ACR Meeting Abstracts

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Abstracts tagged "Joint Structure"

  • Abstract Number: 0792 • ACR Convergence 2024

    Radiographic and Pain Outcomes from a Phase 3 Trial (OA-07) Evaluating the Efficacy and Safety of Repeat Lorecivivint Injections over 3 Years in Subjects with Knee OA

    Yusuf Yazici1, Jeyanesh Tambiah2, Christopher Swearingen3 and Timothy McAlindon4, 1NYU Grossman School of Medicine, La Jolla, CA, 2Biosplice Therapeutics Inc., San Diego, CA, 3Biosplice Therapeutics, Inc, San Diego, CA, 4University of Massachusets, Worchester, MA

    Background/Purpose: Knee OA has unmet need for safe and efficacious symptom and disease-modifying treatments. Lorecivivint (LOR), an intra-articular (IA) CLK/DYRK inhibitor thought to modulate inflammatory…
  • Abstract Number: 0926 • ACR Convergence 2024

    Macrophages and Nociceptor Neurons Form a Sentinel Unit Around Fenestrated Capillaries to Defend the Synovium from Systemic Challenges

    Tetsuo Hasegawa and Menna Clatworthy, University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inflammation, often mediated by circulating immune complexes…
  • Abstract Number: 1180 • ACR Convergence 2024

    Relationship Between Changes in Physical Activity and Early Onset Knee Osteoarthritis in Individuals After ACL Reconstruction

    David Werner1, Yvonne Golightly1, Michael Rosenthal1, Balasrinivasa Sajja1, Christopher Wichman1, Melissa Manzer2, Matthew Tao1 and Elizabeth Wellsandt1, 1University of Nebraska Medical Center, Omaha, NE, 2Private Practice, Omaha

    Background/Purpose: Low physical activity levels are associated with osteoarthritis (OA) development and progression in individuals at risk for OA development. Including both structural and symptomatic…
  • Abstract Number: 1184 • ACR Convergence 2024

    Sustained Clinical Effects After a Single Intra-articular Injection of PCRX-201 for Moderate-to-Severe Osteoarthritis of the Knee

    Stanley Cohen1, Philip G Conaghan2, Marc Hochberg3, Alan Kivitz4, Nino Joy5, Derek Jackson5, Masato Nakazawa5, Mary DiGiorgi5 and Jonathan Slonin5, 1Metroplex Clinical Research Center, dallas, TX, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3University of Maryland School of Medicine, Baltimore, MD, 4Altoona Center for Clinical Research, Duncansville, PA, 5Pacira BioSciences, Inc., Tampa, FL

    Background/Purpose: Osteoarthritis of the knee (OAK) is a common and severe disease. Current treatments provide temporary pain relief, demonstrating unmet need. PCRX-201 is a high…
  • Abstract Number: 1551 • ACR Convergence 2024

    Efficacy of Belimumab on Different Phenotypes of Joint and Skin Manifestations of Systemic Lupus Erythematosus: Preliminary Data from a Multicenter, Nationwide, Cohort of Patients: The BElimumab in Real Life Setting Study-New Joint and Skin (BeRLISS-NeJS)

    Luca Iaccarino1, Marisol Bracalenti2, Alberto Cauli3, Lorenzo Cavagna4, Rossella De Angelis5, Roberto Depascale2, Giacomo Emmi6, Roberto Gerli7, Marcello Govoni8, Alberto Lo Gullo9, Simone Negrini10, Luca Quartuccio11, Maurizio Rossini12, Carlo Salvarani13, Paola Tomietto14, Angelo Vacca15, Margherita Zen16 and doria Andrea2, 1University of Padua, PADOVA, Italy, 2University of Padova, Padova, Italy, 3University of Cagliari, Cagliari, Italy, 4University of Pavia and Fondazione IRCCS Policlinico San Matteo Hospital of Pavia, Pavia, Pavia, Italy, 5Università Politecnica delle Marche, Ancona, Italy, 6University of Trieste, Trieste, Italy, 7University of Perugia, Perugia, Italy, 8Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Ferrara, Italy, Ferrara, Italy, 9Rheumatology Unit, Papardo Hospital, Messina, Italy, 10University of Genova, Genova, Italy, 11Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, Udine, Italy, 12Rheumatology Unit, University of Verona, Verona, Italy, 13Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy, Reggio Emilia, Italy, 14Azienda Sanitaria Universitaria Giuliano Isontina, trieste, Italy, 15University of Bari, Bari, Italy, 16University of Padova, Padova, Padua, Italy

    Background/Purpose: To evaluate the efficacy of belimumab on different skin and joint manifestations of the disease in a multicenter, nationwide, cohort (BeRLISS-NeJS) of patients with…
  • Abstract Number: 2050 • ACR Convergence 2024

    Clinical Enthesitis Concerns Half the Patients with Psoriatic Arthritis, Is More Frequent in Trials Than in Observational Studies and Is Assessed Heterogeneously: A Systematic Review with Meta-analysis of 84,262 Patients from 212 Studies

    caroline pignon1, Laure Gossec2, Bruno Fautrel3, Clementina López Medina4 and Noemie bibas5, 1Faculté de médecine Créteil, PARIS, France, 2Sorbonne Université, Paris, France, 3INSERM, UMRS 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, and Sorbonne University – Assistance Publique-Hôpitaux de Paris, Département de Rhumatologie, Hôpital Pitié-Salpêtrière, Paris, Ile-de-France, France, 4Reina Sofia University Hospital, Cordoba, Spain, 5Sorbonne Université, paris

    Background/Purpose: Enthesitis is considered a hallmark of psoriatic arthritis (PsA), however data on the frequency and consequences of enthesitis are conflicting. To analyze clinical enthesitis in…
  • Abstract Number: 2099 • ACR Convergence 2024

    A Longitudinal Study of Infrapatellar Fat Pad Morphologies as Predictive Markersin Knee Osteoarthritis

    Jean-Pierre Pelletier1, Patrice Paiement1, François Abram2, Marc Dorais3 and Johanne Martel-Pelletier1, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada, 3StatSciences Inc., Notre-Dame de l'Île-Perrot, QC, Canada

    Background/Purpose: Currently, no established marker effectively stratifies knee osteoarthritis (OA) patients into subgroups. The infrapatellar fat pad (IPFP) has been proposed as a potential key…
  • Abstract Number: 1982 • ACR Convergence 2023

    Effect of Denosumab on Knee Pain and Bone Marrow Lesions in Symptomatic Knee Osteoarthritis

    Terence O'Neill1, Matthew Parkes1, Michael Bowes2, Richard Hodgson1 and David Felson3, 1University of Manchester, Manchester, United Kingdom, 2Imorphics, Manchester, United Kingdom, 3Boston University, Boston, MA

    Background/Purpose: There are currently no licensed therapies which reduce progression of knee OA. Current therapies focus on reducing pain, have limited effect, and some have…
  • Abstract Number: 1984 • ACR Convergence 2023

    Therapeutic Effects of Pentosan Polysulfate Sodium on Clinical and Disease Modifying Outcomes in Subjects with Knee Osteoarthritis

    Mukesh Ahuja1, Donna Skerrett2, Curtis Gravance3, Divya Navuru4, Ravi Krishnan5, Charles Inderjeeth6, Philip Bloom7 and Schnitzer Thomas8, 1Paradigm Biopharmaceuticals, Oak Brook, IL, 2Paradigm Biopharmaceuticals, New York, NY, 3Paradigm Biopharmaceuticals, Melba, ID, 4Paradigm Biopharmaceuticals, Melbourne, Australia, 5Paradigm Biopharmaceuticals, Adelaide, Australia, 6University of Western Australia / Linear Clinical Research, Perth, Australia, 7Sportsmed Biologic, Melbourne, Australia, 8Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Osteoarthritis (OA) is an inflammatory joint disease, causing chronic pain, disability, and reduced quality of life. Affected joints may include the knee, hip, and…
  • Abstract Number: 2426 • ACR Convergence 2023

    The Role of β-catenin in Synovial Lining Fibroblast Differentiation

    Sonia Presti1, Gerald F.M. Watts1, Junning Case1, Zhu Zhu2, Teri Bowman1, Hung Nguyen1, Gabriel Nigrovic1, Ce Gao1, Kartik Bhamidipati1, Yuhong Li1, Suppawat Kongthong1, Fan Zhang3, Anna Helena Jonsson1, Accelerating Medicines Partnership Program (AMP RA/SLE) Network4, STARS BWH1, Michael Brenner5, Shideh Kazerounian1 and Kevin Wei5, 1Brigham and Women's Hospital, Boston, MA, 210x Genomics, St. Louis, MO, 3University of Colorado, Aurora, CO, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: In healthy synovium, lining fibroblasts promote joint health by secreting proteoglycans that lubricate the joint cavity. In rheumatoid arthritis (RA), sublining fibroblasts undergo marked…
  • Abstract Number: 0750 • ACR Convergence 2023

    Multispectral Optoacoustic Tomography of the Entheses Reveals Common Metabolic and Architectural Tissue Patterns in Psoriasis and Psoriatic Arthritis Independent of Inflammation

    Filippo Fagni1, Koray Tascilar1, Rita Noversa de Sousa2, Sara Bayat1, Lukas Sollfrank3, Arnd Kleyer4, Michael Sticherling5, Adrian Regensburger6, Ferdinand Knieling6, Georg Schett7, Maximilian Waldner8 and David Simon1, 1Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology / Deutsches Zentrum Immuntherapie, Erlangen, Germany, 2Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3Department Dermatology, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, 4University Hospital Erlangen, Erlangen, Germany, 5Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 6Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, 7Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 8Department of Internal Medicine 1, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Multispectral optoacoustic tomography (MSOT) is a novel imaging platform that combines ultrasound (US) with optoacoustic imaging to allow non-invasive in vivo quantification of key…
  • Abstract Number: 1309 • ACR Convergence 2023

    Refractory RA Patients for Targeted Therapies in Real Life

    Elena Grau Garcia1, Laura Mas Sanchez2, Pablo Francisco Muñoz Martínez3, Carmen Riesco Barcena1, Alba Maria Torrat Noves1, Daniel Ramos Castro1, Anderson Victor Huaylla Quispe1, Iago Alcantara Alvarez1, Belen Villanueva Mañez1, Ernesto Tovar Sugrañes1, Elvira Vicens Bernabeu1, Hikmat Charia1, Marta De la Rubia Navarro2, Luis Gonzalez Puig1, Jose Ivorra Cortes1, Samuel Leal Rodriguez1, Isabel Martinez Cordellat1, Rosa Negueroles Albuixech1, Jose Eloy Oller Rodriguez1, Ines Canovas Olmos1, Carmen Najera Herranz1 and Jose Andres Roman Ivorra4, 1Rheumatology Department. HUP La Fe, Valencia, Spain, 2Rheumatology Department. HUP La Fe, Valéncia, Spain, 3Rheumatology Department. HUP La Fe, Sagunto, Spain, 4Hospital Universitari i Politècnic la Fe, Valencia, Spain

    Background/Purpose: Despite the increasing number of available targeted therapies (TT) in rheumatoid arthritis (RA), a proportion of RA patients fail to respond to their first…
  • Abstract Number: 1732 • ACR Convergence 2023

    Immunopathogenesis and Preclinical Trials in a Humanized Mouse Model of Rheumatoid Arthritis(RA)

    Huiyi Wang1, Kangkang Luo1, Shuxin Xu1, Jiayin Zhou1, Santi Chen2, Jun wang2, Wenzhao Li2, Jing Zhao1 and Cunxiang Ju1, 1GemPharmatech CO., Ltd., Nanjing, China, 2GemPharmatech LLC, La Jolla, CA

    Background/Purpose: The differences between human and mouse immune systems make it challenging to accurately reflect the immunopathogenesis of autoimmune diseases in patients. Therefore, translational research…
  • Abstract Number: 1865 • ACR Convergence 2023

    Is Flexion Contracture in Knee Osteoarthritis Associated with MRI Pathologies over Time? Data from the Osteoarthritis Initiative

    Daniel Chan Chun Kong1, Philip Conaghan2 and Mark Campbell3, 1University of Ottawa, Ottawa, ON, Canada, 2University of Leeds, Leeds, United Kingdom, 3Elisabeth Bruyere Hospital, Ottawa, ON, Canada

    Background/Purpose: Knee flexion contracture (FC) is associated with worse clinical outcomes in those with knee OA. Cross sectional data demonstrated that knee FC was associated…
  • Abstract Number: 1886 • ACR Convergence 2023

    Costotransverse Joint Ankylosis and Association with Syndesmophyte Progression in Patients with Radiographic Axial Spondyloarthritis

    Hong Ki Min1, Se Hee Kim2, Hae-Rim Kim3, Sang-Heon Lee1 and Sang-Hoon Lee2, 1Konkuk University School of Medicine, Seoul, South Korea, 2Kyung Hee University Hospital at Gangdong, Seoul, South Korea, 3Rheumatology, Konkuk University Medical Center, Seoul, South Korea

    Background/Purpose: Costotransverse joint ankylosis in radiographic axial spondyloarthritis (r-axSpA) patients was measured. Furthermore, the association between syndesmophyte progression assessed by CT syndesmophyte score (CTSS) and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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