Abstracts tagged "Inflammation"

Abstract Number: 1291 • 2014 ACR/ARHP Annual Meeting
Relationships Between Inflammation, Disease Severity and Synovial Fluid Calcium Crystals Detected By Scanning Electronic Microscopy in Early Osteoarthritis
Paola Frallonardo¹, Francesca Oliviero¹, Luca Peruzzo², Leonardo Tauro³, Anna Scanu¹, Mariagrazia Lorenzin¹, Augusta Ortolan¹, Leonardo Punzi⁴ and Roberta Ramonda¹, ¹Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ²Institute for Geosciences and Earth Resources IGG-CNR, Padova, Italy, ³Department of Geosciences, University of Padova, Padova, Italy, ⁴Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose The presence of calcium crystals (CC) in synovial fluid (SF) of osteoarthritis (OA) is a well known and frequent feature (1). However, their role…
Abstract Number: 2225 • 2014 ACR/ARHP Annual Meeting
Does Previous Corticosteroid Treatment Affect the Inflammatory Infiltrate Found in Polymyositis Muscle Biopsies?
Mayara Mendes Pinhata¹, Juliana Jesus do Nascimento¹, Suely Kazue Nagahashi Marie² and Samuel Katsuyuki Shinjo¹, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: We conducted this study because there have been no studies evaluating the effect of the use of corticosteroids (CE) on the presence of inflammatory…
Abstract Number: 1204 • 2014 ACR/ARHP Annual Meeting
Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFkB Signaling and Macrophage Migration
Nicholas A. Young¹, Michael Bruss², Mark Gardner³, William Willis³, Xiaokui Mo³, Giancarlo Valiente³, Yu Cao⁴, Zhongfa Liu⁴, Lai-Chu Wu¹ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, columbus, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The major obstacles to successful use of curcumin as an anti-inflammatory agent are its low solubility in water and rapid metabolism, which both translate…
Abstract Number: 2168 • 2014 ACR/ARHP Annual Meeting
Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Many rheumatic diseases are driven by chronic, repeated activation of Toll-like receptors (TLR) causing the initiation and perpetuation of disease. However, TLR-activated innate immune…
Abstract Number: 1195 • 2014 ACR/ARHP Annual Meeting
Activation of the nlrp3 Inflammasome By an Endogenous TLR2 Ligand in Rheumatoid Arthritis
Mary Connolly, Trudy McGarry, Monika Biniecka, Douglas J. Veale and Ursula Fearon, Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: The inflammasome is a large multiprotein complex which plays a key role in innate immunity by mediating the production of pro-inflammatory cytokines interleukin-1β (IL-1β)…
Abstract Number: 1979 • 2014 ACR/ARHP Annual Meeting
Pseudostarvation By AMPK Activator Therapy Is Associated with Reduced Disease Activity and Downregulation of Pro-Inflammatory Responses in Rheumatoid Arthritis (RA)
Lorna Gallagher¹, Ursula Fearon², Douglas J. Veale³, David Kane¹, Luke A. O'Neill⁴ and Ronan Mullan¹, ¹Department of Rheumatology, Tallaght Hospital, TCD, Dublin 24, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Translational Rheumatology Research Group, St. Vincent's University Hospital, Dublin 4, Ireland, ⁴Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland
Background/Purpose AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…
Abstract Number: 1050 • 2014 ACR/ARHP Annual Meeting
A Role for Purinergic Receptor Signalling in Basic Calcium Phosphate Crystal-Induced Inflammation
Clare C. Cunningham¹, Emma M. Corr¹, Geraldine M. McCarthy² and Aisling Dunne¹, ¹School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, ²Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Basic calcium phosphate (BCP) crystals are uniquely associated with osteoarthritis (OA). They are found in the majority of affected joints and closely correlate with…
Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting
Profiling 14-3-3η in Human Primary Cell Based BioMAP^® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology
Alison O'Mahony¹, Ellen L. Berg¹, Walter P. Maksymowych², Yuan Gui³ and Anthony Marotta⁴, ¹BioSeek, South San Francisco, CA, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions. The 14-3-3 eta…
Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Nicholas A. Young¹, Lai-Chu Wu¹, Michael Bruss², Wael N. Jarjour³ and Dana P. Ascherman⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology, Miami VAMC, Miami, FL
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …
Abstract Number: 1978 • 2014 ACR/ARHP Annual Meeting
Role of Monocytes Subsets in the Pathology of Rheumatoid Arthritis: Involvement in Endothelial Dysfunction and Proinflammatory Profile
Chary Lopez-Pedrera, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Rosario Carretero, Yolanda Jiménez Gómez, Ángeles Aguirre Zamorano, Jerusalem calvo-Gutierrez, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras and Nuria Barbarroja, Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain
Background/Purpose Different frequency of monocytes subsets has been reported in rheumatoid arthritis (RA).Human monocytes are divided into three main subpopulations according to expression of the…
Abstract Number: 832 • 2014 ACR/ARHP Annual Meeting
NOD2-Associated Autoinflammatory Disease: The Largest Cohort Study
Qingping Yao¹, Min Shen², Christine McDonald³, Felicitas Lacbawan⁴ and Bo Shen⁵, ¹Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH, ²Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH, ³Pathobiology, Cleveland Clinic, Cleveland, OH, ⁴Molecular Genetics Pathology, Cleveland Clinic, Cleveland, OH, ⁵Gastroenterology, Cleveland Clinic, Cleveland, OH
Background/Purpose NOD2-associated autoinflammatory disease (NAID) is an emerging systemic inflammatory disease. The aim is to report our extended study of the phenotypic and genotypic features of…
Abstract Number: 2933 • 2014 ACR/ARHP Annual Meeting
Metabolic Syndrome, Adipocytokines and Inflammation in Sjögren’s Syndrome
Kristopherson Lustosa Augusto¹, Eloisa Bonfá², Rosa M. R. Pereira¹, Cleonice Bueno³, Vilma S. T. Viana⁴ and Sandra G. Pasoto⁵, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, ³Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
Background/Purpose Systemic inflammation has been linked to increased frequency of metabolic syndrome (MetS) in autoimmune diseases. However, there are no studies concerning the frequency of…
Abstract Number: 1964 • 2014 ACR/ARHP Annual Meeting
Changes in Soluble CD18 Reflect Latency in the Immune System and Predict Radiographic Progression in Early Rheumatoid Arthritis
Tue Wenzel Kragstrup¹, Babak Jalilian¹, Kresten Krarup Keller², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard⁴, Ellen Margrethe Hauge^7,8, Malene Hvid¹, Thomas Vorup-Jensen¹ and Bent Deleuran^1,3, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Aarhus University Hospital, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Glostrup University Hospital, Glostrup, Denmark, ⁵Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁶Odense University Hospital, Odense, Denmark, ⁷Dept. of Anatomi, Aarhus University, Aarhus, Denmark, ⁸Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose In early rheumatoid arthritis (RA), clinical disease characterized by swollen and painful joints is caused by synovitis. However, presence of autoantibodies may precede the…
Abstract Number: 735 • 2014 ACR/ARHP Annual Meeting
Sarcopenia in Systemic Sclerosis: Prevalence and Association with Functional Parameters and Quality of Life
Elise Siegert¹, Kristina Norman², Emilie Preis³, Alexander Makowka³, Gerd Burmester⁴ and Gabriela Riemekasten¹, ¹Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ²Geriatrics Research Group, Charité – University Medicine Berlin, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ⁴Charité – University Medicine Berlin, Berlin, Germany
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease that characterized by endothelial dysfunction, inflammation and fibrosis. It is associated with high mortality and physical impairment.…
Abstract Number: 2876 • 2014 ACR/ARHP Annual Meeting
Interleukin-10 Receptor Blockade during Lcmv Infection Results in Macrophage Activation Syndrome-like Disease in Mice
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Macrophage activation syndrome (MAS) is the rheumatic disease-associated member of a group of hyperinflammatory syndromes characterized by uncontrolled cytokine storm manifest as unremitting fevers,…

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