Abstracts tagged "Joint replacement"

Abstract Number: 445 • 2018 ACR/ARHP Annual Meeting
Interleukin-1β Inhibition with Canakinumab Associates with Reduced Rates of Total Hip and Knee Replacement (THR/TKR) and Osteoarthritis (OA) Symptoms: Exploratory Results from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS)
Matthias Schieker¹, Linda Mindeholm¹, Jens Praestgaard², Celeste Scotti¹, Daniel Solomon³, Tom Thuren⁴, Kasper Dreyer⁵, Ronenn Roubenoff¹ and Paul M. Ridker⁶, ¹Novartis Institutes for Biomedical Research, Basel, Switzerland, ²Novartis Institutes for Biomedical Research, East Hanover, NJ, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Novartis Pharma AG, East Hanover, NJ, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Division of Preventive Medicine, Cardiovascular Diseases, Brigham and Women's Hospital, Boston, MA
Background/Purpose: In osteoarthritis (OA), there are no therapeutics to prevent disease progression. Canakinumab, a monoclonal antibody targeting interleukin-1β, reduced inflammation and cardiovascular events in the…
Abstract Number: 953 • 2018 ACR/ARHP Annual Meeting
Evaluating MRI-Detected Knee Inflammation Prior to Total Knee Replacement As a Predictive Biomarker of Clinically Important Pain Reduction Two Years Later
Manjinder Kaur¹, Lili Zhou², Erin L. Ashbeck², Ernest Vina³, Frank Roemer⁴, Ali Guermazi⁵, David J. Hunter⁶ and C. Kent Kwoh^1,2, ¹Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, Tucson, AZ, ³University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, ⁴Department of Radiology, Boston University School of Medicine, Boston, MA, USA, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶University of Sydney, Sydney, Australia
Background/Purpose: Some patients do not experience clinical improvement after total knee replacement (TKR). Presence of structural abnormalities on MRI before surgery may inform pain prognosis…
Abstract Number: 1154 • 2018 ACR/ARHP Annual Meeting
Patterns of Opioid Use and Patient Characteristics before Total Hip and Knee Replacement
Yinzhu Jin¹, Daniel Solomon^1,2, Patricia D. Franklin³, Yvonne C. Lee⁴, Joyce Lii¹, Jeffrey N. Katz⁵ and Seoyoung C. Kim^6,7, ¹Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Musculoskeletal Center of Excellence, University of Massachusetts Medical School, Worcester, MA, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁶Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Patients with moderate-to-severe hip or knee arthritis often use opioids before undergoing total joint replacement (TJR). Preoperative opioid use may lead to persistent opioid…
Abstract Number: 1178 • 2018 ACR/ARHP Annual Meeting
Patients’ and Healthcare Professionals’ Resource Preferences for a Knowledge Translation Toolkit for Hip and Knee Replacement Rehabilitation
Marie Westby¹, Cheryl L. Koehn², Sheila Kerr³ and Alison Hoens⁴, ¹Centre for Hip Health and Mobility, Vancouver, BC, Canada, ²Arthritis Consumer Experts, Vancouver, BC, Canada, ³Patient Advisor, Vancouver, BC, Canada, ⁴Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Widely varying rehabilitation practices for total joint replacement (TJR) for hip and knee osteoarthritis (OA) contribute to inconsistent patient outcomes and satisfaction. Informed by…
Abstract Number: 1238 • 2018 ACR/ARHP Annual Meeting
The Effect of Antibiotic Therapy on Positive Culture Results Among Patients with Prosthetic Joint Septic Arthritis
Efrat Gur Rosset¹, Mary Louise Fowler², Sarah Lieber³, Robert Shmerling⁴ and Ziv Paz^3,5,6, ¹Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel, ²Boston University School of Medicine, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ⁵Galilee Medical Center, Nahariya, Israel, ⁶Azrieli Faculty of Medicine, Bar-Ilan University, Sefad, Israel
Background/Purpose: Little is known about the effects of antibiotic therapy on synovial and blood culture results among patients with prosthetic joint septic arthritis (PJSA). In…
Abstract Number: 1239 • 2018 ACR/ARHP Annual Meeting
Organisms Associated with Prosthetic Joint Septic Arthritis over the Past Two Decades: Data from a Single Tertiary Medical Center Located in the Northeastern United States
Manny Menachem Arieli¹, Mary Louise Fowler², Sarah Lieber³, Robert Shmerling⁴, Mohammad Naffaa⁵ and Ziv Paz^1,3, ¹Azrieli Faculty of Medicine, Bar-Ilan University, Sefad, Israel, ²Boston University School of Medicine, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ⁵Galilee Medical Center, Israel, Naharriya, Israel
Background/Purpose: In recent years, joint replacement surgery (JRS) has become increasingly common. Prosthetic joint septic arthritis (PJSA) may complicate JRS in up to 1% of…
Abstract Number: 1373 • 2018 ACR/ARHP Annual Meeting
Predictive Probabilities Are Superior in Communicating the Clinical Relevance of Cartilage Thickness As an Imaging Biomarker of Knee Osteoarthritis Progression
C. Kent Kwoh^1,2, Erin L. Ashbeck¹, Edward J. Bedrick³ and Felix Eckstein^4,5, ¹University of Arizona Arthritis Center, Tucson, AZ, ²Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ³Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, ⁴Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁵Chondrometrics GmbH, Ainring, Germany
Background/Purpose: Establishing a threshold of clinically important cartilage loss is of great interest for the design and interpretation of knee OA trials of structure-modifying treatments.…
Abstract Number: 2188 • 2016 ACR/ARHP Annual Meeting
Association Between Extent of Symptomatic Joint Involvement in Osteoarthritis and Comorbid Lung Disease in Patients Scheduled for Joint-Replacement Surgery
Anthony V. Perruccio^1,2,3, Rajiv Gandhi⁴, J. Denise Power^5,6 and Elizabeth M. Badley⁷, ¹The Arthritis Program, University Health Network, Toronto, ON, Canada, ²Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ³Health Care & Outcomes Research, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴University Health Network, Arthritis Program, Toronto, ON, Canada, ⁵Arthritis Program, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, Toronto, ON, Canada, ⁷Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: Comorbidity is highly prevalent in osteoarthritis (OA), although the origin of this is not well understood. The presence of multi-joint symptoms in OA, and…
Abstract Number: 2303 • 2016 ACR/ARHP Annual Meeting
Trends in Gout and Rheumatoid Arthritis Hospitalizations in Canada from 2000-2011
Sharan K. Rai^1,2, J. Antonio Avina-Zubieta^2,3, Natalie McCormick^2,4, Mary A. De Vera^2,5, Diane Lacaille^2,6, Eric C. Sayre² and Hyon K. Choi^7,8, ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁵Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁶Medicine, University of British Columbia, Vancouver, BC, Canada, ⁷Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁸Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: Gout and rheumatoid arthritis (RA) are the two most common forms of inflammatory arthritis worldwide. As hospitalizations for both conditions lead to substantial health…
Abstract Number: 2592 • 2016 ACR/ARHP Annual Meeting
The Impact of Biologic Therapy Introduction on Hip and Knee Replacement Among Rheumatoid Arthritis Patients: An Interrupted Time Series Analysis Using the Clinical Practice Research Datalink
Samuel Hawley¹, René Cordtz², Lene Dreyer³, Christopher J. Edwards⁴, Nigel K Arden⁵, Antonella Delmestri⁵, Cyrus Cooper^1,6, Andrew Judge⁵ and Daniel Prieto-Alhambra⁷, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ²Dept. of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup, Denmark, ³Internal Medicine - Rheumatology Section, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, ⁴University of Southampton, Southampton, United Kingdom, ⁵Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁶Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁷Internal Medicine and Primary Care, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol i Gurina-Institut Català de la Salut; Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Barcelona, Spain
Background/Purpose: In several developed countries it has been observed that the incidence of orthopaedic surgery among rheumatoid arthritis (RA) patients has been in decline, despite…
Abstract Number: 2312 • 2015 ACR/ARHP Annual Meeting
Patient Preferences for Total Knee Replacement Surgery: Two Year Follow-up
Ernest Vina¹, Di Ran², Erin Ashbeck², Said Ibrahim³, Michael J. Hannon⁴, Jin Zhou⁵ and C. Kent Kwoh¹, ¹Rheumatology, University of Arizona, Tucson, AZ, ²Arthritis Center, University of Arizona, Tucson, AZ, ³Medicine, University of Pennsylvania, Philadelphia, PA, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA, ⁵Epidemiology & Biostatistics, University of Arizona, Tucson, AZ
Background/Purpose: Patients’ preferences for total knee replacement (TKR) may determine actual receipt of TKR and may also change over time. Yet, no study has longitudinally…
Abstract Number: 413 • 2014 ACR/ARHP Annual Meeting
Association of Antinuclear Antibodies with Lung Disease, Malignancy and Joint Replacement in Rheumatoid Arthritis
Reshmi Raveendran¹, Bobby Kwanghoon Han², Quan-Zhen Li³ and Nancy J. Olsen¹, ¹Medicine, Penn State MS Hershey Medical Center, Hershey, PA, ²Rheumatology, Cooper Medical School of Rowan University, Camden, NJ, ³Immunology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose Antinuclear antibodies (ANAs) are present in a significant proportion of patients with rheumatoid arthritis (RA). Positivity for ANA in RA has been associated with…
Abstract Number: 65 • 2014 ACR/ARHP Annual Meeting
Impact of Dropout and Total Knee Replacement on Joint Space Narrowing Estimation: Data from Osteoarthritis Initiaive
Jamie E. Collins and Elena Losina, Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA
Impact of dropout and TKR on Joint Space Narrowing estimation: data from Osteoarthritis InitiativeBackground/Purpose: Structural progression in knee osteoarthritis (OA) is often measured by Joint…
Abstract Number: 2968 • 2014 ACR/ARHP Annual Meeting
Improvement Following Total Knee Replacement (TKR) Surgery: Exploring Preoperative Symptoms and Change in Preoperative Symptoms
Ernest R. Vina¹, Michael J. Hannon² and C. Kent Kwoh³, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh and VA Healthcare System, Pittsburgh, PA, ²Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Arizona, Tucson, AZ
Background/Purpose Few have examined the trajectories of preoperative health-related quality of life (HRQL) measures in osteoarthritis (OA) patients who undergo TKR. Yet, the type and…
Abstract Number: 1841 • 2014 ACR/ARHP Annual Meeting
Eventual Joint Failure and Surgery Rates in Rheumatoid Arthritis Remain High in Patients with Moderate Disease Activity in the First 5 Years of Disease
Elena Nikiphorou¹, Lewis Carpenter², Sam Norton³, Josh Dixey⁴, Patrick Kiely⁵, David Walsh^6,7 and Adam Young^1,8, ¹School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, ²Centre for Lifespan & Chronic Illness Research, University of Hertfordshire, Hatfield, United Kingdom, ³Institute of Psychiatry, King's College London, London, United Kingdom, ⁴Rheumatology, New Cross Hospital, Wolverhampton, United Kingdom, ⁵Rheumatology Dept, St. Georges Healthcare NHS Trust, London, United Kingdom, ⁶Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, ⁷Rheumatology, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, United Kingdom, ⁸Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom
Background/Purpose: It is well-established that sustained high disease activity in RA results in worse outcomes. In reality many patients remain in low/moderate disease activity states,…

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