ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 453

The Therapy with Tocilizumab Is Not Associated with Periarticular Demineralisation and Finger Joint Space Narrowing in Rheumatoid Arthritis

Alexander Pfeil1, Ottar Gadeholt2, Joachim Böttcher3, Diane Renz4, Peter Oelzner1 and Gunter Wolf1, 1Department of Internal Medicine III, Jena University Hospital, Jena, Germany, 2Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 3Institut of Interventional and Diagnostic Radiology, SRH Waldklinikum Gera, Gera, Germany, 4Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: , ,

Session Information

Date: Sunday, November 5, 2017

Session Title: Rheumatoid Arthritis – Clinical Aspects Poster I: Treatment Patterns and Response

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Digital X-ray Radiogrammetry (DXR) and Computer-Aided Joint Space Analysis (CAJSA) are established computer based techniques for the quantification of metacarpal bone mineral density and finger joint space width. Tocilizumab as humanized anti-interleukin-6 receptor antibody is a successful therapy strategy in rheumatoid arthritis (RA). The aim of this study was the evaluation metacarpal bone mineral density finger joint space width in RA-patients treated with tocilizumab or methotrexate.

Methods:

The multi-center study includes a retrospective analysis of 44 patients with RA in two matched groups which were treated with methotrexate or tocilizumab. All patients consist of radiographs at baseline and after 2.4 years in the follow-up. DXR was measured to quantify cortical thickness (CT), metacarpal index (MCI) and bone mineral density (BMD) of the metacarpal bones. The CAJSA-technique quantified joint space distance of the metacarpophalangeal joints (JSD-MCP) and proximal interphalangeal joints (JSD-PIP).

Results:

For the methotrexate group a significant change of BMD (-6.16%, p<0.05), CT (-7.05%, p<0.05), MCI (-4.74%, p<0.5), JSD-MCP (-4.51%, p<0.05) and JSD-PIP (-12.29%, p<0.05) was observed between baseline and follow-up. The tocilizumab group no significant difference was detected for BMD (-0.20%, p=n.s), CT (-0.70%, p=n.s.), MCI (-2.05%, p=n.s.), JSD-MCP (-0.76%, p=n.s.) and JSD-PIP (0%, p=n.s.).

Conclusion:

The study presented an absence of periarticular demineralisation and finger joint space narrowing in the treatment with tocilizumab, which highlights the effective treatment strategy of a biologic target in RA as well as the detailed computer based analysis of periarticular minerlisation and finger joint space width by DXR and CAJSA.

Disclosure: A. Pfeil, None; O. Gadeholt, None; J. Böttcher, None; D. Renz, None; P. Oelzner, None; G. Wolf, None.

To cite this abstract in AMA style:

Pfeil A, Gadeholt O, Böttcher J, Renz D, Oelzner P, Wolf G. The Therapy with Tocilizumab Is Not Associated with Periarticular Demineralisation and Finger Joint Space Narrowing in Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/the-therapy-with-tocilizumab-is-not-associated-with-periarticular-demineralisation-and-finger-joint-space-narrowing-in-rheumatoid-arthritis/. Accessed April 6, 2020.

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