Abstracts tagged "Interferons and systemic lupus erythematosus (SLE)"

Abstract Number: 2037 • ACR/ARP Annual Meeting 2019
Understanding Langerhans Cell ADAM17 Levels in Systemic Lupus Erythematosus: Potential Contributor to Photosensitivity
Theresa Lu ¹, Noa Schwartz ², Thomas Li ², William Shipman ³, Dragos Dasoveanu ³, Yong Liu ⁴, Niroshana Anandasabapathy ⁴, Henry Lee ⁴, Ali Jabbari ⁵, James Krueger ⁵, Bebak Mehrara ⁶, Keila Veiga², Kira Minkis ⁴ and David Oliver ², ¹Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery; Weill Cornell Medicine, New York, ⁴Weill Cornell Medicine (Dermatology), New York, ⁵Rockefeller University, New York, ⁶Memorial Sloan Kettering Cancer Center, New York
Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus. Lesions can be disfiguring and have a negative impact on patients’ quality…
Abstract Number: 2572 • ACR/ARP Annual Meeting 2019
Efficacy Analysis of Patients with Systemic Lupus Erythematosus Treated with Belimumab or Placebo Plus Standard Therapy in Phase 3 Trials by Baseline Levels of BLyS mRNA and Type 1 Interferon Inducible Gene Signature Status
Angela R Jones-Leone¹, Shaun Flint ², Roger Abramino Levy ³, David Roth ⁴, Robert Henderson ², Christel Wilkinson ², Beulah Ji ⁵ and Damon L Bass ³, ¹GlaxoSmithKline, Upper Providence, ²GlaxoSmithKline, Stevenage, United Kingdom, ³GlaxoSmithKline, Collegeville, PA, ⁴GSK, Collegeville, PA, ⁵GSK, Uxbridge, Middlesex, United Kingdom
Background/Purpose: Belimumab (BEL) is a B-lymphocyte stimulator (BLyS) inhibitor approved as an add-on to standard of care (SoC) for patients with autoantibody-positive SLE with active…
Abstract Number: 91 • ACR/ARHP Annual Meeting 2018
Type I IFN Production Is Induced By Non-Haematopoietic Tissue Cells but Not Plasmacytoid Dendritic Cells in Preclinical Autoimmunity and SLE
Antonios Psarras^1,2,3, Adewonuola Alase¹, Agne Antanaviciute⁴, Ian Carr⁴, Miriam Wittmann^1,2, George C Tsokos⁵, Paul Emery^1,6 and Edward M Vital^1,2, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, ⁴Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, ⁵Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: SLE is characterized by persistently high type I IFN activity. Plasmacytoid dendritic cells (pDCs) produce large amounts of IFNs in viral infections in response…
Abstract Number: 917 • ACR/ARHP Annual Meeting 2018
Type 1 Interferon Levels Correlates with Age of Diagnosis and Ethnicity in Systemic Lupus Erythematous
Majid Abedi¹, Lilian Borisov², Allison Doyle¹, Francisco Flores², June Fujimoto², Aviva Jacobs¹, Pramod Naranatt¹, Liuliu Pan², William Ricketts³, Jacob Spangler¹, Kristen Warren² and Robert Terbrueggen², ¹DxTerity, Rancho Domiquez, CA, ²DxTerity, Rancho Dominguez, CA, ³Clinical Operations, DxTerity, Rancho Domiquez, CA
Background/Purpose: Low cost, patient-administered, “from home” genomic tests for monitoring disease activity and therapy response could revolutionize treatment and management of Systemic Lupus Erythematous (SLE)…
Abstract Number: 1082 • ACR/ARHP Annual Meeting 2018
Peripheral Blood CD11c+ CD21- Age-Associated B Cells (ABCs) in Human Systemic Lupus Erythematosus Are Associated with Innate Type III Interferon and Disease Activity
Jennifer L. Barnas, Lin Gao, Mary O'Connell, Jennifer Albrecht, Nida Meednu, R. John Looney and Jennifer Anolik, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an interferon-stimulated gene (ISG) signature typically attributed to interferon (IFN)-α. However, ISGs can be induced by other…
Abstract Number: 1896 • ACR/ARHP Annual Meeting 2018
Lupus Keratinocytes Exhibit Skewed Interferon Responses and Dysregulation of a Novel Regulator of Interferon Signaling
Alex Tsoi¹, Grace Hile², Celine C. Berthier³, Mrinal Sarkar⁴, Tamra J. Reed⁵, Ranjitha Uppala⁴, Matthew Patrick⁴, Kalpana Raja⁴, Xianying Xing⁶, Kevin He², Johann Gudjonsson⁴ and Michelle Kahlenberg⁷, ¹Departments of Dermatology and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Dermatology, University of Michigan, University of Michigan, Ann Arbor, MI, ⁷Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric of cutaneous…
Abstract Number: 2685 • ACR/ARHP Annual Meeting 2018
Interferon-Inducible Gene Expression Kit As a Potential Diagnostic Test for Anifrolumab: Analytical Validation for Use in Clinical Trials
Philip Z. Brohawn¹, Brandon W. Higgs¹, Sabina Patel², Adrian Moody³, Peter Cooper³ and Koustubh Ranade⁴, ¹MedImmune LLC, Gaithersburg, MD, ²AstraZeneca, Cambridge, United Kingdom, ³QIAGEN Manchester Ltd., Manchester, United Kingdom, ⁴Translational Medicine, MedImmune LLC, Gaithersburg, MD
Background/Purpose: Anifrolumab is a fully human monoclonal antibody that binds to the type I interferon (IFN) receptor. Its efficacy and safety in the treatment of…
Abstract Number: 2951 • ACR/ARHP Annual Meeting 2018
Ustekinumab Treatment Response in SLE Is Associated with Changes in Type II but Not Type I Interferons
Jarrat Jordan¹, Kristen Sweet², Matteo Cesaroni¹, Keying Ma², Carol Franks², Loqmane Seridi², Jessica Schreiter³, Robert Gordon², Peter E. Lipsky⁴, Shawn Rose², Frédéric Baribaud², Matthew Loza² and Kim Campbell², ¹Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research & Development, LLC, Spring House, PA, ³Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ⁴AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: We previously reported that treatment with ustekinumab (UST), an anti-IL-12/23 p40 neutralizing monoclonal antibody, improved global and organ-specific measures of disease activity in a…
Abstract Number: 1842 • ACR/ARHP Annual Meeting 2017
Subsetting Systemic Lupus Erythematosus By Interferon Gene Signatures and Serologies (anti-dsDNA and Low Complement) Uncovers Significant Clinical Diversity
Michelle Petri¹, Steven Watts², Richard Higgs², MaryAnn Morgan-Cox² and Matthew D Linnik³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Eli Lilly and Company, Indianapolis, IN, ³Immunology, Lilly Biotechnology Center, San Diego, CA
Background/Purpose: Personalized therapy in systemic lupus erythematosus (SLE) will require identifying SLE subsets that will benefit from different targeted therapies. Belimumab, for example, has…
Abstract Number: 1916 • ACR/ARHP Annual Meeting 2017
The Interferon Gamma Release Assay Is a Novel Predictor of Disease Activity in Systemic Lupus Erythematosus
Jenna Thomason¹, Christian Lood² and Grant Hughes³, ¹Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ³Medicine/Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Interferon gamma (IFN-G) is critical cytokine for defense against intracellular pathogens; it is also involved in the pathogenesis of systemic lupus erythematosus (SLE). The…
Abstract Number: 2814 • ACR/ARHP Annual Meeting 2017
Interferon-β Production By B Cells Promotes B Cell Survival and Is Strongly Associated with Active Disease in African Americans with SLE
Jennie Hamilton¹, Qi Wu², PingAr Yang³, Bao Luo⁴, Shanrun Liu⁵, Jun Li⁶, Ignacio Sanz⁷, W. Winn Chatham⁸, Hui-Chen Hsu² and John D. Mountz⁹, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ⁸Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁹University of Alabama at Birmingham, Department of Medicine, Birmingham, AL
Background/Purpose: Plasmacytoid dendritic cells are considered the main source of pathogenic IFN in SLE. However, recent work found that elevated serum type I IFN protein…
Abstract Number: 2817 • ACR/ARHP Annual Meeting 2017
Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero
Gudny Ella Thorlacius¹, Malin Hedlund¹, Margarita Ivanchenko¹, Vijole Ottosson¹, Amina Ossoinak¹, Linda Lagnefeldt¹, Lars Rönnblom², Sven-Erik Sonesson³, Maija-Leena Eloranta⁴ and Marie Wahren-Herlenius¹, ¹Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Women with Sjögren’s syndrome and autoantibodies against Ro/SSA are at risk for pregnancy complications, including neonatal lupus erythematosus (NLE) and a congenital heart block…
Abstract Number: 4 • ACR/ARHP Annual Meeting 2017
Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome
Lucas L. van den Hoogen¹, Joel A.G. van Roon^2,3, Ruth D.E. Fritsch-Stork⁴, Cornelis P.J. Bekker¹, Aridaman Pandit¹, Marzia Rossato⁵ and Timothy R.D.J. Radstake¹, ¹Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…
Abstract Number: 80 • ACR/ARHP Annual Meeting 2017
Production and Characterization of Human Interferon-Epsilon and Interferon-Kappa to Investigate Their Potential Role in Lupus
Bethany D. Harris¹, Jessica Schreiter², Matteo Cesaroni³, Marc Chevrier³, Jarrat Jordan³, Jacqueline Benson³ and Mark R. Walter¹, ¹Microbiology, University of Alabama at Birmingham, Birmingham, AL, ²Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ³Janssen Research and Development, LLC., Spring House, PA
Background/Purpose: IFNє and IFNκ are members of the type-I IFN family that also consists of 12 IFNα subtypes, IFNβ, and IFNω. IFNє and IFNκ share…
Abstract Number: 675 • ACR/ARHP Annual Meeting 2017
Tissue-Based Biomarkers in Cutaneous Lupus Erythematosus: Type I IFN Responsive Protein Mxa and a Marker for Lymphocytic Inflammation (CD45) Correlate with CLASI Cross-Sectionally and Longitudinally
Taylor L. Reynolds¹, Carrie Wager¹, Stefan Hamann¹, Xueli Zhang¹, Galina Marsh¹, Cristina Musselli¹, Nathalie Franchimont¹, Agnes Gardet¹, Robert Dunstan², Dania Rabah¹ and Victoria P Werth³, ¹Biogen, Cambridge, MA, ²Abbvie, Worcester, MA, ³University of Pennsylvania and the VA Medical Center, Philadelphia, PA
Background/Purpose: Cutaneous lupus erythematosus (CLE) is the cutaneous manifestation of SLE, affecting 85% of patients1. CLE is subdivided into acute, subacute and chronic/discoid forms. Discoid…