Abstracts tagged "Inflammation"

Abstract Number: 2502 • 2012 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap-Associated Protein Activation of the Inflammasome Is Enhanced in Lupus M1 Macrophages
J. Michelle Kahlenberg¹, Carolyne K. Smith², Carmelo Carmona-Rivera¹ and Mariana J. Kaplan³, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular traps (NETs) contain numerous bactericidal proteins and are an important defense mechanism against microorganisms. Clearance of NETs is impaired in a subset…
Abstract Number: 1237 • 2012 ACR/ARHP Annual Meeting
Baseline Evaluation of Insulin Resistance in Patients with early Non-Treated Rheumatoid Arthritis
Sara Manrique-Arija¹, María América López-Lasanta², Pilar Espiño- Lorenzo², Pedro Valdivielso³, José Rioja³, Inmaculada Ureña¹, Francisco Gabriel Jimenez- Núñez¹, Carmen M. Romero-Barco¹, Veronica Rodríguez-García¹, Laura Nieves², Mari Carmen Ordoñez-Cañizares², Laura Cano², Maria Victoria Irigoyen² and Antonio Fernández-Nebro⁴, ¹Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain, ²Hospital Carlos Haya. University of Malaga, Malaga, Spain, ³Department of Medicine. University of Malaga, Malaga, Spain, ⁴Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain
Background/Purpose: High levels of inflammatory cytokines are associated with insulin resistance syndrome in long-standing AR. The aim was to analyze insulin resistance (IR), adipokines, inflammatory…
Abstract Number: 310 • 2012 ACR/ARHP Annual Meeting
STAT3 Plays a Central Role in NLRP3 Inflammasome-Mediated IL-1β Production and Pyronecrosis
Jehad H. Edwan¹, Tri M. Tran², Mones Abu-Asab³, Raphaela T. Goldbach-Mansky⁴ and Robert A. Colbert¹, ¹NIAMS NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD, ³NEI NIH, Bethesda, MD, ⁴Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: Gain of function mutations in NLRP3 cause cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID),…
Abstract Number: 2478 • 2012 ACR/ARHP Annual Meeting
Identification of Disease-Specific Neuroimaging Phenotypes in Childhood Inflammatory Brain Diseases
Tania Cellucci¹, Pascal N. Tyrrell², Shehla Sheikh³, Suzanne Laughlin⁴ and Susanne M. Benseler³, ¹Pediatrics/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Cardiology/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Magnetic resonance imaging (MRI) is a key diagnostic modality of childhood inflammatory brain diseases (IBrainD). While overlapping clinical features contribute to significant diagnostic uncertainty,…
Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting
Analysis of Gene Expression Patterns in Rheumatoid Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare
Karen L. Berg¹, Adedayo Hanidu¹, Jon Hill², Xiaoyu Jiang¹, Tom Freeman², Jennifer Swantek¹, Anna Yarlina³, George D. Kalliolias⁴, Lionel B. Ivashkiv⁵ and Gerald H. Nabozny¹, ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ³Hospital for Special Surgery, New York, NY, ⁴Medicine, Hospital for Special Surgery, New York, NY, ⁵Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Synovial macrophages play a key role in RA pathogenesis. Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…
Abstract Number: 314 • 2012 ACR/ARHP Annual Meeting
Transcriptome and Surface Phenotype Analyses Suggest an Alternatively Activated (M2) Function for Hemophagocytes
Scott W. Canna¹, Ana Patrícia Costa Reis², William E. Bernal³, Kathleen E. Sullivan⁴, Michele E. Paessler⁵ and Edward M. Behrens⁶, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁶Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hemophagocytes (HPCs) are activated macrophages identified in situ by having engulfed other hematopoietic cells. HPCs are rarely seen in normal bone marrow, but are…

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