ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 2069 • 2012 ACR/ARHP Annual Meeting

    Proteinase Activated Receptor-4 Stimulation Promotes Leukocyte Adhesion in the Rat Knee Joint

    Jason J. McDougall, Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Proteinase activated receptors (PARs) are a family of G protein-coupled receptors that signal by enzymatic cleavage of the receptor in a specific extracellular domain.…
  • Abstract Number: 1017 • 2012 ACR/ARHP Annual Meeting

    Bye Bye Biopsy: Diffusion Tensor and Dynamic Contrast Enhance Magnetic Resonance Imaging Parameters Reflect Molecular Events of Inflammation in the Synovium

    Vikas Agarwal1, Rishi Awasthi2, Deepak Tripathi3, Vinita Agrawal4, Ram Kishore Singh Rathore5, Kusum Sharma6, CM Pandey7 and Rakesh K. Gupta8, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India,, Lucknow, India, 3Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 4Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 5Mathematics and statistics, Indian Institute of Technology, Kanpur, India, 6Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 7Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, 8Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India

    Background/Purpose: Chronic synovial inflammation is characterized by accumulation of inflammatory cells and increased vascularity.  Synovial histology remains the most definitive way to delineate the severity…
  • Abstract Number: 196 • 2012 ACR/ARHP Annual Meeting

    Sarcoidosis in Northern New England. Clinical Characteristics and Predictive Factors for More Aggressive Therapy

    Alireza Meysami1, Kevin F. Spratt2 and Christopher M. Burns3, 1Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Department of Orthopaedic Surgery, Geisel School of Medicine at Dartmouth, Lebanon, NH, 3Dartmouth Medical School, Lebanon, NH

    ·         Background/Purpose: Sarcoidosis is characterized by a variable clinical presentation. DMARDs and biologics have been used for resistant and/or organ-threatening disease. We analyzed the cases…
  • Abstract Number: 2048 • 2012 ACR/ARHP Annual Meeting

    Four Physician Global Assessments for Overall Status, Inflammation, Damage, and Unexplained Symptoms Are Useful in Usual Care of Patients with Osteoarthritis, Fibromyalgia, Systemic Lupus Erythematosus, and Spondyloarthropathy, As Well As Rheumatoid Arthritis

    Isabel Castrejón1, Martin J. Bergman2 and Theodore Pincus1, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Taylor Hospital, Ridley Park, PA

    Background/Purpose: A physician global estimate (DOCGL) is important in clinical decisions concerning patients with rheumatoid arthritis (RA), and often is the most efficient of the…
  • Abstract Number: 1028 • 2012 ACR/ARHP Annual Meeting

    Semi-Quantitative Assessment of Bone Marrow Edema and Synovitis-Effusion in Osteoarthritis with the Knee Inflammation MRI Scoring System:  A Target Lesion Based Methodology

    Walter P. Maksymowych1, Ulrich Weber2, Marcus Pianta3 and Robert GW Lambert3, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Balgrist University Hospital, Zurich, Switzerland, 3Radiology, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Current MRI scoring methods for assessment of bone marrow lesions (BML) in the knee of patients with osteoarthritis rely on a complex subdivision of…
  • Abstract Number: 50 • 2012 ACR/ARHP Annual Meeting

    Human Chondrocyte Dedifferentiation Is Accompagnied by CD105 Endoglin Expression, ALK-1/Smad1/5 Phosphorylation and Leptin Production – Stimulation by Prednisolone and Aldosterone Through the Glucocorticoid Receptor

    Olivier Malaise1, Biserka Relic2, Mustapha Zeddou1, Edith Charlier1, Florence Quesada Calvo1, Sophie Neuville3, Dominique de Seny2 and Michel G. Malaise4, 1Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, 2Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 3GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 4Department of Rheumatology, University of Liège - CHU Liège, Liège, Belgium

    Background/Purpose:   Leptin, mainly produced by the adipose tissue including fat neighboring the joint, is considered as pro-inflammatory in osteoarthritis (OA). Normal cartilage does not…
  • Abstract Number: 1877 • 2012 ACR/ARHP Annual Meeting

    Is the Amount of T and B Lymphocytes, Natural Killer Cells and Macrophages in Biopsies From Non-Ruptured Chronic Tendinopathic Achilles Tendons Predictive for Long Term Outcome? A >3 Years Prospective Study of 37 Patients

    Maja S. Kragsnæs1, Ulrich Fredberg2, Katrine Stribolt3, Søren G. Kjær1, Knud Bendix3 and Torkell Ellingsen1, 1Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, 2Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark, 3University Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: In biopsies from non-ruptured chronic tendinopathic Achilles tendons, presence of T and B lymphocytes, natural killer cells and macrophages has been reported. Whether the…
  • Abstract Number: 876 • 2012 ACR/ARHP Annual Meeting

    Xanthine Oxidase-Derived ROS Direct Context-Dependent Action of NFAT5 Toward Inflammatory Response in Macrophages

    Nam Hoon Kim, Research Institute of Immunobiology, Catholic university of Korea, Seoul of Korea, Seoul, South Korea

    Background/Purpose: NFAT5, a well known osmo-protective factor, can be activated by isotonic stimuli, such as Toll-like receptor (TLR) triggering. Here, we identified a novel signal…
  • Abstract Number: 43 • 2012 ACR/ARHP Annual Meeting

    Serum Amyloid A Level in Knee Osteoarthritis: Systemic and/or Local Production and Pro-Inflammatory Properties On Human Chondrocytes and Fibroblast-Like Synoviocytes

    Dominique de Seny1, Gaël Cobraiville2, Sophie Neuville2, Edith Charlier3, Biserka Relic1, Florence Quesada Calvo3, Olivier Malaise3, Denis Malaise4, Laurence Lutteri5, Jean-Paul Chapelle5 and Michel G. Malaise1, 1Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 2GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 3Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, 4University of Liège, Liège, Belgium, 5Medical Chemistry - CHU Liège, Liège, Belgium

    Background/Purpose: Knee osteoarthritis (OA) is a disease frequently seen in obese patients, but the relationship might be more linked to fat than to weight. A-SAA…
  • Abstract Number: 1672 • 2012 ACR/ARHP Annual Meeting

    Myosin Skews Effector Immune Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis

    Nicholas Young1, Rahul Sharma2, Alexandra Friedman3, Benjamin Kaffenberger1 and Wael N. Jarjour4, 1Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, 2Medicine, University of Virginia Health System, Charlottesville, VA, 3Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Myositis is associated with an inflammatory process that results in pronounced muscle weakness and is observed in some regulatory T cell (Treg) deficient mouse…
  • Abstract Number: 878 • 2012 ACR/ARHP Annual Meeting

    Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency

    Deepa Hammaker1, Katharyn Topolewski2, Monica Guma3, David L. Boyle4 and Gary S. Firestein5, 1MC 0656, UCSD School of Medicine, La Jolla, CA, 2UCSD School of Medicine, La Jolla, CA, 3Rheumatology, UCSD School of Medicine, La Jolla, CA, 4Div of Rheum, UCSD School of Medicine, La Jolla, CA, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose:   p38 inhibitors have limited efficacy in rheumatoid arthritis (RA), possibly because p38 blockade suppresses IL-10 production and increases JNK and ERK phosphorylation in…
  • Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts

    Aranzazu Mediero1 and Bruce N. Cronstein2, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…
  • Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting

    Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Xenofon Baraliakos1, Frank Heldmann2, Ravi Suppiah3, Fiona M. McQueen4 and Jürgen Braun2, 1Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, 4Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

    Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
  • Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting

    Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1

    Riku Korhonen, Tuija Hömmö, Mirka Laavola, Tiina Keränen, Mari Hämäläinen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland

    Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…
  • Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting

    Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes

    Maria Isabel Guillén1, Julia Platas1, Vicente Mirabet2, Miguel Angel Castejón3, Francisco Gomar4 and Maria Jose Alcaraz1, 1Pharmacology, University of Valencia, Burjasot, Valencia, Spain, 2Generalitat Valenciana, Valencia, Spain, 3De la Ribera University Hospital, Alzira, Spain, 4Surgery, University of Valencia and University Hospital, Valencia, Spain

    Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…
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