Abstracts tagged "Inflammation"

Abstract Number: 1237 • 2012 ACR/ARHP Annual Meeting
Baseline Evaluation of Insulin Resistance in Patients with early Non-Treated Rheumatoid Arthritis
Sara Manrique-Arija¹, María América López-Lasanta², Pilar Espiño- Lorenzo², Pedro Valdivielso³, José Rioja³, Inmaculada Ureña¹, Francisco Gabriel Jimenez- Núñez¹, Carmen M. Romero-Barco¹, Veronica Rodríguez-García¹, Laura Nieves², Mari Carmen Ordoñez-Cañizares², Laura Cano², Maria Victoria Irigoyen² and Antonio Fernández-Nebro⁴, ¹Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain, ²Hospital Carlos Haya. University of Malaga, Malaga, Spain, ³Department of Medicine. University of Malaga, Malaga, Spain, ⁴Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain
Background/Purpose: High levels of inflammatory cytokines are associated with insulin resistance syndrome in long-standing AR. The aim was to analyze insulin resistance (IR), adipokines, inflammatory…
Abstract Number: 310 • 2012 ACR/ARHP Annual Meeting
STAT3 Plays a Central Role in NLRP3 Inflammasome-Mediated IL-1β Production and Pyronecrosis
Jehad H. Edwan¹, Tri M. Tran², Mones Abu-Asab³, Raphaela T. Goldbach-Mansky⁴ and Robert A. Colbert¹, ¹NIAMS NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD, ³NEI NIH, Bethesda, MD, ⁴Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: Gain of function mutations in NLRP3 cause cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID),…
Abstract Number: 2478 • 2012 ACR/ARHP Annual Meeting
Identification of Disease-Specific Neuroimaging Phenotypes in Childhood Inflammatory Brain Diseases
Tania Cellucci¹, Pascal N. Tyrrell², Shehla Sheikh³, Suzanne Laughlin⁴ and Susanne M. Benseler³, ¹Pediatrics/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Cardiology/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Magnetic resonance imaging (MRI) is a key diagnostic modality of childhood inflammatory brain diseases (IBrainD). While overlapping clinical features contribute to significant diagnostic uncertainty,…
Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting
Analysis of Gene Expression Patterns in Rheumatoid Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare
Karen L. Berg¹, Adedayo Hanidu¹, Jon Hill², Xiaoyu Jiang¹, Tom Freeman², Jennifer Swantek¹, Anna Yarlina³, George D. Kalliolias⁴, Lionel B. Ivashkiv⁵ and Gerald H. Nabozny¹, ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ³Hospital for Special Surgery, New York, NY, ⁴Medicine, Hospital for Special Surgery, New York, NY, ⁵Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Synovial macrophages play a key role in RA pathogenesis. Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…
Abstract Number: 314 • 2012 ACR/ARHP Annual Meeting
Transcriptome and Surface Phenotype Analyses Suggest an Alternatively Activated (M2) Function for Hemophagocytes
Scott W. Canna¹, Ana Patrícia Costa Reis², William E. Bernal³, Kathleen E. Sullivan⁴, Michele E. Paessler⁵ and Edward M. Behrens⁶, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁶Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hemophagocytes (HPCs) are activated macrophages identified in situ by having engulfed other hematopoietic cells. HPCs are rarely seen in normal bone marrow, but are…
Abstract Number: 2484 • 2012 ACR/ARHP Annual Meeting
Hepatic Steatosis in Rheumatoid Arthritis: Associations with Disease Characteristics, Pharmacotherapies, and Atherosclerosis
Jon T. Giles¹ and Joan M. Bathon², ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Columbia University, New York, NY
Background/Purpose: Ectopic deposition of liver fat (steatosis) is associated with insulin resistance (IR), cardiovascular disease (CVD), and is a potent risk factor for cirrhosis. RA…
Abstract Number: 1206 • 2012 ACR/ARHP Annual Meeting
Gp96 Exacerbate the Inflammation of Rheumatoid Arthritis
Qi Quan Huang¹, Robert Birkett², J.-P. Jin³ and Richard M. Pope⁴, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Physiology, Wayne State University, Detroit, MI, ⁴Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: The mechanisms that contribute to the persistent activation of macrophages in rheumatoid arthritis (RA) are incompletely understood. Toll-like receptors (TLRs) have been implicated in…
Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
Abstract Number: 2104 • 2012 ACR/ARHP Annual Meeting
Quantitation in Patients with Rheumatoid Arthritis of Inflammation, Joint Damage and “Unexplained Symptoms” (e.g., Fibromyalgia) in Addition to Overall Status, According to 4 Physician Global Estimates Scored 0-10
Isabel Castrejón¹, Martin J. Bergman² and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Taylor Hospital, Ridley Park, PA
Background/Purpose: A physician global estimate (DOCGL) of patient clinical status in rheumatoid arthritis (RA) is scored by many rheumatologists entirely based on inflammation, but others…
Abstract Number: 1051 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging in Inflammatory Bowel Disease Patients with Arthralgia
W. Stomp¹, L.K.P.M. Brakenhoff², F.a. van Gaalen³, D. van der Heijde⁴, H.H. Fidder⁵, D.W. Hommes⁶, M. Reijnierse¹ and J.L Bloem¹, ¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Joint manifestations frequently occur in chronic inflammatory bowel diseases (IBD). Arthralgia, non-inflammatory joint pain without objective evidence of swelling or effusion, is present in…
Abstract Number: 213 • 2012 ACR/ARHP Annual Meeting
Nsaids Suppress the Inflammatory Reaction Related to Muscle Soreness but May Delay Recovery
Matthias Rother¹, Egbert J. Seidel², Alexander Fischer² and Ilka Rother¹, ¹IMR Partner GmbH, Graefelfing, Germany, ²Department of Physical and Rehabilitation Medicine, Sophien- and Hufeland Clinic, Weimar, Germany
Background/Purpose: Eccentric muscle contraction causes an inflammatory reaction with pain peaking 24 to 48 hours after exercise – delayed onset of muscle soreness (DOMS). NSAIDs…
Abstract Number: 2069 • 2012 ACR/ARHP Annual Meeting
Proteinase Activated Receptor-4 Stimulation Promotes Leukocyte Adhesion in the Rat Knee Joint
Jason J. McDougall, Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada
Background/Purpose: Proteinase activated receptors (PARs) are a family of G protein-coupled receptors that signal by enzymatic cleavage of the receptor in a specific extracellular domain.…
Abstract Number: 1017 • 2012 ACR/ARHP Annual Meeting
Bye Bye Biopsy: Diffusion Tensor and Dynamic Contrast Enhance Magnetic Resonance Imaging Parameters Reflect Molecular Events of Inflammation in the Synovium
Vikas Agarwal¹, Rishi Awasthi², Deepak Tripathi³, Vinita Agrawal⁴, Ram Kishore Singh Rathore⁵, Kusum Sharma⁶, CM Pandey⁷ and Rakesh K. Gupta⁸, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India,, Lucknow, India, ³Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁴Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁵Mathematics and statistics, Indian Institute of Technology, Kanpur, India, ⁶Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁷Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁸Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India
Background/Purpose: Chronic synovial inflammation is characterized by accumulation of inflammatory cells and increased vascularity. Synovial histology remains the most definitive way to delineate the severity…
Abstract Number: 196 • 2012 ACR/ARHP Annual Meeting
Sarcoidosis in Northern New England. Clinical Characteristics and Predictive Factors for More Aggressive Therapy
Alireza Meysami¹, Kevin F. Spratt² and Christopher M. Burns³, ¹Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ²Department of Orthopaedic Surgery, Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Dartmouth Medical School, Lebanon, NH
· Background/Purpose: Sarcoidosis is characterized by a variable clinical presentation. DMARDs and biologics have been used for resistant and/or organ-threatening disease. We analyzed the cases…
Abstract Number: 2048 • 2012 ACR/ARHP Annual Meeting
Four Physician Global Assessments for Overall Status, Inflammation, Damage, and Unexplained Symptoms Are Useful in Usual Care of Patients with Osteoarthritis, Fibromyalgia, Systemic Lupus Erythematosus, and Spondyloarthropathy, As Well As Rheumatoid Arthritis
Isabel Castrejón¹, Martin J. Bergman² and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Taylor Hospital, Ridley Park, PA
Background/Purpose: A physician global estimate (DOCGL) is important in clinical decisions concerning patients with rheumatoid arthritis (RA), and often is the most efficient of the…

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