ACR Meeting Abstracts

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Abstracts tagged "inflammatory bowel disease (IBD)"

  • Abstract Number: 1831 • 2018 ACR/ARHP Annual Meeting

    Intestinal Inflammatory Regulation in Murine and Human Spondyloarthropathy Requires High-Affinity T Cell Receptor-Zeta Chain-Associated Protein (ZAP)70-Mediated Runt-Related Transcription Factor (Runx)3 Activity

    Zaied Ahmed Bhuyan1, M. Arifur Rahman2, Muralidhara Maradana1, Ahmed Mehdi3, Giuliana Guggino4, Paul Leo5, Linda Rehaume1, Matthew Brown5, Francesco Ciccia4 and Ranjeny Thomas1, 1The University of Queensland Diamantina Institute, Brisbane, Australia, 2Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, 3Diamantina Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, 4Rheumatology Unit, University of Palermo, Palermo, Italy, 5Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia

    Background/Purpose: Loss of function RUNX3 variants are associated with ankylosing spondylitis (AS) risk but the mechanism is unknown. Disturbances in immune regulation, intestinal microbial dysbiosis…
  • Abstract Number: 1866 • 2018 ACR/ARHP Annual Meeting

    Incidence of Inflammatory Bowel Disease Among Patients Treated with Ixekizumab: An Update on Adjudicated Data from an Integrated Database of Patients with Psoriasis and Psoriatic Arthritis

    Mark C. Genovese1, Jean-Frederic Colombel2, Amanda M. Gellett3, Wen Xu3 and Dana Hardin3, 1Department of Medicine, Stanford University, Palo Alto, CA, 2Department of Gastroenterology, The Mount Sinai Hospital, New York, NY, 3Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Increased incidence of IBD, such as Crohn’s disease (CD) and ulcerative colitis (UC), has been observed in patients (pts) with PsA or plaque psoriasis…
  • Abstract Number: 1223 • 2017 ACR/ARHP Annual Meeting

    Inflammatory Bowel Diseases and the Risks of Fracture and Low Mineral Density: Review of the Literature and Meta-Analysis of Observational Cohorts

    Paulina Szafors1, Thomas Barnetche2, Cédric Lukas3, Jacques Morel4, Cécile Gaujoux-Viala5,6, Bernard Combe7 and Hélène Che8, 1Department of Rheumatology, Lapeyronie Hospital and University of Montpellier, Montpellier, France, 2Rheumatology Department, Pellegrin University Hospital, BORDEAUX, France, 3Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, 4Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, 5Rheumatology, Nîmes University Hospital and EA2415 Montpellier University, Nîmes, France, 6EA 2415, Montpellier University, Nîmes, France, 7Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, 8Rheumatology, University and Hospital Lapeyronie, University of Montpellier, France

    Background/Purpose:   Inflammatory bowel diseases (IBD), such as Crohn disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density caused by chronic…
  • Abstract Number: 1576 • 2017 ACR/ARHP Annual Meeting

    IL-23 Promotes Fecal Microbiota Dysbiosis Associated with Susceptibility to Spondyloarthritis and Ileitis in ZAP-70 Mutant SKG Mice

    Linda Rehaume1, Nicholas Matigian1, Kate Ormerod2, Alicia Kang1, Richard Linedale1, Olga Zbarskaya1, Kristine Kikly3, Joshua Daly2, Nancy Lachner2, Philip Hugenholtz2, Mark Morrison1, Kim-Anh Lê Cao4 and Ranjeny Thomas1, 1The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, 2Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, 3Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, 4School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia

    Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from SpA, or for people at-risk of disease…
  • Abstract Number: 1915 • 2017 ACR/ARHP Annual Meeting

    Gut-Derived TNF As Risk Factor for the Development of Sacroiliac Inflammation

    Karlijn Debusschere1, Heleen Cypers2, Peggy Jacques3, Filip van Den Bosch4, Thomas Renson5, Don Souza6, Martha Brown6, Gerald Nabozny7, Devin Dove6, Alexander Klimowicz8 and Dirk Elewaut9, 1Ghent University - VIB, Ghent, Belgium, 2Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, 3Ghent University Hospital, Ghent, Belgium, 4Rheumatology, Ghent University Hospital, Gent, Belgium, 5Rheumatology, Ghent University Hospital, GENT, Belgium, 6Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 7[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 8Department of Immunology and respiratory discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 9VIB Inflammation Research Center, University of Ghent, Ghent, Belgium

    Background/Purpose: An intruiging link exists between gut and joint inflammation in spondyloarthritis (SpA). About 50% of patients has subclinical (eg. microscopic) gut inflammation, which represents…
  • Abstract Number: 116 • 2017 Pediatric Rheumatology Symposium

    Arthritis as First Presenting Symptom of Inflammatory Bowel Disease: A Case Control Study

    Kathryn Phillippi1, Thomas Sferra2, Nora Singer3 and Elizabeth Brooks4, 1Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children’s Hospital / Case Medical Center, Cleveland, OH, 2Pediatric Gastroenterology, Rainbow Babies and Children's Hospital/Case Medical Center, Cleveland, OH, 3MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio, Cleveland, OH, 4Division of Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children’s Hospital / Case Medical Center, Cleveland, OH, Cleveland, OH

    Background/Purpose: Inflammatory bowel disease (IBD) is associated with extra-intestinal manifestations, the most common of which is arthralgia/arthritis. 4.1- 15% of patients with inflammatory bowel disease…
  • Abstract Number: 92 • 2016 ACR/ARHP Annual Meeting

    Is Patient Support Program (PSP) Participation Associated with Longer Persistence and Greater Adherence Among New Users of Adalimumab?

    Einav Srulovici1,2, Vishvas Garg3, Adi Ghilai2, Becca Feldman2, Moshe Hoshen2, Ran Balicer2, Martha Skup4 and Maya Leventer-Roberts2, 1School of Nursing, University of Haifa, Haifa, Israel, 2Clalit Research Institute, Clalit Health Services, Tel Aviv, Israel, 3AbbVie Inc, North Chicago, IL, 4AbbVie Inc., North Chicago, IL

    Background/Purpose: In Israel, patients treated with adalimumab (ADA) can enroll in a patient support program (PSP) provided by AbbVie, which includes a home visit by…
  • Abstract Number: 693 • 2016 ACR/ARHP Annual Meeting

    The Prevalence of Axial and Peripheral Spondyloarthritis in Inflammatory Bowel Disease: A Systematic Review & Meta-Analysis

    Maren C. Karreman1,2, Jolanda J. Luime3, Johanna M.W. Hazes2 and Angelique E.A.M. Weel1, 1Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 2Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

    Background/Purpose: Inflammatory Bowel Disease (IBD) is a chronic disease that affects up to 0.5% of the population, comprising both Crohn’s Disease (CD) and ulcerative colitis…
  • Abstract Number: 2405 • 2016 ACR/ARHP Annual Meeting

    Musculoskeletal Manifestations As Presenting Symptoms of Inflammatory Bowel Disease in Children and Adolescents

    Rachel Levy1, Gil Amarilyo2,3, Jacob Amir4, Rotem Tal2,3, Amit Assa3,5, Firas Rinawi5 and Liora Harel2,3, 1The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel, 2Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel, 3Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel, 4Mayanei Hayeshua Medical Center, Bnei Brak, Israel, 5Institute of Gastroenterology Hepatology and Liver diseases, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel

    Background/Purpose:   Extra intestinal manifestations occur in 40-50% of patients with inflammatory bowel disease (IBD), with musculoskeletal involvement in 25%. Data regarding musculoskeletal manifestations in…
  • Abstract Number: 2694 • 2016 ACR/ARHP Annual Meeting

    Treatment of ZAP-70 Mutant SKG Mice with Anti-IL-23 Antibody Alters Fecal Microbiota Composition and Prevents Outgrowth of Bacteria Associated with Susceptibility to Spondyloarthritis and Ileitis

    Linda Rehaume1, Nicholas Matigian1, Alicia Kang1, Olga Zbarskaya1, Kristine Kikly2, Nancy Lachner3, Joshua Daly3, Philip Hugenholtz3, Mark Morrison1, Kim-Anh Lê Cao4 and Ranjeny Thomas1, 1Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, 2Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, 3The University of Queensland, Australian Centre for Ecogenomics, Brisbane, Australia, 4Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia

    Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from spondyloarthritis (SpA), or for people at-risk of…
  • Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting

    Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis

    Neha Ohri1,2,3, Mark Gerich3,4, Blair Fennimore3,5, Diana Ir6, Charles Robertson6, Daniel Frank6, Liron Caplan7, Brandie Wagner8 and Kristine Kuhn9,10, 1Division of Rheumatology, Mount Sinai West, New York City, NY, 2Division of Rheumatology, University of Colorado, Aurora, CO, 3Mucosal Inflammation Program, University of Colorado, Aurora, CO, 4Division of Gastroenterology, University of Colorado, Aurora, CO, 5Department of Gastroenterology, University of Colorado, Aurora, CO, 6Division of Infectious Disease, University of Colorado, Aurora, CO, 7Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, 8Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, 9Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 10Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose:  The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…
  • Abstract Number: 3164 • 2016 ACR/ARHP Annual Meeting

    Spondyloarthritis Pathogenesis Involves Interplay Between Gut Microbiota and Genetic Background

    Tejpal Gill1, Mark Asquith2, Stephen Brooks3, James T. Rosenbaum2 and Robert A. Colbert1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Oregon Health & Science University, Portland, OR, 3NIAMS/NIH, Bethesda, MD

    Background/Purpose: HLA-B27 and human b2m expression in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). While aspects of rat SpA have been studied…
  • Abstract Number: 2827 • 2015 ACR/ARHP Annual Meeting

    Analysis of HLA-B27 Transgenic Rats Reveals Specific Gut Transcriptome and Microbiome Signatures Associated with Inflammation

    Tejpal Gill1, Mark Asquith2, Stephen Brooks1, James T. Rosenbaum3 and Robert A. Colbert4, 1NIAMS/NIH, Bethesda, MD, 2OHSU, Portland, OR, 3Devers Eye Institute, Legacy Hospital system, Portland, OR, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: HLA-B27 and human beta 2-microglobulin expression in rats (transgenic; TG) induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA) with associated gastrointestinal inflammation. While…
  • Abstract Number: 2828 • 2015 ACR/ARHP Annual Meeting

    Profiling Immunogenic Bacteria within the Microbiota of ZAP-70 Mutant SKG Mice Associated with Spondyloarthritis and Ileitis Using IgA-SEQ

    Linda Rehaume1, Alicia Kang1, Olga Zbarskaya1, Jane Mullaney1, Matthew Kim1, Paraic O Cuiv1, Nicola Angel2, Philip Hugenholtz2, Mark Morrison1 and Ranjeny Thomas1, 1Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, 2Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia

    Background/Purpose: IgA production is the main barrier mechanism of mucosal surfaces. High affinity IgA is generated through T cell-dependent mechanisms and preferentially binds to invasive…
  • Abstract Number: 37 • 2015 ACR/ARHP Annual Meeting

    Cardiovascular Disease in Immune-Mediated Inflammatory Diseases: Cross Sectional Analysis of the Influence of Demographic and Traditional Cardiovascular Risk Factors

    Luis Rodriguez-Rodriguez1,2, Pedro P Perrotti3, Adrìa Aterido3, Jesús Tornero4, Carlos Ferrandiz5, Juan D. Cañete6, Antonio Fernandez-Nebro7, Javier P Gisbert8, Eugeni Domènech9,10, María López-Lasanta3, Sara Marsal3, Benjamín Fernández-Gutiérrez1,11 and IMID Consortium, 1Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 2Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 3Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 4Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, 5Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 6Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, 7Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, 8Gastroenterology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 9Gastroenterology & Hepatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10CIBERehd, Madrid, Spain, 11Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

    Background/Purpose : Our aim was 1) to analyze the association between demographic and traditional cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in subjects affected…
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