Abstracts tagged "Inflammation"

Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting
Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
Nicholas A. Young¹, Giancarlo R. Valiente², Lai-Chu Wu¹, Michael Bruss³, Craig Burd⁴ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, ³Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…
Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting
Role Of IL33 In The Inflammation Of Takayasu Arteritis
David Saadoun¹, Marlène Garrido², Julien Gaudric³, Cloé Comarmond⁴, Michele Rosenzwacjg⁵ and Patrice Cacoub⁶, ¹Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ²I3 laboratory, Pitié-Salpétrière, Paris, France, ³Department of Vascular surgery GHPS, Paris, France, ⁴Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, ⁵Department of Immunology GHPS, Paris, France, ⁶Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France
Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting
Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?
Kimberly P. Liang¹, Douglas P. Landsittel², Suresh R. Mulukutla³, Steven E. Reis⁴, Marc C. Levesque⁵, Donald M. Jones⁶, Rachel Gartland⁷, Ali Shoushtari⁸, Flordeliza S. Villanueva³, Hunter C. Champion⁸ and Larry W. Moreland⁵, ¹Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, ³Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
Abstract Number: 1877 • 2012 ACR/ARHP Annual Meeting
Is the Amount of T and B Lymphocytes, Natural Killer Cells and Macrophages in Biopsies From Non-Ruptured Chronic Tendinopathic Achilles Tendons Predictive for Long Term Outcome? A >3 Years Prospective Study of 37 Patients
Maja S. Kragsnæs¹, Ulrich Fredberg², Katrine Stribolt³, Søren G. Kjær¹, Knud Bendix³ and Torkell Ellingsen¹, ¹Diagnostic Centre, Region Hospital Silkeborg, Silkeborg, Denmark, ²Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark, ³University Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: In biopsies from non-ruptured chronic tendinopathic Achilles tendons, presence of T and B lymphocytes, natural killer cells and macrophages has been reported. Whether the…
Abstract Number: 876 • 2012 ACR/ARHP Annual Meeting
Xanthine Oxidase-Derived ROS Direct Context-Dependent Action of NFAT5 Toward Inflammatory Response in Macrophages
Nam Hoon Kim, Research Institute of Immunobiology, Catholic university of Korea, Seoul of Korea, Seoul, South Korea
Background/Purpose: NFAT5, a well known osmo-protective factor, can be activated by isotonic stimuli, such as Toll-like receptor (TLR) triggering. Here, we identified a novel signal…
Abstract Number: 43 • 2012 ACR/ARHP Annual Meeting
Serum Amyloid A Level in Knee Osteoarthritis: Systemic and/or Local Production and Pro-Inflammatory Properties On Human Chondrocytes and Fibroblast-Like Synoviocytes
Dominique de Seny¹, Gaël Cobraiville², Sophie Neuville², Edith Charlier³, Biserka Relic¹, Florence Quesada Calvo³, Olivier Malaise³, Denis Malaise⁴, Laurence Lutteri⁵, Jean-Paul Chapelle⁵ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ³Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ⁴University of Liège, Liège, Belgium, ⁵Medical Chemistry - CHU Liège, Liège, Belgium
Background/Purpose: Knee osteoarthritis (OA) is a disease frequently seen in obese patients, but the relationship might be more linked to fat than to weight. A-SAA…
Abstract Number: 1672 • 2012 ACR/ARHP Annual Meeting
Myosin Skews Effector Immune Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis
Nicholas Young¹, Rahul Sharma², Alexandra Friedman³, Benjamin Kaffenberger¹ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Medical Center, Columbus, OH, ²Medicine, University of Virginia Health System, Charlottesville, VA, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Myositis is associated with an inflammatory process that results in pronounced muscle weakness and is observed in some regulatory T cell (Treg) deficient mouse…
Abstract Number: 878 • 2012 ACR/ARHP Annual Meeting
Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency
Deepa Hammaker¹, Katharyn Topolewski², Monica Guma³, David L. Boyle⁴ and Gary S. Firestein⁵, ¹MC 0656, UCSD School of Medicine, La Jolla, CA, ²UCSD School of Medicine, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: p38 inhibitors have limited efficacy in rheumatoid arthritis (RA), possibly because p38 blockade suppresses IL-10 production and increases JNK and ERK phosphorylation in…
Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting
Adenosine A_2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Aranzazu Mediero¹ and Bruce N. Cronstein², ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…
Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting
Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Xenofon Baraliakos¹, Frank Heldmann², Ravi Suppiah³, Fiona M. McQueen⁴ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
Abstract Number: 882 • 2012 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects of Phosphodiesterase 4 Inhibition Are Mediated by Mitogen-Activated Protein Kinase Phosphatase-1
Riku Korhonen, Tuija Hömmö, Mirka Laavola, Tiina Keränen, Mari Hämäläinen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
Background/Purpose: MAP kinase phosphatase-1 (MKP-1) is a nuclear tyrosine/threonine phosphatase that limits p38 MAP kinase activity. MKP-1 KO mice display excessive inflammatory response, and exhibit…
Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Maria Isabel Guillén¹, Julia Platas¹, Vicente Mirabet², Miguel Angel Castejón³, Francisco Gomar⁴ and Maria Jose Alcaraz¹, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Generalitat Valenciana, Valencia, Spain, ³De la Ribera University Hospital, Alzira, Spain, ⁴Surgery, University of Valencia and University Hospital, Valencia, Spain
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…
Abstract Number: 1632 • 2012 ACR/ARHP Annual Meeting
Arhalofenate Is a Novel Dual-Acting Agent with Uricosuric and Anti-Inflammatory Properties
Yun-Jung Choi, Vanina Larroca, Annette Lucman, Vic Vicena, Noe Abarca, Tim Rantz, Brian E. Lavan and Charles A. McWherter, Biology, Metabolex, Inc., Hayward, CA
Background/Purpose: In most patients with gout, elevated serum urate is linked to excess uric acid reabsoprtion in the proximal renal tubule by anion transporters/exchangers, including…
Abstract Number: 872 • 2012 ACR/ARHP Annual Meeting
Monocyte Chemoattractant Protein-1 and Eotaxin Are Associated with Parameters of Cardiac Dysfunction in Juvenile Dermatomyositis
Thomas Schwartz¹, Ivar Sjaastad², Berit Flatø³, Maria Vistnes¹, Geir Christensen¹ and Helga Sanner³, ¹Institute for Experimental Medical Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ²Institute for Clinical Medicine, University of Oslo, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, ³Department of Rheumatology, Oslo University Hospital, Institute for Clinical Medicine, University of Oslo, Oslo, Norway
Background/Purpose : Juvenile dermatomyositis (JDM) is a vasculopathic disease affecting not only skeletal muscle and skin, but other organs as well. Previously we have shown…
Abstract Number: 1635 • 2012 ACR/ARHP Annual Meeting
Polyarthritis Caused by TIARP (TNFAIP9) Deficiency Critically Dependent On Dysregulated STAT3, NF-κB Signaling and Cell Death in Macrophage
Asuka Inoue¹, Isao Matsumoto¹, Naoto Umeda¹, Yuki Tanaka¹, Satoru Takahashi² and Takayuki Sumida¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan
Background/Purpose: TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein induced by TNFα and IL-6 in adipose tissue. Recently, we found that TIARP is dominantly expressed…

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