Abstracts tagged "innate immunity and systemic sclerosis"

Abstract Number: 117 • 2018 ACR/ARHP Annual Meeting
Hypomorphic A20 Expression Modulates Fibrosis Susceptibility: Implications for Systemic Sclerosis?
Swati Bhattacharyya¹, Wenxia Wang², Brian M. Jeong², Hiam Abdala-Valencia³, Roberta Goncalves Marangoni¹, Sergejs Berdnikovs Ph.D.⁴ and John Varga¹, ¹Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine, Northwestern University, Chicago, IL
Background/Purpose: Mutiple organ fibrosis, a hallmark of systemic sclerosis (SSc), remains poorly understood. Recent GWAS have uncovered consistent genetic linkage between TNFAIP3, encoding the ubiquitin-editing…
Abstract Number: 811 • 2016 ACR/ARHP Annual Meeting
Basophils Are Activated and Stimulate Both B Cells and Fibroblasts in Systemic Sclerosis
Benjamin Chaigne¹, Nicolas Dumoitier², Alexis Regent¹, Benjamin Terrier³, Jonathan London², Matthieu Groh¹, Nathalie Thieblemont⁴ and Luc Mouthon⁵, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, ³Internal Medicine, Cochin Hospital, Paris, France, ⁴Inserm U1016, Paris, France, ⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Systemic sclerosis (SSc) is a rare multisystem connective tissue disease characterized by skin and internal organs fibrosis and vascular abnormalities, along with the presence…
Abstract Number: 2999 • 2015 ACR/ARHP Annual Meeting
Maternal Microchimerism Is Increased in Multiple Cellular Subsets of Patients with Systemic Sclerosis Compared to Healthy Controls
Sami B. Kanaan¹, Whitney Harrington^2,3, Laurence S. Loubiere⁴, Tessa M. Aydelotte¹ and J. Lee Nelson^1,5, ¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, ²Seattle Children's Hospital, Seattle, WA, ³Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, ⁴University of Birmingham, Birmingham, United Kingdom, ⁵University of Washington, Seattle, WA
Background/Purpose: Microchimerism (Mc) is naturally acquired through bi-directional exchange of small amounts of cells or DNA between mother and fetus during pregnancy. Higher amounts of…

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