ACR Meeting Abstracts

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Abstracts tagged "Juvenile idiopathic arthritis"

  • Abstract Number: 0867 • ACR Convergence 2022

    Regulatory Haplotype of CXCR4 Is Associated with sJIA and Corelates with Enhanced Neutrophil and CD14+ Monocyte Migration

    Hiroto Nakano1, Emily Shuldiner2, Anne Hinks3, Marc Sudman4, Elaine Remmers5, Colleen Satorius6, Elizabeth Schmitz1, Victoria Arthur7, Patricia Woo8, Alexei Grom9, Dirk Foell10, John Bohnsack11, Marco Gattorno12, Seza Ozen13, Sampath Prahalad14, Rae Yeung15, Elizabeth Mellins2, Sheila Oliveira16, Jordi Antón17, Claudio Len18, Carol Lake19, Ly-Lan Bergeron20, Michelle Millwood21, Estefania de los santos21, Mariana Correia Marques22, Juvenile Arthritis Consortium for the Immunochip23, The Genomic Ascertainment Cohort Investigators24, INCHARGE Consortium25, Carl Langefeld26, Susan Thompson27, Wendy Thomson28 and Michael Ombrello1, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2Stanford University, Stanford, CA, 3The University of Manchester, Manchester, United Kingdom, 4Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5National Human Genome Research Institute, Bethesda, MD, 6NHGRI, NIH, Bethesda, MD, 7Boston Children's Hospital, Boston, MA, 8University College London, London, United Kingdom, 9Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10University Hospital Münster, Münster, Germany, 11University of Utah, Salt Lake City, UT, 12Pediatric Clinic and Rheumatology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy, 13Hacettepe University Faculty of Medicine, Ankara, Turkey, 14Emory + Children's Pediatric Institute, Atlanta, GA, 15The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 16Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil, 17Pediatric Rheumatology Department. Hospital Sant Joan de Déu. Universitat de Barcelona, Esplugues de Llobregat, Spain, 18Universidade Federal de São Paulo, São Paulo, Brazil, 19NIH, Gaithersburg, MD, 20NIH/NIAMS, Vienna, VA, 21NIAMS, NIH, Bethesda, MD, 22National Institute of Arthritis and Musculoskeletal and Skin Diseases / Children`s National Hospital, Bethesda, MD, 23Juvenile Arthritis Consortium for the Immunochip, Bethesda, MD, 24The Genomic Ascertainment Cohort Investigators, Bethesda, MD, 25International Childhood Arthritis Genetics Consortium, Bethesda, MD, 26Wake Forest School of Medicine, Winston Salem, NC, 27Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Blue Ash, OH, 28Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a rare inflammatory disease that causes spiking fever, skin rash, chronic arthritis, and inflammation of the heart and…
  • Abstract Number: 1934 • ACR Convergence 2022

    Transition Readiness Before versus After Adolescents with Rheumatic Disease Transition to Adult Care

    Christina Ma1, Alessana Carmona2, Habeba Talaat2, Julie Herrington3, Tania Cellucci4, Stephanie Garner2, Mark Matsos2, KAREN BEATTIE2 and Michelle Batthish2, 1McMaster University, Canada, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3ACPAC, Hamilton, ON, Canada, 4McMaster Children's Hospital, Hamilton, ON, Canada

    Background/Purpose: The transition from pediatric to adult rheumatology care is associated with increased disease activity and morbidity for patients with rheumatic disease. Consequently, there has…
  • Abstract Number: 0740 • ACR Convergence 2022

    Real-World Demographics, Clinical Characteristics, and Treatment Patterns of Patients Treated with Emapalumab for Secondary Hemophagocytic Lymphohistiocytosis in the United States: The REAL-HLH Study

    Carl Allen1, Shanmuganathan Chandrakasan2, Michael Jordan3, Jennifer Leiding4, Abiola Oladapo5, Priti Pednekar6, Kelly Walkovich7 and John Yee8, 1Baylor College of Medicine, Houston, TX, 2Emory University School of Medicine, Atlanta, GA, 3University of Cincinnati, Cincinnati, OH, 4Johns Hopkins University, Baltimore, MD, 5Swedish Orphan Biovitrum AB, Boston, MA, 6PRECISIONheor, Los Angeles, CA, 7University of Michigan Health, Ann Arbor, MI, 8Sobi - North America, Waltham, MA

    Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening, hyperinflammatory syndrome caused by overproduction of proinflammatory cytokines, e.g., interferon gamma (IFNγ). Secondary HLH (sHLH), a subtype…
  • Abstract Number: 0868 • ACR Convergence 2022

    Spondyloarthritis and Neonatal Factors Affecting the Gut Microbiome

    Joy Um1, Douglas Einstadter2, Myung-Yong Um3 and Maria Antonelli1, 1Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 2Center for Health Care Research and Policy, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 3Department of Social Welfare, Sungkyunkwan University, Seoul, Republic of Korea

    Background/Purpose: Spondyloarthritis (SpA) consists of clinically and genetically related but phenotypically distinct disorders, including ankylosing spondylitis, enteropathic arthritis, psoriatic arthritis, reactive arthritis, and enthesitis-related arthritis…
  • Abstract Number: 1939 • ACR Convergence 2022

    Safety and Humoral Response Following the Second and Third Doses of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents with Juvenile-onset Autoimmune Inflammatory Rheumatic Diseases

    Merav Heshin-Bekenstein1, amit ziv2, NATASA TOPLAK3, Adi Miller Barmak4, Siman Lazauskas5, Danielle Kadishevich6, Efrat Ben Nun6, Esther Saiag7, Yonatan Butbul Aviel4, Gabi Shefer7, Sara Pel8, Ori Elkayam7 and Yosef Uziel9, 1Dana Dwek Children's Hospital, Tel Aviv Medical Center Israel, Binyamina, Israel, 2Meir Hospital, Kfar Saba, Israel, 3University of Ljubljana, Ljubljana, Slovenia, 4Rambam Medical Center, Haifa, Israel, 5Tel Aviv Medical Center, Tel Aviv, Israel, 6Meir Medical Center, Kfar Saba, Israel, 7Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 8Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel, 9Meir Medical Center, Kfar Saba; Sackler School of Medicine, Tel Aviv University, Kfar Saba, Israel

    Background/Purpose: Long-term data on the safety and dynamics of the immune response to the BNT162b2 mRNA COVID-19 vaccine in adolescents with juvenile-onset autoimmune inflammatory rheumatic…
  • Abstract Number: 0808 • ACR Convergence 2022

    Transitional Care in Juvenile Idiopathic Arthritis: Timing, Prevalence of Subtypes and Treatment Profile in a Spanish Tertiary Hospital

    Cristobal Pavez Perales1, Alba Torrat Novés2, José Ivorra Cortés1, Samuel Leal Rodriguez1, Anderson V Huaylla Quispe3, Carmen Riesco Bárcena2, Laura Mas Sanchez1, Pablo Muñoz Martinez4, Elena Grau García1, Elvira Vicens Bernabeu1, José Eloy Oller Rodrígez1, Francisco Miguel Ortiz Sanjuan5, Isabel Martínez-Cordellat1, Rosa Negueroles Albuixech1, Berta Lopez Montecinos6, Carmen Nájera Herranz1, Inés Cánovas Olmos1, Daniel Ramos Castro1, Inmaculada Calvo Penades7, Luis González Puig8 and José andrés Román ivorra9, 1Rheumatology Department. Hospital Universitario y Politécnico La Fe, València, Spain, 2Rheumatology Department. Hospital Universitario y Politécnico La Fe, València, 3Rheumatology Department. Hospital Universitario y Politécnico La Fe, València, Comunidad Valenciana, Spain, 4Rheumatology Department. Hospital Universitario y Politécnico La Fe, Sagunto, Spain, 5Rheumatology Department. Hospital Universitario y Politécnico La Fe, Spain, Spain, 6Pediatric Rheumatology Unit. Hospital Universitario y Politécnico La Fe, València, Comunidad Valenciana, Spain, 7Pediatric Rheumatology Unit, Hospital Universitario y Politécnico La Fe, València, Spain, 8Rheumatology Department. Hospital Universitario y Politécnico La Fe, Torrente, Valencia, Spain, 9Hospital Universitari i Politécnic la Fe, València, Spain

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the leading cause of chronic inflammatory rheumatic disease in children. It's classified into subtypes with different relative prevalences depending…
  • Abstract Number: 0870 • ACR Convergence 2022

    Knee Acoustic Emissions as a Noninvasive Biomarker of Articular Health in Juvenile Idiopathic Arthritis

    Sevda Gharehbaghi1, Emily Moise1, Priya Brito2, Lori Ponder3, Omer Inan1 and Sampath Prahalad4, 1Georgia Institute of Technology, Atlanta, GA, 2Emory University, Atlanta, GA, 3Children's Healthcare of Atlanta, Atlanta, GA, 4Emory + Children's Pediatric Institute, Atlanta, GA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) refers to all forms of autoimmune arthritis in children with undetermined etiology, and thus it is the most prevalent chronic…
  • Abstract Number: 1943 • ACR Convergence 2022

    Prevalence and Evolution of Undifferentiated Periodic Fever Syndromes in an Academic Pediatric Rheumatology Practice

    Jacob Anderson1, Catherine Bingham2, Lisabeth Scalzi3, Natalya Gaffney4, Kimberly Hays5, Brandt Groh2 and Timothy Hahn2, 1Phoenix Children's Hospital, Phoenix, AZ, 2Penn State Children's Hospital, Hershey, PA, 3Penn State Health, Hummelstown, PA, 4Self-Employed, Carlisle, PA, 5Penn State Health, Hershey, PA

    Background/Purpose: Periodic Fever Syndromes (PFS) are common referrals to pediatric rheumatology clinics. While the syndrome of Periodic Fevers, Aphthous stomatitis, Pharyngitis, and Adenitis (PFAPA) is…
  • Abstract Number: 0850 • ACR Convergence 2022

    Outcomes of Patients with Juvenile Idiopathic Arthritis Following Failure of Initial Tumor Necrosis Factor Inhibitor Medication in the Childhood Arthritis and Rheumatology Research Alliance Registry

    Melissa Mannion1, Shahla Amin2, Stephen Balevic3, Colleen Correll4, Timothy Beukelman1 and , for the CARRA Registry Investigators5, 1University of Alabama at Birmingham, Birmingham, AL, 2Childhood Arthritis and Rheumatology Research Alliance, Washington, DC, 3Duke University, Durham, NC, 4University of Minnesota, Minneapolis, MN, 5CARRA, Washington, DC

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are the most commonly used first biologics to treat juvenile idiopathic arthritis (JIA), but it is unknown what subsequent…
  • Abstract Number: 0873 • ACR Convergence 2022

    Celiac-Associated Arthritis: Clinical Features, Treatment, and Outcomes

    Ana Luiza Altaffer1 and Pamela Weiss2, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2Children's Hospital of Philadelphia, Glen Mills, PA

    Background/Purpose: Although arthritis is recognized as one of the extra-intestinal manifestations of celiac disease, little is known about the clinical course and outcomes of celiac-associated…
  • Abstract Number: 1944 • ACR Convergence 2022

    Description and Delays in Care in the Bridge to Adult Care from Childhood for Young Adults with Rheumatic Disease (BACC YARD) Program, a Pediatric-to-Adult Rheumatology Transition Program

    John Bridges1, Livie Huie2, Amanda Alexander3, Randy Cron2, Maria Danila2, Victoria Gennaro4, Laura Hughes2, Bailey Lipham5, Linda McAllister6, Matthew Mullen7, Annelle Reed4, Daniel Reiff2, Carolyn Smith4, Emily Smitherman2, Matthew Stoll2, Peter Weiser2 and Melissa Mannion2, 1University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Homewood, AL, 4Children's of Alabama, Birmingham, AL, 5University of Alabama Medical School, Birmingham, AL, 6Children's of Alabama, Trussville, AL, 7University of Alabama-Birmingham, Vestavia Hills, AL

    Background/Purpose: Children with chronic rheumatic conditions age and require transfer to adult rheumatologists for continued care. The transition period from pediatric to adult-oriented care is…
  • Abstract Number: 0851 • ACR Convergence 2022

    Responsiveness of Patient-Reported Physical Function Measures in Juvenile Arthritis

    Alysha Taxter1, Laura Schanberg2, Marc Natter3 and for the CARRA Registry investigators4, 1Nationwide Children's Hospital, Columbus, OH, 2Duke University Medical Center, Durham, NC, 3Boston Children's Hospital, Boston, MA, 4CARRA, Washington, DC

    Background/Purpose: The ACR Pediatric Criteria (ACR Pedi) contains a core set of outcome variables, including a measure of functional ability, to evaluate improvement over time…
  • Abstract Number: 0874 • ACR Convergence 2022

    A Tale of Many Canadas: Associations of Ethnicity with Juvenile Idiopathic Arthritis Categories and Disease Severity at Presentation in a Multicultural Universal Healthcare Setting: Results from ReACCh-Out

    Stephanie Wong1, Lori Tucker2, Kristin Houghton3, David Cabral4, Mercedes Chan2, Ross Petty3, Andrea Human2, Kimberly Morishita3, Rae Yeung5, Kiem Oen6, Ciaran Duffy7, Roberta Berard8, Gaelle Chedeville9, Thomas Loughin10, Matthew Berkowitz10 and Jaime Guzman11, 1University of British Columbia, Vancouver, BC, Canada, 2British Columbia Children's Hospital, Vancouver, BC, Canada, 3University of British Columbia - Vancouver, Vancouver, BC, Canada, 4BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 5The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 6University of Manitoba, Toronto, ON, Canada, 7University of Ottawa, Ottawa, ON, Canada, 8London Health Sciences Centre, London, ON, Canada, 9McGill University, Montréal, QC, Canada, 10Simon Fraser University, Vancouver, BC, Canada, 11University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada

    Background/Purpose: The distribution of Juvenile Idiopathic Arthritis (JIA) categories and disease severity at presentation vary across countries, however it is unclear how much of this…
  • Abstract Number: 2209 • ACR Convergence 2022

    Efficacy of Secukinumab in Enthesitis-related Arthritis and Juvenile Psoriatic Arthritis Subtypes of Juvenile Idiopathic Arthritis: Results from a Randomized, Phase 3 Study

    Hermine Brunner1, Elena Chertok2, Joke Dehoorne3, Gerd Horneff4, Tilmann Kallinich5, Ingrid Louw6, Maria Alessio7, Sandrine Compeyrot-Lacassagne8, Bernard Lauwerys9, Neil Martin10, Katherine Marzan11, W Patrick Knibbe12, Ruvie Martin13, Xuan Zhu14, sarah whelan15, Luminita Pricop16, Daniel Lovell17, Alberto Martini18 and Nicola Ruperto19, 1Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Department of Pediatrics, Cincinnati, OH, 2Voronezh State Medical University, Voronezh, Russia, 3University Hospital Gent, Gent, Belgium, 4Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 5Charité - Universitätsmedizin Berlin, Nuremberg, Germany, 6Panaroma Medical Centre, Cape Town, South Africa, 7Policlinico Federico II di Napoli, Napoli, Italy, 8Great Ormond Street Hospital for Children, London, United Kingdom, 9Cliniques Universitaires Saint-Luc, Brussels, Belgium, 10Royal Hospital for Children, Glasgow, Scotland, United Kingdom, 11Children's Hospital Los Angeles, Los Angeles, CA, 12St. Luke's Hospital System, Meridian, ID, 13Novartis Pharmaceutical Corporation, East Hanover, NJ, 14Novartis Pharmaceuticals Corporation, Basking Ridge, NJ, 15Novartis Ireland Ltd, Crumlin, Dublin, Ireland, 16Novartis Pharmaceuticals Corporation, East Hanover, NJ, 17Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 18Istituto Giannina Gaslini, Genova, Italy, 19IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy

    Background/Purpose: Juvenile idiopathic arthritis (JIA) categories of enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) represent pediatric counterparts of adult non-radiographic axial spondyloarthritis and psoriatic…
  • Abstract Number: 0853 • ACR Convergence 2022

    Reliability of MRI Lesions Comprising the Preliminary OMERACT Juvenile Idiopathic Arthritis MRI Score (OMERACT JAMRI-SIJ): What Is the Impact of Systematic Reader Calibration?

    Walter P Maksymowych1, Nisha Varma2, Arthur Meyers3, Jennifer Stimec4, Nikolay Tzaribachev5, Jonathan Akikusa6, Tarimobo Otobo4, Marion von Rossum7, Andrea Doria4 and Nele Herregods8, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Department of Paediatric Radiology, The Royal Children's Hospital Melbourne, Melbourne, Australia, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Department of Diagnostic Imaging, SickKids, University of Toronto, Toronto, ON, Canada, 5PRI Research Institute, Bad Bramstedt, Germany, 6Rheumatology Service, Royal Children’s Hospital, Melbourne, Melbourne, Australia, 7Emma Children’s Hospital, Dept Pediatrics, Amsterdam University Medical Centers, Amsterdam, Netherlands, 8Ghent University Hospital, Ghent, Belgium

    Background/Purpose: The evaluation of the sacroiliac joints (SIJ) in children with Juvenile Idiopathic Arthritis (JIA) increasingly relies on the use of MRI since radiography is…
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