ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 879 • 2013 ACR/ARHP Annual Meeting

    Serological Biomarkers Of Specific Mode Of Action For Early Identification Of Rheumatoid Arthritis Patients Who Respond To Anti-IL6 Or Anti-TNF Treatment

    Anne C. Bay-Jensen1, Natasja Stæhr Gudman2, Anne Sofie Siebuhr1, Claus Christiansen3 and Morten Asser Karsdal2, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 3Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized debilitating joint destruction, if not treated aggressively in the patient in most need of treatment. …
  • Abstract Number: 1861 • 2013 ACR/ARHP Annual Meeting

    Neurotrophins Are Involved In Vascular Remodeling Of Giant Cell Arteritis

    Kim Heang Ly1,2, Alexis Régent3, Elsa Molina4, Sofiane Saada4, Philippe Sindou4, Claire Le Jeunne5, Antoine Brezin6, Veronique witko-Sarsat3, Philippe Bertin7, Francois Labrousse8, Pierre-Yves Robert9, Anne-Laure Fauchais10, Elisabeth Vidal10, Luc Mouthon11 and Marie-Odile Jauberteau4, 1CHU Dupuytren, Limoges, Limoges, France, 2Immunology Laboratory, EA3842, Limoges Medical school, Limoges, France, 3Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, 4Immunology Laboratory, EA 3842, Limoges Medical School, Limoges, France, 5Department of Internal Medicine, Hotel-Dieu Hospital, AP-HP, Paris, Paris, France, 6Service d’ophtalmologie, hôpital Cochin, AP-HP, Paris, France, 7Hôpital Dupuytren, Limoges, France, 8Department of Pathology, Limoges University Hospital, Limoges, France, 9Departement of Ophthalmology, Limoges University Hospital, Limoges, France, 10Department of Internal Medicine A, Dupuytren Hospital, Limoges University Hospital, Limoges, France, 11Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France

    Background/Purpose: Giant cell arteritis (GCA) is a large-vessels vasculitis. Hhistopathological findings show cellular infiltrates, internal elastic lumina disruption and intimal hyperplasia leading to luminal stenosis.…
  • Abstract Number: 887 • 2013 ACR/ARHP Annual Meeting

    Atherosclerosis and Cardiovascular Disease In Systemic Lupus Eryhematosus Are Related To An Inflammatory/Oxidative Status Linked To The Autoimmune Condition and The Clinical Activity Of The Disease. Effect Of Statins Treatment

    Chary Lopez-Pedrera1, Patricia Ruiz-Limon1, Carlos Perez-Sanchez1, Mª Angeles Aguirre2, Nuria Barbarroja1, Tomás Cerdó-Ráez3, Maria Laura Bertolaccini4, Munther A. Khamashta5, Antonio Rodriguez-Ariza6, Yolanda Almaden7, Husam Khraiwesh8, Jose Antonio Gonzalez-Reyes9, Jose Manuel Villalba10, Eduardo Collantes11 and Mª Jose Cuadrado12, 1Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, 2Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 3Imibic, Córdoba, Spain, 4Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, 5Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, 6Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 7Imibic, Códoba, Spain, 8UCO, Córdoba, Spain, 9Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, 10Cell Biology, Physiology and Immunology, University of Cordoba, Agrifood Campus of International Excelence (ciA3), Cordoba, Spain, 11Rheumatology, Hospital Reina Sofia, Cordoba, Spain, 12Lupus Research Unit, The Rayne Institute, London, United Kingdom

    Background/Purpose: Atherosclerosis (AT) and cardiovascular disease (CVD) are enhanced systemic lupus erythematosus (SLE). Although there is evidence that statins have anti-inflammatory properties, their mechanism of…
  • Abstract Number: 1846 • 2013 ACR/ARHP Annual Meeting

    Mitochondrial Dysfunction Induces An Inflammatory, Tissue-Degrading, and Angiogenic Response In Normal Human Synoviocytes

    M. Noa Valcárcel-Ares1, Romina R. Riveiro-Naveira1, Jesus Loureiro1, Carlos Vaamonde-García1, Laura Hermida-Carballo1, Francisco J. Blanco2 and Maria J. López-Armada1, 1Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, 2Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain

    Background/Purpose: Tissues affected with inflammatory arthritis (IA) are subjected to great levels of oxidative stress. Synoviocytes from IA patients present a higher rate of mitochondrial…
  • Abstract Number: 858 • 2013 ACR/ARHP Annual Meeting

    Monosodium Urate Crystal Induced Macrophage Inflammation Is Attenuated By Chondroitin Sulfate: Pre-Clinical Model For Gout Prophylaxis?

    Eric W. Orlowsky1, Thomas V. Stabler2, Eulalia Montell3, Josep Verges3 and Virginia B. Kraus2, 1Divsion of Rheumatology, Dept of Internal Medicine, Duke University Medical Center, Durham, NC, 2Medicine/Rheumatology, Duke University Medical Center, Durham, NC, 3Pre-Clinical R&D Area, Pharma Science Division, Bioibérica, Barcelona, Spain

    Background/Purpose:  Gout is one of the most common forms of inflammatory arthritis and is characterized by acute episodes of joint pain. Monosodium urate (MSU) crystals…
  • Abstract Number: 1794 • 2013 ACR/ARHP Annual Meeting

    The Jak Inihibitor Tofacitinib Suppresses Synovial Jak-Stat Signalling In Rheumatoid Arthritis

    D. L Boyle1, N. Wei2, A. K. Singhal3, D. R. Mandel4, P Mease5, A. Kavanaugh6, R. Shurmur7, J. Hodge8, Z. Luo9, S. Krishnaswami10, D. Gruben9, S. H. Zwillich9, K. Soma9, J. D. Bradley9 and G. S. Firestein11, 1Div of Rheum, UCSD School of Medicine, La Jolla, CA, 2Arthritis Treatment Center, Frederick, MD, 3Southwest Rheumatology Research LLC, Mesquite, TX, 4Office of David R Mandel MD, Inc., Mayfield Village, OH, 5Seattle Rheumatology Associates, Seattle, WA, 6UCSD School of Medicine, La Jolla, CA, 7Associated Internal Medicine Specialists, Battle Creek, MI, 8Pfizer Inc, Collegeville, PA, 9Pfizer Inc, Groton, CT, 10Clinical Pharmacology, Pfizer Inc, Groton, CT, 11Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Tofacitinib is a novel oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The specific JAK-STAT (signal transducer and activator of…
  • Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting

    Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?

    Nicholas A. Young1, Giancarlo R. Valiente2, Lai-Chu Wu1, Michael Bruss3, Craig Burd4 and Wael N. Jarjour5, 1Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, 3Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 4Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, 5Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…
  • Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting

    Role Of IL33 In The Inflammation Of Takayasu Arteritis

    David Saadoun1, Marlène Garrido2, Julien Gaudric3, Cloé Comarmond4, Michele Rosenzwacjg5 and Patrice Cacoub6, 1Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 2I3 laboratory, Pitié-Salpétrière, Paris, France, 3Department of Vascular surgery GHPS, Paris, France, 4Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, 5Department of Immunology GHPS, Paris, France, 6Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France

    Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
  • Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting

    Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?

    Kimberly P. Liang1, Douglas P. Landsittel2, Suresh R. Mulukutla3, Steven E. Reis4, Marc C. Levesque5, Donald M. Jones6, Rachel Gartland7, Ali Shoushtari8, Flordeliza S. Villanueva3, Hunter C. Champion8 and Larry W. Moreland5, 1Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, 3Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, 4Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 7Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
  • Abstract Number: 1403 • 2013 ACR/ARHP Annual Meeting

    Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Is Expressed In a TNF-Dependent Manner In RA Synovial Tissues

    Borbala Aradi1, Masaru Kato1, Mária Filková2, Stephanie Kasper3, Kerstin Klein1, Michael Bader1, Michael Scharl3, Beat A Michel4, Renate E Gay1, Edit I Buzas5, Steffen Gay1 and Astrid Jüngel1, 1Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 3Division of Gastroenterology and Hepatology, University Hospital Zürich and Zürich Center for Integrative Human Physiology, Zurich, Switzerland, 4Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 5Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary

    Background/Purpose: Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2) is a protein phosphatase that has been associated with the development of autoimmune diseases in GWA studies.…
  • Abstract Number: 385 • 2013 ACR/ARHP Annual Meeting

    Systemic Inflammation In Patients With Inflammatory Joint Disease Does Not Influence Statin Dose Needed To Obtain Low Density Lipoprotein Cholesterol Goal In Cardiovascular Prevention

    Silvia Rollefstad1, Eirik Ikdahl2, Tore K. Kvien3,4, Terje R. Pedersen4,5, Ingar Holme6 and Anne G. Semb2, 1Rhuematology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Faculty of Medicine, University of Oslo, Oslo, Norway, 5Centre of Preventive Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway, 6Department of biostatistics, epidemiology and health economics, Oslo University Hospital-Ullevaal, Oslo, Norway

    Background/Purpose: There is a lipid paradox in rheumatoid arthritis (RA): despite low lipids influenced by systemic inflammation, there is an increased risk of cardiovascular (CV)…
  • Abstract Number: 1332 • 2013 ACR/ARHP Annual Meeting

    Metaflammation, PEDF and Chemerin: Potential Systemic Factors Which Link Obesity To Response To Therapy In Early Rheumatoid Arthritis

    Elisa Gremese, Barbara Tolusso, Anna Laura Fedele, Maria Rita Gigante, Angela Carbonella, Silvia Canestri, Clara Di Mario and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: Obesity per se is a systemic, low-grade inflammatory state and the adipose tissue is an endocrine organ that releases bioactive substances, including pro-inflammatory cytokines,…
  • Abstract Number: 371 • 2013 ACR/ARHP Annual Meeting

    Inflammatory Cell Infiltrates In The Heart Of Patients With Coronary Artery Disease With and Without Inflammatory Rheumatic Disease: A Biopsy Study

    Jacqueline Kirsti Andersen1, Ingvild Oma2, Ingjerd Lien Kveldstad2, Knut Mikkelsen3, Terje Veel4, Sven M. Almdahl5, Matthew H. Liang6, Øystein T. Førre7, Morten Fagerland8 and Ivana Hollan9, 1Gjøvik University College, Gjøvik, Norway, 2Innlandet Hospital Trust, Lillehammer, Norway, 3Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 4Feiringklinikken, Feiring, Norway, 5Cardiothoracic surgery, University Hospital of North Norway, Tromsø, Norway, 6Harvard Medical School, Boston, MA, 7Oslo University Hospital, Oslo, Norway, 8Department of Biostatistics, Oslo University Hospital, Oslo, Norway, 9Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway

    Background/Purpose:  Systemic rheumatic diseases (SRDs) are associated with increased cardiovascular (CV) morbidity due to accelerated atherosclerosis. However, SRDs are associated also with cardiac vasculitis that…
  • Abstract Number: 1294 • 2013 ACR/ARHP Annual Meeting

    Anti-Inflammatory Effect Of Resveratrol As a Dietary Supplement In An Antigen-Induced Arthritis Rat Model

    Romina R. Riveiro-Naveira1, Jesus Loureiro1, Alberto Centeno-Cortés2, Eduardo López-Peláez2, Carlos Vaamonde-García1, M. Noa Valcárcel-Ares1, Francisco J. Blanco3 and Maria J. López-Armada1, 1Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, 2Experimental Surgery Unit, CHU A Coruña, A Coruña, Spain, 3Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain

    Background/Purpose: Inflammatory cells like macrophages, lymphocytes and neutrophils in hyperplasic synovial tissue have been identified as key players in the onset and development of rheumatoid…
  • Abstract Number: 245 • 2013 ACR/ARHP Annual Meeting

    C-Reactive Protein But Not Erythrocyte Sedimentation Rate Is Associated With Decrease In Muscle Strength In Patients With Knee Osteoarthritis: A 2 Year Follow Up Study

    Diana C Sanchez-Ramirez1, Marike van der Leeden2, Martin van der Esch3, Leo D. Roorda2, Sabine Verschueren4, Jaap van Dieen5, Joost Dekker6 and Willem F. Lems7, 1Human movement sciences, VU university Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, 3Amsterdam Rehabilitation Research Center, Reade, Amsterdam, Netherlands, 4Department of Rehabilitation Sciences, KU University of Leuven, Leuven, Belgium, 5Faculty of Human Movement Sciences, VU University, Amsterdam, Netherlands, 6Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 7Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: In patients with knee osteoarthritis activity limitations and disease progression have been associated with muscle weakness (OA). Muscle weakness might be determined by factors…
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