Abstracts tagged "inflammatory arthritis"

Abstract Number: 1972 • 2018 ACR/ARHP Annual Meeting
Resolving the Synovial Fluid Proteome and Peptidome for Disease-Specific Mediators of Inflammatory Arthritis
Shalini Mahendran¹, Eleftherios Diamandis² and Vinod Chandran³, ¹Laboratory Medicine and Pathobiology, University of Toronto, Mount Sinai Hospital, Toronto, ON, Canada, ²Pathology and Laboratory Medicine, University of Toronto, Mount Sinai Hospital, University Health Network, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Idiopathic inflammatory arthritis (IA) is a T-cell driven chronic condition characterized an imbalance in cell proliferation and apoptosis leading to significant synovial hyperplasia and…
Abstract Number: 2076 • 2018 ACR/ARHP Annual Meeting
Transmembrane TNF (tmTNF) Transgenic Mice Exhibit Enlarged Lymph Nodes and Elevated Numbers of High Endothelial Cells Associated with Increased Lymphocyte Recruitment
Kim Jeucken¹, Jan Piet van Hamburg², Merlijn Kaaij³, Leonie van Duivenvoorde³, Dominique Baeten³ and Sander W. Tas², ¹2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The NF-κB family of transcription factors plays a crucial role in chronic inflammatory diseases and can be activated via two distinct pathways. Non-canonical NF-κB…
Abstract Number: 2432 • 2018 ACR/ARHP Annual Meeting
Peripartum Issues in the Inflammatory Arthritis (IA) Patient: A Survey of the Rapport (Rheumatoid Arthritis Pharmacovigilence Program and Outcomes Research in New Therapies) Registry
Tharindri Dissanayake¹, Stephanie Keeling² and Walter P. Maksymowych³, ¹Department of Medicine, University of Alberta, Division of Rheumatology, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada
Background/Purpose: Multiple issues surround the peripartum period for IA patients including medication use, risk of disease flare and potential impact on neonatal outcomes. We aimed…
Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting
Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration
Richard Bell¹, Emily Wu^1,2, Homaira Rahimi³ and Edward Schwarz^1,4,5, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, ⁴University of Rochester, Rochester, NY, ⁵Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
Abstract Number: 1334 • 2017 ACR/ARHP Annual Meeting
Identification of Key Regulators for Resolution of Chronic Inflammatory Arthritis through a Systems Approach
Jin-Sun Kong Sr.¹, Ji-Hwan park², Seung-Ah Yoo Sr.¹, Jung Hee Koh³, Daehee Hwang⁴ and Wan-Uk Kim Sr.⁵, ¹The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ²Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Center for Plant Aging Research, DGIST, Daegu 42988, South Korea, Department of New Biology, DGIST, Daegu 42988, South Korea, Daegu, Korea, Republic of (South), ⁵The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: Collagen-induced arthritis(CIA), a representative animal model of chronic inflammatory arthritis, follows phases of induction, peak of inflammation and resolution. This study aims to identify…
Abstract Number: 1398 • 2017 ACR/ARHP Annual Meeting
Sleep and Physical Activity: An Objective Profile of People with Rheumatoid Arthritis
Sean McKenna¹, Marie Tierney², Sandy Fraser³, Aoife O'Neill⁴ and Norelee Kennedy¹, ¹Department of Clinical Therapies, University of Limerick, Ireland, Limerick, Ireland, ²Discipline of General Practice, National University of Galway, Ireland, Galway, Ireland, ³Department of Rheumatology, University Hospitals Limerick, Ireland, Limerick, Ireland, ⁴Department of Mathematics, University of Limerick, Ireland, Limerick, Ireland
Background/Purpose: Regular physical activity is important for people with rheumatoid arthritis (RA). Sleep requirements for adults should be on a ‘sleep needs spectrum’ of between…
Abstract Number: 2056 • 2017 ACR/ARHP Annual Meeting
Performance and Validity of Musculoskeletal Ultrasound in the Assessment of Synovial Inflammation in Experimental Acute Gout
Raquel Largo¹, Juan Pablo Medina², Sandra Perez-Baos², Victor Najera-Aleson², Aranzazu Mediero², Gabriel Herrero-Beaumont¹ and Esperanza Naredo³, ¹Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ²Joint and Bone Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ³Rheumatology, Joint and Bone Research Unit, IIS-FJD, Hospital Universitario Fundación Jiménez Díaz., Madrid, Spain
Background/Purpose: Musculoskeletal ultrasound (MS-US) has not been validated as a reliable technique to evaluate joint inflammation in an acute gout rabbit model. Rabbit has been…
Abstract Number: 197 • 2017 ACR/ARHP Annual Meeting
Process Evaluation of the Making It Work Program, an Online Program to Help People with Inflammatory Arthritis Remain Employed
Kathy Tran¹, Xi yuan Li², Xiang Chuin Seah³, Catherine Backman⁴, Brendan vanAs³, Pam Rogers², Monique Gignac⁵, John M. Esdaile³, Carter Thorne⁶, Linda Li² and Diane Lacaille⁷, ¹Simon Fraser University, Arthritis Research Canada, Richmond, BC, Canada, ²Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Rehab Medicine, University of British Columbia, Richmond, BC, Canada, ⁵Instititue for Work and Health, Toronto, ON, Canada, ⁶University of Toronto, Newmarket, ON, Canada, ⁷University of British Columbia, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: Inflammatory arthritis (IA) commonly affects ability to work, yet few arthritis services exist addressing employment. We report on the process evaluation of the Making…
Abstract Number: 1076 • 2017 ACR/ARHP Annual Meeting
TGF-β1 Induces AXL in Murine and Human Synovium and Protects Ankle Joints, but Not Knee Joints, during Murine Inflammatory Arthritis
Claire E.J. Waterborg, Mathijs G.A. Broeren, Esmeralda N. Blaney Davidson, Marije I. Koenders, Peter L. van Lent, Peter M. van der Kraan and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) manifests in a symmetrical fashion in anatomically distinct synovial joints. The innate immune system, which plays a crucial role in the…
Abstract Number: 1093 • 2017 ACR/ARHP Annual Meeting
Effectiveness of the Outreach Model for Rheumatology Specialty Clinics to On-Reserve First Nations in Canada: System-Level and Individual Measures of Performance and Outcomes
Sujay Nagaraj¹, Claire Barber², Margaret Kargard³, Tyler White³ and Cheryl Barnabe⁴, ¹McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada, ²Medicine, University of Calgary, Calgary, AB, Canada, ³Siksika Health Services, Siksika, AB, Canada, ⁴Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Inflammatory arthritis (IA) disproportionately affects Canada’s First Nations population. A Model of Care (MoC) consisting of rheumatology specialty services embedded in the primary care…
Abstract Number: 1240 • 2017 ACR/ARHP Annual Meeting
Active Disease Is Associated with Dependency in Inflammatory Arthritis
Havva Ozturk Durmaz¹, Alper Sari², Berkan Armagan², Abdulsamet Erden³, Levent Kilic², Omer Karadag⁴, Sedat Kiraz², Sule Apras Bilgen³ and Umut Kalyoncu³, ¹Physical Medicine and Rehabilitation, Ahi Evran University Faculty of Medicine, Kırsehir, Turkey, ²Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Department of Internal Medicine, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: The independency is one of the major concerns according to patients' perspective. For instance, independency is top ranking problem in psoriatic arthritis patients and…
Abstract Number: 1245 • 2017 ACR/ARHP Annual Meeting
Transition in Work Status and Quality of Life in People with Inflammatory Arthritis
Wiebke Bartels¹, Eric C. Sayre², Pam Rogers³ and Diane Lacaille⁴, ¹Science, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ⁴University of British Columbia, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: People with inflammatory arthritis (IA) frequently have to stop working due to their arthritis. It is assumed that economic and psychosocial consequences of premature…
Abstract Number: 1295 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcome in Patients with SLE Compared to Patients with Other Inflammatory Rheumatic Diseases: Real World Data from a Prospective Pregnancy Register
Rebecca Fischer-Betz¹, Christina Bungartz², Matthias Schneider¹, Jutta Richter¹, Anja Weiss², Angela Zink³ and Anja Strangfeld⁴, ¹Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ²German Rheumatism Research Center, Berlin, Germany, ³Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany, ⁴Epidemiology, German Rheumatism Research Center, Berlin, Germany
Background/Purpose: SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. With careful pre-pregnancy counseling and monitoring…
Abstract Number: 1298 • 2017 ACR/ARHP Annual Meeting
Tough Choices: Understanding the Medication Decision-Making Process for Women with Inflammatory Arthritis during Pregnancy and Lactation
Tayseer Haroun¹, Amanda M. Eudy^2,3,4,5, Malithi Jayasundara², W. Benjamin Nowell^6,7, Jeffrey R. Curtis⁸, Charlotte Whitney White⁹, Rachelle Crow-Hercher⁹, Seth D. Ginsberg¹⁰ and Megan E. B. Clowse^4,11, ¹Department of Medicine/Division of Rheumatology, Duke University Medical Center, Durham, NC, ²Rheumatology, Duke University Medical Center, Durham, NC, ³Duke University, Durham, NC, ⁴Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, ⁵Duke University Medical Center, Chapel Hill, NC, ⁶CreakyJoints/Global Health Living Foundation, Upper Nyack, NY, ⁷Global Healthy Living Foundation, Upper Nyack, NY, ⁸Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁹Arthritis Power, Upper Nyack, NY, ¹⁰Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ¹¹Duke University Medical Center, Durham, NC
Background/Purpose: With new data demonstrating medication compatibility in pregnancy and lactation, it is important to understand how this information can best reach patients. We sought…
Abstract Number: 1316 • 2017 ACR/ARHP Annual Meeting
Risk of Preterm Delivery Associated with Perinatal Exposure to Dmards in Women with Inflammatory Arthritis: A Population-Based Cohort Study
Nicole W. Tsao^1,2, Eric C. Sayre², Mohsen Sadatsafavi¹, J. Antonio Avina-Zubieta^2,3, Stephanie Ensworth⁴ and Mary A. De Vera^1,2, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Given the limited data on impacts of perinatal medication use, our objective was to investigate the association between conventional synthetic DMARD (csDMARD) use preconception…

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