ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 951 • 2013 ACR/ARHP Annual Meeting

    The Anti-IL-17A Monoclonal Antibody Secukinumab (AIN457) Inhibits Pro-Inflammatory Mediator Release From Human Primary Synoviocytes Costimulated With IL-17 and TNF

    Christine Huppertz, Marija Curcic Djuric, Robert Hennze and Frank Kolbinger, Autoimmunity, Transplantation and Inflammatory Disease, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, SWITZERLAND, Basel, Switzerland

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are targets of the pro-inflammatory IL-17 cytokines and a major source of inflammatory mediators in the inflamed synovium in rheumatoid arthritis…
  • Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting

    Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression

    Anne Sofie Siebuhr1, Kristian Kjaer Petersen2, Lars Arendt-Nielsen3, Line Egsgaard2, Thomas Navndrup Eskehave4, Ole Simonsen5, Claus Christiansen4,6, Hans Christian Hoeck4, Morten Asser Karsdal7 and Anne C. Bay-Jensen8, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, 3Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, 4Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, 5Frederikshavn Hospital, Frederikshavn, Denmark, 6Nordic Bioscience, Herlev, Denmark, 7Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 8Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

    Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…
  • Abstract Number: 934 • 2013 ACR/ARHP Annual Meeting

    Interleukin-12B Is Up-Regulated By Decoy Receptor 3 In Specifically Rheumatoid Synovial Fibroblasts

    Koji Fukuda1, Yasushi Miura1,2, Toshihisa Maeda1, Shinya Hayashi3 and Masahiro Kurosaka3, 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, 3Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand (FasL), LIGHT,…
  • Abstract Number: 2567 • 2012 ACR/ARHP Annual Meeting

    Predictive Value of Selected Markers of Inflammation and Platelet Activation for Complete Remission in ANCA – Associated Vasculitis

    Gunnar Tomasson1, Paul A. Monach2, Kahraman Tanriverdi3, Ulrich Specks4, John H. Stone5, Linna Ding6, Fernando Fervenza4, Gary S. Hoffman7, Cees G.M. Kallenberg8, Carol A. Langford9, Deborah J. Phippard10, Philip Seo11, Robert F. Spiera12, E. William St. Clair13, Nadia Tchao10, Jane E. Freedman3 and Peter A. Merkel14, 1Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland, 2Rheumatology, Boston University, Boston, MA, 3Department of Cardiology, University of Massachusetts, Wochester, MA, 4Mayo Clinic, Rochester, MN, 5Rheumatology, Massachusetts General Hospital, Boston, MA, 6NIAID, Bethesda, MD, 7Rheumatic & Immunologic Dis, Cleveland Clinic, Cleveland, OH, 8Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 9Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 10Immune Tolerance Network, Bethesda, MD, 11Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 12Rheumatology, Hospital for Special Surgery, New York, NY, 13Medicine, Duke University Medical Center, Durham, NC, 14University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Most subjects with ANCA –associated vasculitis (AAV) respond to treatment for remission induction, but predictors for complete disease remission are lacking. We have previously…
  • Abstract Number: 1338 • 2012 ACR/ARHP Annual Meeting

    Anti-Tumor Necrosis Factor Therapy Reduces Serum Levels of Chemerin in Rheumatoid Arthritis: A New Mechanism by which Anti-Tumor Necrosis Factor Might Reduce Inflammation

    M.M. Herenius1, A.S.F. Oliveira1, C.A. Wijbrandts1, D. Gerlag1, Paul P. Tak2 and Maria C. Lebre3, 1Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands, 3Clinical Immunology and Rheumatology & Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Chemerin is a specific chemoattractant for macrophages and dendritic cells (DC). In addition, it can rapidly stimulate macrophage adhesion to extracellular matrix proteins and…
  • Abstract Number: 673 • 2012 ACR/ARHP Annual Meeting

    Altered Soluble Mediators in Individuals with Incomplete Lupus (ILE) in the Lupus Autoimmunity in Relatives (LAUREL) Study

    Melissa E. Munroe1, Jill M. Norris2, Joel M. Guthridge3, Diane L. Kamen4, Kathy Moser Sivils5, Timothy B. Niewold6, Gary S. Gilkeson7, Michael H. Weisman8, Mariko L. Ishimori8, Daniel J. Wallace9, David R. Karp10, John B. Harley11 and Judith A. James12, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Epidemiology, Colorado School of Public Health, Aurora, CO, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 7Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 8Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Cedars-Sinai Medical Center, Los Angeles, CA, 10Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, 11Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: SLE is a complex autoimmune disease marked by autoantibody production and immune dysregulation. Identification of at-risk populations is essential to minimize morbidity and mortality…
  • Abstract Number: 2518 • 2012 ACR/ARHP Annual Meeting

    The Sphingosine-1-Phosphate Pathway Is a Key Regulator of Bone Substrate-Mediated Osteoclast Differentiation in Inflammatory Arthritis

    P. Edward Purdue1, Jon Hill2, Steven R. Goldring3, Nikolaus, B. Binder3, Jennifer L. Swantek4, Zhenxin Shen5, Tania N. Crotti5, Gerald H. Nabozny4 and Kevin P. McHugh5, 1Research, Hospital for Special Surgery, New York, NY, 2Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, 3Hospital for Special Surgery, New York, NY, 4Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 5Orthopedic Surgery, Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA

    Background/Purpose: Multiple lines of evidence have established that osteoclasts are required for physiologic bone resorption and pathological bone loss in inflammatory disorders. Isolation of differentiated…
  • Abstract Number: 1267 • 2012 ACR/ARHP Annual Meeting

    Inflammatory Burden Predicts Progression of Carotid Plaque in Rheumatoid Arthritis: A 24-Month Longitudinal Analysis

    Churl Hyun Im1, Na Ri Kim1, Jong Wan Kang1, Young Ji Kim1, Kyung Hye Kim1, Eon Jeong Nam1 and Young Mo Kang2, 1Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, 2Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea

    Background/Purpose: Carotid atherosclerosis, which is associated with the increased risk of cardiovascular (CV) disease, is increased in rheumatoid arthritis (RA) patients. In our previous study,…
  • Abstract Number: 339 • 2012 ACR/ARHP Annual Meeting

    Differences Between Juvenile and Adult Rodents with Collagen Induced Arthritis

    Tracy D. Wilson-Gerwing1, Isaac V. Pratt2, David M.L. Cooper2, Tawni I. Silver3 and Alan M. Rosenberg4, 1Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, 2Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada, 3Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, 4Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is among the most common chronic diseases of childhood.  Arthritis is a potentially disabling disease that can result in ongoing…
  • Abstract Number: 2502 • 2012 ACR/ARHP Annual Meeting

    Neutrophil Extracellular Trap-Associated Protein Activation of the Inflammasome Is Enhanced in Lupus M1 Macrophages

    J. Michelle Kahlenberg1, Carolyne K. Smith2, Carmelo Carmona-Rivera1 and Mariana J. Kaplan3, 1Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD

    Background/Purpose: Neutrophil extracellular traps (NETs) contain numerous bactericidal proteins and are an important defense mechanism against microorganisms.  Clearance of NETs is impaired in a subset…
  • Abstract Number: 1237 • 2012 ACR/ARHP Annual Meeting

    Baseline Evaluation of Insulin Resistance in Patients with early Non-Treated Rheumatoid Arthritis

    Sara Manrique-Arija1, María América López-Lasanta2, Pilar Espiño- Lorenzo2, Pedro Valdivielso3, José Rioja3, Inmaculada Ureña1, Francisco Gabriel Jimenez- Núñez1, Carmen M. Romero-Barco1, Veronica Rodríguez-García1, Laura Nieves2, Mari Carmen Ordoñez-Cañizares2, Laura Cano2, Maria Victoria Irigoyen2 and Antonio Fernández-Nebro4, 1Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain, 2Hospital Carlos Haya. University of Malaga, Malaga, Spain, 3Department of Medicine. University of Malaga, Malaga, Spain, 4Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain

    Background/Purpose: High levels of inflammatory cytokines are associated with insulin resistance syndrome in long-standing AR. The aim was to analyze insulin resistance (IR), adipokines, inflammatory…
  • Abstract Number: 310 • 2012 ACR/ARHP Annual Meeting

    STAT3 Plays a Central Role in NLRP3 Inflammasome-Mediated IL-1β Production and Pyronecrosis

    Jehad H. Edwan1, Tri M. Tran2, Mones Abu-Asab3, Raphaela T. Goldbach-Mansky4 and Robert A. Colbert1, 1NIAMS NIH, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD, 3NEI NIH, Bethesda, MD, 4Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose: Gain of function mutations in NLRP3 cause cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID),…
  • Abstract Number: 2478 • 2012 ACR/ARHP Annual Meeting

    Identification of Disease-Specific Neuroimaging Phenotypes in Childhood Inflammatory Brain Diseases

    Tania Cellucci1, Pascal N. Tyrrell2, Shehla Sheikh3, Suzanne Laughlin4 and Susanne M. Benseler3, 1Pediatrics/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2Cardiology/Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 3Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 4Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Magnetic resonance imaging (MRI) is a key diagnostic modality of childhood inflammatory brain diseases (IBrainD). While overlapping clinical features contribute to significant diagnostic uncertainty,…
  • Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting

    Analysis of Gene Expression Patterns in Rheumatoid  Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare

    Karen L. Berg1, Adedayo Hanidu1, Jon Hill2, Xiaoyu Jiang1, Tom Freeman2, Jennifer Swantek1, Anna Yarlina3, George D. Kalliolias4, Lionel B. Ivashkiv5 and Gerald H. Nabozny1, 1Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 2Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, 3Hospital for Special Surgery, New York, NY, 4Medicine, Hospital for Special Surgery, New York, NY, 5Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: Synovial macrophages play a key role in RA pathogenesis.  Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…
  • Abstract Number: 314 • 2012 ACR/ARHP Annual Meeting

    Transcriptome and Surface Phenotype Analyses Suggest an Alternatively Activated (M2) Function for Hemophagocytes

    Scott W. Canna1, Ana Patrícia Costa Reis2, William E. Bernal3, Kathleen E. Sullivan4, Michele E. Paessler5 and Edward M. Behrens6, 1Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, 2Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, 5Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, 6Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Hemophagocytes (HPCs) are activated macrophages identified in situ by having engulfed other hematopoietic cells. HPCs are rarely seen in normal bone marrow, but are…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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