Abstracts tagged "Inflammation"

Abstract Number: 1672 • 2012 ACR/ARHP Annual Meeting
Myosin Skews Effector Immune Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis
Nicholas Young¹, Rahul Sharma², Alexandra Friedman³, Benjamin Kaffenberger¹ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, ²Medicine, University of Virginia Health System, Charlottesville, VA, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Myositis is associated with an inflammatory process that results in pronounced muscle weakness and is observed in some regulatory T cell (Treg) deficient mouse…
Abstract Number: 878 • 2012 ACR/ARHP Annual Meeting
Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency
Deepa Hammaker¹, Katharyn Topolewski², Monica Guma³, David L. Boyle⁴ and Gary S. Firestein⁵, ¹MC 0656, UCSD School of Medicine, La Jolla, CA, ²UCSD School of Medicine, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: p38 inhibitors have limited efficacy in rheumatoid arthritis (RA), possibly because p38 blockade suppresses IL-10 production and increases JNK and ERK phosphorylation in…
Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting
Adenosine A_2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Aranzazu Mediero¹ and Bruce N. Cronstein², ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…
Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting
Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Xenofon Baraliakos¹, Frank Heldmann², Ravi Suppiah³, Fiona M. McQueen⁴ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1
Riku Korhonen, Tuija Hömmö, Mirka Laavola, Tiina Keränen, Mari Hämäläinen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…
Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Maria Isabel Guillén¹, Julia Platas¹, Vicente Mirabet², Miguel Angel Castejón³, Francisco Gomar⁴ and Maria Jose Alcaraz¹, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Generalitat Valenciana, Valencia, Spain, ³De la Ribera University Hospital, Alzira, Spain, ⁴Surgery, University of Valencia and University Hospital, Valencia, Spain
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…
Abstract Number: 1632 • 2012 ACR/ARHP Annual Meeting
Arhalofenate Is a Novel Dual-Acting Agent with Uricosuric and Anti-Inflammatory Properties
Yun-Jung Choi, Vanina Larroca, Annette Lucman, Vic Vicena, Noe Abarca, Tim Rantz, Brian E. Lavan and Charles A. McWherter, Biology, Metabolex, Inc., Hayward, CA
Background/Purpose: In most patients with gout, elevated serum urate is linked to excess uric acid reabsoprtion in the proximal renal tubule by anion transporters/exchangers, including…
Abstract Number: 872 • 2012 ACR/ARHP Annual Meeting
Monocyte Chemoattractant Protein-1 and Eotaxin Are Associated with Parameters of Cardiac Dysfunction in Juvenile Dermatomyositis
Thomas Schwartz¹, Ivar Sjaastad², Berit Flatø³, Maria Vistnes¹, Geir Christensen¹ and Helga Sanner³, ¹Institute for Experimental Medical Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ²Institute for Clinical Medicine, University of Oslo, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, ³Department of Rheumatology, Oslo University Hospital, Institute for Clinical Medicine, University of Oslo, Oslo, Norway
Background/Purpose : Juvenile dermatomyositis (JDM) is a vasculopathic disease affecting not only skeletal muscle and skin, but other organs as well. Previously we have shown…
Abstract Number: 1635 • 2012 ACR/ARHP Annual Meeting
Polyarthritis Caused by TIARP (TNFAIP9) Deficiency Critically Dependent On Dysregulated STAT3, NF-κB Signaling and Cell Death in Macrophage
Asuka Inoue¹, Isao Matsumoto¹, Naoto Umeda¹, Yuki Tanaka¹, Satoru Takahashi² and Takayuki Sumida¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan
Background/Purpose: TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein induced by TNFα and IL-6 in adipose tissue. Recently, we found that TIARP is dominantly expressed…
Abstract Number: 832 • 2012 ACR/ARHP Annual Meeting
Peroxisome Proliferator-Activated Receptor Gamma Agonist Treatment for Rheumatoid Arthritis: A Proof-of-Concept Randomized Controlled Trial
Michelle J. Ormseth¹, Annette M. Oeser², Andrew Cunningham², Aihua Bian², Ayumi Shintani², S. Bobo Tanner³ and C. Michael Stein⁴, ¹Rheumatology, Vanderbilt Medical Center, Nashville, TN, ²Vanderbilt Medical Center, Nashville, TN, ³Div of Rheumatology & Allergy, Vanderbilt Medical Center, Nashville, TN, ⁴School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: Rheumatoid arthritis (RA), a chronic inflammatory disease, is associated with insulin resistance. Experimental evidence indicates that the relationship between insulin resistance and inflammation is…
Abstract Number: 1600 • 2012 ACR/ARHP Annual Meeting
Gene Targeting of an Integrin-Mediated Signaling Adaptor Molecule, Crk-Associated Substrate Lymphocyte Type Reduced the Severity of Collagen-Induced Arthritis. Its Possible Involvement in the Pathophysiology of Rheumatoid Arthritis
Satoshi Iwata, Tomoki Katayose, Yoshiko Kichikawa, Hiromi Ichihara, Hiroshi Kawasaki, Osamu Hosono, Hirotoshi Tanaka and Chikao Morimoto, Department of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Background/Purpose: It has been reported that the expression levels of β1 integrins and the ligands such as VCAM-1 are elevated in the affected joints of…
Abstract Number: 782 • 2012 ACR/ARHP Annual Meeting
Anti-TNF Therapy Slows Radiographic Progression of Ankylosing Spondylitis
Nigil Haroon¹, Robert D. Inman², Thomas J. Learch³, Michael H. Weisman⁴, Michael M. Ward⁵, John D. Reveille⁶ and Lianne S. Gensler⁷, ¹Medicine/Rheumatology, University Health Network, Toronto Western Research Institute, University of Toronto, Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³Cedars-Sinai, Los Angeles, CA, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁶Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁷Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: The influence of anti-TNF therapy on radiographic progression in ankylosing spondylitis (AS) is not well established. We studied this effect on radiographic progression in…
Abstract Number: 2669 • 2012 ACR/ARHP Annual Meeting
TLR7 Ligation Contributes to Monocyte Migration in Rheumatoid Arthritis
Nathan D. Chamberlain¹, Seung-jae Kim¹, Michael Volin², William Swedler³, Suncica Volkov¹ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to characterize the expression of TLR7 in rheumatoid arthritis (RA) peripheral blood (PB) cells and to examine the…
Abstract Number: 1516 • 2012 ACR/ARHP Annual Meeting
TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb
Romy Christmann¹, Allison Mathes², Giuseppina Stifano², Alsya J. Affandi³, Andreea Bujor³, Cristina Padilla³ and Robert Lafyatis³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, Boston University, Boston, MA
Background/Purpose: to investigate the expression of Thymic Stromal Lymphopoietin (TSLP) in diffuse cutaneous systemic sclerosis (dcSSc) patients and explore its effects in vivo and in vitro…
Abstract Number: 737 • 2012 ACR/ARHP Annual Meeting
Citrullination of ENA-78/CXCL5 Results in Conversion From a Non-Monocyte Recruiting to a Monocyte Recruiting Chemokine
Ken Yoshida¹, Olex Korchynskyi², Paul P. Tak³, Takeo Isozaki⁴, Jeffrey H. Ruth⁵, Phillip Campbell⁶, Dominique L. Baeten⁷, Danielle M. Gerlag⁷, M. Asif Amin⁸ and Alisa E. Koch⁹, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Department of Cellular Proliferation and Apoptosis, Institute of Cell Biology, Lviv, Ukraine, ³Departments of Experimental Immunology and Internal Medicine, GlaxoSmithKline U.K. and Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁸Department of Medicine, University of Michigan, Ann Arbor, MI, ⁹Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Citrullination is a post-translational modification that is the conversion of arginine to citrulline in proteins mediated by peptidylarginine deiminase (PAD). Antibodies directed towards the…

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