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Abstracts tagged "infliximab"

  • Abstract Number: 427 • 2013 ACR/ARHP Annual Meeting

    US Veterans With Rheumatoid Arthritis Who Switch Among Tumor Necrosis Factor Blocking Agents Have No Additional Clinical Benefit With The Change In Therapy and Incur Higher Costs

    Grant W. Cannon1, Scott L. DuVall2, Candace L. Hayden3, Liron Caplan4, Jeffrey R. Curtis5, Kaleb Michaud6, Ted R. Mikuls7, Andreas M. Reimold8, David H. Collier9, George Joseph9, David J. Harrison9 and Brian C. Sauer10, 1Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 2VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, 3Epidemiology, VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, 4Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO, 5Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 9Amgen Inc., Thousand Oaks, CA, 10Epdemiology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT

    Background/Purpose:  While tumor necrosis factor (TNF) blockers can be effective in treating rheumatoid arthritis (RA), the benefit of switching among TNF blockers is not clear.…
  • Abstract Number: 314 • 2013 ACR/ARHP Annual Meeting

    Impact Of Low Infliximab Dose Regimen On Treatment Response and Drug Survival In 462 Patients With Psoriatic Arthritis. Results From The Nationwide Registries Danbio and Icebio

    Bente Glintborg1,2, Bjorn Gudbjornsson3,4, Niels Steen Krogh5, Emina Omerovic2, Natalia Manilo6, Mette Holland-Fischer7, Hanne M. Lindegaard8, Anne Gitte Loft9, Henrik Nordin10, Laura Johnsen11, Sussi Flejsborg Oeftiger12, Annette Hansen13, Claus Rasmussen14, Gerdur Grondal15, Árni Jón Geirsson16 and Merete Lund Hetland1,2,17, 1The Danish Rheumatologic Database (DANBIO), Glostrup Hospital, Glostrup, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, 3Department of Rheumatology, Center for Rheumatology Research (ICEBIO), Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland, 4Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 5ZiteLab ApS, Copenhagen, Denmark, 6Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark, 7Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 8Department of Rheumatology, Odense University Hospital, Odense, Denmark, 9Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, 10Department of Infectious Diseases and Rheumatology, Rigshospitalet, Copenhagen, Denmark, 11Department of Rheumatology, Helsingør and Hillerød Hospital, Hillerød, Denmark, 12Department of Rheumatology, Køge Hospital, Køge, East Timor, 13Department of Rheumatology, Gentofte University Hospital, Copenhagen, Denmark, 14Vendsyssel Teaching Hospital/Aalborg University, Hjoerring, Denmark, 15Department of Rheumatology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, 16Rheumatology, Department of Rheumatology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, 17Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark

    Background/Purpose: International guidelines recommend that in psoriatic arthritis infliximab should be dosed with 5 mg/kg bodyweight every 8th week. Data on the use of lower…
  • Abstract Number: 2458 • 2013 ACR/ARHP Annual Meeting

    Change Over Time In The Profile Of Ankylosing Spondylitis Patients Treated With Infliximab In Canadian Routine Care

    Denis Choquette1, Michael Starr2, Majed M. Khraishi3, William G. Bensen4, Saeed A. Shaikh5, Jude F. Rodrigues6, Dalton E. Sholter7, Maqbool K. Sheriff8, Julie Vaillancourt9, John S. Sampalis9, Allen J. Lehman10, Susan M. Otawa10, Francois Nantel11 and May Shawi12, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2Montreal General Hospital, Montreal, QC, Canada, 3Nexus Clinical Research, St John's, NF, Canada, 4Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, 5Medicine, McMaster University, St Catharines, ON, Canada, 6Rheumatology, Windsor, ON, Canada, 7Rheumatology Associates, Edmonton, AB, Canada, 8Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 9JSS Medical Research, Montreal, QC, Canada, 10Medical Affairs, Janssen Inc., Toronto, ON, Canada, 11Janssen Inc., Toronto, ON, Canada, 12Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada

    Background/Purpose: Canadian provincial reimbursement policies in regards with infliximab coverage status have evolved in the last decade. The objective of this study was to describe…
  • Abstract Number: 2369 • 2013 ACR/ARHP Annual Meeting

    Long-Term Outcome Of Infliximab Therapy In Rheumatoid Arthritis Patients: Results From Japanese Multicenter Registry System

    Nobunori Takahashi1, Toshihisa Kojima2, Atsushi Kaneko3, Yuji Hirano4 and Naoki Ishiguro1, 1Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya, Japan, 3Orthopedic Surgery, Nagoya Medical Center, Nagoya, Japan, 4Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan

    Background/Purpose: After demonstration of effectiveness of anti-tumor necrosis factor (TNF) agents in patients with rheumatoid arthritis (RA), their use has become common practice in treating…
  • Abstract Number: 2320 • 2013 ACR/ARHP Annual Meeting

    Ultrasonographic Monitoring Of Response To Infliximab In Patients With Rheumatoid Arthritis

    Xiaomei Leng1, Weiguo Xiao2, Xiaochun Zhu3, Zhonghui Xu1, Wei Yu1, Jing Lu2, Jiakai Wang2, Xiaoru Xia3, Yongji Li3, Yi Liu4, Yi Zhao4, Honghao Tang5, Dongbao Zhao6, Yeqing Shi6, Huji Xu7, Jun Bao7, Lin Chen7, Ling Lin7, Ling Zhou7, Guoqiang Chen8, Weihong Zhang8 and Yan Zhao1, 1Peking Union Medical College Hospital, Beijing, China, 2The First Hospital of China Medical University, Shenyang, China, 3The First Hospital of Wenzhou Medical College, Wenzhou, China, 4Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, 5West China Hospital of Sichuan University, Chengdu, China, 6Changhai Hospital of Shanghai, Shanghai, China, 7Shanghai Changzheng Hospital, Shanghai, China, 8The First People’s Hospital of Foshan, Foshan, China

     Background/Purpose: To evaluate the efficacy of treatment with infliximab on joint inflammation and bone erosion in rheumatoid arthritis (RA) patients using ultrasonography. Methods: 80 eligible…
  • Abstract Number: 2227 • 2012 ACR/ARHP Annual Meeting

    Low Dosage with Escalating Dosage of Infliximab in Psoriatic Arthritis Gives the Same Treatment Results as Standard Dosage of Adalimumab or Etanercept: Results From the Nationwide Registry ICEBIO

    Bjorn Gudbjornsson1 and Niels Steen Krogh2, 1Department of Rheumatology, Center for Rheumatology Research (ICEBIO), Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland, 2ZiteLab ApS, Copenhagen, Denmark

    Background/Purpose: To explore differences in response to low dosage (2.3mg/kg) regimen of infliximab with possible escalating dosage in comparison to standard dosage of etanercept and…
  • Abstract Number: 2033 • 2012 ACR/ARHP Annual Meeting

    Infliximab Is an Effective Therapy in Pediatric Renal Sarcoidosis

    Elisa Wershba1, Laura Lewandowski1, Heather Van Mater2 and C. Egla Rabinovich1, 1Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 2Duke Pediatric Rheumatology, Duke University Medical Center, Durham, NC

    Background/Purpose:   Renal sarcoidosis is an unusual form of a rare multisystem disease, and there is little data to guide therapy. The cytokines implicated in…
  • Abstract Number: 1677 • 2012 ACR/ARHP Annual Meeting

    Safety and Efficacy of Intra-Articular Infliximab Therapy for Treatment Resistant Temporomandibular Joint Arthritis in Children

    Matthew L. Stoll1, Anthony B. Morlandt2, Suwat Teerawattanapong2, Daniel Young3, Peter D. Waite4 and Randy Q. Cron1, 1Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Department of Oral and Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, AL, 3Radiology, University of Alabama at Birmingham, Birmingham, AL, 4Oral and Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Temporomandibular joint (TMJ) arthritis occurs in as much as 80% of children with juvenile idiopathic arthritis (JIA) and can result in substantial facial deformity.…
  • Abstract Number: 1641 • 2012 ACR/ARHP Annual Meeting

    When Can Biological Therapy Be Resumed in Patients with Rheumatic Conditions Who Develop Tuberculosis Infection During Tumour Necrosis Factors Antagonists Therapy? Study Based On the Biobadaser Data Registry

    Maria Victoria Hernández1, Miguel A. Descalzo2, Juan D. Cañete1, Raimon Sanmarti3 and BIOBADASER Study Group4, 1Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, 2Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 4Research Unit. Spanish Society of Rheumatology, Madrid, Spain

    Background/Purpose: Tuberculosis infection (TI) is one of the most serious adverse events related to tumour necrosis factor (TNF) antagonists. According to the current treatment guidelines…
  • Abstract Number: 1314 • 2012 ACR/ARHP Annual Meeting

    Validation of Algorithms Using Genome-Wide SNP Analysis for Prediction of Remission or Low Disease Activity for Infliximab or Etanercept-Treated RA Patients

    Tsukasa Matsubara1, Satoru Koyano2, Keiko Funahashi2, James E. Middleton2, Takako Miura1, Kosuke Okuda1, Takeshi Nakamura1, Akira Sagawa3, Takeo Sakurai4, Hiroaki Matsuno5, Tomomaro Izumihara6, Eisuke Shono7, Kou Katayama8, Toyomitsu Tsuchida9, Mitsuyoshi Iwahashi10, Tomomi Tsuru11 and Motohiro Oribe12, 1Matsubara Mayflower Hospital, Kato, Japan, 2Research Institute of Joint Diseases, Kobe, Japan, 3Sagawa Akira Rheumatology Clinic, Sapporo, Japan, 4Inoue Hospital, Takasaki, Japan, 5Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, 6Izumihara Rheumatic and Medical Clinic, Kagoshima, Japan, 7Shono Rheumatology Clinic, Fukuoka, Japan, 8Katayama Orthopedic Rheumatology Clinic, Asahikawa, Japan, 9Tsuchida Clinic, Chiba, Japan, 10Higashi-Hiroshima Memorial Hospital, Higashi-hiroshima, Japan, 11PS Clinic, Fukuoka, Japan, 12Oribe Rheumatism and Internal Medicine Clinic, Oita, Japan

    Background/Purpose: Achievement of remission or low disease activity with infliximab (IFX) and etanercept (ETN) treatment is currently one of the most important matters in RA…
  • Abstract Number: 473 • 2012 ACR/ARHP Annual Meeting

    The Addition of Another Disease-Modifying Anti-Rheumatic Drug to Methotrexate in Place of Infliximab Reduces the Flare Rate During 2 Years After Infliximab Discontinuation in Patients with Rheumatoid Arthritis

    Hideto Kameda1, Takahiko Kurasawa1, Hayato Nagasawa2, Koichi Amano3 and Tsutomu Takeuchi4, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Saitama Medical Ctr, Kawagoe, Japan, 3Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan, 4Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: The treatment strategy for rheumatoid arthritis (RA) should be divided into remission-induction phase and its maintenance phase. To date, the usefulness of the combination…
  • Abstract Number: 485 • 2012 ACR/ARHP Annual Meeting

    Immunogenicity of Infliximab Is Related to Reduction of Frequency of Infliximab Administration in Rheumatoid Arthritis and Spondyloarthritis Patients

    Mathieu Verdet1, Clément Guillou2, Marie-Laure Potier2, Martine Hiron2, Fabienne Jouen3, Olivier Boyer4, Thierry Lequerré5 and Olivier Vittecoq6, 1Rheumatology, Rouen University Hospital, Bois Guillaume, France, 2Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, 3Immunology, Rouen University Hospital, Rouen Cedex, France, 4Immunology, INSERM U905, University of Rouen, Rouen, France, 5Rheumatology Department & Inserm 905, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, 6Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France

    Background/Purpose: To analyze the clinical and biological characteristics associated with presence of antibodies to Infliximab, in rheumatoid arthritis (RA) and spondyloarthritis patients (SpA). Methods: Sera…
  • Abstract Number: 275 • 2012 ACR/ARHP Annual Meeting

    Pediatric Rheumatology Practitioners Experience with Biologics in Juvenile Dermatomyositis: Survey Results

    Anjali Patwardhan1, Kelly A. Rouster-Stevens2, Harry L. Gewanter3, Grant D. Syverson4, Renee F. Modica5, Kara M. Schmidt6 and Charles H. Spencer7, 1Pediatric Rheumatology, Nationwide Childrens Hospital, Columbus, OH, 2Pediatric Rheumatologist, Emory-Children's Center, Atlanta,, GA, 3Pediatric & Adolescent HP, Pediatric & Adolescent HP, Midlothian, VA, 4Pediatric Rheumatology, Medical College of Wisconsin, Wauwatosa, WI, 5Pediatric Rheumatology, University of Florida, Gainesville, FL, 6Pediatric Rheumatology, Univ of Louisville, Louisville, KY, 7Rheumatology, Nationwide Childrens Hospital, Columbus, OH

    Background/Purpose: Biologic therapy is increasingly prescribed in rheumatologic disorders.  Juvenile dermatomyositis (JDM), the most common inflammatory myopathy in children, can be challenging to manage in…
  • Abstract Number: 211 • 2012 ACR/ARHP Annual Meeting

    Efficacy and Safety of Disease Modifying Drugs, Biologic Therapies and Immunoglobulin in Patients with Polymyositis and Dermatomyositis: A Systematic Literature Review

    JA Martinez-Lopez Sr.1, J. Graña Sr.2, Santiago Muñoz-Fernandez3, I. Rua-Figueroa4, José M. Pego-Reigosa5, Estíbaliz Loza Sr.6 and SER group for the study of systemic autoimmune diseases7, 1Fundacion Jimenez Diaz, Madrid, Spain, 2Hospital Juan Canalejo, Spain, 3Unit Rheumatology, Hospital Infanta Sofía, Madrid, Spain, 4Rheumatology, Hospital de GC Dr Negrin, Las Palmas GC, Spain, 5Rheumatology, Hospital do Meixoeiro, Vigo, Spain, 6Research Unit. Sociedad Española de Reumatología, Madrid, Spain, 7Madrid

    Background/Purpose: The aim of this study was to systematically review the efficacy and safety of available drugs in patients with polymyositis (PM) or dermatomyositis (DM)Methods:…
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