ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "Interferons and systemic lupus erythematosus (SLE)"

  • Abstract Number: 2037 • 2019 ACR/ARP Annual Meeting

    Understanding Langerhans Cell ADAM17 Levels in Systemic Lupus Erythematosus: Potential Contributor to Photosensitivity

    Theresa Lu 1, Noa Schwartz 2, Thomas Li 2, William Shipman 3, Dragos Dasoveanu 3, Yong Liu 4, Niroshana Anandasabapathy 4, Henry Lee 4, Ali Jabbari 5, James Krueger 5, Bebak Mehrara 6, Keila Veiga2, Kira Minkis 4 and David Oliver 2, 1Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York, 2Hospital for Special Surgery, New York, 3Hospital for Special Surgery; Weill Cornell Medicine, New York, 4Weill Cornell Medicine (Dermatology), New York, 5Rockefeller University, New York, 6Memorial Sloan Kettering Cancer Center, New York

    Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus.  Lesions can be disfiguring and have a negative impact on patients’ quality…
  • Abstract Number: 2572 • 2019 ACR/ARP Annual Meeting

    Efficacy Analysis of Patients with Systemic Lupus Erythematosus Treated with Belimumab or Placebo Plus Standard Therapy in Phase 3 Trials by Baseline Levels of BLyS mRNA and Type 1 Interferon Inducible Gene Signature Status

    Angela R Jones-Leone1, Shaun Flint 2, Roger Abramino Levy 3, David Roth 4, Robert Henderson 2, Christel Wilkinson 2, Beulah Ji 5 and Damon L Bass 3, 1GlaxoSmithKline, Upper Providence, 2GlaxoSmithKline, Stevenage, United Kingdom, 3GlaxoSmithKline, Collegeville, PA, 4GSK, Collegeville, PA, 5GSK, Uxbridge, Middlesex, United Kingdom

    Background/Purpose: Belimumab (BEL) is a B-lymphocyte stimulator (BLyS) inhibitor approved as an add-on to standard of care (SoC) for patients with autoantibody-positive SLE with active…
  • Abstract Number: 2685 • 2018 ACR/ARHP Annual Meeting

    Interferon-Inducible Gene Expression Kit As a Potential Diagnostic Test for Anifrolumab: Analytical Validation for Use in Clinical Trials

    Philip Z. Brohawn1, Brandon W. Higgs1, Sabina Patel2, Adrian Moody3, Peter Cooper3 and Koustubh Ranade4, 1MedImmune LLC, Gaithersburg, MD, 2AstraZeneca, Cambridge, United Kingdom, 3QIAGEN Manchester Ltd., Manchester, United Kingdom, 4Translational Medicine, MedImmune LLC, Gaithersburg, MD

    Background/Purpose: Anifrolumab is a fully human monoclonal antibody that binds to the type I interferon (IFN) receptor. Its efficacy and safety in the treatment of…
  • Abstract Number: 2951 • 2018 ACR/ARHP Annual Meeting

    Ustekinumab Treatment Response in SLE Is Associated with Changes in Type II but Not Type I Interferons

    Jarrat Jordan1, Kristen Sweet2, Matteo Cesaroni1, Keying Ma2, Carol Franks2, Loqmane Seridi2, Jessica Schreiter3, Robert Gordon2, Peter E. Lipsky4, Shawn Rose2, Frédéric Baribaud2, Matthew Loza2 and Kim Campbell2, 1Janssen Research and Development, LLC., Spring House, PA, 2Janssen Research & Development, LLC, Spring House, PA, 3Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, 4AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: We previously reported that treatment with ustekinumab (UST), an anti-IL-12/23 p40 neutralizing monoclonal antibody, improved global and organ-specific measures of disease activity in a…
  • Abstract Number: 91 • 2018 ACR/ARHP Annual Meeting

    Type I IFN Production Is Induced By Non-Haematopoietic Tissue Cells but Not Plasmacytoid Dendritic Cells in Preclinical Autoimmunity and SLE

    Antonios Psarras1,2,3, Adewonuola Alase1, Agne Antanaviciute4, Ian Carr4, Miriam Wittmann1,2, George C Tsokos5, Paul Emery1,6 and Edward M Vital1,2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 4Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, 5Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 6Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: SLE is characterized by persistently high type I IFN activity. Plasmacytoid dendritic cells (pDCs) produce large amounts of IFNs in viral infections in response…
  • Abstract Number: 917 • 2018 ACR/ARHP Annual Meeting

    Type 1 Interferon Levels Correlates with Age of Diagnosis and Ethnicity in Systemic Lupus Erythematous

    Majid Abedi1, Lilian Borisov2, Allison Doyle1, Francisco Flores2, June Fujimoto2, Aviva Jacobs1, Pramod Naranatt1, Liuliu Pan2, William Ricketts3, Jacob Spangler1, Kristen Warren2 and Robert Terbrueggen2, 1DxTerity, Rancho Domiquez, CA, 2DxTerity, Rancho Dominguez, CA, 3Clinical Operations, DxTerity, Rancho Domiquez, CA

    Background/Purpose: Low cost, patient-administered, “from home” genomic tests for monitoring disease activity and therapy response could revolutionize treatment and management of Systemic Lupus Erythematous (SLE)…
  • Abstract Number: 1082 • 2018 ACR/ARHP Annual Meeting

    Peripheral Blood CD11c+ CD21- Age-Associated B Cells (ABCs) in Human Systemic Lupus Erythematosus Are Associated with Innate Type III Interferon and Disease Activity

    Jennifer L. Barnas, Lin Gao, Mary O'Connell, Jennifer Albrecht, Nida Meednu, R. John Looney and Jennifer Anolik, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an interferon-stimulated gene (ISG) signature typically attributed to interferon (IFN)-α. However, ISGs can be induced by other…
  • Abstract Number: 1896 • 2018 ACR/ARHP Annual Meeting

    Lupus Keratinocytes Exhibit Skewed Interferon Responses and Dysregulation of a Novel Regulator of Interferon Signaling

    Alex Tsoi1, Grace Hile2, Celine C. Berthier3, Mrinal Sarkar4, Tamra J. Reed5, Ranjitha Uppala4, Matthew Patrick4, Kalpana Raja4, Xianying Xing6, Kevin He2, Johann Gudjonsson4 and Michelle Kahlenberg7, 1Departments of Dermatology and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, 4Dermatology, University of Michigan, Ann Arbor, MI, 5Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, 6Dermatology, University of Michigan, University of Michigan, Ann Arbor, MI, 7Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which 70% of patients experience disfiguring skin inflammation (grouped under the rubric of cutaneous…
  • Abstract Number: 4 • 2017 ACR/ARHP Annual Meeting

    Downregulation of microRNAs in Plasmacytoid Dendritic Cells Is Associated with a Type I Interferon Signature in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

    Lucas L. van den Hoogen1, Joel A.G. van Roon2,3, Ruth D.E. Fritsch-Stork4, Cornelis P.J. Bekker1, Aridaman Pandit1, Marzia Rossato5 and Timothy R.D.J. Radstake1, 1Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: The most prominent alteration in the immune system of patients with SLE is a type I interferon (IFN) signature, which we recently also reported…
  • Abstract Number: 80 • 2017 ACR/ARHP Annual Meeting

    Production and Characterization of Human Interferon-Epsilon and Interferon-Kappa to Investigate Their Potential Role in Lupus

    Bethany D. Harris1, Jessica Schreiter2, Matteo Cesaroni3, Marc Chevrier3, Jarrat Jordan3, Jacqueline Benson3 and Mark R. Walter1, 1Microbiology, University of Alabama at Birmingham, Birmingham, AL, 2Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, 3Janssen Research and Development, LLC., Spring House, PA

    Background/Purpose: IFNє and IFNκ are members of the type-I IFN family that also consists of 12 IFNα subtypes, IFNβ, and IFNω. IFNє and IFNκ share…
  • Abstract Number: 675 • 2017 ACR/ARHP Annual Meeting

    Tissue-Based Biomarkers in Cutaneous Lupus Erythematosus: Type I IFN Responsive Protein Mxa and a Marker for Lymphocytic Inflammation (CD45) Correlate with CLASI Cross-Sectionally and Longitudinally

    Taylor L. Reynolds1, Carrie Wager1, Stefan Hamann1, Xueli Zhang1, Galina Marsh1, Cristina Musselli1, Nathalie Franchimont1, Agnes Gardet1, Robert Dunstan2, Dania Rabah1 and Victoria P Werth3, 1Biogen, Cambridge, MA, 2Abbvie, Worcester, MA, 3University of Pennsylvania and the VA Medical Center, Philadelphia, PA

    Background/Purpose: Cutaneous lupus erythematosus (CLE) is the cutaneous manifestation of SLE, affecting 85% of patients1. CLE is subdivided into acute, subacute and chronic/discoid forms. Discoid…
  • Abstract Number: 831 • 2017 ACR/ARHP Annual Meeting

    Interferon-Alpha Disrupts Tolerance in a Mouse Model of B Cell Anergy

    Dario Ferri1, Yuriy Baglaenko2, Kieran Manion2, Nan-Hua Chang2 and Joan E. Wither3, 1Immunology, University of Toronto, Toronto, ON, Canada, 2Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by the production of anti-nuclear antibodies that deposit within tissues leading to organ damage. A central mediator of…
  • Abstract Number: 1014 • 2017 ACR/ARHP Annual Meeting

    The Rheumatic Disease Data Refinery: A Case Study in Integrative Genomics Reveals Complex IFN Signatures in Therapeutic Studies in SLE

    Jaclyn N Taroni and Casey S. Greene, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Over the past 15 years, more than 10,000 whole tissue biopsies from patients with rheumatic diseases have been deposited into publicly available gene expression…
  • Abstract Number: 1842 • 2017 ACR/ARHP Annual Meeting

    Subsetting Systemic Lupus Erythematosus By Interferon Gene Signatures and Serologies (anti-dsDNA and Low Complement) Uncovers Significant Clinical Diversity

    Michelle Petri1, Steven Watts2, Richard Higgs2, MaryAnn Morgan-Cox2 and Matthew D Linnik3, 1Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, 2Eli Lilly and Company, Indianapolis, IN, 3Immunology, Lilly Biotechnology Center, San Diego, CA

    Background/Purpose:   Personalized therapy in systemic lupus erythematosus (SLE) will require identifying SLE subsets that will benefit from different targeted therapies.  Belimumab, for example, has…
  • Abstract Number: 1916 • 2017 ACR/ARHP Annual Meeting

    The Interferon Gamma Release Assay Is a Novel Predictor of Disease Activity in Systemic Lupus Erythematosus

    Jenna Thomason1, Christian Lood2 and Grant Hughes3, 1Medicine, University of Washington, Seattle, WA, 2Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 3Medicine/Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Interferon gamma (IFN-G) is critical cytokine for defense against intracellular pathogens; it is also involved in the pathogenesis of systemic lupus erythematosus (SLE). The…
  • 1
  • 2
  • 3
  • 4
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology