Abstracts tagged "Interferons and skin"

Abstract Number: 2101 • 2018 ACR/ARHP Annual Meeting
UV-Induced Skin Inflammation Is Exacerbated in Lupus-Prone Ro60 Knockout Female Mice with Interferon Priming
Masaoki Kawasumi¹, Daiki Rokunohe¹, Xizhang Sun², Lena Tanaka², Sladjana Skopelja-Gardner³, Edward Chiou², Anne Davidson⁴, Sandra L. Wolin⁵ and Keith B. Elkon², ¹Medicine/Dermatology, University of Washington, Seattle, WA, ²Medicine/Rheumatology, University of Washington, Seattle, WA, ³University of Washington, Seattle, WA, ⁴Feinstein Institute for Medical Research, Manhasset, NY, ⁵National Cancer Institute, Frederick, MD
Background/Purpose: Photosensitivity is a major symptom of lupus, and excessive sunlight can cause skin rashes and flares of disease activity in systemic lupus erythematosus (SLE).…
Abstract Number: 897 • 2017 ACR/ARHP Annual Meeting
Cutaneous Lupus Is Driven By an Exaggerated Interferon Kappa Loop Which Primes for Interferon Alpha Responses
Johann Gudjonsson¹, Mrinal Sarkar¹, Alex Tsoi², Celine C. Berthier³, Grace Hile⁴, Yun Liang⁴, Jianhua Liu⁵, Paul Harms⁶ and J. Michelle Kahlenberg⁷, ¹Dermatology, University of Michigan, Ann Arbor, MI, ²Departments of Dermatology and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ³Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Pathology, University of Michigan, Ann Arbor, MI, ⁷Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous inflammation is a common and disfiguring manifestation for 70% of patients with systemic lupus erythematosus, yet our understanding of the pathogenesis of cutaneous…
Abstract Number: 1391 • 2015 ACR/ARHP Annual Meeting
Differential Expression of Interferon Gamma in Exudate from Hidradenitis Suppurativa Lesions Compared to Chronic Wounds
Anirban Banerjee¹, Victoria K. Shanmugam^1,2, Sean McNish¹ and Kara Couch¹, ¹Division of Rheumatology, The George Washington University, Washington, DC, ²Director, Division of Rheumatology, The George Washington University, Washington, DC
Background/Purpose: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease which affects 1% to 4% of young adults. The purpose of the current study was…
Abstract Number: 544 • 2013 ACR/ARHP Annual Meeting
Ultraviolet-B Induced Plasmacytoid Dendritic Cell Migration and Type 1 Interferon Signaling In The Skin
Clayton Sontheimer¹, Thomas H. Teal², Nalini Agrawal², Denny Liggitt³ and Keith B. Elkon⁴, ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Comparative Medicine, University of Washington, Seattle, WA, ⁴Department of Medicine & Immunology, University of Washington, Seattle, WA
Background/Purpose: Plasmacytoid dendritic cells (pDCs) are highly specialized cells of the innate immune system that secrete very high levels of interferon alpha (IFN-a) following nucleic…

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