ACR Meeting Abstracts

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Abstracts tagged "joint destruction"

  • Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting

    Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort

    Rik Schelbergen1, Wouter de Munter2, Martijn van den Bosch3, Floris Lafeber4, Annet Sloetjes3, Thomas Vogl5, Johannes Roth5, Peter M. van der Kraan6, Arjen B. Blom3, Wim B van den Berg3 and Peter L. van Lent3, 1Radboud university medical center, Nijmegen, Netherlands, 2Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 6Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
  • Abstract Number: 1123 • 2014 ACR/ARHP Annual Meeting

    Impact of Genes Modulating Serum Low-Density Lipoprotein Cholesterol Levels on Progression of Joint Destruction in Japanese Patients with Rheumatoid Arthritis

    Shinji Yoshida1, Katsunori Ikari1, Koichiro Yano1, Yoshiaki Toyama2, Atsuo Taniguchi3, Hisashi Yamanaka1 and Shigeki Momohara3, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, 3Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose Patients with rheumatoid arthritis (RA) have a higher prevalence of dyslipidemia than healthy individuals. Since RA is a chronic inflammatory disease, an inflammatory response…
  • Abstract Number: 513 • 2014 ACR/ARHP Annual Meeting

    Analysis of Shoulder Joint Destruction in Rheumatoid Arthritis Patients Treated with Biologics

    Yukio Yonemoto, Koichi Okamura, Tetsuya Kaneko, Chisa Okura and Kenji Takagishi, Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan

    Background/Purpose The assessment of joint destruction in rheumatoid arthritis (RA) patients being treated with biologics is normally mainly carried out for small joints. There are…
  • Abstract Number: 125 • 2014 ACR/ARHP Annual Meeting

    PD Signal Detected By Ultrasonography Relates to Joint Destruction in Rheumatoid Arthritis Under Biologics Therapy in Real World

    Maasa Hama1, Yumiko Sugiyama1, Naomi Tsuchida1, Yosuke Kunishita1, Daiga Kishimoto1, Reikou Kamiyama1, Kaoru Minegishi-Takase1, Ryusuke Yoshimi1, Yohei Kirino2, Mitsuhiro Takeno3, Atsuhisa Ueda1 and Yoshiaki Ishigatsubo1, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan

    Background/Purpose: Biologic DMARD (biologics) therapy for rheumatoid arthritis (RA) strongly suppresses joint destruction regardless of its efficacy for disease activity. On the contrary power Doppler…
  • Abstract Number: 119 • 2014 ACR/ARHP Annual Meeting

    Sonographic Evaluation of the Fifth Metatarsophalangeal Joint Erosion in Rheumatoid Arthritis

    Nevsun Inanc1, Gulsen Ozen1, Sibel Z. Aydin2, Esen Kasapoglu Gunal3 and Haner Direskeneli1, 1Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 2Department of Rheumatology, Koc University Faculty of Medicine, Istanbul, Turkey, 3Department of Rheumatology, Goztepe Medeniyet University Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: Joint erosions in RA correlate with structural damage progression and functional capacity. Therefore, detection and the follow-up of erosions are of paramount importance for…
  • Abstract Number: 79 • 2013 ACR/ARHP Annual Meeting

    Synovial Activation In Experimental OA Drives Immuno suppressive Effects Of Adipose-derived Stem Cells After Local Administration and Protects Against Chondrogenesis In Ligaments

    Peter L.E.M. van Lent1, Rik Schelbergen1, Menno C. ter Huurne2, Arjen B. Blom1, Johannes Roth3, Thomas Vogl4, Christian Jorgensen5 and Wim B. van den Berg6, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 4Institute of Immunology, University of Muenster, Muenster, Germany, 5Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, 6Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: A substantial subpopulation of patients with early osteoarthritis (OA) show a thickened synovial lining layer comprising macrophages expressing an activated phenotype (reflected by production of…
  • Abstract Number: 174 • 2013 ACR/ARHP Annual Meeting

    Genetic Association On Disease Severity In Rheumatoid Arthritis: A Validation Study In Japanese Patients

    Shinji Yoshida1, Katsunori Ikari1, Koichiro Yano1, Yoshiaki Toyama2, Atsuo Taniguchi3, Hisashi Yamanaka1 and Shigeki Momohara3, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, 3Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: The disease severity of rheumatoid arthritis (RA) is objectively measured by radiographic joint destruction, which is reflective of the cumulative burden of inflammation. Recently,…
  • Abstract Number: 1726 • 2013 ACR/ARHP Annual Meeting

    Survivin Inhibition Disturbs Bcl-6 and Blimp-1 Control Of Lymphocyte Maturation and Alleviates Antigen-Induced Arthritis

    Mattias Svensson1, Karin Andersson1, Malin Erlandsson1, Ing-Marie Jonsson2 and Maria Bokarewa1, 1Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation Research, Göteborgs University, Göteborg, Sweden

    Background/Purpose: Survivin is a proto-oncogene known to regulate cell division and apoptosis. In patients with rheumatoid arthritis, survivin has emerged as an independent predictor of…
  • Abstract Number: 1457 • 2013 ACR/ARHP Annual Meeting

    Inhibitory Effect Of Abatacept On Joint Damage In Rheumatoid Arthritis Patients With Or Without Concomitant Methotrexate: A Retrospective Multicenter Analysis Of 12 Months Of Abatacept Treatment In Routine Clinical Practice

    Isao Matsushita1, Hiraku Motomura1, Eiko Seki1 and Tomoatsu Kimura2, 1Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Japan, 2Department of rthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Japan

    Background/Purpose: Abatacept is approved for use with or without methotrexate (MTX). The purpose of this study was to clarify the inhibitory effect of abatacept on…
  • Abstract Number: 1453 • 2013 ACR/ARHP Annual Meeting

    Repeated High Or Low Multi-Biomarker Disease Activity (VECTRA® DA Algorithm) Scores Associated With Radiographic Outcomes In Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors

    Shintaro Hirata1, Wanying Li2, Nadine A. Defranoux2, Rebecca Bolce2, Eric H. Sasso2, Satoshi Kubo1, Shunsuke Fukuyo1, Kentaro Hanami3, Kunihiro Yamaoka1, Kazuyoshi Saito1 and Yoshiya Tanaka1, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2Crescendo Bioscience Inc., South San Francisco, CA, 3The first department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan

    Background/Purpose: A novel multi-biomarker disease activity (MBDA) score that is based on the serum concentrations of 12 biomarkers has been shown to correlate with clinical…
  • Abstract Number: 1849 • 2012 ACR/ARHP Annual Meeting

    Value of Matrices Developed to Identify Early Rheumatoid Arthritis Patients with Rapid Radiographic Progression Despite Methotrexate Therapy: A Comparison of Their Performance in the Early Rheumatoid Arthritis Espoir Cohort

    Bruno Fautrel1, Benjamin Granger2, Bernard Combe3, Francis Guillemin4, Alain Saraux5 and Xavier Le Loët6, 1Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, 2Biostatistics - GRC08-EEMOIS, Université Pierre et Marie Curie - Paris 6 ; AP-HP, Paris, France, 3CHU Lapeyronie, Montpellier, France, 4Hopitaux de Brabois, Nancy, France, 5Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, 6Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France

    Background/Purpose: Rapid radiographic progression (RRP) – i.e., increase of the Sharp/van der Heijde score (vSHS) ≥ 5 points during the 1st year – is a…
  • Abstract Number: 1040 • 2012 ACR/ARHP Annual Meeting

    Combined High-Resolution Single Photon Emission Computed Tomography and Magnetic Resonance Imaging for Therapy Monitoring in Rheumatoid Arthritis

    Philipp Sewerin1, Christian Buchbender2, Katalin Mattes-György3, Falk Miese2, Hans-Jörg Wittsack2, Christof Specker4, Gerald Antoch2, Matthias Schneider5, Axel Scherer2 and Ben Ostendorf1, 1Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, 2Diagnostic and Interventional Radiology, Heinrich-Heine-University, Düsseldorf, Germany, 3Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany, 4Department of rheumatology and clinical immunology, Hospital Essen Sued, Essem, Germany, 5Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany

    Background/Purpose: To evaluate whether combined multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labelled disphosphonates (Tc99m-DPD) and magnetic resonance imaging (MRI) detect changes in inflammation…
  • Abstract Number: 1022 • 2012 ACR/ARHP Annual Meeting

    Imaging of Ankle Joints by MRI in Murine Models of Inflammatory Arthritis

    Shawn M. Rose1, Harris R. Perlman2, Emily Alex Waters3 and Thomas Meade3, 1Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Chemistry of Life Processes Institute, Northwestern University, Evanston, IL

    Background/Purpose: One of the fundamental shortcomings in the field of experimental rheumatology is the inability to non-invasively monitor the development of inflammatory arthritis longitudinally.  Magnetic…
  • Abstract Number: 894 • 2012 ACR/ARHP Annual Meeting

    Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts

    A. Krabben1, A. G. Wilson2, R. Knevel1, A. Zhernakova3, E. Brouwer3, E. Lindqvist4, T. Saxne4, G. Stoeken-Rijsbergen1, J. A. B. van Nies1, D. P. C. de Rooy1, T.W.J. Huizinga1, B. P. C. Koeleman5, R. E. M. Toes1, P. K. Gregersen6 and A. H. M. van der Helm-van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Infection & Immunity, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, 4Rheumatology, Lund University, Lund, Sweden, 5Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 6Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY

    Background/Purpose: The severity of RA is reflected by the severity of radiological joint destruction. It is highly variable between patients and up to 58% of…
  • Abstract Number: 895 • 2012 ACR/ARHP Annual Meeting

    Transcriptomics of Synovial Tissue of Early Human (CHECK) and Experimental OA Identify Pathways Associated with Cartilage Damage

    Arjen B. Blom1, Peter L.E.M. van Lent2, Martijn H. van den Bosch1, Hans Cats3, Peter M. van der Kraan1 and Wim B. van den Berg4, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Many osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. Mechanisms through which synovial activation contributes to the joint pathology that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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