Abstracts tagged "Inflammation"

Abstract Number: 0328 • ACR Convergence 2025
High synovial fluid leukocyte counts and markers of TLR activation correlate with poorer response to injections in patients with knee OA
Lance Murphy¹, Baofeng Hu², Vu Nguyen³, Bryant England⁴, Katherine Wysham⁵, Mercedes Quinones⁶, Joshua Baker³ and Carla Scanzello³, ¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²University of Pennsylvania, Wynnewood, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁶Washington DC VA Medical Center, Bethesda, MD
Background/Purpose: Toll-like receptors (TLRs) are pattern-recognition receptors of the innate immune response and are important in driving the initial activation of myeloid lineage cells to…
Abstract Number: 0097 • ACR Convergence 2025
Aberrant histone marks increase the inflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) by suppressing NUB1 induction
Yosuke Ono¹, Camilla R.L. Machado², Eunice Choi¹, Wei Wang¹, David Boyle¹ and Gary Firestein², ¹University of California, San Diego, San Diego, ²University of California, San Diego, San Diego, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) play a central role in cartilage destruction and cytokine production in rheumatoid arthritis (RA). Neddylation, a post-translational modification involving NEDD8 conjugation,…
Abstract Number: 2329 • ACR Convergence 2025
Increased Risk of Atrial Fibrillation In Patients With Psoriasis: A Systematic Review And Meta-Analysis
Sehneet Grewal, Rubab Rizwan, Sri Varsha Banda and Mohammad Hazique, Nuvance Health, Poughkeepsie, NY
Background/Purpose: Psoriasis, a chronic inflammatory skin condition, is increasingly linked to systemic cardiovascular risks. Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with…
Abstract Number: 1974 • ACR Convergence 2025
Serial ferritin as a diagnostic surrogate marker in Hemophagocytic Lymphohistiocytosis (HLH), a retrospective single-center study
Chen Chao¹, Anna Lichtiger², Xianhong Xie³, Melissa Fazzari⁴ and Ayesha Bibi⁵, ¹Rheumatology Division, Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, NY, ²Internal Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, The Bronx, NY, ³Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, ⁴Department of Epidemiology & Population Health, Albert Einstein College of Medicine,, Bronx, NY, ⁵Rheumatology Division, Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Woodbridge Township, NJ
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is an immune-mediated disorder characterized by cytokine dysregulation, resulting in multi-organ involvement and high mortality. (1-2) There is a time lag…
Abstract Number: 1650 • ACR Convergence 2025
Malondialdehyde-Acetaldehyde and Citrulline Modified Proteins are Overexpressed in Cardiac Tissues in Rheumatoid Arthritis-Associated Heart Failure and Mediate Endothelial Cell Dysfunction
Hannah Johnson¹, Wenxian Zhou², Michael Duryee¹, Engle Sharp¹, Kimberley Sinanan¹, Carlos Hunter¹, Tate Johnson¹, Mabruka Alfaidi¹, Daniel Anderson³, Geoffrey Thiele¹ and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Bellevue, NE, ^30587964, Durham, NC
Background/Purpose: Previous reports show that malondialdehyde-acetaldehyde (MAA) adducts are overexpressed in RA, especially in joint/lung tissues, and that they colocalize with citrulline (CIT). This is…
Abstract Number: 1182 • ACR Convergence 2025
Cardiac Sarcoidosis in Black Patients: A Biopsy-Confirmed Cohort Study
Roshan Subedi¹, Haya Haddad², Rachel Barish¹, Tania Vora¹, Nana Afari-Armah³, Ajay Kadakkal¹, Farooq Sheikh¹ and Florina Constantinescu¹, ¹Medstar Washington Hospital Center, Washington, DC, ²Medstar Washington Hospital Center, Silver Spring, MD, ³Medstar Washington Hospital Center, Washington
Background/Purpose: Sarcoidosis is an inflammatory disease characterized by non-necrotizing granulomatous inflammation that can affect any organ. Approximately 5% of patients with sarcoidosis develop clinically significant…
Abstract Number: 0973 • ACR Convergence 2025
Effects of a Novel Hybrid Protein Based on S100 on Macrophage Polarization and Its Therapeutic Efficacy in a Bleomycin-Induced Systemic Sclerosis Mouse Model.
Takuya Kotani¹, Takayasu Suzuka², Shogo Matsuda³ and Tohru Takeuchi⁴, ¹Division of Rheumatology, Department of Internal Medicine IV, Osaka Medical and Pharmaceutical University, Osaka, Japan, ²Division of Rheumatology, Department of Internal Medicine IV, Osaka Medical and Pharmaceutical University, Takatsuki, Japan, ³Department of Internal Medicine IV, Division of Rheumatology, Osaka Medical and Pharmaceutical University, Osaka, Japan, ⁴Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University, Takatsuki, Japan
Background/Purpose: S100 proteins are involved in the inflammatory responses of autoimmune diseases. We previously showed that S100 proteins regulate macrophage function via CD68. Based on…
Abstract Number: 0889 • ACR Convergence 2025
Potentially pathogenic memory CD4 T cells with a B cell helper phenotype expand in ACPA+ individuals during progression to rheumatoid arthritis
Ziyuan He¹, Marla Glass¹, Pravina Venkatesan², Alexandra Ferrannini³, Marie Feser⁴, Christy Bennett¹, David Boyle⁵, Kristen Demoruelle⁶, Kristine Kuhn⁷, Fan Zhang⁸, Thomas Bumol⁹, Ananda Goldrath³, Peter Skene³, V. Michael Holers¹⁰, Xiaojun Li¹, Adam Savage¹, Gary Firestein¹¹, Kevin Deane¹², Troy Torgerson¹³ and Mark Gillespie¹, ¹Allen Institute for Immunology, Seattle, WA, ²Allen Insitute, Seattle, WA, ³Allen Institute for Immunology, Seattle, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵UCSD, La Jolla, CA, ⁶University of Colorado Anschutz Medical Campus, Golden, CO, ⁷²⁰²² - ²⁰²³ / Adult/ University of Colorado, Aurora, CO, ⁸The University of Colorado, Aurora, CO, ⁹Allen Institute for Immunology, San Diego, CA, ¹⁰University of Colorado, Denver, CO, ¹¹University of California, San Diego, San Diego, CA, ¹²University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ¹³Allen Institute for Immunology, Enumclaw, WA
Background/Purpose: Prior to the onset of clinically apparent inflammatory arthritis (IA)/synovitis (clinical RA), ACPA+ ‘at-risk’ individuals (ARI) show alterations in the abundance of effector T…
Abstract Number: 0307 • ACR Convergence 2025
Cytokine Profiling of Molecular Endotypes of Knee Osteoarthritis: Insights from the IMI-APPROACH cohort
Monica T. Hannani¹, Jaume Bacardit², Jonathan Larkin³, Virpi Glumoff³, Morten A. Karsdal¹, Anne-Christine Bay-Jensen¹, Ali Mobasheri³ and Christian Thudium⁴, ¹Nordic Bioscience A/S, Herlev, Denmark, ²Newcastle University, Newcastle upon Tyne, United Kingdom, ³University of Oulu, Oulu, Finland, ⁴Nordic Bioscience, Herlev, Denmark
Background/Purpose: There has been a surging interest in characterizing subpopulations of osteoarthritis (OA) to facilitate recruitment of the right subgroups for drug development. The APPROACH…
Abstract Number: 0093 • ACR Convergence 2025
Soluble CD13 engages protease-activated receptor 4 to promote synovial inflammation and angiogenesis in rheumatoid arthritis
Chenyang Lu¹, Megan N Mattichak², Simin Xu¹, William D Brodie³, Neha Khanna², Hafsa Amin², Qi Wu², Phillip Campbell², David Fox⁴ and Pei-Suen Tsou⁵, ¹Division of Rheumatology, Department of Internal Medicine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangzhou, China (People's Republic), ²Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, ⁴University of Michigan, Dexter, MI, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Soluble CD13 (sCD13), the soluble form of aminopeptidase N/CD13, exhibits potent chemoattractant, angiogenic, and arthritogenic properties. While we previously identified certain G protein-coupled receptors…
Abstract Number: 2310 • ACR Convergence 2025
Neuropeptide influence in nociception and inflammation through immune system modulation in SPA patients
ELENA GRAU GARCIA¹, SAMUEL LEAL², Jose Ivorra Cortes³, Pablo Muñoz-Martínez⁴, Laura Mas Sanchez⁵, Daniel Ramos Castro⁶, Alba Maria Torrat Noves⁷, Iago Alcantara Alvarez⁸, Belen Villanueva Manes⁹, Miguel Simeo Vinaixa⁸, Andres Perez Hurtado¹⁰ and José Andrés Román Ivorra¹¹, ¹HUP La Fe, Valencia, Comunidad Valenciana, Spain, ²Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, ³Hospital Universitario La Fe, Valencia, Comunidad Valenciana, Spain, ⁴Hospital Universitario y Politécnico La Fe, Sagunto, Spain, ⁵Hospital Universitari i Politecnic La Fe, València, Spain, ⁶Hospital Universitari i Politecnic La Fe, Valencia, Spain, ⁷Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Spain, ⁸Rheumatology Department. HUP La Fe, Valencia, Spain, ⁹Hospital La Fe, València, Spain, ¹⁰Hospital Universitario y Politècnico La Fe, València, Comunidad Valenciana, Spain, ¹¹Hospital Universitari i Politècnic La Fe, Valencia, Spain
Background/Purpose: NGFβ and CGRP are neuropeptides with a significant role in peripheral inflammation, pain modulation and immune responses. Neuropeptides regulatory mechanisms in spondyloarthritis (SpA) remain…
Abstract Number: 1949 • ACR Convergence 2025
Relapsing Polychondritis: Mimicking Asthma while Airways get Damaged
Eric Robbins¹ and Marcela ferrada², ¹University of Maryland, baltimore, ²University of Maryland, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is an autoimmune disorder that can present with airway inflammation, leading to dyspnea, cough, and fatigue. These respiratory symptoms are frequently…
Abstract Number: 1625 • ACR Convergence 2025
Factor VIII as a Potential Biomarker of Disease Activity in Relapsing Polychondritis
Ashika Ajitumar¹, Eric Robbins², Yusuf Mastoor² and Marcela ferrada³, ¹University of Maryland, baltimore, MD, ²University of Maryland, baltimore, ³University of Maryland, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is a rare autoimmune disease marked by episodic inflammation of cartilaginous tissues. A major challenge in its clinical management is the…
Abstract Number: 1176 • ACR Convergence 2025
VISIBLE Post-Inflammatory Pigmentation Journeys: Exploring the Impact of Pigmentation
Tarek Dawamne¹, Olivia Choi, MD, PhD, FAAD², Alison Tran³, Jacob Beer⁴, Katelyn Rowland², Theodore Alkousakis², Oyediran Adelakun², Elizabeth Skobelev², Sancharitha Ramji², Tony Ma⁵, Daphne Chan² and Jenna Lester⁶, ¹Texas A&M School of Engineering Medicine, Houston, TX, USA, Houston, TX, ²Johnson & Johnson, Horsham, PA, USA, Horsham, PA, ³Lake Granbury Medical Center, Department of Dermatology, Dallas, TX, USA, Dallas, TX, ⁴Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami, FL, USA, Miami, FL, ⁵Johnson & Johnson, Spring House, PA, USA, Spring House, PA, ⁶University of California, San Francisco, CA, USA, San Francisco, CA
Background/Purpose: Post-inflammatory pigment alteration (PIPA) following resolution of psoriasis plaques is an important, neglected problem that disproportionately impacts people of color.1-3 VISIBLE, an ongoing Phase…
Abstract Number: 0958 • ACR Convergence 2025
Asynchronous Resolution of Inflammation and Fibrosis in A Prolonged Experimental Model Suggests Distinct Temporal Dynamics And Resolution Mechanisms in Systemic Sclerosis
Aurore Collet¹, Manel Jendoubi², Thomas Guerrier², Alexis Largy², Silvia Speca², Sylvain Dubucquoi¹ and David Launay³, ¹Univ. Lille, Inserm, CHU Lille, U¹²⁸⁶ – INFINITE – Institute for Translational Research in Inflammation, Lille, France ; CHU Lille, Institut d’Immunologie, Lille, France, Lille, France, ²Univ. Lille, Inserm, CHU Lille, U¹²⁸⁶ – INFINITE – Institute for Translational Research in Inflammation, Lille, France, Lille, France, ³Univ. Lille, Inserm, CHU Lille, U¹²⁸⁶ – INFINITE – Institute for Translational Research in Inflammation, Lille, France ; CHU Lille, Département de Médecine interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), Lille France, Lille, France
Background/Purpose: Systemic sclerosis (SSc) is characterized by tissue fibrosis, which is defined as excessive and irreversible extracellular matrix (ECM) accumulation, leading to organ dysfunction. In…

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