Abstracts tagged "Inflammation"

Abstract Number: 1374 • ACR Convergence 2020
Secukinumab in the Treatment of Dactylitis in Patients with Psoriatic Arthritis: Post Hoc Analysis Results from a Randomized Phase 3 Trial
Bruce Kirkham¹, Peter Nash², Sandra Navarra³, Erhard Quebe-Fehling⁴, Corine Gaillez⁴, Carlos Sastre⁴ and Philip Mease⁵, ¹Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, ²School of Medicine Griffith University, Brisbane, Queensland, Australia, ³University of Santo Tomas, Manila, Philippines, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Seattle Rheumatology Associates, P.L.L.C., Seattle, WA
Background/Purpose: Dactylitis is a key and frequent clinical manifestation of psoriatic arthritis (PsA)1 associated with significant disease burden and impaired function.2–3 Randomized controlled trials designed…
Abstract Number: 1697 • ACR Convergence 2020
Immune Related Adverse Events from Checkpoint Inhibitor Therapy: Survey of Hospitalists’ Awareness and Experiences
Cassandra Calabrese¹, Alexa Meara² and Varalakshmi Janamanchi¹, ¹Cleveland Clinic, Cleveland, OH, ²Ohio State University Wexner School of Medicine, Columbus, OH
Background/Purpose: The introduction of immunologic checkpoint inhibitor therapy (ICI) has caused a paradigm shift in the world of cancer treatment. Their use, however, is attended…
Abstract Number: 025 • 2020 Pediatric Rheumatology Symposium
HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile Localized Scleroderma
Christina Schutt¹, Emily Mirizio ², Kaila Schollaert-Fitch ² and Kathryn Torok ², ¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, ²Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by…
Abstract Number: L10 • 2019 ACR/ARP Annual Meeting
Tocilizumab Effects on Coagulation Factor XIII in Patients with Rheumatoid Arthritis
Roberta Gualtierotti¹, Francesca Ingegnoli ², Massimo Boscolo ³, Samantha Griffini ³, Elena Grovetti ⁴ and Massimo Cugno ⁵, ¹Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Lombardia, Italy, ²UOC Reumatologia Clinica, ASST Pini-CTO, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy, ³Medicina Interna, Ospedale Maggiore Policlinico, IRCCS Fondazione Ca' Granda Milano, Italy, Milan, ⁴Medicina Interna, Ospedale Maggiore Policlinico, IRCCS Fondazione Ca' Granda Milano, Milan, ⁵Medicina Interna, Ospedale Maggiore Policlinico, IRCCS Fondazione Ca' Granda Milano, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with a prothrombotic state. Tocilizumab, an interleukin-6 receptor inhibitor, is highly effective in controlling…
Abstract Number: 887 • 2019 ACR/ARP Annual Meeting
Critical Role of the Cholinergic System Involvement in Osteoarthritis
Alice Courties¹, Ariane Do ¹, Sarah Leite ², Audrey Pigenet ², Morgane Belle ³, Geoffroy Nourissat ⁴, Alain Sautet ⁵, Alain Chedotal ³, Uwe Maskos ⁶, Francis Berenbaum ⁷ and Jérémie Sellam ¹, ¹Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ²Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ³Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France, Paris, France, ⁴Chirurgie orthopédique, Clinique Maussins, Groupe Ramsay générale de santé, 67 rue de Romainville, 75019, Paris, Paris, France, ⁵Chirurgie orthopédique, AP-HP Hôpital Saint-Antoine, Paris, Paris, France, ⁶Unité de neurobiologie intégrative des systèmes cholinergiques, CNRS UMR 3571, Institut Pasteur, Paris, Paris, France, ⁷Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France
Background/Purpose: The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred as the 'cholinergic anti-inflammatory pathway'. ACh interacts with members of…
Abstract Number: 979 • 2019 ACR/ARP Annual Meeting
Platelet Derived Growth Factor Receptor Alpha (PDGFRα) Blockade Inhibits Arthritis in Mice
Bhanupriya Madarampalli¹, Paul Panipinto ¹, Erica Chow ¹, Kendahl Sugai ¹, Fanqi Shi ¹ and Erika Noss ¹, ¹University of Washington, Seattle, WA
Background/Purpose: The interplay between infiltrating immune cells and activated joint stromal cells drives inflammation, cartilage destruction, and bone erosion in rheumatoid arthritis (RA). Among joint…
Abstract Number: 1228 • 2019 ACR/ARP Annual Meeting
Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) Ameliorates Monosodium Urate Crystals (MSUC)-induced Inflammation in a Mouse Air-pouch Model of Gout
Vitaly Kliminski ¹ and Yair Molad², ¹Laboratory of Inflammation Research, Felsenstein Medical Research Center, Tel Aviv University, Petach Tikva, Israel, ²Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petach Tikva, HaMerkaz, Israel
Background/Purpose: Myeloid cells membrane-bound TREM-1 (mTREM-1) amplifies toll like receptor (TLR)-4-mediated myeloid cells activation, accompanied by release of soluble TREM-1 (sTREM-1) that acts as a…
Abstract Number: 1521 • 2019 ACR/ARP Annual Meeting
Ixekizumab Is Effective in the Treatment of Radiographic Axial Spondyloarthritis Regardless of the Level of C-Reactive Protein or Magnetic Resonance Imaging Scores
Walter P. Maksymowych¹, Gaia Gallo ², Rebecca Bolce ³, Fangyi Zhao ², Vladimir Geneus ³, Mikkel Østergaard ⁴, Kurisu Tada ⁵, Atul Deodhar ⁶ and Lianne Gensler ⁷, ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²Eli Lilly and Company, Indianapolis, IN, ³Eli Lilly and Company, Indianapolis, ⁴Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁵Juntendo University School of Medicine, Tokyo, Japan, ⁶Oregon Health & Science University, Portland, OR, ⁷University San Francisco California, San Francisco, CA
Background/Purpose: IL-17 plays an important role in the pathogenesis of radiographic axial spondyloarthritis (r-axSpA). Elevated CRP levels in serum predict response to TNF inhibitors (TNFi).1-4…
Abstract Number: 1910 • 2019 ACR/ARP Annual Meeting
Inflammatory Processes in Experimental Spondyloarthritis Are Accompanied by Formation of Ectopic Lymphoid Structures and B Cell Lineage Alterations in the Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg ¹, Jasper Rip ², George Kollias ³, Leonie van Duivenvoorde ¹, Martijn Nolte ⁴, Dominique Baeten ¹ and Sander Tas ¹, ¹Amsterdam Rheumatology & immunology Center, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands, ²Department of Pulmonary Medicine, Erasmus MC, Rotterdam, Rotterdam, Netherlands, ³Division of Immunology, Biomedical Sciences Center ”Alexander Fleming”, Vari, Greece, Vari, Greece, ⁴Sanquin Research and Landsteiner Laboratory, Molecular & Cellular Hemostasis, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Tumour necrosis factor a (TNF) is important in immune-mediated inflammatory diseases such as spondyloarthritis (SpA). Transmembrane (tm)TNF-transgenic (tg) mice that overexpress tmTNF develop typical…
Abstract Number: 1973 • 2019 ACR/ARP Annual Meeting
Protective Effects of Intra-Articular Formulated Liraglutide in Osteoarthritis: Preclinical Studies
Francis Berenbaum¹, Coralie Meurot ², Margot Vieubled ², Laure Sudre ³, carole bougault ⁴, revital rattenbach ², celine martin ² and claire jacques ⁵, ¹Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France, ²4P Pharma, Lille, France, ³Sorbonne Université-Inserm CDR Saint-Antoine, paris, France, ⁴Université de Lyon - CNRS, lyon, France, ⁵Sorbonne Université-Inserm CDR Saint-Antoine, Paris
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease affecting millions of individuals worldwide. Its development has been reported to be associated with cartilage degradation and…
Abstract Number: 1992 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulation Mitigates Mitochondrial Inflammaging, Enhances Mitochondrial Metabolism and Reduces Reactive Oxygen Species-Mediated Mitochondrial Injury In Vitro and In Vivo in Osteoarthritis
Cristina Castro¹, Carmen Corciulo ², Maria Solecio ³, Benjamin Friedman ⁴, Fengxia Liang ⁵, Zhi Li ⁶, Samson Jacob ⁷, David Fenyo ⁸, Evgeny Pavlov ⁹ and Bruce Cronstein ⁴, ¹Immunology and Inflammation Training Program at Skirball Institute of Graduate Biomolecular Sciences, New York University School of Medicine (NYUSoM), NYC, ²Division of Translational Medicine NYUSoM, NYC, ³NYU College of Dentistry, NYC, ⁴Department of Medicine, Division of Rheumatology NYUSoM, NYC, ⁵Department of Cell Biology, NYU Langone Health, NYC, ⁶Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Helalth, NYC, ⁷Institute for Systems Genetics, NYU Langone Health, NYC, ⁸Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYC, ⁹Basic Science and Craniofacial Biology, NYU College of Dentistry, NYC
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population and one of the contributing factors in OA…
Abstract Number: 2154 • 2019 ACR/ARP Annual Meeting
Role of Insulin Resistance and Inflammation on Resting Energy Expenditure in Patients with Rheumatoid Arthritis
Beatriz Hanaoka¹ and Barbara Gower ², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham
Background/Purpose: In patients with rheumatoid arthritis(RA), elevated resting energy expenditure(REE) is associated with rheumatoid cachexia and protein catabolism driven by pro-inflammatory cytokines. IR is also…
Abstract Number: 2355 • 2019 ACR/ARP Annual Meeting
Antirheumatic Therapy Is Associated with Reduced Complement Activation in Rheumatoid Arthritis
Thao Nguyen¹, Ingrid Hokstad ², Gia Deyab ³, Tom Eirik Mollnes ⁴, Stefan Agewall ⁴, Morten Fagerland ⁴, Gro Eilertsen ⁵, Mark Feinberg ⁶, Knut Mikkelsen ², Øystein Førre ⁴ and Ivana Hollan ⁷, ¹Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ²Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Oppland, Norway, ³Innlandet Hospital Trust, Bærum, Akershus, Norway, ⁴Oslo University Hospital, Oslo, Norway, ⁵The Artic University of Norway, Tromsø, Norway, ⁶Harvard Medical School and Brigham and Women´s Hospital, Boston, Boston, MA, ⁷Lillehammer Hospital for Rheumatic Diseases and Brigham and Women’s Hospital, Boston, Lillehammer, Oppland, Norway
Background/Purpose: Inflammation and immune dysregulation appear to significantly contribute to increased risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA). The complement system is a…
Abstract Number: 2779 • 2019 ACR/ARP Annual Meeting
Higher Disease Activity Is Associated with More Spinal Radiographic Progression in Patients with Axial Spondyloarthritis Independently of Prior Exposure to TNF Inhibitors
Alexandre Sepriano¹, Sofia Ramiro ², Stephanie Wichuk ³, Praveena Chiowchanwisawakit ⁴, Terrie MacCosham ³, Joel Paschke ⁵, Désirée van der Heijde ¹, Robert B.M. Landewé ⁶ and Walter Maksymowych ⁷, ¹Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, ³University of Alberta, Edmonton, Canada, ⁴Mahidol University, Bangkok, Thailand, ⁵CARE Arthritis, Edmonton, Canada, ⁶Amsterdam University Medical Center, Amsterdam, Netherlands, ⁷University of Alberta and CARE Arthritis, Edmonton, Canada
Background/Purpose: The association between disease activity and spinal radiographic progression in radiographic axial spondyloarthritis (r-axSpA) has been previously shown in a cohort of patients (pts)…
Abstract Number: 4 • 2019 ACR/ARP Annual Meeting
AMP Deaminase 2 Surface Expression Counteracting CD73-Driven Generation of Anti-Inflammatory Extracellular Adenosine
Lisa Ehlers¹, Aditi Kuppe ¹, Cindy Strehl ¹, Marieluise Kirchner ², Frank Buttgereit ³ and Timo Gaber ¹, ¹Charite University Hospital Berlin, Berlin, Germany, ²Max Delbrück Center for Molecular Medicine, BIH Core Facility Proteomics, Berlin, Germany, ³Charité-Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Adenosine and its nucleotides represent crucial immunomodulators in the extracellular environment. ATP and ADP are released from stressed cells in states of inflammation, whereas…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].