Abstracts tagged "informatics"

Abstract Number: 0456 • ACR Convergence 2024
Use of Machine Learning to Evaluate Incremental Value of Actigraphy Data for Classifying Treatment Response in Patients with Rheumatoid Arthritis
Jeffrey Curtis¹, Yujie Su², Cassie Clinton³, David Curtis⁴, Laura Stradford⁵, Patrick Zueger⁶, William Benjamin Nowell⁷, Pankaj Patel⁸, Esteban Rivera⁹, Kelly Gavigan⁴, Shilpa Venkatachalam¹⁰ and Fenglong Xie³, ¹FASTER Medicine, Hoover, AL, ²Illumination Health, Hoover, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Global Healthy Living Foundation, Upper Nyack, NY, ⁵Global Healthy Living Foundation, Nyack, NY, ⁶AbbVie Inc, North Chicago, IL, ⁷Regeneron, New York, NY, ⁸AbbVie Inc., North Chicago, IL, ⁹Global Healthy Living Foundation, Long Island City, NY, ¹⁰Global Healthy Living Foundation, New York, NY
Background/Purpose: Digital health technology to collect electronic patient reported outcomes (ePRO) and biosensor data are increasingly used to generate real-world data in pharmacoepidemiology. However, the…
Abstract Number: 2692 • ACR Convergence 2024
Transcriptomic Profiling of Kidney Biopsies Implicates Th17 and IL-17 in ANCA-Associated Vasculitis
Ivana Stojkic¹, Arnon Arazi², Huijuan Song³, Pearlly Yan⁴, Estela Puchulu-Campanella³, Hubao Wang³, Lynn Fussner³, Brad Rovin³, Samir Parikh⁵, Stacy Ardoin⁶, Daniel Koboldt⁷, James Fitch⁷ and Salem Almaani⁸, ¹Nationwide, Columbus, OH, ²Feinstein Institutes for Medical Research, Melrose, MA, ³The Ohio State University, Columbus, OH, ⁴The Ohio State University, Columbus, ⁵Ohio State University, Columbus, OH, ⁶Nationwide Children's Hospital, Columbus, OH, ⁷Steve and Cindy Rasmussen Institute for Genomic Medicine, Columbus, OH, ⁸The Ohio State University Medical Center, Columbus, OH
Background/Purpose: ANCA-associated vasculitis (AAV) is a severe autoimmune disease targeting small vessels, with significant kidney involvement. Despite current therapies, up to 28% of patients progress…
Abstract Number: 0608 • ACR Convergence 2024
Systematic Analysis Demonstrates the Added Value of CB-CAPs to SLE Diagnosis in a Large Validation Cohort
Andrew Concoff¹, Touba Warsi², Sepehr Taghavi², Sudha Kumar², Abigail Patalinghug², Christine Schleif², Brittany Partain³, Joseph Ahearn⁴, Chau-Ching Liu⁵, Nicole Wilson⁵, Susan Manzi⁵ and Tyler O'Malley⁶, ¹Exagen, Inc., Los Angeles, CA, ²Exagen, Carlsbad, CA, ³Exagen, Boston, MA, ⁴Allegheny Health Network, Wexford, PA, ⁵Allegheny Health Network, Pittsburgh, PA, ⁶Exagen, Vista, CA
Background/Purpose: Cell bound complement activation products (CB-CAPs) including erythrocyte-bound C4d (EC4d) and B-lymphocyte C4d (BC4d) demonstrate increased diagnostic accuracy compared to conventional SLE markers (anti-dsDNA,…
Abstract Number: 0709 • ACR Convergence 2024
Linear Combination of Principal Components Achieves Top Performance in Identifying Rheumatologist-Diagnosed Systemic Sclerosis from Electronic Health Records
Yiming Luo, Gongbo Zhang, Chunhua Weng and Elana Bernstein, Columbia University Irving Medical Center, New York, NY
Background/Purpose: Systemic sclerosis (SSc) is a rare systemic autoimmune rheumatic disease. International Classification of Diseases (ICD) code counts (for example, using ≥ 2 ICD-10 codes…
Abstract Number: 0728 • ACR Convergence 2024
Glomerular Proteomic Signature in ANCA-associated Glomerulonephritis
Ivana Stojkic¹, Arnon Arazi², Huijuan Song³, Pearlly Yan⁴, Estela Puchulu-Campanella⁴, Hubao Wang³, Lynn Fussner³, Brad Rovin³, Samir Parikh⁵ and Salem Almaani⁶, ¹Nationwide, Columbus, OH, ²Feinstein Institutes for Medical Research, Melrose, MA, ³The Ohio State University, Columbus, OH, ⁴The Ohio State University, Columbus, ⁵Ohio State University, Columbus, OH, ⁶The Ohio State University Medical Center, Columbus, OH
Background/Purpose: Crescentic glomerulonephritis (AAGN) is a common manifestation of ANCA-associated vasculitis (AAV) but does not occur in all patients. It is unclear whether the immune…
Abstract Number: 0816 • ACR Convergence 2024
Distinct Transcript and Protein Dysregulation Patterns in Dermatomyositis and Systemic Lupus Erythematosus
James Ward¹, Mythri Ambatipudi², Zerai Manna³, Michael Smith⁴, Melissa de los Reyes⁵, Adam Schiffenbauer⁶, Saifur Rahman⁷, Kamelia Zerrouki⁵, Fredrick Miller¹, Mariana Kaplan⁸, Jian-Liang Li¹, Kerry Casey⁹, Lisa Rider¹⁰ and Sarfaraz Hasni⁶, ¹National Institute of Environmental Health Sciences, NIH, Durham, NC, ²Harvard Medical School, Boston, MA, ³NIH, Bethesda, MD, ⁴Horizon Therapeutics, Alexandria, VA, ⁵AstraZeneca, Gaithersburg, MD, ⁶NATIONAL INSTITUTES OF HEALTH, Bethesda, MD, ⁷AstraZeneca, Gaithersburg, ⁸NIAMS/NIH, Bethesda, MD, ⁹Regeneron Pharmaceuticals, Terrytown, NY, ¹⁰NIEHS, NIH, Garrett Park, MD
Background/Purpose: Systemic lupus erythematosus (SLE) and dermatomyositis (DM) are hypothesized to be triggered by shared genetic and environmental factors leading to aberrant activation of innate…
Abstract Number: 0901 • ACR Convergence 2024
Intergenic Alu Elements Are Uniquely Expressed in Dermatomyositis and Correlate with Interferon Stimulated Genes
Rayan Najjar¹, Andrew Mammen² and Tomas Mustelin¹, ¹University of Washington, Seattle, WA, ²NIH, Bethesda, MD
Background/Purpose: As genes constitute < 2% of our genomes, there is a need to explore potential roles of other genomic elements in autoimmune disease. We…
Abstract Number: 1063 • ACR Convergence 2024
AI –Driven Precision in Rheumatologic Emergencies: Unveiling the Capability of Top Healthcare Chatbots
Abi Fadairo-Azinge¹, Jinoos Yazdany² and Matt Sakumoto³, ¹University of California San Francisco UCSF, SAN-FRANCISCO, CA, ²University of California San Francisco, San Francisco, CA, ³Sutter Health Virtual-First Primary Care Physician & CMIO Sutter West Bay Region Sutter Health,Assistant Clinical Professor,Department of Medicine, UCSF, SAN-FRANCISCO, CA
Background/Purpose: Rheumatologic emergencies are severe, with mortality rates up to 50% even with timely intervention. Associated morbidity includes permanent organ failure and significant disability. This…
Abstract Number: 1076 • ACR Convergence 2024
Assessing the Reliability of ChatGPT on Recombinant Zoster Vaccination for Patients with Rheumatic and Musculoskeletal Diseases
Akhil Sood, Pegah Jahangiri, Amanda Moyer and Janice Lin, Stanford University, Palo Alto, CA
Background/Purpose: As artificial intelligence (AI) platforms continue to evolve, large language models (LLMs) such as ChatGPT by OpenAI are increasingly being utilized by patients and…
Abstract Number: 1932 • ACR Convergence 2024
Effects of Clinical Decision Support on Transition Readiness Assessment in Pediatric Rheumatology
Chrisana Pokorny¹ and Bethany Marston², ¹University of Rochester, Webster, NY, ²University of Rochester, Rochester, NY
Background/Purpose: Pediatric to adult transition is often challenging among young adults with rheumatic diseases. Structured transition programs can improve adherence to care, quality of life,…
Abstract Number: 1944 • ACR Convergence 2024
Enhancing Rheumatology Consultations with AI-Powered Triage: The ReumAI Pilot Study
Antonio Gomez-Centeno¹, Mariña Sabaris-Vilas², Javier Segura-Sanchez³ and Fermin Garcia-Sancho³, ¹Hospital Quiron Barcelona, Barcelona, Spain, ²Hospital Quirón Barcelona, Barcelona, Spain, ³TamoeInnovation S.L., Madrid, Spain
Background/Purpose: In private healthcare settings, patients often have direct access to specialists without prior referral. However, in rheumatology, this can lead to inefficiencies due to…
Abstract Number: 2151 • ACR Convergence 2024
Rheumatology on Reddit: A Descriptive Analysis
Alfredo Madrid García¹, Beatriz Merino Barbancho², Inés Pérez - Sancristóbal³, Dalifer Freites Nuñez⁴, Luis Rodriguez Rodriguez⁵, lydia Abasolo Alcazar⁶, Leticia Leon⁷ and Benjamin fernandez-Gutierrez⁷, ¹Fundación para la Investigación Biomédica del Hospital Clínico San Carlos (IDISCC), Madrid, Madrid, Spain, ²Life supporting technologies. Escuela Técnica Superior de Ingenieros de Telecomunicación. Universidad Politécnica de Madrid., Madrid, Spain, ³Department of Rheumatology, Hospital Clinico San Carlos,, Madrid, Madrid, Spain, ⁴Hospital Clínico San Carlos. Madrid. Spain., Madrid, Spain, ⁵Hospital Clinico San Carlos, Madrid, Madrid, Spain, ⁶IdISSC. HCSC, Madrid, Spain, ⁷Hospital Clinico San Carlos, Madrid, Spain
Background/Purpose: Over the past decade, social media data have gained special interest across various sectors, specially in medicine where these data are being utilized for…
Abstract Number: 0001 • ACR Convergence 2024
Type I Interferon and Anifrolumab Effects on Bone Marrow and Blood Plasma Cells in Systemic Lupus Erythematosus
Diana Alzamareh¹, Nida Pellett², Daria Krenitsky², Wesley Durrett¹, Javier Rangel-Moreno¹, Jennifer Anolik² and Jennifer Barnas¹, ¹University of Rochester, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of pathogenic anti-nuclear antibodies (ANA) by plasma cells (PC). Importantly, long-lived plasma…
Abstract Number: 2183 • ACR Convergence 2024
Accuracy of AI Tools for Diagnosis of Connective Tissue Disease
Indira Sriram¹, Gabriel Tarshish² and Megan Curran², ¹University of Colorado, Aurora, CO, ²Children's Hospital Colorado, Aurora, CO
Background/Purpose: In this work, we study the ability of generative artificial intelligence (AI) based tools to diagnose pediatric rheumatological diseases. Specifically, we seek to answer…
Abstract Number: 0125 • ACR Convergence 2024
Electronic Health Record Rule-Based Computable Phenotype of Antiphospholipid Syndrome
Emily Balczewski¹, Amala Ambati², Wenying Liang¹, Jacqueline Madison¹, Yu Zuo¹, Karandeep Singh³ and Jason Knight¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Toledo, OH, ³University of California -- San Diego, San Diego, CA
Background/Purpose: Electronic health record (EHR) data provide a widely available, inexpensive, and information-rich tool that is underutilized in the research of rare diseases like antiphospholipid…

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