Abstracts tagged "inflammatory bowel disease (IBD)"

Abstract Number: 2071 • 2018 ACR/ARHP Annual Meeting
Inflammation at Distant Immunocompetent Sites Combined with a Protocol of Forced Exercise Induces Mild Joint Inflammation
Giulia Rossana Gulino¹, Margot Van Mechelen^1,2 and Rik Lories^1,2, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rheumatology, UZ Leuven, Leuven, Belgium
Background/Purpose: Psoriatic arthritis is a chronic joint disease clinically associated with psoriasis. Some patients also have signs of inflammatory bowel disease. Enthesitis, inflammation at the…
Abstract Number: 2826 • 2018 ACR/ARHP Annual Meeting
Emergence of Severe Spondyloarthropathy Related Entheseal Pathology Following Successful Vedolizumab Therapy for Inflammatory Bowel Disease
Sayam Dubash^1,2, Marianayagam Thiraupathy³, Ilaria Tinazzi⁴, Tariq Al Araimi⁵, Christian Pagnoux⁶, Adam Weizman⁷, Pascal Richette^8,9, My-Linh Tran Minh¹⁰, Mattieu Allez¹⁰, Animesh Singh¹¹, Francesco Ciccia¹², John Hamlin¹³, Ai Lyn Tan^1,2, Helena Marzo-Ortega^1,2 and Dennis McGonagle^1,2, ¹Rheumatology, Chapel Allerton Hospital, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³East and North Hertfordshire NHS Trust, Stevenage, United Kingdom, ⁴Rheumatology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy, ⁵Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁶Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁷Gastroenterology, Mount Sinai Hospital, Toronto, ON, Canada, ⁸Rheumatology, Université Paris Diderot, Paris, France, ⁹Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France, ¹⁰Department of Gastroenterology, APHP, Hôpital Saint Louis, Sorbonne Paris-Cité University, Paris, France, ¹¹Rheumatology, The Royal Free Hospital, London, United Kingdom, ¹²Rheumatology, University of Palermo, Palermo, Italy, ¹³Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Vedolizumab therapy for inflammatory bowel disease (IBD) has been associated with mild spondyloarthritis (SpA) related features including sacroiliitis and synovitis. Herein, we report a…
Abstract Number: 1223 • 2017 ACR/ARHP Annual Meeting
Inflammatory Bowel Diseases and the Risks of Fracture and Low Mineral Density: Review of the Literature and Meta-Analysis of Observational Cohorts
Paulina Szafors¹, Thomas Barnetche², Cédric Lukas³, Jacques Morel⁴, Cécile Gaujoux-Viala^5,6, Bernard Combe⁷ and Hélène Che⁸, ¹Department of Rheumatology, Lapeyronie Hospital and University of Montpellier, Montpellier, France, ²Rheumatology Department, Pellegrin University Hospital, BORDEAUX, France, ³Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, ⁴Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, ⁵Rheumatology, Nîmes University Hospital and EA2415 Montpellier University, Nîmes, France, ⁶EA 2415, Montpellier University, Nîmes, France, ⁷Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ⁸Rheumatology, University and Hospital Lapeyronie, University of Montpellier, France
Background/Purpose: Inflammatory bowel diseases (IBD), such as Crohn disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density caused by chronic…
Abstract Number: 1576 • 2017 ACR/ARHP Annual Meeting
IL-23 Promotes Fecal Microbiota Dysbiosis Associated with Susceptibility to Spondyloarthritis and Ileitis in ZAP-70 Mutant SKG Mice
Linda Rehaume¹, Nicholas Matigian¹, Kate Ormerod², Alicia Kang¹, Richard Linedale¹, Olga Zbarskaya¹, Kristine Kikly³, Joshua Daly², Nancy Lachner², Philip Hugenholtz², Mark Morrison¹, Kim-Anh Lê Cao⁴ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ²Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, ³Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ⁴School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from SpA, or for people at-risk of disease…
Abstract Number: 1915 • 2017 ACR/ARHP Annual Meeting
Gut-Derived TNF As Risk Factor for the Development of Sacroiliac Inflammation
Karlijn Debusschere¹, Heleen Cypers², Peggy Jacques³, Filip van Den Bosch⁴, Thomas Renson⁵, Don Souza⁶, Martha Brown⁶, Gerald Nabozny⁷, Devin Dove⁶, Alexander Klimowicz⁸ and Dirk Elewaut⁹, ¹Ghent University - VIB, Ghent, Belgium, ²Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ³Ghent University Hospital, Ghent, Belgium, ⁴Rheumatology, Ghent University Hospital, Gent, Belgium, ⁵Rheumatology, Ghent University Hospital, GENT, Belgium, ⁶Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁸Department of Immunology and respiratory discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁹VIB Inflammation Research Center, University of Ghent, Ghent, Belgium
Background/Purpose: An intruiging link exists between gut and joint inflammation in spondyloarthritis (SpA). About 50% of patients has subclinical (eg. microscopic) gut inflammation, which represents…
Abstract Number: 116 • 2017 Pediatric Rheumatology Symposium
Arthritis as First Presenting Symptom of Inflammatory Bowel Disease: A Case Control Study
Kathryn Phillippi¹, Thomas Sferra², Nora Singer³ and Elizabeth Brooks⁴, ¹Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children’s Hospital / Case Medical Center, Cleveland, OH, ²Pediatric Gastroenterology, Rainbow Babies and Children's Hospital/Case Medical Center, Cleveland, OH, ³MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio, Cleveland, OH, ⁴Division of Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children’s Hospital / Case Medical Center, Cleveland, OH, Cleveland, OH
Background/Purpose: Inflammatory bowel disease (IBD) is associated with extra-intestinal manifestations, the most common of which is arthralgia/arthritis. 4.1- 15% of patients with inflammatory bowel disease…
Abstract Number: 92 • 2016 ACR/ARHP Annual Meeting
Is Patient Support Program (PSP) Participation Associated with Longer Persistence and Greater Adherence Among New Users of Adalimumab?
Einav Srulovici^1,2, Vishvas Garg³, Adi Ghilai², Becca Feldman², Moshe Hoshen², Ran Balicer², Martha Skup⁴ and Maya Leventer-Roberts², ¹School of Nursing, University of Haifa, Haifa, Israel, ²Clalit Research Institute, Clalit Health Services, Tel Aviv, Israel, ³AbbVie Inc, North Chicago, IL, ⁴AbbVie Inc., North Chicago, IL
Background/Purpose: In Israel, patients treated with adalimumab (ADA) can enroll in a patient support program (PSP) provided by AbbVie, which includes a home visit by…
Abstract Number: 693 • 2016 ACR/ARHP Annual Meeting
The Prevalence of Axial and Peripheral Spondyloarthritis in Inflammatory Bowel Disease: A Systematic Review & Meta-Analysis
Maren C. Karreman^1,2, Jolanda J. Luime³, Johanna M.W. Hazes² and Angelique E.A.M. Weel¹, ¹Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands
Background/Purpose: Inflammatory Bowel Disease (IBD) is a chronic disease that affects up to 0.5% of the population, comprising both Crohn’s Disease (CD) and ulcerative colitis…
Abstract Number: 2405 • 2016 ACR/ARHP Annual Meeting
Musculoskeletal Manifestations As Presenting Symptoms of Inflammatory Bowel Disease in Children and Adolescents
Rachel Levy¹, Gil Amarilyo^2,3, Jacob Amir⁴, Rotem Tal^2,3, Amit Assa^3,5, Firas Rinawi⁵ and Liora Harel^2,3, ¹The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel, ²Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel, ³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel, ⁴Mayanei Hayeshua Medical Center, Bnei Brak, Israel, ⁵Institute of Gastroenterology Hepatology and Liver diseases, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
Background/Purpose: Extra intestinal manifestations occur in 40-50% of patients with inflammatory bowel disease (IBD), with musculoskeletal involvement in 25%. Data regarding musculoskeletal manifestations in…
Abstract Number: 2694 • 2016 ACR/ARHP Annual Meeting
Treatment of ZAP-70 Mutant SKG Mice with Anti-IL-23 Antibody Alters Fecal Microbiota Composition and Prevents Outgrowth of Bacteria Associated with Susceptibility to Spondyloarthritis and Ileitis
Linda Rehaume¹, Nicholas Matigian¹, Alicia Kang¹, Olga Zbarskaya¹, Kristine Kikly², Nancy Lachner³, Joshua Daly³, Philip Hugenholtz³, Mark Morrison¹, Kim-Anh Lê Cao⁴ and Ranjeny Thomas¹, ¹Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ³The University of Queensland, Australian Centre for Ecogenomics, Brisbane, Australia, ⁴Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from spondyloarthritis (SpA), or for people at-risk of…
Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting
Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis
Neha Ohri^1,2,3, Mark Gerich^3,4, Blair Fennimore^3,5, Diana Ir⁶, Charles Robertson⁶, Daniel Frank⁶, Liron Caplan⁷, Brandie Wagner⁸ and Kristine Kuhn^9,10, ¹Division of Rheumatology, Mount Sinai West, New York City, NY, ²Division of Rheumatology, University of Colorado, Aurora, CO, ³Mucosal Inflammation Program, University of Colorado, Aurora, CO, ⁴Division of Gastroenterology, University of Colorado, Aurora, CO, ⁵Department of Gastroenterology, University of Colorado, Aurora, CO, ⁶Division of Infectious Disease, University of Colorado, Aurora, CO, ⁷Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ⁸Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, ⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ¹⁰Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…
Abstract Number: 3164 • 2016 ACR/ARHP Annual Meeting
Spondyloarthritis Pathogenesis Involves Interplay Between Gut Microbiota and Genetic Background
Tejpal Gill¹, Mark Asquith², Stephen Brooks³, James T. Rosenbaum² and Robert A. Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Oregon Health & Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD
Background/Purpose: HLA-B27 and human b2m expression in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). While aspects of rat SpA have been studied…
Abstract Number: 37 • 2015 ACR/ARHP Annual Meeting
Cardiovascular Disease in Immune-Mediated Inflammatory Diseases: Cross Sectional Analysis of the Influence of Demographic and Traditional Cardiovascular Risk Factors
Luis Rodriguez-Rodriguez^1,2, Pedro P Perrotti³, Adrìa Aterido³, Jesús Tornero⁴, Carlos Ferrandiz⁵, Juan D. Cañete⁶, Antonio Fernandez-Nebro⁷, Javier P Gisbert⁸, Eugeni Domènech^9,10, María López-Lasanta³, Sara Marsal³, Benjamín Fernández-Gutiérrez^1,11 and IMID Consortium, ¹Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ²Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ³Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁴Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ⁵Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁶Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁷Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, ⁸Gastroenterology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁹Gastroenterology & Hepatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ¹⁰CIBERehd, Madrid, Spain, ¹¹Rheumatology, Hospital Clínico San Carlos, Madrid, Spain
Background/Purpose : Our aim was 1) to analyze the association between demographic and traditional cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in subjects affected…
Abstract Number: 664 • 2015 ACR/ARHP Annual Meeting
Patient Reported Outcomes and Assessment of the Quality of Life in a Cohort of Patients Affected By Enteropathic Spondyloarthritis: Definitive Results of a Monocentric Prospective Observational Study at One Year
Chiara Avellini¹, Laura Bolognini², Alessia Farinelli¹, Monia Ciferri³, Greta Gambacorta³, Devis Benfaremo³, Serena Cedraro³, Matteo Rossini³, William Capeci³, Lucia Manfredi³, Laura Postacchini³, Giammarco Fava², Piergiorgio Mosca², Giovanni Pomponio³, Michele Maria Luchetti³ and Armando Gabrielli³, ¹Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ²Gastroenterologia, Azienda "Umberto I-G.M.Lancisi-G.Salesi", Ancona, Italy, ³Clinica Medica, Università Politecnica delle Marche, Ancona, Italy
Background/Purpose: Enteropathic spondyloarthritis (ES) are included in the group of the spondyloarthritis (SpA). Because articular involvement is the most frequent extra-intestinal manifestation in patients with…
Abstract Number: 1390 • 2015 ACR/ARHP Annual Meeting
Hidradenitis Suppuritiva Is Associated with Inflammatory Eye Disease
Abrahim U. Syed¹, Didem Uzunaslan², Careen Y. Lowder³, Sunil Srivastava³, Juan J. Maya¹ and Rula A Hajj-Ali⁴, ¹Internal Medicine, Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH, ³Cole Eye Institute, Cleveland Clinic, Cleveland, OH, ⁴Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Hidradenitis Suppurativa (HS) is an inflammatory skin condition that can cause profound morbidity. Patients can present with recurrent nodules, sinus tract formation, abscesses and/or…

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