Abstracts tagged "Inflammation"

Abstract Number: 0048 • ACR Convergence 2024
Role of the Chemokine CCL22 in Rheumatoid Arthritis Development
Marcelo Afonso¹, Masa Filipovic¹, Alexandra Argyriou², Alexandra Circiumaru³, Mikael Ringh¹, Konstantin Carlberg¹, Vijay Joshua¹, Szu-Jing Chen¹, Marianne Engström¹, Heidi Wähämaa¹, Tomas Ekström¹, Marc H Wadsworth II⁴, Ravi Kumar¹, Aaron Winkler⁵, Vivianne Malmström¹, Anca Catrina¹, Karine Chemin¹, Aase Hensvold¹ and Bence Réthi¹, ¹Karolinska Institutet, Stockholm, Sweden, ²Karolinska Institutet, Solna, Sweden, ³Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden, ⁴Pfizer, Cambridge, ⁵Pfizer Inc., Cambridge, MA
Background/Purpose: Understanding alterations of the immune homeostasis in individuals at risk of rheumatoid arthritis (RA) can be a key to achieve earlier diagnosis and prevention.…
Abstract Number: 0275 • ACR Convergence 2024
Targeting IRAK4 in Monosodium Urate Crystals Induced Inflammation
Sadiq Umar¹ and Sriram Ravindran², ¹University of Illinois at Chicago, Chicago, IL, ²University of Illinois, Chicago
Background/Purpose: Gout, the leading cause of inflammatory arthritis, is becoming increasingly prevalent worldwide, affecting both developed and developing countries. This condition results from the deposition…
Abstract Number: 0624 • ACR Convergence 2024
Coexisting Tubulointerstitial Inflammation and Damage Is a Risk Factor for Chronic Kidney Disease in Patients with Lupus Nephritis
Dong-Jin Park¹, Hyemin Jeong², Sung-Eun Choi³, Ji-Hyoun Kang² and Shin-Seok Lee⁴, ¹Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Chonnam National University Hospital, Gwangju, South Korea, ³Chonnam National University Medical School & Hospital, Gwangju, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, KR, Gwangju, Republic of Korea
Background/Purpose: Conflicting studies have reported varying associations between tubulointerstitial inflammation (TII), tubulointerstitial damage (TID), and the long-term outcomes of lupus nephritis (LN), due to analyzing…
Abstract Number: 0891 • ACR Convergence 2024
Shared and Disease-Specific Mechanisms of Autoimmunity Using Single Cell Sequencing of Peripheral Immune Cells
Jacquelyn Nestor¹, Rachelly Normand¹, Wamia Said¹, Sergio Aguilar², Nandini Samanta¹, Sidney Martin¹, Roya Best¹, Hoang Anh Tran¹, Adrien Antoinette¹, Eilish Dillon³, Devin King³, April Jorge⁴, Maureen Leonard⁴, Pritha Sen³, Kerry Reynolds⁴, John Stone⁵, Michelle Rengarajan¹, Tanuja Chitnis⁶, Kevin Wei⁷, Deepak Rao³, Andrew Luster⁸, Gary Reynolds¹ and Alexandra-Chloe Villani¹, ¹Massachusetts General Hospital, Harvard Medical School, Broad Institute of MIT and Harvard, Boston, MA, ²National Center for Genomic Analysis, Barcelona, Spain, ³Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Massachusetts General Hospital , Harvard Medical School, Concord, MA, ⁶Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁷Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁸Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Rheumatologic diseases are characterized by distinct clinical presentations and patterns of organ involvement, yet share many genetic risk factors and treatment responses. This suggests…
Abstract Number: 1089 • ACR Convergence 2024
Endothelial Activation in Gout
Michael Toprover¹, Binita Shah², Kamelia Drenkova², Michael Pillinger³ and Michael Garshick⁴, ¹New York University Langone Health, New York, NY, ²NYU Langone Health, New York, NY, ³New York University Grossman School of Medicine, New York,, NY, ⁴NYU Langone Health, Tenafly, NJ
Background/Purpose: Gout is the most common inflammatory arthritis and is associated with increased cardiovascular (CV) disease and cardiovascular mortality. Our prior studies have suggested that…
Abstract Number: 1660 • ACR Convergence 2024
Systemic Inflammation and Transcriptional Reprogramming Contribute to Progression to Active Rheumatoid Arthritis in ACPA+ Individuals
Mark Gillespie¹, Ziyuan He¹, Adam Savage¹, Pravina Venkatesan¹, Marla Glass¹, Lauren Okada², Nhung Tran², Yudong He², Samir Rachid Zaim¹, Padmapriyadarshini Ravisankar², Christy Bennett¹, Julian Reading², Jessica Garber², Palak Genge², Veronica Hernandez², Alexander Heubeck², Erin Kawelo², Upaasana Krishnan², Kevin Lee², Regina Mettey², Blessing Musgrove², Vaishnavi Parthasarathy², Cole Phalen², Charles Roll², Tyanna Stuckey², Morgan Weiss¹, Claire Gustafson², Qiuyu Gong², Emma Kuan², Tao Peng², Lucas Graybuck², Kristen Demoruelle³, Kristine Kuhn⁴, David Boyle⁵, Fan Zhang⁴, Thomas Bumol⁶, Ananda Goldrath², Xiaojun Li¹, V. Michael Holers⁷, Peter Skene¹, Gary Firestein⁸, Kevin Deane⁹ and Troy Torgerson¹⁰, ¹Allen Institute for Immunology, Seattle, WA, ²Allen Institute for Immunology, Seattle, ³University of Colorado Anschutz Medical Campus, Golden, CO, ⁴University of Colorado, Aurora, CO, ⁵UCSD, La Jolla, CA, ⁶Allen Institute for Immunology, San Diego, CA, ⁷University of Colorado, Denver, CO, ⁸University of California, San Diego, San Diego, CA, ⁹University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ¹⁰Allen Institute for Immunology, Enumclaw, WA
Background/Purpose: Elevated levels of RA-associated autoantibodies (ACPA, RF) prior to the clinical onset of inflammatory arthritis (IA) define a state of risk for future development…
Abstract Number: 1975 • ACR Convergence 2024
Accurate Detection of Arthritis Using Hand-held Thermal Imaging and Machine Learning
shaye Kivity¹, Nadav Sheffer², Keren Netzer³, Lior Luria³, Yael Pri-Paz Basson⁴, Oshrat Tayer-Shifman⁵, Rotem Sivan-Hoffman⁶, Rami ghanayem⁶ and Oshrit Hoffer⁷, ¹Meir medical center, CFAR SABA, Israel, ²School of Medical Engineering, Afeka Tel Aviv Academic College of Engineering, Tel-Aviv, Israel, ³Rheumatology Unit, Meir Medical Center, Kfar Saba, Israel, ⁴meir hospital, zur moshe, Israel, ⁵Meir Medical Center, Ra'anana, Israel, ⁶Radiology Department, Meir Medical Center, Kfar Saba, Israel, ⁷School of Electrical Engineering, Afeka, Tel Aviv Academic Collage of Engineering, Kfar saba, Israel
Background/Purpose: Rapid and accurate detection of arthritis is crucial for initiating timely treatment and preventing long-term joint damage. Imaging techniques such as Ultra sound and…
Abstract Number: 2177 • ACR Convergence 2024
CD59 Complement Membrane Regulator Deficiency: 12 Years of Clinical and Molecular Follow-up of 29 Patients
Dror Mevorach, Netanel Karbian, Marian Zeibak and Adi Tabib, Hadassah-University Hospital, Jerusalem, Israel
Background/Purpose: We have described in 2013, homozygous CD59-deficient children that manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), with hemolytic anemia and recurrent strokes.…
Abstract Number: 2593 • ACR Convergence 2024
A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research
Miriam Bollmann¹, Oskar Landberg², Negar Ayoubzadeh², Charlotte A. Jonsson², Inger Gjertsson² and Mattias Svensson², ¹University of Gothenburg, Göteborg, Sweden, ²University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
Abstract Number: 0049 • ACR Convergence 2024
Inflammatory Priming by Anti-MAA Antibodies in Rheumatoid Arthritis
Marcelo Afonso¹, Jitong Sun¹, Koji Sakuraba¹, Alexandra Circiumaru², Denis Lagutkin¹, Masa Filipovic¹, Anca Catrina¹, Caroline Grönwall¹, Aase Hensvold¹ and Bence Réthi¹, ¹Karolinska Institutet, Stockholm, Sweden, ²Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden
Background/Purpose: We have previously shown that autoantibodies targeting malondialdehyde-acetaldehyde protein adducts (anti-MAA) in rheumatoid arthritis (RA) patients boosted osteoclast differentiation and induced bone erosion in mice…
Abstract Number: 0300 • ACR Convergence 2024
Evaluation of Long-term Primary Patency of Iliocaval Stenting in Patients with Retroperitoneal Fibrosis/chronic Periaortitis
Raymond Lay¹, Sara Achenbach², Cynthia Crowson¹, Umar Ghaffar¹, Michelle Burke¹, Haraldur Bjarnason¹, Newton Neidert¹, Kenneth Warrington¹ and Matthew Koster¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, Rochester, MN
Background/Purpose: Idiopathic retroperitoneal fibrosis (RPF) / chronic periaortitis (CP) is an uncommon condition characterized by a fibroinflammatory periarterial soft tissue thickening around the infra-renal abdominal…
Abstract Number: 0686 • ACR Convergence 2024
The Role of Inflammation in Systemic Sclerosis: CRP-Associated Phenotypes and Prognostic Implications
cristiana sieiro santos¹, Miriam Retuerto², Paula Pérez García², Jose Ordas Martínez³, Pedro Baenas², Clara Moriano Morales² and Elvira Díez Álvarez⁴, ¹Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, ²Complejo Asistencial Universitario de León, León, Spain, ³Complejo Asistencial Universitario de Leon, Leon, ⁴Complejo Asistencial Universitario de León, Leon, Spain
Background/Purpose: Systemic sclerosis (SSc) manifests through a diverse interplay of inflammatory, fibrotic, and vascular alterations, intricately entwined in its pathogenesis, which encompasses immune system dysregulation,…
Abstract Number: 0894 • ACR Convergence 2024
HOXD13 Regulation of Primary Cilia in Rheumatoid Arthritis Synovial Fibroblasts: Implications for Joint-Specific Pathogenesis
Masoumeh Mirrahimi¹, Kerstin Klein², Alexandra Khmelevskaya³, Eva Camarillo Retamosa³, Miranda Houtmen³, Oliver Distler¹ and Caroline Ospelt¹, ¹Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland, ²University of Bern, Bern, Switzerland, ³Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Zurich, Switzerland
Background/Purpose: Rheumatoid arthritis (RA) follows a characteristic pattern of joint involvement. The embryonic development of limbs and joints influences certain joints' propensity to develop arthritis.…
Abstract Number: 1128 • ACR Convergence 2024
A Meta-Analysis of Statin Efficacy in Controlling Disease Activity in Psoriasis
Barbara Abreu Lopez¹, Ernesto Calderon Martinez², Tania Siu Xiao³, Zulma Sosa Carcamo⁴, Alejandra Maria Aleman Reyes⁵, Felix Ricardo Bonilla Bonilla⁶, María Isabel Murillo Pineda⁵, Edgar Josué Sanabria Herrera⁷, Alberto Ayala Aguilar⁸, Adreina Del Valle Rojas Marron⁹, Valentina Contreras Duran,¹⁰, Kevin J. Lopez Romero¹¹ and Marcela Garzon¹², ¹Universidad de Carabobo, Carabobo, Venezuela, ²The University of Texas Science Medical Center at Houston, Tomball, ³Thomas Jefferson University Hospital, Philadelphia, ⁴Universidad Evangélica de El Salvador, San Salvador, El Salvador, ⁵Universidad Católica de Honduras, Tegucigalpa, Honduras, ⁶Hospital Militar Central, San Salvador, El Salvador, ⁷Universidad Nacional Autónoma de Honduras, Tegucigalpa, ⁸Baylor College of Medicine, Houston, ⁹Universidad de Oriente Núcleo Anzoátegui, Barcelona, Venezuela, ¹⁰MD Anderson Cancer Center, Texas, Houston, ¹¹Universidad de El Salvador, San Salvador, El Salvador, ¹²Universidad de Los Andes, Bogotá, Colombia
Background/Purpose: Psoriasis is a chronic inflammatory skin disorder that is associated with an increased risk of cardiovascular diseases. Chronic inflammation in psoriasis can produce excessive…
Abstract Number: 1664 • ACR Convergence 2024
Identification of Spatial Determinants of Treatment Response in Rheumatoid Arthritis Synovia
ilya Korsunsky¹, Roopa Madhu², Kevin Wei³, Kartik Bhamidipati¹, Miles Tran¹, Sonia Presti¹, Anna Helena Jonsson⁴, Ellen Gravallese⁵, Michael Brenner⁶, Soumya Raychaudhuri¹, Jennifer Seifert⁷, Costantino Pitzalis⁸, Fan Zhang⁹, Larry Moreland¹⁰, V. Michael Holers¹⁰, Michael Clayman¹¹, Myles Lewis¹², Ce Gao¹, Michael J Zuscik¹³ and Accelerating Medicines Partnership Autoimmune and Immune-Mediated Disease¹⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Brookline, MA, ³Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁴University of Colorado School of Medicine, Aurora, CO, ⁵Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA, ⁶Brigham and Women's Hospital, Harvard Medical School, Newton, MA, ⁷University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, ⁸QMUL, Bromley Kent, United Kingdom, ⁹University of Colorado, Aurora, CO, ¹⁰University of Colorado, Denver, CO, ¹¹University of Colorado School of Medicine, Burlington, MA, ¹²Queen Mary University of London, London, United Kingdom, ¹³Department of Orthopedic Surgery, University of Colorado School of Medicine, Aurora, CO, ¹⁴Multiple Institutions, Oklahoma City
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune infiltration of the synovial tissue, resulting in joint damage. In RA, synovia exhibit distinct…

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