ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Knee osteoarthritis"

  • Abstract Number: 0729 • ACR Convergence 2021

    A Multicenter, Observational, Extension Study Evaluating the Safety, Tolerability, and Efficacy of a Single Lorecivivint Injection in Knee OA Subjects

    Ismail Simsek1, Christopher Swearingen1, Heli Ghandehari1, Sarah Kennedy2, Jeyanesh Tambiah1, Yusuf Yazici3 and Nebojsa Skrepnik4, 1Biosplice Therapeutics, Inc., San Diego, CA, 2Biosplice Therapeutics, Inc, San Diego, CA, 3New York University School of Medicine, La Jolla, CA, 4Tucson Orthopaedic Institute, Tucson

    Background/Purpose: Lorecivivint (LOR), a novel intra-articular (IA) CLK/DYRK inhibitor that modulates Wnt and inflammatory pathways, is in development as a knee osteoarthritis (OA) treatment. To…
  • Abstract Number: 0730 • ACR Convergence 2021

    Safety, Tolerability, and Pharmacokinetics of an Intra-articular Corticosteroid Injection Administered 7 Days Before or After Intra-articular Lorecivivint Injection into the Same Knee of Healthy Volunteers: An Open-Label, Parallel-Arm Study

    Amy Halseth1, Nancy Lane2, Sarah Kennedy3, Christopher Swearingen1, Victor Lopez1, Ismail Simsek1, Mark Fineman1 and Yusuf Yazici4, 1Biosplice Therapeutics, Inc., San Diego, CA, 2University of California Davis, Hillsborough, CA, 3Biosplice Therapeutics, Inc, San Diego, CA, 4New York University School of Medicine, La Jolla, CA

    Background/Purpose: Knee osteoarthritis (OA) is a painful condition leading to joint damage and impaired function. Intra-articular (IA) corticosteroid injections are frequently prescribed to treat pain.…
  • Abstract Number: 911 • 2019 ACR/ARP Annual Meeting

    Perfusion in Bone Marrow Lesions Assessed on Dynamic Contrast-enhanced MRI and Its Association with Pain in Knee Osteoarthritis: A Cross-sectional Study

    Cecilie Daugaard1, Robert Riis 2, Elisabeth Bandak 3, Janus Nybing 4, Stine Hangaard 3, Henrik Gudbergsen 3, Marius Henriksen 3, Henning Bliddal 3 and Mikael Boesen 4, 1The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Frederiksberg, Sjelland, Denmark, 2Dept. of Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, 3The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Copenhagen, Denmark, 4Dept. of Radiology, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Copenhagen, Denmark

    Background/Purpose: In osteoarthritis (OA) structural changes are only weakly associated with pain. The reason for this discrepancy remains unknown and the exact cause of knee…
  • Abstract Number: 2169 • 2019 ACR/ARP Annual Meeting

    Reporting of Adverse Events in Randomized Controlled Trials of Therapeutic Exercise for Knee Osteoarthritis: A Systematic Review

    Johan vonHeideken 1 and Maura D. Iversen2, 1Karolinska Institutet, Stockholm, Sweden, 2Northeastern University, Boston

    Background/Purpose: CONSORT guidelines recommend the reporting of adverse events (AEs) and drop outs, along with a description of each. However, the application of these guidelines…
  • Abstract Number: 2194 • 2019 ACR/ARP Annual Meeting

    Surgical and Medical Weight Loss Threshold Dictates Decreases in Knee Osteoarthritis Pain but Not Reductions in Inflammatory Biomarkers

    Fernando Bomfim1, Shannon Chen 1, Stephen Zak 2, Taylor Jazrawi 1, Madeline Kundler 2, Vivienne Qie 2, Laura Peralta 2, Jose Aleman 2, Christine Ren-Fielding 2, Holly Lofton 2, Jyoti Patel 2, Mukundan Attur 3, Steven B. Abramson 3 and Jonathan Samuels 1, 1NYU Langone Health, New York, 2NYU Langone Health, New York, NY, 3NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY

    Background/Purpose: Weight loss in obese patients can reduce knee osteoarthritis (OA) pain, even when physical therapy and intra-articular injections have failed. The impacts of either…
  • Abstract Number: 2201 • 2019 ACR/ARP Annual Meeting

    Developing a Comprehensive Patient-Specific Disease Progression Prediction Model for Knee Osteoarthritis Using Machine/Deep Learning Methods

    Afshin Jamshidi 1, Mickael Leclercq 2, Jean-Pierre Pelletier 3, Aurèlie Labbe 4, François Abram 5, Arnaud Droit 6 and Johanne Martel-Pelletier7, 1University of Montreal Hospital Research Centre (CRCHUM); Laval University Hospital Research Centre, Québec, QC, Canada, 2Laval University Hospital Research Centre, q, QC, Canada, 3University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 4Department of Decision Sciences, HEC Montréal, Montreal, QC, Canada, 5ArthroLab Inc., Montreal, QC, Canada, 6Laval University Hospital Research Centre, Québec, QC, Canada, 7University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada

    Background/Purpose: Current assessment of knee osteoarthritis (OA) is primarily based on a patient’s personal and familial history, clinical features, and on radiographies. However, such information…
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