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Abstracts tagged "Inflammation"

  • Abstract Number: 887 • 2013 ACR/ARHP Annual Meeting

    Atherosclerosis and Cardiovascular Disease In Systemic Lupus Eryhematosus Are Related To An Inflammatory/Oxidative Status Linked To The Autoimmune Condition and The Clinical Activity Of The Disease. Effect Of Statins Treatment

    Chary Lopez-Pedrera1, Patricia Ruiz-Limon1, Carlos Perez-Sanchez1, Mª Angeles Aguirre2, Nuria Barbarroja1, Tomás Cerdó-Ráez3, Maria Laura Bertolaccini4, Munther A. Khamashta5, Antonio Rodriguez-Ariza6, Yolanda Almaden7, Husam Khraiwesh8, Jose Antonio Gonzalez-Reyes9, Jose Manuel Villalba10, Eduardo Collantes11 and Mª Jose Cuadrado12, 1Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, 2Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 3Imibic, Córdoba, Spain, 4Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, 5Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, 6Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 7Imibic, Códoba, Spain, 8UCO, Córdoba, Spain, 9Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, 10Cell Biology, Physiology and Immunology, University of Cordoba, Agrifood Campus of International Excelence (ciA3), Cordoba, Spain, 11Rheumatology, Hospital Reina Sofia, Cordoba, Spain, 12Lupus Research Unit, The Rayne Institute, London, United Kingdom

    Background/Purpose: Atherosclerosis (AT) and cardiovascular disease (CVD) are enhanced systemic lupus erythematosus (SLE). Although there is evidence that statins have anti-inflammatory properties, their mechanism of…
  • Abstract Number: 1846 • 2013 ACR/ARHP Annual Meeting

    Mitochondrial Dysfunction Induces An Inflammatory, Tissue-Degrading, and Angiogenic Response In Normal Human Synoviocytes

    M. Noa Valcárcel-Ares1, Romina R. Riveiro-Naveira1, Jesus Loureiro1, Carlos Vaamonde-García1, Laura Hermida-Carballo1, Francisco J. Blanco2 and Maria J. López-Armada1, 1Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, 2Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain

    Background/Purpose: Tissues affected with inflammatory arthritis (IA) are subjected to great levels of oxidative stress. Synoviocytes from IA patients present a higher rate of mitochondrial…
  • Abstract Number: 858 • 2013 ACR/ARHP Annual Meeting

    Monosodium Urate Crystal Induced Macrophage Inflammation Is Attenuated By Chondroitin Sulfate: Pre-Clinical Model For Gout Prophylaxis?

    Eric W. Orlowsky1, Thomas V. Stabler2, Eulalia Montell3, Josep Verges3 and Virginia B. Kraus2, 1Divsion of Rheumatology, Dept of Internal Medicine, Duke University Medical Center, Durham, NC, 2Medicine/Rheumatology, Duke University Medical Center, Durham, NC, 3Pre-Clinical R&D Area, Pharma Science Division, Bioibérica, Barcelona, Spain

    Background/Purpose:  Gout is one of the most common forms of inflammatory arthritis and is characterized by acute episodes of joint pain. Monosodium urate (MSU) crystals…
  • Abstract Number: 1794 • 2013 ACR/ARHP Annual Meeting

    The Jak Inihibitor Tofacitinib Suppresses Synovial Jak-Stat Signalling In Rheumatoid Arthritis

    D. L Boyle1, N. Wei2, A. K. Singhal3, D. R. Mandel4, P Mease5, A. Kavanaugh6, R. Shurmur7, J. Hodge8, Z. Luo9, S. Krishnaswami10, D. Gruben9, S. H. Zwillich9, K. Soma9, J. D. Bradley9 and G. S. Firestein11, 1Div of Rheum, UCSD School of Medicine, La Jolla, CA, 2Arthritis Treatment Center, Frederick, MD, 3Southwest Rheumatology Research LLC, Mesquite, TX, 4Office of David R Mandel MD, Inc., Mayfield Village, OH, 5Seattle Rheumatology Associates, Seattle, WA, 6UCSD School of Medicine, La Jolla, CA, 7Associated Internal Medicine Specialists, Battle Creek, MI, 8Pfizer Inc, Collegeville, PA, 9Pfizer Inc, Groton, CT, 10Clinical Pharmacology, Pfizer Inc, Groton, CT, 11Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Tofacitinib is a novel oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The specific JAK-STAT (signal transducer and activator of…
  • Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting

    Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?

    Nicholas A. Young1, Giancarlo R. Valiente2, Lai-Chu Wu1, Michael Bruss3, Craig Burd4 and Wael N. Jarjour5, 1Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, 3Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, 5Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…
  • Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting

    Role Of IL33 In The Inflammation Of Takayasu Arteritis

    David Saadoun1, Marlène Garrido2, Julien Gaudric3, Cloé Comarmond4, Michele Rosenzwacjg5 and Patrice Cacoub6, 1Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 2I3 laboratory, Pitié-Salpétrière, Paris, France, 3Department of Vascular surgery GHPS, Paris, France, 4Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, 5Department of Immunology GHPS, Paris, France, 6Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France

    Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
  • Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting

    Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?

    Kimberly P. Liang1, Douglas P. Landsittel2, Suresh R. Mulukutla3, Steven E. Reis4, Marc C. Levesque5, Donald M. Jones6, Rachel Gartland7, Ali Shoushtari8, Flordeliza S. Villanueva3, Hunter C. Champion8 and Larry W. Moreland5, 1Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, 3Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, 4Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 7Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
  • Abstract Number: 1877 • 2012 ACR/ARHP Annual Meeting

    Is the Amount of T and B Lymphocytes, Natural Killer Cells and Macrophages in Biopsies From Non-Ruptured Chronic Tendinopathic Achilles Tendons Predictive for Long Term Outcome? A >3 Years Prospective Study of 37 Patients

    Maja S. Kragsnæs1, Ulrich Fredberg2, Katrine Stribolt3, Søren G. Kjær1, Knud Bendix3 and Torkell Ellingsen1, 1Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, 2Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark, 3University Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: In biopsies from non-ruptured chronic tendinopathic Achilles tendons, presence of T and B lymphocytes, natural killer cells and macrophages has been reported. Whether the…
  • Abstract Number: 876 • 2012 ACR/ARHP Annual Meeting

    Xanthine Oxidase-Derived ROS Direct Context-Dependent Action of NFAT5 Toward Inflammatory Response in Macrophages

    Nam Hoon Kim, Research Institute of Immunobiology, Catholic university of Korea, Seoul of Korea, Seoul, South Korea

    Background/Purpose: NFAT5, a well known osmo-protective factor, can be activated by isotonic stimuli, such as Toll-like receptor (TLR) triggering. Here, we identified a novel signal…
  • Abstract Number: 43 • 2012 ACR/ARHP Annual Meeting

    Serum Amyloid A Level in Knee Osteoarthritis: Systemic and/or Local Production and Pro-Inflammatory Properties On Human Chondrocytes and Fibroblast-Like Synoviocytes

    Dominique de Seny1, Gaël Cobraiville2, Sophie Neuville2, Edith Charlier3, Biserka Relic1, Florence Quesada Calvo3, Olivier Malaise3, Denis Malaise4, Laurence Lutteri5, Jean-Paul Chapelle5 and Michel G. Malaise1, 1Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 2GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 3Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, 4University of Liège, Liège, Belgium, 5Medical Chemistry - CHU Liège, Liège, Belgium

    Background/Purpose: Knee osteoarthritis (OA) is a disease frequently seen in obese patients, but the relationship might be more linked to fat than to weight. A-SAA…
  • Abstract Number: 1672 • 2012 ACR/ARHP Annual Meeting

    Myosin Skews Effector Immune Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis

    Nicholas Young1, Rahul Sharma2, Alexandra Friedman3, Benjamin Kaffenberger1 and Wael N. Jarjour4, 1Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, 2Medicine, University of Virginia Health System, Charlottesville, VA, 3Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Myositis is associated with an inflammatory process that results in pronounced muscle weakness and is observed in some regulatory T cell (Treg) deficient mouse…
  • Abstract Number: 878 • 2012 ACR/ARHP Annual Meeting

    Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency

    Deepa Hammaker1, Katharyn Topolewski2, Monica Guma3, David L. Boyle4 and Gary S. Firestein5, 1MC 0656, UCSD School of Medicine, La Jolla, CA, 2UCSD School of Medicine, La Jolla, CA, 3Rheumatology, UCSD School of Medicine, La Jolla, CA, 4Div of Rheum, UCSD School of Medicine, La Jolla, CA, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose:   p38 inhibitors have limited efficacy in rheumatoid arthritis (RA), possibly because p38 blockade suppresses IL-10 production and increases JNK and ERK phosphorylation in…
  • Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts

    Aranzazu Mediero1 and Bruce N. Cronstein2, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…
  • Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting

    Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Xenofon Baraliakos1, Frank Heldmann2, Ravi Suppiah3, Fiona M. McQueen4 and Jürgen Braun2, 1Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, 4Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

    Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
  • Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting

    Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1

    Riku Korhonen, Tuija Hömmö, Mirka Laavola, Tiina Keränen, Mari Hämäläinen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland

    Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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