ACR Meeting Abstracts

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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 038 • 2023 Pediatric Rheumatology Symposium

    HLA-DRB1*15 Alleles in Systemic Juvenile Idiopathic Arthritis with Lung Disease and Macrophage Activation Syndrome in Italy

    Claudia Bracaglia1, Manuela Pardeo1, Maria Troiano2, Giuseppe Testa2, Ivan Caiello1, Arianna De Matteis3, Matteo Trevisan1, Franco Locatelli4, Marco Andreani2 and Fabrizio De Benedetti1, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 2Laboratory of Transplant Immunogenetics, Department of Haematology/Oncology, Cell and Gene, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Lazio, Italy, 3Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Roma, Italy, 4Ospedale Pediatrico Bambino Gesù, Department of Hematology/Oncology, Cell and Gene Therapy, Roma, Italy

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is characterized by unique clinical features and it is considered as a polygenic autoinflammatory disease. Macrophage activation syndrome (MAS)…
  • Abstract Number: 095 • 2023 Pediatric Rheumatology Symposium

    Systemic Juvenile Idiopathic Arthritis Associated Lung Disease in Europe

    Claudia Bracaglia1, Francesca Minoia2, Christoph Kessel3, Sebastiaan Vastert4, Manuela Pardeo1, Alessia Arduini1, Sarka Fingerhutova5, Irina Nikishina6, Ozge Basaran7, Nural Kiper8, Mikhail Kostik9, Mia Glerup10, Roberta Caorsi11, AnnaCarin Horne12, Giovanni Filocamo2, Helmut Wittkowski3, Marija Jelusic13, Jordi Anton14, Samira Khaldi-Plassart15, Alexandre Belot15, Gerd Horneff16, Seraina Palmer Sarrott17, Elvira Cannizzaro Schneider18, Lampros Fotis19, Pavla Dolezalova5, Angelo Ravelli20, Seza Ozen7 and Fabrizio De Benedetti1, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy, 2Fondazione IRCCS Ca' Grande Ospedale Maggiore Policlinico, Milano, Italy, 3Department of Pediatric Rheumatology & Immunology, WWU Medical Center (UKM), Muenster, Germany, 4Wilhelmina Children’s Hospital, Department of Pediatric Immunology and Rheumatology, Utrecht, The Netherlands, Utrecht, Netherlands, 5Centre for Paediatric Rheumatology and Autoinflammatory Diseases, Department of Paediatrics and Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic, 6V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia, 7Department of Pediatrics, Division of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey, 8Department of Pediatrics, Division of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey, 9Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia, 10Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, 11Department of Pediatrics and Rheumatology, IRRCS Istituto G. Gaslini, Genova, Italy, 12Department of pediatric rheumathology Karolinska University Hospital and Department of pediatrics, Karolinska Institute, Stockholm, Sweden, 13Department of Paediatrics, University of Zagreb School of Medicine, University Hospital Centre, Zagreb, Croatia, 14Pediatric Rheumatology, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain, 15Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France, 16Pediatrics, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, 17Paediatric Rheumatology University Children’s Hospital Zurich, Zurich, Zurich, Switzerland, 18Paediatric Rheumatology University Children’s Hospital Zurich, Zurich, Switzerland, 19Pediatric Rheumatology Division, 3rd Department of Pediatrics, National and Kapodistrian University of Athens,‘’ATTIKON’’ General University Hospital, Athens, Greece, 20IRRCS Istituto Giannina Gaslini and Università degli Studi di Genova, Genova, Italy

    Background/Purpose: Chronic parenchymal lung disease (LD) is a new emerging severe life-threatening complication of sJIA. The number of sJIA patients with LD is apparently increasing…
  • Abstract Number: 098 • 2023 Pediatric Rheumatology Symposium

    Characterization of Pulmonary Nodules in Juvenile-onset Systemic Sclerosis: A Single Center Case-Series

    Jonathan Li1, Franziska Rosser1, Sameh Tadros1 and Kathryn Torok2, 1UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Given the high prevalence of intestinal lung disease (ILD) in systemic sclerosis (SSc) and the low sensitivity of pulmonary function testing for diagnosing ILD,…
  • Abstract Number: 0003 • ACR Convergence 2022

    Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease (RECITAL): A Sub-group Analysis of a Multi-centre Randomised Controlled Trial

    Toby Maher1, Veronica Tudor2, Peter Saunders3, Michael Gibbons4, Sophie Fletcher5, Helen Parfrey6, Chris Denton7, Rachel Hoyles3, Elizabeth Renzoni2, Maria Kokosi2, Athol Wells2, Deborah Ashby8, Matyas Szigeti8 and Philip Molyneaux8, 1University of Southern California, Los Angeles, CA, 2Royal Brompton Hospital, London, United Kingdom, 3Oxford University Hospitals, Oxford, United Kingdom, 4Royal Devon and Exeter Hospital, Exeter, United Kingdom, 5Southampton University Hospitals, Southampton, United Kingdom, 6Addenbrookes Hospital, Cambridge, United Kingdom, 7University College London, London, United Kingdom, 8Imperial College London, London, United Kingdom

    Background/Purpose: The RECITAL trial (NCT01862926) compared rituximab to cyclophosphamide as first line therapy for patients with severe or progressive interstitial lung disease due to idiopathic…
  • Abstract Number: 0438 • ACR Convergence 2022

    Characterization of Interstitial Lung Disease in the Presence of Antineutrophil Cytoplasmic Antibodies

    Khai-Tuan Andrew Bui1, Rachel Richard2, Ariane Drouin3, Nader Toban1, Marianne Levesque4, Rosalie-Selene Meunier5, Carolyn Ross6 and Jean-Paul Makhzoum3, 1Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 2Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Laval, QC, Canada, 3Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 4Division of Respirology, Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 5Hopital Sacre-Coeur, Universite de Montreal, Montréal, QC, Canada, 6University of Montreal, Montréal, QC, Canada

    Background/Purpose: Various pulmonary manifestations may occur in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ANCA-related interstitial lung disease (ILD) has recently been described in…
  • Abstract Number: 1060 • ACR Convergence 2022

    Clinical Characteristics and Prognosis of Patients with Systemic Sclerosis Sine Scleroderma: Data from the International EUSTAR Database

    Alain Lescoat1, Suiyuan Huang2, PATRICIA E CARREIRA3, Elise Siegert4, Jeska de Vries-Bouwstra5, Jörg Distler6, Vanessa Smith7, Branimir Anic8, Francesco Del Galdo9, Nemanja Damjanov10, Simona Rednic11, camillo Ribi12, Dominique Farge Bancel13, Anna-Maria Hoffmann-vold14, Armando Gabrielli15, Oliver Distler16, Dinesh Khanna17 and Yannick Allanore18, 1CHU Rennes - University Rennes 1, Rennes, France, 2University of Michigan, Ann Arbor, MI, 3HOSPITAL 12 DE OCTUBRE, Madrid, Spain, 4Charité Hospital, Berlin, Germany, 5Leiden University Medical Center, Leiden, Netherlands, 6Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 7Department of Rheumatology, Ghent University Hospital – Department of Internal Medicine, Ghent University, Belgium – Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Gent, Belgium, 8Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Zagreb, Croatia, 9Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health and NIHR Biomedical Research Centre, University of Leeds, Leeds, United Kingdom, 10Institute of Rheumatology, Belgrade, Serbia, 11Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, 12Service of Immunology and Allergy / CHUV, Lausanne, Switzerland, 13Saint Louis Hospital, Paris, France, 14Oslo University Hospital, Oslo, Norway, 15Università Politecnica delle Marche, Ancona, Italy, 16Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 17Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 18Department of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, Paris, France

    Background/Purpose: This study aimed to characterise the main clinical features of patients with systemic sclerosis (SSc) sine scleroderma (ssSSc) in comparison with the limited cutaneous…
  • Abstract Number: 1520 • ACR Convergence 2022

    Rituximab and Tocilizumab and Their Effect on Lung Disease Progression in Scleroderma. a Retrospective Cohort Study at a Single Centre

    Nina Goldman1, Aoife Tynan2, Shivani Shah2, Claire Beesley1, Rizgar Mageed3, Chris Denton1 and Voon Ong4, 1University College London, London, United Kingdom, 2Division of Medicine, Department of Rheumatology, University College London, London, United Kingdom, 3Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University, London, United Kingdom, 4UCL Medical School Royal Free Campus, London, United Kingdom

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality in systemic sclerosis (SSc). Emerging evidence suggests a beneficial effect of tocilizumab…
  • Abstract Number: 1874 • ACR Convergence 2022

    Autoantibodies Are Common in Patients with Idiopathic Interstitial Lung Disease Suggesting a High Prevalence of Undiagnosed Autoimmune Connective Tissue Disease

    Sarah Tansley1, Caroline Cotton2, Fionnuala McMorrow1, Hui Lu1, Aravinthan Loganathan1, Zoe Betteridge1, Robert New3, Lisa Spencer4, Neil McHugh1 and Robert Cooper4, 1University of Bath, Bath, United Kingdom, 2Liverpool University Hospital, Liverpool, United Kingdom, 3NCA, Manchester, 4University of Liverpool, Liverpool

    Background/Purpose: In some patients, interstitial lung disease (ILD) may be the dominant or even sole overt manifestation of an otherwise unrecognised autoimmune connective tissue disease…
  • Abstract Number: 0035 • ACR Convergence 2022

    Anti-Peroxiredoxin 6 and Anti- Myosin Light Polypeptide 6 Autoantibodies with Interstitial Lung Disease and Severe Disease in Juvenile Dermatomyositis

    Rie Karasawa1, James Jarvis2, Toshiko Sato1, Megumi Tanaka1, Terrance P O'Hanlon3, Payam Noroozi-Farhadi4, Willy A. Flegel5, Kazuo Yudoh1 and Lisa G Rider3, 1Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, 2Department of Pediatrics, University at Buffalo Clinical and Translational Research Center, Buffalo, NY, 3Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, 4NIEHS, NIH, Garrett Park, MD, 5NIH, Garrett Park, MD

    Background/Purpose: Juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) are among the most common forms of inflammatory rheumatic diseases in children. Anti-endothelial cell antibodies (AECA)…
  • Abstract Number: 0508 • ACR Convergence 2022

    Detecting the Critical Factors in the Pathogenesis of Anti-melanoma Differentiation-associated Gene 5–positive Dermatomyositis (MDA5 DM) by Gene Expression Analysis of Peripheral Blood

    Yoshinobu Koyama1, Yoshiharu Sato2, Yu Nakai1 and Moe Sakamoto1, 1Japanese Red Cross Okayama Hospital, Okayama, Japan, 2DNA Chip Research Inc, Tokyo, Japan

    Background/Purpose: MDA5 DM is a distinct subtype of DM that is characterized by high mortality due to rapid progressive interstitial lung disease (ILD). MDA5 is…
  • Abstract Number: 1062 • ACR Convergence 2022

    Lung Magnetic Resonance Imaging in Systemic Sclerosis Associated Interstitial Lung Disease: Potentiality and Comparison with Other Imaging Techniques

    Marco Di Battista1, Chiara Romei2, Simone Barsotti1, Mattia Da Rio3, Giammarco De Mattia3, Alessio Milazzo2, Annalisa De Liperi2, Alessandra Della Rossa3 and Marta Mosca1, 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 2Radiology Unit, University of Pisa, Pisa, Toscana, Italy, 3Rheumatology Unit, University of Pisa, PISA, Toscana, Italy

    Background/Purpose: Interstitial lung disease (ILD) is one of the most severe complications in systemic sclerosis (SSc). The diagnosis and monitoring of ILD is based on…
  • Abstract Number: 1524 • ACR Convergence 2022

    Risk Factors for Lung Function Decline in Systemic Sclerosis Interstitial Lung Disease in a Large Single-Center Cohort

    Ahmad Ramahi1, Alain Lescoat2, David Roofeh1, Vivek Nagaraja1, Rajaie Namas3, Suiyuan Huang1, John Varga1, David O’Dwyer1, Bonnie Wang1, Kevin Flaherty1, Ella Kazerooni1 and Dinesh Khanna4, 1University of Michigan, Ann Arbor, MI, 2CHU Rennes - University Rennes 1, Rennes, France, 3Medical Subspecialties Institute, Division of Rheumatology at Cleveland Clinic, Abu Dhabi, United Arab Emirates, 4Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of scleroderma-related mortality. This work identifies factors associated with SSc-ILD decline on pulmonary function…
  • Abstract Number: 1959 • ACR Convergence 2022

    Increased Mortality in Patients with RA-Associated Interstitial Lung Disease: Data from a French Administrative Healthcare Database

    Pierre-Antoine Juge1, Lidwine Wemeau2, Sebastien Ottaviani3, guillaume desjeux4, Joe Zhuo5, Virginie Vannier-Moreau6, René-Marc Flipo7, Bruno Crestani8 and Philippe Dieude9, 1Rheumatology department, Bichat Hospital, Paris, France, 2Pulmonology department, Lille University hospital, Lille, France, 3Hopital Bichat-Claude Bernard, Paris, France, 4e-Health Services Sanoia, Gemenos, France, 5BMS, Lawrenceville, NJ, 6BMS, Rueil-Malmaison, 7Hôpital Roger Salengro, Lille, France, 8Hopital Bichat, Paris University, Paris, France, 9Université Paris Cité, Paris, France

    Background/Purpose: Interstitial lung disease (ILD) is a common extra-articular manifestation of RA. Studies have shown variability in the prevalence and mortality rate of patients with…
  • Abstract Number: 0048 • ACR Convergence 2022

    Combination of Repetitive Inhalant Endotoxin Exposure and Collagen-induced Arthritis Interact in a Testosterone-dependent Manner to Drive Inflammatory Lung Disease Processes and Arthritis Severity in Mice

    Elizabeth Ramler1, Ted Mikuls2, Geoffrey Thiele3, Amy Nelson3, Michael Duryee3, Rohit Gaurav3, Todd Wyatt1, Aaron Schwabb3, carlos hunter3, Bryant England3 and Jill Poole3, 1University of Nebraska Medical Center, Omaha, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Respiratory-related diseases are among the most common causes of death in rheumatoid arthritis (RA). Although autoimmune diseases are reported in higher frequency in females,…
  • Abstract Number: 0520 • ACR Convergence 2022

    Combination Therapy of Mycophenolate Mofetil and Pirfenidone vs. Mycophenolate Alone: Results from the Scleroderma Lung Study III

    Dinesh Khanna1, Cathie Spino2, Elana Bernstein3, Jonathan Goldin4, Donald Tashkin4, Michael roth4 and On Behalf of SLS III Investigators2, 1Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Columbia University, New York, NY, 4University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Scleroderma Lung Study (SLS) II established mycophenolate mofetil (MMF) as an active therapy for scleroderma-related interstitial lung disease (SSc-ILD) and the need to consider…
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