Abstracts tagged "Joint Structure"

Abstract Number: 2099 • ACR Convergence 2024
A Longitudinal Study of Infrapatellar Fat Pad Morphologies as Predictive Markersin Knee Osteoarthritis
Jean-Pierre Pelletier¹, Patrice Paiement¹, François Abram², Marc Dorais³ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l'Île-Perrot, QC, Canada
Background/Purpose: Currently, no established marker effectively stratifies knee osteoarthritis (OA) patients into subgroups. The infrapatellar fat pad (IPFP) has been proposed as a potential key…
Abstract Number: 1984 • ACR Convergence 2023
Therapeutic Effects of Pentosan Polysulfate Sodium on Clinical and Disease Modifying Outcomes in Subjects with Knee Osteoarthritis
Mukesh Ahuja¹, Donna Skerrett², Curtis Gravance³, Divya Navuru⁴, Ravi Krishnan⁵, Charles Inderjeeth⁶, Philip Bloom⁷ and Schnitzer Thomas⁸, ¹Paradigm Biopharmaceuticals, Oak Brook, IL, ²Paradigm Biopharmaceuticals, New York, NY, ³Paradigm Biopharmaceuticals, Melba, ID, ⁴Paradigm Biopharmaceuticals, Melbourne, Australia, ⁵Paradigm Biopharmaceuticals, Adelaide, Australia, ⁶University of Western Australia / Linear Clinical Research, Perth, Australia, ⁷Sportsmed Biologic, Melbourne, Australia, ⁸Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is an inflammatory joint disease, causing chronic pain, disability, and reduced quality of life. Affected joints may include the knee, hip, and…
Abstract Number: 2426 • ACR Convergence 2023
The Role of β-catenin in Synovial Lining Fibroblast Differentiation
Sonia Presti¹, Gerald F.M. Watts¹, Junning Case¹, Zhu Zhu², Teri Bowman¹, Hung Nguyen¹, Gabriel Nigrovic¹, Ce Gao¹, Kartik Bhamidipati¹, Yuhong Li¹, Suppawat Kongthong¹, Fan Zhang³, Anna Helena Jonsson¹, Accelerating Medicines Partnership Program (AMP RA/SLE) Network⁴, STARS BWH¹, Michael Brenner⁵, Shideh Kazerounian¹ and Kevin Wei⁵, ¹Brigham and Women's Hospital, Boston, MA, ²10x Genomics, St. Louis, MO, ³University of Colorado, Aurora, CO, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, Boston, MA, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In healthy synovium, lining fibroblasts promote joint health by secreting proteoglycans that lubricate the joint cavity. In rheumatoid arthritis (RA), sublining fibroblasts undergo marked…
Abstract Number: 0750 • ACR Convergence 2023
Multispectral Optoacoustic Tomography of the Entheses Reveals Common Metabolic and Architectural Tissue Patterns in Psoriasis and Psoriatic Arthritis Independent of Inflammation
Filippo Fagni¹, Koray Tascilar¹, Rita Noversa de Sousa², Sara Bayat¹, Lukas Sollfrank³, Arnd Kleyer⁴, Michael Sticherling⁵, Adrian Regensburger⁶, Ferdinand Knieling⁶, Georg Schett⁷, Maximilian Waldner⁸ and David Simon¹, ¹Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology / Deutsches Zentrum Immuntherapie, Erlangen, Germany, ²Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, ³Department Dermatology, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, ⁴University Hospital Erlangen, Erlangen, Germany, ⁵Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, ⁶Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, ⁷Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ⁸Department of Internal Medicine 1, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany
Background/Purpose: Multispectral optoacoustic tomography (MSOT) is a novel imaging platform that combines ultrasound (US) with optoacoustic imaging to allow non-invasive in vivo quantification of key…
Abstract Number: 1309 • ACR Convergence 2023
Refractory RA Patients for Targeted Therapies in Real Life
Elena Grau Garcia¹, Laura Mas Sanchez², Pablo Francisco Muñoz Martínez³, Carmen Riesco Barcena¹, Alba Maria Torrat Noves¹, Daniel Ramos Castro¹, Anderson Victor Huaylla Quispe¹, Iago Alcantara Alvarez¹, Belen Villanueva Mañez¹, Ernesto Tovar Sugrañes¹, Elvira Vicens Bernabeu¹, Hikmat Charia¹, Marta De la Rubia Navarro², Luis Gonzalez Puig¹, Jose Ivorra Cortes¹, Samuel Leal Rodriguez¹, Isabel Martinez Cordellat¹, Rosa Negueroles Albuixech¹, Jose Eloy Oller Rodriguez¹, Ines Canovas Olmos¹, Carmen Najera Herranz¹ and Jose Andres Roman Ivorra⁴, ¹Rheumatology Department. HUP La Fe, Valencia, Spain, ²Rheumatology Department. HUP La Fe, Valéncia, Spain, ³Rheumatology Department. HUP La Fe, Sagunto, Spain, ⁴Hospital Universitari i Politècnic la Fe, Valencia, Spain
Background/Purpose: Despite the increasing number of available targeted therapies (TT) in rheumatoid arthritis (RA), a proportion of RA patients fail to respond to their first…
Abstract Number: 1732 • ACR Convergence 2023
Immunopathogenesis and Preclinical Trials in a Humanized Mouse Model of Rheumatoid Arthritis(RA)
Huiyi Wang¹, Kangkang Luo¹, Shuxin Xu¹, Jiayin Zhou¹, Santi Chen², Jun wang², Wenzhao Li², Jing Zhao¹ and Cunxiang Ju¹, ¹GemPharmatech CO., Ltd., Nanjing, China, ²GemPharmatech LLC, La Jolla, CA
Background/Purpose: The differences between human and mouse immune systems make it challenging to accurately reflect the immunopathogenesis of autoimmune diseases in patients. Therefore, translational research…
Abstract Number: 1865 • ACR Convergence 2023
Is Flexion Contracture in Knee Osteoarthritis Associated with MRI Pathologies over Time? Data from the Osteoarthritis Initiative
Daniel Chan Chun Kong¹, Philip Conaghan² and Mark Campbell³, ¹University of Ottawa, Ottawa, ON, Canada, ²University of Leeds, Leeds, United Kingdom, ³Elisabeth Bruyere Hospital, Ottawa, ON, Canada
Background/Purpose: Knee flexion contracture (FC) is associated with worse clinical outcomes in those with knee OA. Cross sectional data demonstrated that knee FC was associated…
Abstract Number: 1886 • ACR Convergence 2023
Costotransverse Joint Ankylosis and Association with Syndesmophyte Progression in Patients with Radiographic Axial Spondyloarthritis
Hong Ki Min¹, Se Hee Kim², Hae-Rim Kim³, Sang-Heon Lee¹ and Sang-Hoon Lee², ¹Konkuk University School of Medicine, Seoul, South Korea, ²Kyung Hee University Hospital at Gangdong, Seoul, South Korea, ³Rheumatology, Konkuk University Medical Center, Seoul, South Korea
Background/Purpose: Costotransverse joint ankylosis in radiographic axial spondyloarthritis (r-axSpA) patients was measured. Furthermore, the association between syndesmophyte progression assessed by CT syndesmophyte score (CTSS) and…
Abstract Number: 1982 • ACR Convergence 2023
Effect of Denosumab on Knee Pain and Bone Marrow Lesions in Symptomatic Knee Osteoarthritis
Terence O'Neill¹, Matthew Parkes¹, Michael Bowes², Richard Hodgson¹ and David Felson³, ¹University of Manchester, Manchester, United Kingdom, ²Imorphics, Manchester, United Kingdom, ³Boston University, Boston, MA
Background/Purpose: There are currently no licensed therapies which reduce progression of knee OA. Current therapies focus on reducing pain, have limited effect, and some have…
Abstract Number: 0267 • ACR Convergence 2022
Cancer Risk with Biologic and Targeted Synthetic DMARDs in Patients with Rheumatic Diseases and Previous Malignancy: Results from the BIOBADASER Register
Juan Molina¹, Fernando Sanchez-Alonso², Cristina Bohorquez³, Cesar Diaz-Torne⁴, Carolina Perez-Garcia⁵, Juan Maria Blanco-Madrigal⁶, Paloma Vela-Casampere⁷, José María Älvaro-Gracia¹ and Isabel Castrejon⁸, ¹Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain, ³University Hospital Príncipe de Asturias, Immune System Diseases-Rheumatology Service, Alcalá de Henares, Madrid, Spain, ⁴Department of Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁵Department of Rheumatology, Hospital del Mar, Barcelona, Spain, ⁶Department of Rheumatology, Hospital de Basurto, Bilbao, Spain, ⁷Hospital General Universitario Alicante, Alicante, Spain, ⁸Hospital Universitario Gregorio Marañón, Madrid, Spain
Background/Purpose: To investigate the occurrence and relative risk of incident malignancy in patients with rheumatic diseases and previous malignancy treated with biologic and targeted synthetic…
Abstract Number: 0404 • ACR Convergence 2022
Site-Specific Responses of Joint and Entheses to Tofacitinib in Patients with Ankylosing Spondylitis: A Post Hoc Analysis of a Phase 3 Trial
Raphael Micheroli¹, Tim Killeen², Hyejin Jo³, Kenneth Kwok³, Bassel Elzorkany⁴, Caroline Ospelt⁵, Adrian Ciurea⁶ and Michael Nissen⁷, ¹University Hospital Zurich, Department of Rheumatology, Zürich, Switzerland, ²Pfizer Ltd, Tadworth, Switzerland, ³Pfizer Inc, New York, NY, ⁴Department of Rheumatology, Cairo University, Cairo, Egypt, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, ⁶University Hospital Zurich, Zürich, Switzerland, ⁷Hopitaux Universitaires de Genève, Geneva, Switzerland
Background/Purpose: Sites of peripheral joint and enthesitis involvement in AS vary. Tofacitinib is an oral Janus kinase inhibitor for the treatment of AS. Differential site-specific…
Abstract Number: 0504 • ACR Convergence 2022
Three-dimensional Ground Reaction Force Symmetry Metrics Largely Fail to Explain Cartilage Worsening in the Contralateral Knee in Persons with Unilateral Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Patrick Corrigan¹, Cara Lewis², Kerry Costello², Ali Guermazi², Frank Roemer³, Deepak Kumar², David Felson², Kathryn Bacon², Tuhina Neogi⁴, Michael LaValley⁵, Michael Nevitt⁶, Cora E. Lewis⁷, James Torner⁸ and Joshua Stefanik⁹, ¹Saint Louis University, St. Louis, MO, ²Boston University, Boston, MA, ³Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany, ⁴Boston University School of Medicine, Boston, MA, ⁵Boston University School of Public Health, Arlington, MA, ⁶University of California San Francisco, Orinda, CA, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸University of Iowa, Iowa City, IA, ⁹Northeastern University, Boston, MA
Background/Purpose: Knee osteoarthritis (KOA) often starts as a unilateral disease and commonly progresses to bilateral KOA. There is a need to identify mechanisms that explain…
Abstract Number: 0610 • ACR Convergence 2022
Patient-derived Organoids Reveal Transcriptional Regulation of Synovial Lining Fibroblast Differentiation
Sonia Presti¹, Gerald FM Watts¹, Zhu Zhu¹, Kartik Bhamidipati¹, Junning Case¹, Yuhong Li¹, Teri Bowman¹, Suppawat Kongthong¹, ilya Korsunsky¹, Michael Brenner² and Kevin Wei³, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Synovial lining fibroblasts secrete factors into the joint cavity that promote joint lubrication1. In inflammatory arthritis, sublining fibroblasts undergo marked expansion while lining fibroblasts…
Abstract Number: 0803 • ACR Convergence 2022
Performance of Adenosine Deaminase Activity in Sinovial Fluid for the Early Diagnosis of Tuberculous Arthritis: A Meta Analysis
Juan Carlos Cortés-Quiroz¹, Javier Ena², José Antonio Bernal³ and José Rosas⁴, ¹Marina Baixa Hospital, Mutxamel, Spain, ²Department of Internal Medicine. Marina Baixa Hospital, Villajoyosa, Spain, ³Rheumatology Department. Marina Baixa Hospital, Alicante, Spain, ⁴Rheumatology Department, Hospital Marina Baixa, Villajoyosa, Spain
Background/Purpose: Adenosine deaminase (ADA) activity has shown good performance in diagnosing pleural, peritoneal, and meningeal tuberculosis. This study aimed to evaluate the performance of measuring…
Abstract Number: 0972 • ACR Convergence 2022
Automated Joint Space Width Measurement for Hand Osteoarthritis: A Deep Learning Approach
Zhiheng Chang¹, Juan Shan², Yue Wang², Xinyue Sun³, Jeffrey Driban⁴, Timothy McAlindon⁵, Jeffrey Duryea⁶, Lena Schaefer⁶, Charles Eaton⁷ and Ming Zhang⁸, ¹Wentworth Institute of Technol, Boston, MA, ²Pace University, New York, NY, ³Shandong University, Qing Dao, Shandong, China, ⁴Tufts Medical Center, Westborough, MA, ⁵Tufts Medical Center, Arlington, MA, ⁶Brigham and Women's Hospital, Boston, MA, ⁷Brown University, Pawtucket, RI, ⁸Boston University, Westford, MA
Background/Purpose: Hand osteoarthritis (OA) can be assessed visually through radiographs using Kellgren and Lawrence (KL) system. However, the KL grading system is not fully objective…

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