Frederiksberg, Sjelland, Denmark, ²Dept. of Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, ³The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Copenhagen, Denmark, ⁴Dept. of Radiology, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Copenhagen, Denmark
Background/Purpose: In osteoarthritis (OA) structural changes are only weakly associated with pain. The reason for this discrepancy remains unknown and the exact cause of knee…
Abstract Number: 2169 • 2019 ACR/ARP Annual Meeting
Reporting of Adverse Events in Randomized Controlled Trials of Therapeutic Exercise for Knee Osteoarthritis: A Systematic Review
Johan vonHeideken ¹ and Maura D. Iversen², ¹Karolinska Institutet, Stockholm, Sweden, ²Northeastern University, Boston
Background/Purpose: CONSORT guidelines recommend the reporting of adverse events (AEs) and drop outs, along with a description of each. However, the application of these guidelines…
Abstract Number: 2194 • 2019 ACR/ARP Annual Meeting
Surgical and Medical Weight Loss Threshold Dictates Decreases in Knee Osteoarthritis Pain but Not Reductions in Inflammatory Biomarkers
Fernando Bomfim¹, Shannon Chen ¹, Stephen Zak ², Taylor Jazrawi ¹, Madeline Kundler ², Vivienne Qie ², Laura Peralta ², Jose Aleman ², Christine Ren-Fielding ², Holly Lofton ², Jyoti Patel ², Mukundan Attur ³, Steven B. Abramson ³ and Jonathan Samuels ¹, ¹NYU Langone Health, New York, ²NYU Langone Health, New York, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY
Background/Purpose: Weight loss in obese patients can reduce knee osteoarthritis (OA) pain, even when physical therapy and intra-articular injections have failed. The impacts of either…
Abstract Number: 2201 • 2019 ACR/ARP Annual Meeting
Developing a Comprehensive Patient-Specific Disease Progression Prediction Model for Knee Osteoarthritis Using Machine/Deep Learning Methods
Afshin Jamshidi ¹, Mickael Leclercq ², Jean-Pierre Pelletier ³, Aurèlie Labbe ⁴, François Abram ⁵, Arnaud Droit ⁶ and Johanne Martel-Pelletier⁷, ¹University of Montreal Hospital Research Centre (CRCHUM); Laval University Hospital Research Centre, Québec, QC, Canada, ²Laval University Hospital Research Centre, q, QC, Canada, ³University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁴Department of Decision Sciences, HEC Montréal, Montreal, QC, Canada, ⁵ArthroLab Inc., Montreal, QC, Canada, ⁶Laval University Hospital Research Centre, Québec, QC, Canada, ⁷University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada
Background/Purpose: Current assessment of knee osteoarthritis (OA) is primarily based on a patient’s personal and familial history, clinical features, and on radiographies. However, such information…