Abstracts tagged "Inflammation"

Abstract Number: 675 • 2016 ACR/ARHP Annual Meeting
Association Between Structural Lesions in the Sacroiliac Joints and Spinal Inflammatory Lesions in Patients with Non-Radiographic Axial Spondyloarthritis
Maxime Dougados¹, Robert G Lambert², Stephanie Wichuk³, Jean-Claude Becker⁴, Jack F Bukowski⁵, Heather Jones⁶, Lisa Marshall⁶, Annette Szumski⁷ and Walter Maksymowych³, ¹Rheumatology, Paris Descartes University, Paris, France, ²Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Becker Clinical Research Consulting, New York, NY, ⁵Clinical Affairs, Pfizer, Collegeville, PA, ⁶Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ⁷inVentiv Health, Princeton, NJ
Background/Purpose: The relevance of structural lesions in non-radiographic axial SpA (nr-axSpA) is unclear, particularly without signs of MRI inflammation. In a post hoc analysis we…
Abstract Number: 2135 • 2016 ACR/ARHP Annual Meeting
Knee Osteoarthritis Pain Is Differentially Associated with Tissue Degradation and Joint Inflammation
Anne C. Bay-Jensen¹, Steven B. Abramson², Jonathan Samuels³, Inger Byrjalsen⁴, Svetlana Krasnokutsky Samuels⁵, Tina Manon-Jensen⁶, Morten Asser Karsdal¹ and Mukundan Attur⁷, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology Research, NYU School of Medicine and NYU Hospital for Joint Diseases, New York, NY, ³Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁴Nordic Bioscience, Clinical Development, Herlev, Denmark, ⁵Svetlana Krasnokutsky, NYU Hospital for Joint Diseases, New York, NY, ⁶Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁷Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Osteoarthritis (OA) is a disease characterized by pain and tissue destruction, in some cases concomitant with inflammation. The link between pain and tissue destruction…
Abstract Number: 3044 • 2016 ACR/ARHP Annual Meeting
Endothelin 1 Induces a Myofibroblastic Phenotype in Vascular Smooth Muscle Cells. A Mechanism Potentially Contributing to Vascular Remodeling and Intimal Hyperplasia in Giant Cell Arteritis
Ester Planas-Rigol¹, Nekane Terrades-Garcia², Marc Corbera-Bellalta², Ester Lozano², Marco Antonio Alba², Georgina Espígol-Frigolé³, Sergio Prieto-González², Marta Segarra², Jose Hernández-Rodríguez², Sara Preciado⁴, Rodolfo Lavilla⁴ and Maria C. Cid², ¹Vasculitis research unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Vasculitis Research Unit, Systemic Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁴Laboratory of Organic Chemistry, Faculty of Pharmacy. Barcelona Science Park, Barcelona, Spain
Background/Purpose: Giant cell arteritis (GCA) is a vascular inflammatory disease involving large and medium sized arteries, particularly the cranial vessels. Inflammation-induced vascular remodeling leads to…
Abstract Number: 746 • 2016 ACR/ARHP Annual Meeting
Discrepancy in Rituximab-Induced B-Cell Depletion in Peripheral Blood and the Kidney and Relationship with Clinical Response in Patients with Lupus Nephritis
Ruth J. Pepper¹, Venkat Reddy², Scott Henderson³ and Maria J. Leandro⁴, ¹UCL Centre for Nephrology, Royal Free Hospital, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ³UCL Centre for Nephrology, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Patients with lupus nephritis (LN) achieve variable clinical response following Rituximab (RTX) based B-cell depletion therapy, with rituximab treatment aiming to decrease the use…
Abstract Number: 2138 • 2016 ACR/ARHP Annual Meeting
Transcriptional Analysis of Synovial Tissue Reveals Sustained Inflammatory Chemokine Expression Despite Minimal Histopathologic Change in the Destabilization of Medial Meniscus Model of Murine Knee Osteoarthritis
Nisha Sambamurthy^1,2, Vu Nguyen^1,2, Jason G. Lieberthal³, George R. Dodge^4,5 and Carla R. Scanzello^1,2,5, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³Internal Medicine, Mount Auburn Hospital, Cambridge, MA, ⁴Research, CMC Veterans Affairs Medical Center, Philadelphia, PA, ⁵Department of Orthopedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: The destabilization of medial meniscus (DMM) model of instability-induced OA replicates disease-related tissue pathology (including cartilage erosion, osteophytosis) and pain-related joint dysfunction, making it…
Abstract Number: 3046 • 2016 ACR/ARHP Annual Meeting
Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome
Sean Eddy¹, Viji Nair¹, Hemang Parikh², Maja Lindenmeyer³, Laura Mariani¹, Felix H. Eichinger¹, Huateng Huang¹, Wenjun Ju², Casey Greene⁴, Peter C. Grayson⁵, Clemens Cohen³, Jeffrey Krischer², Peter A. Merkel⁶ and Matthias Kretzler¹, ¹Division of Nephrology, University of Michigan, Ann Arbor, MI, ²University of South Florida, Tampa, FL, ³University of Munich, Munich, Germany, ⁴Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…
Abstract Number: 889 • 2016 ACR/ARHP Annual Meeting
The Utility of Patient-Reported Outcomes in Predicting Disease Activity in Patients with Takayasu’s Arteritis
Antoine G. Sreih¹, Tanaz A. Kermani², Gunnar Tomasson³, Joshua F. Baker⁴, David Cuthbertson⁵, Renee Borchin⁶, Simon Carette⁷, Lindsy J. Forbess⁸, Gary S. Hoffman⁹, Nader A. Khalidi¹⁰, Curry L. Koening¹¹, Carol A. McAlear¹², Paul A. Monach¹³, Larry W. Moreland¹⁴, Christian Pagnoux¹⁵, Philip Seo¹⁶, Robert F. Spiera¹⁷, Kenneth J. Warrington¹⁸, Steven R. Ytterberg², Carol A. Langford¹⁹ and Peter A. Merkel²⁰, ¹Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Dept of Public Health Sciences, University of Iceland, Reykjavik, IS, ⁴Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁶University of South Florida, Tampa, FL, ⁷Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Rheumatology, Cleveland Clinic, Cleveland, OH, ¹⁰Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ¹¹Rheumatology, University of Utah, Salt Lake City, UT, ¹²University of Pennsylvania, Philadelphia, PA, ¹³Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁴Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁵Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada, ¹⁶Medicine, Johns Hopkins University, Baltimore, MD, ¹⁷Hospital for Special Surgery, Cornell, New York, NY, ¹⁸Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN, ¹⁹Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ²⁰Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA
Background/Purpose: Takayasu’s arteritis (TAK) is a relapsing large vessel vasculitis. There are currently no reliable predictors of disease relapse. This study explored whether changes in…
Abstract Number: 2155 • 2016 ACR/ARHP Annual Meeting
Crosstalk Between IL-6 and TNF-Alpha Signaling Pathway in Rheumatoid Arthritis Synovial Fibroblasts
Alvaro Valin¹, Yolanda Ruano², Manuel J. Del Rey³, Carmen M. García-Herrero³, Eduardo Martín-Guerrero¹, Beatriz Bravo⁴, Juan D. Cañete⁵, José L. Rodríguez-Peralto² and Jose L. Pablos^3,6, ¹Grupo de Enfermedades Inflamatorias y Autoimmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Pathology Department, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Servicio de Traumatología y Cirugía Ortopédica, Hospital 12 de Octubre, Madrid, Spain, ⁵Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁶Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Although elevated IL-6 and its soluble receptor (sIL6R) have been found in the serum and synovium of arthritic patients, the molecular mechanisms by which…
Abstract Number: 892 • 2016 ACR/ARHP Annual Meeting
FDG-PET CT Evaluation By Visual Grading Is Not Sufficiently Discriminative to Assess Disease Activity in Takayasu’s Arteritis Patients with ‘Persistent’ Disease
Ali Ugur Unal¹, Fuat Dede², Tanju Yusuf Erdil², Tunc Ones², Fatma Alibaz-Oner³ and Haner Direskeneli⁴, ¹Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ²Department of Nuclear Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Takayasu arteritis (TAK) is a large-vessel vasculitis in which assessment of disease activity is challenging. Recent studies support that 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed…
Abstract Number: 2164 • 2016 ACR/ARHP Annual Meeting
Depression and the Risk of Psoriatic Arthritis Among Patients with Psoriasis: A Population-Based Cohort Study
Ryan Lewinson^1,2, Isabelle Vallerand^1,3, Mark Lowerison³, Laurie Parsons⁴, Alexandra Frolkis^1,3, Gilaad Kaplan^3,4, Andrew Bulloch^3,5,6, Scott Patten^3,5 and Cheryl Barnabe^3,4, ¹Leaders in Medicine Program, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Biomedical Engineering Program, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ³Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁵Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁶Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Depression and the Risk of Psoriatic Arthritis among Patients with Psoriasis: A Population-based Cohort Study Background/Purpose: The factors that contribute to the development of psoriatic…
Abstract Number: 903 • 2016 ACR/ARHP Annual Meeting
Temporal Arteritis: Is There Any Correlation Between Ultrasonographic Arterial Wall Involvement and the Inflammatory Cellular Infiltrate at Histological Examination?
Giuseppe Germanò¹, Pierluigi Macchioni², Alberto Cavazza³, Niccolò Possemato², Mariagrazia Catanoso⁴, Luca Cimino⁵ and Carlo Salvarani⁶, ¹Unit of Rheumatology, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ²Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁴Rheumatology Service, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁵Ophthalmology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy
Background/Purpose: Ultrasonographic alterations such as the halo sign and the compression test are now accepted as surrogate markers of artery inflammation. No data have yet…
Abstract Number: 2174 • 2016 ACR/ARHP Annual Meeting
Effect of Anti-Rheumatic Treatment on Selenium Levels in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Gia Deyab¹, Ingrid Hokstad², Milada Cvancarova Småstuen³, Stefan Agewall⁴, Jon Elling Whist⁵ and Ivana Hollan^5,6,7,8, ¹Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, ²Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, ³Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, ⁴University of Oslo, Oslo, Norway, ⁵Innlandet Hospital Trust, Lillehammer, Norway, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷Harvard Medical School, Boston, MA, ⁸Lillehammer Hospital for Rheumatic Diseases, Lillahammer, Norway
Background/Purpose: The cause of the increased cardiovascular risk in inflammatory rheumatic diseases (IRDs) is still unclear. Intriguingly, selenium-deficiency, which might be caused by poor diet or…
Abstract Number: 9 • 2016 ACR/ARHP Annual Meeting
Effects of Alcohol Consumption on the Severity of Inflammation in Hand and Foot Joints Detected with MR Imaging
L. Mangnus¹, M. Reijnierse² and A.H.M. van der Helm- van Mil³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Moderate alcohol consumption is associated with a lower risk on RA development. (1,2) It is also associated with less severe systemic inflammation. Based on these…
Abstract Number: 1124 • 2016 ACR/ARHP Annual Meeting
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…
Abstract Number: 2257 • 2016 ACR/ARHP Annual Meeting
Regulation of Mitochondrial Proton Gradient Is Critical for NLRP3 Inflammasome Activation
Jehad H. Edwan, Raphaela Goldbach-Mansky and Robert A. Colbert, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].