Abstracts tagged "Inflammation"

Abstract Number: 0063 • ACR Convergence 2025
Effect of alpha-ketoglutarate on Synovial Fibroblasts-Mediated Inflammation in Arthritis
Surabhi Gautam, Vinay Devulapalli, Akash Sathiyamurthi, Jayla Whittaker and Pallavi Bhattaram, Emory University, Atlanta, GA
Background/Purpose: Rheumatoid arthritis (RA) and related autoimmune joint disease patients exhibit cyclic episodes of resolution and exacerbation of joint inflammation, referred to as flares. Fibroblast-like…
Abstract Number: 2497 • ACR Convergence 2025
Unraveling the Complexity of Interferon Responses in Peripheral Blood Mononuclear Cells in Systemic Sclerosis at Single-Cell Resolution
Pietro Bearzi¹, Elena Pachera², Astrid Hofman³, Laura Much⁴, Lumeng Li¹, Kristina Bürki³, Cosimo Bruni⁵, Mike Becker⁶, Anna-Maria Hoffmann-Vold⁷, Roberto Giacomelli⁸ and Oliver Distler⁹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zürich, Switzerland, ²University Hospital Zurich, Zurich, Switzerland, ³Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁵University of Zurich, Zurich, Switzerland, ⁶Dept. of Rheumatology, University Hospital Zurich, Zürich, Switzerland, ⁷Oslo University Hospital, Oslo, Norway, ⁸i) Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Biomedico; ii) Rheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy, ⁹Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: Autoimmunity is a hallmark of SSc pathogenesis. Emerging evidence suggests that interferon (IFN) signaling plays a role in predicting SSc patients at risk of…
Abstract Number: 2070 • ACR Convergence 2025
Characterization of Hospitalization, Patient Demographics and Impact of Idiopathic Inflammatory Myopathies on Hospitalization Outcomes in Adult Fracture Patients: A National Inpatient Sample Analysis.
Pranathi Bandarupalli¹, Vineeth Potluri², Amr Alemairy², Harsharn Grewal² and Shudipan Chakraborthy², ¹Mercy St Vincent Medical Center, Toledo, OH, ²Mercy Health St. Vincent Medical Center, Toledo, OH
Background/Purpose: Idiopathic Inflammatory Myopathies (IIM), including polymyositis and dermatomyositis, are rare systemic autoimmune disorders characterized by chronic muscle inflammation and progressive muscle weakness. Patients with…
Abstract Number: 1776 • ACR Convergence 2025
Preclinical Development of a Novel TL1A-Targeting Antibody with Extended Half-life and Low Immunogenicity Risk for the Treatment of Inflammatory Diseases
Yali Zhou¹, Huilin Li¹, Hang Su¹, Mingjun Zhao¹, Haiying Wang¹, Qiong Wang¹, Xiaojin Zhang², Yanliu Fan¹, Lulu Li¹, Miaomiao Wang¹, Jinglu Xia¹, Wenyue Zong¹, Jingjing Li¹, Simin Yi¹, Bing Zou¹, Zhen Lu¹, Yali Wang¹, Yupeng Zhu¹, Lingjian Yang¹, Zenglin Pei¹, Barry Duplantis³, Yuhao Wang³, Yi Li¹ and Quan Yu¹, ¹Ailux, Shanghai, China (People's Republic), ²XtalPi, Shanghai, China (People's Republic), ³Ailux, Boston, MA
Background/Purpose: Autoimmune and inflammatory diseases such as inflammatory bowel disease (IBD) and psoriasis are driven by dysregulated cytokine networks. TL1A, a member of the TNF…
Abstract Number: 1337 • ACR Convergence 2025
The Association Between Glucagon-Like Peptide-1 Receptor Agonist and Rheumatoid Arthritis: A Population-Based Case Control Study
Ariel Israel¹, Fadi Hassan², Jalal Kurtam², Jamal Awad², Eugene Merzon¹ and Mohammad Naffaa³, ¹Leumit Health Services, Tel-Aviv, Israel, ²Galilee Medical Center, Nahariya, Israel, ³The Azriel's Faculty of Medicine, Bar-Ilan University, Safed, Israel; The Rheumatology Unity, Galilee Medical Center, Naharyia, Israel
Background/Purpose: The increasing use of glucagon-like peptide-1 receptor agonists (GLP1-RAs) for diabetes mellitus (DM) and weight loss has the potential modify the risk for rheumatoid…
Abstract Number: 1117 • ACR Convergence 2025
Inflammatory Arthritis after Hematopoietic Stem Cell Transplant: A Case Series and Literature Review
Scott Yeudall¹, Mark Levis², Jonathan Webster² and Laura Cappelli³, ¹The Johns Hopkins Hospital, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Hematopoietic stem cell transplant (HSCT) is a commonly employed treatment for hematologic malignancies including acute leukemias and lymphomas but can be complicated by graft-versus-host…
Abstract Number: 0916 • ACR Convergence 2025
UVB-Irradiated Keratinocyte Extracellular Vesicles Trigger Innate Immune Activation via Type I Interferons and STING Pathway
Ahmed Eldaboush¹, Darae Kang² and Victoria Werth³, ¹Department of Dermatology, Perelman Shool of Medicine, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Potomac, MD, ³University of Pennsylvania, Wynnewood, PA
Background/Purpose: Extracellular vesicles (EVs) are cell-derived nanoparticles that mediate cell-cell communication. EVs are implicated in photosensitive autoimmune diseases like dermatomyositis (DM) and systemic lupus (SLE),…
Abstract Number: 0464 • ACR Convergence 2025
Synovial Inflammation is not Associated With Reoperation in Patients With Rheumatoid Arthritis Undergoing Total Hip or Knee Arthroplasty
Solana Cushing¹, Kelsey Gripp², Edward DiCarlo³, Deanna Jannat-Khah¹, Yoshimi Endo³, Jose Rodriguez³, Mark Figgie³, Bella Mehta⁴ and Susan Goodman³, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ
Background/Purpose: Reoperations following arthroplasty are a significant burden to patients and surgeons. In patients with RA who receive total hip (THA) or knee (TKA) arthroplasty,…
Abstract Number: 0207 • ACR Convergence 2025
The Feasibility and Clinical Effects of Anti-Inflammatory Diet Intervention In Patients Diagnosed With Long COVID (Post-Acute Sequelae of SARS CoV-2, PASC)
Suzi Hong¹, Marcos Monteon², Kathleen Bundy³, Chloe Delgado Ramirez³, Phoebe Senowitz³, Monica Guma⁴, Nina Acebo⁵, Chris Pruitt⁶, Tanya Shekhtman³, Shahrokh Golshan⁷ and Susan Lee⁸, ¹Herbert Wertheim School of Public Health and Human Longevity Science UCSD; Department of Psychiatry UCSD, San Diego, ²University of California, San Diego, San Diego, ³Department of Family Medicine, Center for Integrative Health, Krupp Endowment Fund, UCSD, La Jolla, ⁴University of California San Diego, San Diego, CA, ⁵University of California, San Diego, La Jolla, ⁶Herbert Wertheim School of Public Health and Human Longevity Science, UCSD, La Jolla, ⁷Department of Pyschiatry, UCSD, La Jolla, ⁸Department of Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: There have been over 777 million cases of acute COVID-19 infections worldwide as of April 2025. Although many patients recover, an estimated 10-30% of…
Abstract Number: 0060 • ACR Convergence 2025
Dietary Management of Rheumatoid Arthritis: A Functional Investigation of the Synbiotic Medical Food, SBD121
Ryan Green¹, Daniela Diaz-Infante Morales¹, Alicia Ballok¹, Kristine Kuhn², Christopher Ritchlin³, Mark Charbonneau¹, Eric Schott¹ and Gerardo Toledo¹, ¹Solarea Bio Inc, Waltham, MA, ²²⁰²² - ²⁰²³ / Adult/ University of Colorado, Aurora, CO, ³University of Rochester Medical Center, Canandaigua, NY
Background/Purpose: Rheumatoid arthritis (RA), affecting approximately 1% of the global population RA is a leading cause of disability worldwide. Despite available treatments, including methotrexate (MTX)…
Abstract Number: 2495 • ACR Convergence 2025
IL-6/STAT3 Signaling is Central for Chemokine Production in E2-Induced Dermal Inflammation
Nicolas Ancona¹, Yucui Li², Ludivine Renaud³, Carol Feghali-Bostwick³ and DeAnna Baker Frost³, ¹MUSC Rheumatology & Immunology, Charleston, SC, ²Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi, Medical University Taiyuan, Shanxi, China (People's Republic), ³Medical University of South Carolina, Charleston, SC
Background/Purpose: Scleroderma (SSc) is an autoimmune disease characterized by dermal inflammation and fibrosis. Patients with SSc have high systemic levels of estradiol (E2), a form…
Abstract Number: 2046 • ACR Convergence 2025
Utilization of the All of Us Research Program to Study the Impact of Genetic Background on Autoinflammatory Diseases
Song Wu¹, Zuoming Deng², Peter Gorevic¹ and Qingping Yao¹, ¹Stony Brook University, Stony Brook, NY, ²Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: A widely recognized model of disease pathogenesis is the potential interplay of gene x gene x environment. Low penetrance variants in the NOD-like receptor…
Abstract Number: 1736 • ACR Convergence 2025
Multi-Model Evaluation of the Impact of CD14 on Synovial Inflammation and Pain During PTOA.
Kevin Burt¹, Sanique South², Natalie Adamczyk³, Shingo Ishihara³, Vu Nguyen⁴, Robert Mauck⁴, Anne-Marie Malfait⁵, Timothy Griffin⁶, Rachel Miller⁷ and Carla Scanzello¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Oregon, Eugene, ³Rush University, Chicago, ⁴University of Pennsylvania, Philadelphia, ⁵Rush University, Oak Park, IL, ⁶Oklahoma Medical Research Foundation, Oklahoma City, ⁷Rush University Medical Center, Chicago, IL
Background/Purpose: Soluble CD14, a co-receptor of inflammatory toll-like receptor signaling that is produced primarily by monocytes/macrophages, is present in synovial fluid in patients with OA…
Abstract Number: 1325 • ACR Convergence 2025
Plasma Matrix Metalloproteinases and Heart Failure Outcomes in Rheumatoid Arthritis
Tate Johnson¹, Michael Duryee¹, Punyasha Roul², Grant Cannon³, Gary Kunkel⁴, Beth Wallace⁵, Isaac Smith⁶, John Richards⁷, Katherine Wysham⁸, Gail Kerr⁹, Andreas Reimold¹⁰, Pascale Schwab¹¹, Daniel Anderson¹², Joshua Baker¹³, Geoffrey Thiele¹, Ted Mikuls¹ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²UNMC, Omaha, NE, ³University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁴University of Utah and George E Wahlen VAMC, Salt Lake City, UT, ⁵Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, ⁶Duke University Hospital, Durham, NC, ⁷Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, ⁸VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁹Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, ¹⁰Dallas VA Medical Center, Dallas, TX, ¹¹VA Portland and Oregon Health & Science University, Portland, OR, ^120587964, Durham, NC, ¹³University of Pennsylvania, Philadelphia, PA
Background/Purpose: The mechanisms of heart failure (HF) risk in RA remain incompletely understood. HF with preserved ejection fraction (HFpEF) is over-represented in RA, which may…
Abstract Number: 1114 • ACR Convergence 2025
Multi-omics Integration Analysis of the Cross-scale Mechanism of MTX-induced T2DM Risk and the Precise Intervention Strategy of Leonurine
Mei-Feng Shi¹, Fang-Shu Zou¹, Xiao-Na Ma¹, Wei Feng¹, Yi-Fang Zhang², Chang-Song Lin¹, Min-Ying Liu² and Qiang Xu¹, ¹Guangzhou University of Traditional Chinese Medicine, Guangzhou, China (People's Republic), ²The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China (People's Republic)
Background/Purpose: Methotrexate (MTX) is a first-line treatment for autoimmune diseases, including rheumatoid arthritis (RA). Its potential risk of inducing type 2 diabetes mellitus (T2DM) remains…

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