Abstracts tagged "Inflammation"

Abstract Number: 2288 • 2016 ACR/ARHP Annual Meeting
Inflammatory Status and Serum Uric Acid Determine High-Density Lipoprotein Cholesterol Levels in a Non-Rheumatic Population
Mariano Andrés¹, María Amparo Quintanilla², Eliseo Pascual³, Pedro Morillas² and FAPRES study group, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Servicio de Cardiología, Hospital General Universitario de Elche, Elche, Spain, ³Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: In inflammatory disorders, highest incidence of cardiovascular (CV) events paradoxically occurs at lower lipid levels [ARD.70:482], especially for high-density lipoprotein cholesterol (HDLc). Current data…
Abstract Number: 189 • 2016 ACR/ARHP Annual Meeting
Nutraceutical Therapy with Polyphenol-Rich Pomegranate Fruit Extract (POMx) Inhibits Systemic NFκB-Mediated Inflammation in a Murine Model of Endotoxemia
Nicholas A. Young¹, Misha Mobeen², Tariq M Haqqi³ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ⁴Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Background/Purpose: The pomegranate fruit is cultivated worldwide for dietary consumption, but has been used therapeutically in Eastern medicine from times dating back to ancient Egypt…
Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting
Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor
John Barnett¹, Lisa Robinson², Jonathan Soboloff³, Rosana Schafer⁴, Ida Holaskova⁵, Meenal Elliott¹, Michelle Witt², Raphael Hirsch⁶ and Harry Blair⁷, ¹Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, ²Pathology, West Virginia University, Morgantown, WV, ³Dept of Medical Genetics and Molecular Biochemistry, Temple University, Philadelphia, PA, ⁴Dept Micro, Immun & Cell Biol, West Virginia University, Morgantown, WV, ⁵West Virginia University, Morgantown, WV, ⁶Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…
Abstract Number: 2343 • 2016 ACR/ARHP Annual Meeting
A Phase 2, Multi-Center, Randomized, Double-Blind, Active-Controlled, Parallel Group Study to Evaluate the Safety and Dose Effectiveness of Intradermal Injections of Purified Apis Mellifera Toxin to Improve Pain and Physical Function in Patients with Osteoarthritis of the Knee
Douglas R. Schumacher¹, Anna Jakubowska² and Christopher M.H. Kim³, ¹Radiant Research, Columbus, OH, ²Apimeds, Inc., Jungwongu, Seongnam, Gyeonggido, Korea, The Republic of, ³CHA University, Bundanggu, Seongnam, Gyeongghido, Korea, The Republic of
Background/Purpose: This Phase 2a/b trial evaluated the safety and dose effectiveness of honeybee toxin (purified Apis melliferatoxin) injections to improve pain and physical function in…
Abstract Number: 271 • 2016 ACR/ARHP Annual Meeting
Impaired Satellite Cell Activation and Myofiber Transition during Skeletal Muscle Regeneration in Patients with Polymyositis and Dermatomyositis
Beatriz Hanaoka¹, Prabhakara R. Nagareddy², Marilyn Campbell³, Leslie J. Crofford⁴, Charlotte A. Peterson⁵, Lisa G. Rider⁶ and Frederick W. Miller⁷, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Nutritional Sciences, University of Alabama at Birmingham, Birmingham, AL, ³University of Kentucky, Lexington, KY, ⁴Medicine, Vanderbilt University Medical Center, Nasville, TN, ⁵College of Health Sciences, University of Kentucky, Lexington, KY, ⁶Rheumatology, George Washington University, Washington, DC, ⁷Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Satellite cells are myogenic stem cells that are essential for myofiber repair, growth and homeostasis in postnatal life. A decline in satellite cell performance…
Abstract Number: 1471 • 2016 ACR/ARHP Annual Meeting
Myocardial 18f-Fluorodeoxyglucose (18F-FDG) Uptake in RA Patients without Clinical Cardiovascular Disease Is Higher Than in Controls and Decreases with Treatment
Isabelle Amigues¹, Jon T. Giles², Afshin Zartoshti³, Rachelle Morgenstern⁴, Raul Flores⁵, Sabahat Bokhari⁶ and Joan Bathon⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁴Cardiology, columbia university college of physicians and surgeons, New York city, NY, ⁵Medicine, Columbia University, New York Presbyterian, New York city, NY, ⁶Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Symptomatic heart failure (HF) and HF-associated mortality rates are higher in RA compared with the non-RA population, even after controlling for coronary artery…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
Abstract Number: 288 • 2016 ACR/ARHP Annual Meeting
Glucose Homeostasis Influences the Risk of Incident Knee Osteoarthritis
Jeffrey Driban¹, Charles B. Eaton², Mamta Amin³, Alina Stout⁴, Lori Lyn Price⁵, Bing Lu⁶, Grace H. Lo⁷, Timothy E. McAlindon⁸ and Mary Barbe⁹, ¹Tufts Medical Center, Boston, MA, ²Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ³Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Clinical Care Research, Tufts Medical Center, Boston, MA, ⁶Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁷Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Knee osteoarthritis (KOA), particularly accelerated KOA, is associated with older age and being overweight. Greater age and weight are associated with impaired glucose homeostasis…
Abstract Number: 1528 • 2016 ACR/ARHP Annual Meeting
Incretin Axis in Non Diabetic Rheumatoid Arthritis Patients
Beatriz Tejera¹, De Vera-González AM², Alejandra González Delgado³, Raquel López-Mejías⁴, Begoña Ubilla⁴, Fernanda Genre⁴, Jose M Olmos⁵, José L Hernández⁶, Miguel Angel Gonzalez-Gay⁴ and Ivan Ferraz-Amaro⁷, ¹Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ²Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ³Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁵Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, ⁶Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL. Universidad de Cantabria. RETICEF, Santander, Spain, ⁷Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain
Background/Purpose: Cross-sectional study that encompassed 361 non-diabetes individuals; 151 patients with RA and 210 age- and sex-matched controls. IR by homeostatic model assessment (HOMA2), insulin,…
Abstract Number: 2489 • 2016 ACR/ARHP Annual Meeting
Joint Damage Appears As Severe As Inflammation According to Physician Visual Analog Scales in Patients with Rheumatoid Arthritis Regardless of Disease Severity at 2 Sites, Which May Limit Results of a Treat-to-Target Strategy
Theodore Pincus¹, Isabel Castrejón¹, Kathryn Gibson² and Joel Block³, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Liverpool Hospital and University of New South Wales, Liverpool, Australia, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of global status (DOCGL) on a 0-10 visual analog scale (VAS) was developed initially to assess inflammation in patients with rheumatoid…
Abstract Number: 12 • 2015 ACR/ARHP Annual Meeting
Delta-like 1 Enhances the Production of Pro-Inflammatory Mediators By Fibroblast-like Synoviocytes
Chiyoko Sekine, Department of Clinical Research Medicine, Teikyo University School of Medicine, Tokyo, Japan
Background/Purpose: Notch signaling is known to regulate cell fate decision and differentiation during embryonic and post-natal development. I have been reported that a Notch ligand…
Abstract Number: 1053 • 2015 ACR/ARHP Annual Meeting
Phosphatidylinositol-3-Kinase Delta Pathway a Novel Therapeutic Target for Sjogren’s Syndrome
Saba Nayar¹, Joana Campos¹, Christopher Buckley¹, Rodger Allen², W.A. Fahy², Andrew Payne² and Francesca Barone¹, ¹University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ²UCB Pharma, Slough, United Kingdom
Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by B cell hyper-activation and exocrine gland infiltration that results in loss of glandular function,…
Abstract Number: 2209 • 2015 ACR/ARHP Annual Meeting
Stimulation of the Adenosine A2A Receptor (A2AR) Regulates the Expression of Netrin-1 (Ntn1) and Its Receptors (Unc5b, DCC) and Inhibits Wear Particle-Induced Inflammatory Osteolysis in a Model of Joint Prosthesis Loosening
Aranzazu Mediero¹, Bhama Ramkhelawon², Miguel Perez-Aso³, Kathryn Moore² and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³Provital S.A., Barberà del Vallès, Spain, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Ntn1 is a member of the family of axonal guidance proteins that plays a role in leukocyte function and inflammation and is critical for…
Abstract Number: 30 • 2015 ACR/ARHP Annual Meeting
Complications of Inflammatory Arthritis in First Nations and Non-First Nations Populations of Alberta, Canada
Cheryl Barnabe¹, Gilaad Kaplan², J Antonio Avina-Zubieta³, Diane Lacaille⁴, Brenda Hemmelgarn⁵ and JM Esdaile⁶, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, ³Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Division of Nephrology, University of Calgary, Calgary, AB, Canada, ⁶Rheumatology, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: With markedly improved control of the acute effects of inflammatory arthritis, the major causes of morbidity and premature death now arise from the complications…
Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting
Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype
Robert Good¹, Sarah L. Trinder², Christopher P. Denton³, David Abraham⁴ and Alan M. Holmes¹, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…

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