Abstracts tagged "Integrins"

Abstract Number: 851 • 2018 ACR/ARHP Annual Meeting
Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome
Gautam Sule¹, William J. Kelley¹, Srilakshmi Yalavarthi¹, Alison Banka¹, Andrew Vreede², Omolola Eniola-Adefeso¹ and Jason S. Knight³, ¹University of Michigan, Ann Arbor, MI, ²Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ³., University of Michigan, Ann Arbor, MI
Background/Purpose: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of…
Abstract Number: 2929 • 2017 ACR/ARHP Annual Meeting
WNT5A Promotes Tissue Fibrosis By Wnt/PCP-Dependent Activation of Latent TGF-β
Chih-Wei Chen¹, Thuong Trinh-Minh², Neng-Yu Lin², Yun Zhang³, Florian Groeber⁴, Christian Beyer⁵, Georg Schett⁶ and Jörg Distler⁷, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ²Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁴Translational Center Würzburg, Fraunhofer Ins. IGB, Würzburg, Germany, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Canonical Wnt/β-catenin signaling has emerged as a core pathway of fibrosis. They role of non-canonical Wnt signaling, however, has not been systematically studied. In…
Abstract Number: 1645 • 2016 ACR/ARHP Annual Meeting
Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of ASP5094, an Anti-Alpha-9-Integrin Monoclonal Antibody, Following Single Intravenous Doses in Healthy Subjects
Tianli Wang¹, Christopher Lademacher², Paul Blahunka², Corrie Howieson², Txheng Yang², Tomasz Wojtkowski², Mina Kikuchi² and Robert Townsend², ¹Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development, Inc., Northbrook, IL, ²Astellas Pharma Global Development, Inc., Northbrook, IL
Background/Purpose: ASP5094 is a recombinant humanized anti-alpha-9 integrin IgG1 monoclonal antibody (mAb) under development for the treatment of rheumatoid arthritis. This first-in-human placebo‑controlled single ascending‑dose…
Abstract Number: 1964 • 2014 ACR/ARHP Annual Meeting
Changes in Soluble CD18 Reflect Latency in the Immune System and Predict Radiographic Progression in Early Rheumatoid Arthritis
Tue Wenzel Kragstrup¹, Babak Jalilian¹, Kresten Krarup Keller², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard⁴, Ellen Margrethe Hauge^7,8, Malene Hvid¹, Thomas Vorup-Jensen¹ and Bent Deleuran^1,3, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Aarhus University Hospital, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Glostrup University Hospital, Glostrup, Denmark, ⁵Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁶Odense University Hospital, Odense, Denmark, ⁷Dept. of Anatomi, Aarhus University, Aarhus, Denmark, ⁸Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose In early rheumatoid arthritis (RA), clinical disease characterized by swollen and painful joints is caused by synovitis. However, presence of autoantibodies may precede the…
Abstract Number: 744 • 2014 ACR/ARHP Annual Meeting
Integrin Inhibitor Modulates Pulmonary Fibrosis in the Reactive Oxygen Species Murine Model of Systemic Sclerosis
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Neal Roberts³, Domenica Altavilla², Francesco Squadrito², Antonino Saitta⁴ and Gianfilippo Bagnato⁵, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³University of Louisville, Louisville, KY, ⁴Internal Medicine, University of Messina, Messina, Italy, ⁵Via C. Colombo, 41, Universita Messina, Villafranca Tirrena, Italy
Background/Purpose: Systemic sclerosis (SSc) is an acquired connective tissue disorder in which inflammation, immune dysregulation and vascular damage lead to fibroblast activation that results in…
Abstract Number: 1439 • 2013 ACR/ARHP Annual Meeting
Safety, Pharmacokinetics, and Pharmacodynamics Of SAN-300, a Novel Monoclonal Antibody Against Very Late Antigen-1: Results Of a Phase 1 Study In Healthy Volunteers and Patients With Active Rheumatoid Arthritis
Charles Inderjeeth¹, Andrew Redfern¹, Michael Huang², Yun Hardiman², Theresa Grant², Lawrence C. Fritz², David Fuller³, David Haughey⁴ and Mark C. Totoritis², ¹Linear Clinical Research Ltd, Perth, Australia, ²Santarus, Inc., San Diego, CA, ³INC Research, Inc., New South Wales, Australia, ⁴ICON Development Solutions, Whitesboro, NY
Background/Purpose: Very late antigen-1 (VLA-1; α1β1 integrin), a cell adhesion molecule expressed on activated lymphocytes and monocytes/macrophages, binds extracellular matrix molecules and facilitates migration, proliferation,…
Abstract Number: 67 • 2013 ACR/ARHP Annual Meeting
Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) As a Potential Mediator In Osteoarthritis
Richard F. Loeser¹ and David A. Long², ¹Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ²Section Of Molecular Medicine, Wake Forest University, Winston-Salem, NC
Background/Purpose: We recently reported changes in gene expression in knee joint tissue from 12 week-old and 12 month-old mice after OA was induced by surgical…
Abstract Number: 2278 • 2012 ACR/ARHP Annual Meeting
Single Nucleotide Polymorphisms (SNPs) of Integrin-á-M (ITGAM) Are Associated with Susceptibility to Systemic Lupus Erythematosus (SLE) in an Asian Lupus Cohort
Weng-Giap Law¹, Kok Ooi Kong², Bernard Pui Lam Leung¹, Chack-Yung Yu³, Yeong W. Song⁴, Yun Deng⁵, Hiok-Hee Chng², Betty P. Tsao⁶ and Hwee-Siew Howe⁷, ¹Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ²Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ³Department of Pediatrics, 7Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Seoul National University, Seoul, South Korea, ⁵Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ⁶Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, ⁷Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore
Background/Purpose: SLE is a systemic autoimmune disease where lupus nephritis (LN) is a major cause of morbidity and mortality. Integrin-a-M (ITGAM) is critical for the…
Abstract Number: 786 • 2012 ACR/ARHP Annual Meeting
Crosstalk Between Integrins and TGFβ in the Pathogenesis and Treatment of Multiple Presentations of Scleroderma
Elizabeth E. Gerber¹, Fredrick M. Wigley², Elaine C. Davis³, David L. Huso⁴ and Harry C. Dietz¹, ¹Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada, ⁴Comparative Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Scleroderma, defined as pathologic fibrosis of the skin, has many clinical presentations. In the most commonly recognized form, systemic sclerosis (SSc), previously healthy individuals…
Abstract Number: 666 • 2012 ACR/ARHP Annual Meeting
Leukadherin 1, a CR3 Mimetic, Negatively Regulates Toll Like Receptor (TLR) Dependent Inflammatory Responses via Degradation of an Adaptor Protein
Kristen Lee¹, Joanne H. Reed², Vineet Gupta³, Tejaskumar Patel², Jill P. Buyon⁴ and Robert M. Clancy², ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL 33136, U.S.A., Miami, FL, ⁴Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Systemic Lupus Erythematosus is characterized by continuous and cyclic stimulation of the innate immune system by endogenous nucleic acids. Immune complexes of Ro60, ssRNA…

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