Abstracts tagged "joint destruction"

Abstract Number: 1981 • 2019 ACR/ARP Annual Meeting
Functional Differences Between Osteoclasts and Osteoclast-like Cells Differentiated from Peripheral Blood Mononuclear Cells in Patients with Rheumatoid Arthritis
Kazuhiro Yokota¹, Yoshimi Aizaki ¹, Shinya Tanaka ², Kojiro Sato ³, Yasuto Araki ¹, Noritsune Kouzu ⁴, Yuho Kadono ², Hiromi Oda ⁵ and Toshihide Mimura ¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, ³Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan, ⁴Medical Kouzu orthopedic and Yachiyo radiation center, Chiba, Japan, ⁵Department of Orthopedic Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Osteoclasts (OCs) are giant multinucleated cells formed from precursors of the monocyte/macrophage lineage and are believe to play a major role in the bone…
Abstract Number: 1498 • 2018 ACR/ARHP Annual Meeting
Serum MMP-3 More Than 155ng/Ml at Baseline Predicts One-Year Radiographic Progression in Patients with Rheumatoid Arthritis
Jian-Da Ma¹, Jun-Wei Wang², Yan-Hui Xu², Kui-Min Yang², Le-Feng Chen², Jian-Zi Lin² and Lie Dai², ¹Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong, China, ²Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
Background/Purpose: Core disease activity indicators of rheumatoid arthritis (RA) have been found to be limited in predicting joint destruction progression. We previously reported that continuously…
Abstract Number: 53 • 2017 ACR/ARHP Annual Meeting
Poly-γ-Glutamic Acid Inhibits RANKL- Induced Osteoclast Differentiation and Prevents Bone Destruction in Rheumatoid Arthritis: Human and CIA Mouse Model
Bitnara Lee¹, Jong-Dae Ji² and Tae-Hwan Kim¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Rheumatology, Korea University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by chronic inflammation and bone destruction. Osteoclasts, which are bone-resorbing cells, are generally known…
Abstract Number: 250 • 2017 ACR/ARHP Annual Meeting
An Ultrasonographic Study for Investigating Relationships with the Signs of Uric Deposition and Bone Erosion in Patients with Hyperuricemia
Ikuko Tanaka¹, Takashi Kato², Motokazu Kai³, Kunikazu Ogawa³, Hisaji Oshima⁴ and Shigenori Tamaki⁵, ¹NAGOYA Rheumatology Clinic, Nagoya, Japan, ²Department of Radiology, National Center for Geratrics and Gerontology, Obu, Japan, ³Mie Rheumatology Clinic, Suzuka, Japan, ⁴Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ⁵Nagoya Rheumatology Clinic, Nagoya, Japan
Background/Purpose: Joint ultrasonography (US) is a noninvasive examination that can evaluate arthritis and uric acid deposition at gout attacks. The purpose of this study was…
Abstract Number: 453 • 2017 ACR/ARHP Annual Meeting
The Therapy with Tocilizumab Is Not Associated with Periarticular Demineralisation and Finger Joint Space Narrowing in Rheumatoid Arthritis
Alexander Pfeil¹, Ottar Gadeholt², Joachim Böttcher³, Diane Renz⁴, Peter Oelzner¹ and Gunter Wolf¹, ¹Department of Internal Medicine III, Jena University Hospital, Jena, Germany, ²Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, ³Institut of Interventional and Diagnostic Radiology, SRH Waldklinikum Gera, Gera, Germany, ⁴Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany
Background/Purpose: Digital X-ray Radiogrammetry (DXR) and Computer-Aided Joint Space Analysis (CAJSA) are established computer based techniques for the quantification of metacarpal bone mineral density and…
Abstract Number: 2792 • 2017 ACR/ARHP Annual Meeting
Th22 Cells Are a Potent Inducer of Osteoclastogenesis in Rheumatoid Arthritis
Yusuke Miyazaki¹, Shingo Nakayamada², Satoshi Kubo¹, Kazuhisa Nakano², Kei Sakata³, Shigeru Iwata⁴, Ippei Miyagawa⁵ and Yoshiya Tanaka⁶, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyshu, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁶The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: CD4+ T cells can differentiate into functionally distinct subsets and play a pivotal role in rheumatoid arthritis (RA). Th22 cells have been identified as…
Abstract Number: 2909 • 2017 ACR/ARHP Annual Meeting
Only Very High Radiographic Progression Affects HAQ-DI, Results from the Swiss Scqm Cohort
Ruediger Mueller¹, Reto Thalmann², Hendrik Schulze-Koops³, Nicole Graf⁴ and Johannes von Kempis², ¹Rheumatology, MD, St. Gallen, Switzerland, ²Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, ³Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Germany, ⁴Graf Biostatistics, Winterthur, Switzerland
Background/Purpose: The aim of treatment of rheumatoid arthritis is to control disease activity and to inhibit joint damage. Progression of damage is analysed by conventional…
Abstract Number: 2263 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA)
Giuliana Ascone¹, Irene Di Ceglie¹, Wouter de Munter¹, Birgitte Walgreen², Annet Sloetjes¹, Peter M. van der Kraan¹, Ernst Lindhout³, Mike Martens³ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental, Radboud university medical center, Nijmegen, Netherlands, ³Future Diagnostics Solutions (FDs), Wijchen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease largely driven by immune complexes and their interaction with FcγRs present on macrophages within the synovium.…
Abstract Number: 2369 • 2016 ACR/ARHP Annual Meeting
Obesity and Severity of Joint Space Narrowing Are Associated with Viscosupplementation Failure in Patients with Knee Osteoarthritis. Post-Hoc Analysis of a Double-Blind, Controlled, Multicentre, Randomized Trial
Florent Eymard¹, Xavier Chevalier² and Thierry Conrozier³, ¹Department of Rheumatology, APHP Henri Mondor Hospital, Paris, France, ²Rheumatology, Hopital Henri Mondor, Créteil, France, ³Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France
Background/Purpose: Viscosupplementation (VS) is still controversial. One of the key points is the lack of well-identified factors of response. We aimed to identify clinical…
Abstract Number: 588 • 2016 ACR/ARHP Annual Meeting
Radiographic Progression Is Less Significant in Anti-Carbamylated Antibody-Positive Patients with Rheumatoid Arthritis (RA) Who Were Clinically Active and Under the Treatment with Biological Dmards
Kazuko Shiozawa¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹The Rheumatic Diseases Center, Kohnan Kakogawa Hospital, Kakogawa, Japan, ²Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: A newly discovered anti-carbamylated protein antibody (anti-CarP) is found prior to disease-onset, associates with the conversion towards arthralgia and with a more severe disease…
Abstract Number: 509 • 2015 ACR/ARHP Annual Meeting
In Early Undifferentiated Polyarthritis, 14-3-3η Seroreversion or Sustained Negativity Is Associated with Better Radiographic Outcomes, Even in DAS-28 Remitters
Gilles Boire^1,2, Nathalie Carrier³, Artur de Brum-Fernandes^1,4, Patrick Liang^1,4, Ariel Masetto^2,5, Yuan Gui⁶, Jane Savill⁶, Sara Michienzi⁶, Henri Ménard⁷, Walter Maksymowych⁸ and Anthony Marotta⁶, ¹Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ²Department of Medicine/Division of Rheumatology, University of Sherbrooke, Sherbrooke, QC, Canada, ³Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ⁶Augurex Life Sciences Corp., Vancouver, BC, Canada, ⁷MSK Research Axis, McGill University Health Center Research Institute, Montreal, QC, Canada, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Advancements in RA treatment approaches with DMARDs and biological agents have enabled disease remission goals that were previously considered unattainable. The concept of "tight…
Abstract Number: 1318 • 2015 ACR/ARHP Annual Meeting
Prediction of Large Joint Destruction in Patients with Rheumatoid Arthritis Using FDG-PET/CT: A Prospective Study
Takahito Suto, Koichi Okamura, Yukio Yonemoto, Chisa Okura and Kenji Takagishi, Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Background/Purpose: The assessments of joint damage in patients with rheumatoid arthritis (RA) are mainly restricted to small joints in the hands and feet. However, the…
Abstract Number: 1607 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Factor Is Associated with the Distribution of Hand Joint Destruction in a Dose-Dependent Manner
Chikashi Terao¹, Noriyuki Yamakawa², Koichiro Yano³, I.M. Markusse⁴, Katsunori Ikari³, Shinji Yoshida³, Moritoshi Furu⁵, Motomu Hashimoto⁵, Hiromu Ito⁵, Takao Fujii⁶, Koichiro Ohmura⁷, Kosaku Murakami⁷, Meiko Takahashi², Masahide Hamaguchi⁸, Yasuharu Tabara², Atsuo Taniguchi³, Shigeki Momohara³, Soumya Raychaudhuri⁹, Cornelia F. Allaart¹⁰, Hisashi Yamanaka¹¹, Tsuneyo Mimori¹² and Fumihiko Matsuda¹³, ¹Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴LUMC, Leiden, Netherlands, ⁵Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Dept of Rheum/Clinical Immun, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁷Dept of Rheum & Clinical Immun, Kyoto Univ Grad School of Med, Kyoto, Japan, ⁸Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan, ⁹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁰Rheumatology, LUMC, Leiden, Netherlands, ¹¹Tokyo Women's Medical University, Tokyo, Japan, ¹²Dept of Rheum & Clinical Immun, Kyoto Univ Grad Schl of Med, Kyoto, Japan, ¹³Genomic Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. Although many studies have addressed correlates associated with the speed of joint destruction,…
Abstract Number: 3189 • 2015 ACR/ARHP Annual Meeting
Enhancement of Mitochondrial Biogenesis Inhibits Cell Proliferation and MMP-3/RANKL Secretion in Rheumatoid Arthritis Fibroblast-like Synovial Cells and Joint Destruction in Arthritis Model Mice
Takeshi Ueha¹, Yoshitada Sakai¹, Masayuki Morishita², Toshihisa Maeda², Koji Fukuda², Miho Inoue², Risa Harada², Masaya Minoda², Yasushi Miura^3,4,5, Akira Hashiramoto⁶ and Masahiro Kurosaka^1,4, ¹Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ³Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ⁶Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: Joint destruction in rheumatoid arthritis (RA) progresses via the hyperproliferation of the synovium and secretion of MMP-3/RANKL from fibroblast-like synoviocytes (FLS). In tumors, we previously…
Abstract Number: 2505 • 2014 ACR/ARHP Annual Meeting
Long-Term Treatment with Tocilizumab (TCZ) Strongly Suppresses Joint Destruction in Biologic-naïve Patients with Rheumatoid Arthritis (RA) Regardless of Inflammation Status
Akira Sagawa, Sagawa Akira Rheumatology Clinic, Sapporo,060-0001, Japan
Background/Purpose: It is still difficult to completely prevent the progression of joint destruction with any of the currently available biologics. It has been reported that…

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