Abstracts tagged "innate immunity"

Abstract Number: 1165 • 2015 ACR/ARHP Annual Meeting
Age-Dependent Effects of HLA-B27/β2m Expression on Host Immunity and the Intestinal Microbiota
Mark Asquith¹, Phoebe Lin², Sean Davin³, Patrick Stauffer⁴, Stephen R. Planck⁵ and James T. Rosenbaum⁶, ¹OHSU, Portland, OR, ²Casey Eye Institute, Oregon Health and Science University, Portland, OR, ³Oregon Health and Science University, Portland, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Casey Eye Institute, Oregon Health & Science University, Portland, OR, ⁶Devers Eye Institute, Legacy Hospital system, Portland, OR
Background/Purpose: The HLA-B27/β2m transgenic rat is a leading model of Anklylosing Spondylitis (AS) and other B27-associated spondyloarthopathies. The development of both bowel and joint inflammation…
Abstract Number: 1365 • 2015 ACR/ARHP Annual Meeting
Innate Lymphoid Cells. New Players in Systemic Sclerosis Correlate with Extent of Skin and Lung Fibrosis
Thomas Wohlfahrt¹, Stefanie Weber¹, Matthias Englbrecht², Clara Dees³, Christian Beyer³, Oliver Distler⁴, Georg Schett¹, Jorg HW Distler^1,3 and Andreas Ramming¹, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Research of Systemic Autoimmune Diseases, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Type 2 innate lymphoid cells (ILC2s), are recently identified as population of cells with lymphoid morphology lacking re-arranged antigen-specific receptors. Although findings in animal…
Abstract Number: 1813 • 2015 ACR/ARHP Annual Meeting
Novel Mechanism of Action of Anti-Malarial Drugs in the Inhibition of Type I Interferon Production
Jie An¹, Joshua Woodward², Mark Minie³, YuFeng Peng⁴, Tomikazu Sasaki⁵ and Keith B. Elkon⁶, ¹Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ²Department of Microbiology, University of Washington, Seattle, WA, ³Department of Bioengineering, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA, ⁵Department of Chemistry, University of Washington, Seattle, WA, ⁶Department of Medicine & Immunology, University of Washington, Seattle, WA
Background/Purpose: Anti-malarial drugs (AMD) such as Hydroxychloroquine (HCQ) and Quinacrine (QC) are effective in the treatment of skin rash and arthritis in systemic lupus erythematosus…
Abstract Number: 2704 • 2015 ACR/ARHP Annual Meeting
Neutrophil-Derived Lactoferrin Regulates the Activity of NFAT5 in Rheumatoid Arthritis Synovial Fibroblasts Via Toll-like Receptor 4
Kunihiko Umekita, Shunichi Miyauchi, Kazuyoshi Kubo, Hajime Nomura, Kazumi Umeki, Koushou Iwao, Mao Komura and Akihiko Okayama, Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan
Background/Purpose: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in the rheumatoid arthritis (RA) joints resulting in increased expression…
Abstract Number: 965 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR4 Signaling By TAK242 Ameliorates Experimental Organ Fibrosis
Swati Bhattacharyya¹, Wenxia Wang¹, Zenshiro Tamaki², Yasuhiro Tsukimi³, Masashi Yamasaki³ and John Varga⁴, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Takeda Pharmaceutical Company Limited, Kanagawa, Japan, ⁴Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Our recent studies implicate innate immune signaling through Toll like receptor 4 (TLR4) in scleroderma pathogenesis. Aberrant production and accumulation of the endogenous TLR4…
Abstract Number: 752 • 2014 ACR/ARHP Annual Meeting
Potential Roles of Toll-like Receptor 4 in the Murine Models of Systemic Sclerosis
Takehiro Takahashi, Yoshihide Asano, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Shinji Noda, Kaname Akamata and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Bleomycin (BLM)-induced fibrosis model and tight skin mice (TSK/+) model are well-established experimental murine models of human systemic sclerosis (SSc). Growing evidence has demonstrated…
Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting
S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium
Peter L. van Lent¹, Rik Schelbergen², Arjen B. Blom¹, Tomas Leanderson³, Helena Eriksson⁴ and Wim B. van den Berg⁵, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Immunology Group, Lund University, Lund, Sweden, ⁴BioScience, Active Biotech AB, Lund, Sweden, ⁵Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…
Abstract Number: 2843 • 2014 ACR/ARHP Annual Meeting
SLE Patients Carrying a Disease-Associated PTPN22 R620W Variant Show Reduced Interferon-Inducing Capacity
Yaya Wang¹, David Ewart², Ami Yamamoto², Emily C. Baechler¹, Parastoo Fazeli³ and Erik J. Peterson², ¹Medicine, University of Minnesota, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Division of Rheumatic and Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose Type 1 interferons (IFN) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Increased expression of IFN-regulated genes, termed the IFN-signature, correlates with…
Abstract Number: 2784 • 2014 ACR/ARHP Annual Meeting
Contribution at the Spinal Level of Innate and Adaptive Immunity to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice
Sarah Woller¹, Cody Ocheltree², Tony Yaksh¹ and Marpiat Corr³, ¹Anesthesiology, UCSD, La Jolla, CA, ²Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA, ³University of California at San Diego, La Jolla, CA
Background/Purpose Individuals with arthritis frequently develop persistent pain despite adequate treatment of synovitis. There is a need to better understand the mechanisms underlying pain occurring…
Abstract Number: 2173 • 2014 ACR/ARHP Annual Meeting
Role of Natural Killer Cells and Gamma Delta T Cells in Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis
Priyanka Gaur¹, Ramnath Misra² and Amita Aggarwal², ¹Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis Related Arthritis (ERA) is the most common form of Juvenile Idiopathic Arthritis (JIA) in India. ERA is associated with increased frequency of Th17…
Abstract Number: 1812 • 2014 ACR/ARHP Annual Meeting
Investigation of the Sting/Interferon Pathway Activation in a Novel Vasculopathy and Pulmonary Syndrome
Yin Liu¹, Adriana Almeida de Jesus^2,3, Bernadette Marrero⁴, Dan Yang⁵, Gina A. Montealegre Sanchez⁶, Steve Brooks⁷, Zuoming Deng⁸, Amy Paller⁹, Manfred Boehm⁵ and Raphaela Goldbach-Mansky⁶, ¹Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ³Translational Autoinflammatory Diseases Section, NIAMS/NIH, Bethesda, MD, ⁴Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ⁵Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ⁶Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁷NIAMS/NIH, Bethesda, MD, ⁸Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁹Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have recently studied a group of patients with a prominent interferon (IFN) signature in the blood, distinct from IL-1 mediated autoinflammatory diseases. Six…
Abstract Number: 1722 • 2014 ACR/ARHP Annual Meeting
TLR4 and TLR7 Are Required for Gadolinium Based Contrast Agent Induction of Dermal and Pulmonary Fibrosis in an Adenine-Induced Model of Chronic Renal Failure
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose : Nephrogenic Systemic Fibrosis (NSF) is a generalized progressive fibrotic disorder that occurs in some patients with renal insufficiency exposed to various gadolinium based…
Abstract Number: 1600 • 2014 ACR/ARHP Annual Meeting
Is There a Role for Inflammasome Activation in PsA Pathogenesis and Its Comorbidities?
Rodolfo Perez Alamino¹, Raquel Cuchacovich², Arnold Zea³ and Luis R. Espinoza⁴, ¹internal Medicine, LSUHSC, New Orleans, LA, ²Rheumatology, LSU Medical Center, New Orleans, LA, ³Stanley Scott Cancer Center, New Orleans, LA, ⁴Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA
Background/Purpose . New data has emerged about the role of the inflammasome in psoriasis and psoriatic arthritis (PsA). The assembly of the inflammasome components in…
Abstract Number: 1472 • 2014 ACR/ARHP Annual Meeting
Synovial Fluid from Rheumatoid Arthritis Patients Modulates the Immunophenotype and Viability of Monocytes
Maria Sole Chimenti, Alberto Bergamini, Eleonora Baffari, Eleonora Ballanti, Alessia Musto, Paola Conigliaro and Roberto Perricone, Rheumatology, allergology and clinical immunology, Department of "Medicina dei Sistemi", University of Rome "Tor Vergata", Rome, Italy
Background/Purpose Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by infiltration of the synovium by inflammatory cells that destroys the cartilage and the…
Abstract Number: 1196 • 2014 ACR/ARHP Annual Meeting
Inflammation Develops in a Toll-like Receptor 9-Independent Manner in Experimental Arthritis and Rheumatoid Arthritis
Julie Mussard¹, Matthieu Ribon¹, Gaelle Clavel², Marie-Christophe Boissier³ and Patrice Decker¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology. Toll-like receptor (TLR) 9 recognizes pathogen-derived DNA and even self DNA under certain circumstances.…

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