Abstracts tagged "Inflammation"

Abstract Number: 878 • 2013 ACR/ARHP Annual Meeting
Responders To Tocilizumab Identified By Serological Measurement Of Connective Tissue Type I Collagen In Patients With Rheumatoid Arthritis
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen¹, Diana J. Leeming², Adam Platt³, Inger Byrjalsen⁴, Claus Christiansen⁵, Désirée van de Heijde⁶ and Morten Asser Karsdal², ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Roche Products Ltd, Welwyn Garden City, United Kingdom, ⁴Nordic Bioscience, Herlev, Denmark, ⁵Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ⁶Department of Rheumatology, Leiden Univerisity, Leiden, Netherlands
Background/Purpose: As biological treatments for rheumatoid arthritis (RA) are only effective in a subpopulation of patients and the treatment can have serious side effects, there…
Abstract Number: 2089 • 2013 ACR/ARHP Annual Meeting
Downregulation Of Mir-10a Is Associated With Increased Von Willebrand Factor Antigen, Disease Activity Score and Earlier Diagnosis In Children With Untreated Juvenile Dermatomyositis
Dong Xu^1,2, Akadia Kachaochana¹, Gabrielle A. Morgan³, Chiang-Ching Huang⁴ and Lauren M. Pachman^2,3, ¹Program of Excellence in Cure-Juvenile Myositis (JM) Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ²Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ⁴Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI
Background/Purpose: We previously reported (Arthritis Rheum 2012;64 Suppl 10:1670) that miRNA array studies of diagnostic muscle biopsies obtained from untreated children with Juvenile Dermatomyositis (JDM)…
Abstract Number: 879 • 2013 ACR/ARHP Annual Meeting
Serological Biomarkers Of Specific Mode Of Action For Early Identification Of Rheumatoid Arthritis Patients Who Respond To Anti-IL6 Or Anti-TNF Treatment
Anne C. Bay-Jensen¹, Natasja Stæhr Gudman², Anne Sofie Siebuhr¹, Claus Christiansen³ and Morten Asser Karsdal², ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized debilitating joint destruction, if not treated aggressively in the patient in most need of treatment. …
Abstract Number: 2484 • 2012 ACR/ARHP Annual Meeting
Hepatic Steatosis in Rheumatoid Arthritis: Associations with Disease Characteristics, Pharmacotherapies, and Atherosclerosis
Jon T. Giles¹ and Joan M. Bathon², ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Columbia University, New York, NY
Background/Purpose: Ectopic deposition of liver fat (steatosis) is associated with insulin resistance (IR), cardiovascular disease (CVD), and is a potent risk factor for cirrhosis. RA…
Abstract Number: 1206 • 2012 ACR/ARHP Annual Meeting
Gp96 Exacerbate the Inflammation of Rheumatoid Arthritis
Qi Quan Huang¹, Robert Birkett², J.-P. Jin³ and Richard M. Pope⁴, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Physiology, Wayne State University, Detroit, MI, ⁴Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: The mechanisms that contribute to the persistent activation of macrophages in rheumatoid arthritis (RA) are incompletely understood. Toll-like receptors (TLRs) have been implicated in…
Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
Abstract Number: 2104 • 2012 ACR/ARHP Annual Meeting
Quantitation in Patients with Rheumatoid Arthritis of Inflammation, Joint Damage and “Unexplained Symptoms” (e.g., Fibromyalgia) in Addition to Overall Status, According to 4 Physician Global Estimates Scored 0-10
Isabel Castrejón¹, Martin J. Bergman² and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Taylor Hospital, Ridley Park, PA
Background/Purpose: A physician global estimate (DOCGL) of patient clinical status in rheumatoid arthritis (RA) is scored by many rheumatologists entirely based on inflammation, but others…
Abstract Number: 1051 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging in Inflammatory Bowel Disease Patients with Arthralgia
W. Stomp¹, L.K.P.M. Brakenhoff², F.a. van Gaalen³, D. van der Heijde⁴, H.H. Fidder⁵, D.W. Hommes⁶, M. Reijnierse¹ and J.L Bloem¹, ¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Joint manifestations frequently occur in chronic inflammatory bowel diseases (IBD). Arthralgia, non-inflammatory joint pain without objective evidence of swelling or effusion, is present in…
Abstract Number: 213 • 2012 ACR/ARHP Annual Meeting
Nsaids Suppress the Inflammatory Reaction Related to Muscle Soreness but May Delay Recovery
Matthias Rother¹, Egbert J. Seidel², Alexander Fischer² and Ilka Rother¹, ¹IMR Partner GmbH, Graefelfing, Germany, ²Department of Physical and Rehabilitation Medicine, Sophien- and Hufeland Clinic, Weimar, Germany
Background/Purpose: Eccentric muscle contraction causes an inflammatory reaction with pain peaking 24 to 48 hours after exercise – delayed onset of muscle soreness (DOMS). NSAIDs…
Abstract Number: 2069 • 2012 ACR/ARHP Annual Meeting
Proteinase Activated Receptor-4 Stimulation Promotes Leukocyte Adhesion in the Rat Knee Joint
Jason J. McDougall, Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada
Background/Purpose: Proteinase activated receptors (PARs) are a family of G protein-coupled receptors that signal by enzymatic cleavage of the receptor in a specific extracellular domain.…
Abstract Number: 1017 • 2012 ACR/ARHP Annual Meeting
Bye Bye Biopsy: Diffusion Tensor and Dynamic Contrast Enhance Magnetic Resonance Imaging Parameters Reflect Molecular Events of Inflammation in the Synovium
Vikas Agarwal¹, Rishi Awasthi², Deepak Tripathi³, Vinita Agrawal⁴, Ram Kishore Singh Rathore⁵, Kusum Sharma⁶, CM Pandey⁷ and Rakesh K. Gupta⁸, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India,, Lucknow, India, ³Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁴Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁵Mathematics and statistics, Indian Institute of Technology, Kanpur, India, ⁶Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁷Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁸Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India
Background/Purpose: Chronic synovial inflammation is characterized by accumulation of inflammatory cells and increased vascularity. Synovial histology remains the most definitive way to delineate the severity…
Abstract Number: 196 • 2012 ACR/ARHP Annual Meeting
Sarcoidosis in Northern New England. Clinical Characteristics and Predictive Factors for More Aggressive Therapy
Alireza Meysami¹, Kevin F. Spratt² and Christopher M. Burns³, ¹Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ²Department of Orthopaedic Surgery, Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Dartmouth Medical School, Lebanon, NH
· Background/Purpose: Sarcoidosis is characterized by a variable clinical presentation. DMARDs and biologics have been used for resistant and/or organ-threatening disease. We analyzed the cases…
Abstract Number: 2048 • 2012 ACR/ARHP Annual Meeting
Four Physician Global Assessments for Overall Status, Inflammation, Damage, and Unexplained Symptoms Are Useful in Usual Care of Patients with Osteoarthritis, Fibromyalgia, Systemic Lupus Erythematosus, and Spondyloarthropathy, As Well As Rheumatoid Arthritis
Isabel Castrejón¹, Martin J. Bergman² and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Taylor Hospital, Ridley Park, PA
Background/Purpose: A physician global estimate (DOCGL) is important in clinical decisions concerning patients with rheumatoid arthritis (RA), and often is the most efficient of the…
Abstract Number: 1028 • 2012 ACR/ARHP Annual Meeting
Semi-Quantitative Assessment of Bone Marrow Edema and Synovitis-Effusion in Osteoarthritis with the Knee Inflammation MRI Scoring System: A Target Lesion Based Methodology
Walter P. Maksymowych¹, Ulrich Weber², Marcus Pianta³ and Robert GW Lambert³, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ³Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Current MRI scoring methods for assessment of bone marrow lesions (BML) in the knee of patients with osteoarthritis rely on a complex subdivision of…
Abstract Number: 50 • 2012 ACR/ARHP Annual Meeting
Human Chondrocyte Dedifferentiation Is Accompagnied by CD105 Endoglin Expression, ALK-1/Smad1/5 Phosphorylation and Leptin Production – Stimulation by Prednisolone and Aldosterone Through the Glucocorticoid Receptor
Olivier Malaise¹, Biserka Relic², Mustapha Zeddou¹, Edith Charlier¹, Florence Quesada Calvo¹, Sophie Neuville³, Dominique de Seny² and Michel G. Malaise⁴, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ²Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ³GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ⁴Department of Rheumatology, University of Liège - CHU Liège, Liège, Belgium
Background/Purpose: Leptin, mainly produced by the adipose tissue including fat neighboring the joint, is considered as pro-inflammatory in osteoarthritis (OA). Normal cartilage does not…

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