Abstracts tagged "Inflammation"

Abstract Number: 271 • 2016 ACR/ARHP Annual Meeting
Impaired Satellite Cell Activation and Myofiber Transition during Skeletal Muscle Regeneration in Patients with Polymyositis and Dermatomyositis
Beatriz Hanaoka¹, Prabhakara R. Nagareddy², Marilyn Campbell³, Leslie J. Crofford⁴, Charlotte A. Peterson⁵, Lisa G. Rider⁶ and Frederick W. Miller⁷, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Nutritional Sciences, University of Alabama at Birmingham, Birmingham, AL, ³University of Kentucky, Lexington, KY, ⁴Medicine, Vanderbilt University Medical Center, Nasville, TN, ⁵College of Health Sciences, University of Kentucky, Lexington, KY, ⁶Rheumatology, George Washington University, Washington, DC, ⁷Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Satellite cells are myogenic stem cells that are essential for myofiber repair, growth and homeostasis in postnatal life. A decline in satellite cell performance…
Abstract Number: 1471 • 2016 ACR/ARHP Annual Meeting
Myocardial 18f-Fluorodeoxyglucose (18F-FDG) Uptake in RA Patients without Clinical Cardiovascular Disease Is Higher Than in Controls and Decreases with Treatment
Isabelle Amigues¹, Jon T. Giles², Afshin Zartoshti³, Rachelle Morgenstern⁴, Raul Flores⁵, Sabahat Bokhari⁶ and Joan Bathon⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁴Cardiology, columbia university college of physicians and surgeons, New York city, NY, ⁵Medicine, Columbia University, New York Presbyterian, New York city, NY, ⁶Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Symptomatic heart failure (HF) and HF-associated mortality rates are higher in RA compared with the non-RA population, even after controlling for coronary artery…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
Abstract Number: 288 • 2016 ACR/ARHP Annual Meeting
Glucose Homeostasis Influences the Risk of Incident Knee Osteoarthritis
Jeffrey Driban¹, Charles B. Eaton², Mamta Amin³, Alina Stout⁴, Lori Lyn Price⁵, Bing Lu⁶, Grace H. Lo⁷, Timothy E. McAlindon⁸ and Mary Barbe⁹, ¹Tufts Medical Center, Boston, MA, ²Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ³Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Clinical Care Research, Tufts Medical Center, Boston, MA, ⁶Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁷Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Knee osteoarthritis (KOA), particularly accelerated KOA, is associated with older age and being overweight. Greater age and weight are associated with impaired glucose homeostasis…
Abstract Number: 1528 • 2016 ACR/ARHP Annual Meeting
Incretin Axis in Non Diabetic Rheumatoid Arthritis Patients
Beatriz Tejera¹, De Vera-González AM², Alejandra González Delgado³, Raquel López-Mejías⁴, Begoña Ubilla⁴, Fernanda Genre⁴, Jose M Olmos⁵, José L Hernández⁶, Miguel Angel Gonzalez-Gay⁴ and Ivan Ferraz-Amaro⁷, ¹Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ²Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ³Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁵Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, ⁶Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL. Universidad de Cantabria. RETICEF, Santander, Spain, ⁷Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain
Background/Purpose: Cross-sectional study that encompassed 361 non-diabetes individuals; 151 patients with RA and 210 age- and sex-matched controls. IR by homeostatic model assessment (HOMA2), insulin,…
Abstract Number: 2489 • 2016 ACR/ARHP Annual Meeting
Joint Damage Appears As Severe As Inflammation According to Physician Visual Analog Scales in Patients with Rheumatoid Arthritis Regardless of Disease Severity at 2 Sites, Which May Limit Results of a Treat-to-Target Strategy
Theodore Pincus¹, Isabel Castrejón¹, Kathryn Gibson² and Joel Block³, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Liverpool Hospital and University of New South Wales, Liverpool, Australia, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of global status (DOCGL) on a 0-10 visual analog scale (VAS) was developed initially to assess inflammation in patients with rheumatoid…
Abstract Number: 12 • 2015 ACR/ARHP Annual Meeting
Delta-like 1 Enhances the Production of Pro-Inflammatory Mediators By Fibroblast-like Synoviocytes
Chiyoko Sekine, Department of Clinical Research Medicine, Teikyo University School of Medicine, Tokyo, Japan
Background/Purpose: Notch signaling is known to regulate cell fate decision and differentiation during embryonic and post-natal development. I have been reported that a Notch ligand…
Abstract Number: 1053 • 2015 ACR/ARHP Annual Meeting
Phosphatidylinositol-3-Kinase Delta Pathway a Novel Therapeutic Target for Sjogren’s Syndrome
Saba Nayar¹, Joana Campos¹, Christopher Buckley¹, Rodger Allen², W.A. Fahy², Andrew Payne² and Francesca Barone¹, ¹University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ²UCB Pharma, Slough, United Kingdom
Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by B cell hyper-activation and exocrine gland infiltration that results in loss of glandular function,…
Abstract Number: 2209 • 2015 ACR/ARHP Annual Meeting
Stimulation of the Adenosine A2A Receptor (A2AR) Regulates the Expression of Netrin-1 (Ntn1) and Its Receptors (Unc5b, DCC) and Inhibits Wear Particle-Induced Inflammatory Osteolysis in a Model of Joint Prosthesis Loosening
Aranzazu Mediero¹, Bhama Ramkhelawon², Miguel Perez-Aso³, Kathryn Moore² and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³Provital S.A., Barberà del Vallès, Spain, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Ntn1 is a member of the family of axonal guidance proteins that plays a role in leukocyte function and inflammation and is critical for…
Abstract Number: 30 • 2015 ACR/ARHP Annual Meeting
Complications of Inflammatory Arthritis in First Nations and Non-First Nations Populations of Alberta, Canada
Cheryl Barnabe¹, Gilaad Kaplan², J Antonio Avina-Zubieta³, Diane Lacaille⁴, Brenda Hemmelgarn⁵ and JM Esdaile⁶, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, ³Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Division of Nephrology, University of Calgary, Calgary, AB, Canada, ⁶Rheumatology, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: With markedly improved control of the acute effects of inflammatory arthritis, the major causes of morbidity and premature death now arise from the complications…
Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting
Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype
Robert Good¹, Sarah L. Trinder², Christopher P. Denton³, David Abraham⁴ and Alan M. Holmes¹, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…
Abstract Number: 2467 • 2015 ACR/ARHP Annual Meeting
Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNFα, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis
Ian D. Ferguson¹, Patricia Griffin², Hiroshi Yano³, Joshua J. Michel², Jeffrey A. Dvergsten⁴, Sarah L. Gaffen⁵, Margalit E. Rosenkranz¹, Daniel A. Kietz¹ and Abbe N. Vallejo¹, ¹Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Department of Pediatrics, Duke University Medical Center, Durham, NC, ⁵Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
Background/Purpose: T cells are considered effectors of immunopathology in JIA. In previous work, we reported dominance of senescent CD8T cells in synovial fluid of children…
Abstract Number: 87 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA) Risk Gene CCR6 Polymorphism: Drug-Induced “Reversal” of ER Binding and the Expression of Inflammatory Mediators -Potential Molecular Mechanism Links Between Estrogen and RA
Ming-Fen Ho¹, Richard M. Weinshilboum², Liewei Wang², James N. Ingle³ and Tim Bongartz⁴, ¹Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Rochester, Rochester, MN, ²Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, ³Department of Medical Oncology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 SNP rs3093024, is in tight linkage disequilibrium with rs3093023 which has been associated with RA risk. RA…
Abstract Number: 1176 • 2015 ACR/ARHP Annual Meeting
Interleukin-37 Prevents New-Onset Joint Inflammation but Does Not Inhibit Existing Experimental Arthritis
Marije I. Koenders¹, Debbie M. Roeleveld¹, Charles Dinarello², Peter M. van der Kraan¹ and Leo Joosten³, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ³Internal Medicine, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-37 (IL-37) is a recently identified cytokine with potent anti-inflammatory and immunosuppressive functions. This cytokine has been shown to be expressed in synovial tissue…
Abstract Number: 2613 • 2015 ACR/ARHP Annual Meeting
Patient Reported Physical Capacity Correlates with Phenylalanine Serum Levels in Patients with Early Untreated Rheumatoid Arthritis
Aulikki Kononoff¹, Leena Arstila^1,2, Hannu Kautiainen^3,4, Pia Elfving¹, Elina Savolainen⁵, Helena Niinisalo^6,7 and Oili Kaipiainen-Seppanen¹, ¹Department of Medicine, Kuopio University Hospital, Kuopio, Finland, ²Iisalmi Hospital, Iisalmi, Finland, ³Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland, ⁴Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland, ⁵Kuopio Municipal Hospital, Kuopio, Finland, ⁶Suonenjoki Health Center, Suonenjoki, Finland, ⁷Varkaus Hospital, Varkaus, Finland
Background/Purpose: Lipolysis is increased in rheumatoid arthritis (RA), and lipid-induced insulin resistance coincides with anabolic resistance. Ability to maintain skeletal muscle mass is impaired in…

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