Abstracts tagged "Inflammation"

Abstract Number: 189 • 2016 ACR/ARHP Annual Meeting
Nutraceutical Therapy with Polyphenol-Rich Pomegranate Fruit Extract (POMx) Inhibits Systemic NFκB-Mediated Inflammation in a Murine Model of Endotoxemia
Nicholas A. Young¹, Misha Mobeen², Tariq M Haqqi³ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ⁴Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Background/Purpose: The pomegranate fruit is cultivated worldwide for dietary consumption, but has been used therapeutically in Eastern medicine from times dating back to ancient Egypt…
Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting
Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor
John Barnett¹, Lisa Robinson², Jonathan Soboloff³, Rosana Schafer⁴, Ida Holaskova⁵, Meenal Elliott¹, Michelle Witt², Raphael Hirsch⁶ and Harry Blair⁷, ¹Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, ²Pathology, West Virginia University, Morgantown, WV, ³Dept of Medical Genetics and Molecular Biochemistry, Temple University, Philadelphia, PA, ⁴Dept Micro, Immun & Cell Biol, West Virginia University, Morgantown, WV, ⁵West Virginia University, Morgantown, WV, ⁶Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…
Abstract Number: 2343 • 2016 ACR/ARHP Annual Meeting
A Phase 2, Multi-Center, Randomized, Double-Blind, Active-Controlled, Parallel Group Study to Evaluate the Safety and Dose Effectiveness of Intradermal Injections of Purified Apis Mellifera Toxin to Improve Pain and Physical Function in Patients with Osteoarthritis of the Knee
Douglas R. Schumacher¹, Anna Jakubowska² and Christopher M.H. Kim³, ¹Radiant Research, Columbus, OH, ²Apimeds, Inc., Jungwongu, Seongnam, Gyeonggido, Korea, The Republic of, ³CHA University, Bundanggu, Seongnam, Gyeongghido, Korea, The Republic of
Background/Purpose: This Phase 2a/b trial evaluated the safety and dose effectiveness of honeybee toxin (purified Apis melliferatoxin) injections to improve pain and physical function in…
Abstract Number: 271 • 2016 ACR/ARHP Annual Meeting
Impaired Satellite Cell Activation and Myofiber Transition during Skeletal Muscle Regeneration in Patients with Polymyositis and Dermatomyositis
Beatriz Hanaoka¹, Prabhakara R. Nagareddy², Marilyn Campbell³, Leslie J. Crofford⁴, Charlotte A. Peterson⁵, Lisa G. Rider⁶ and Frederick W. Miller⁷, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Nutritional Sciences, University of Alabama at Birmingham, Birmingham, AL, ³University of Kentucky, Lexington, KY, ⁴Medicine, Vanderbilt University Medical Center, Nasville, TN, ⁵College of Health Sciences, University of Kentucky, Lexington, KY, ⁶Rheumatology, George Washington University, Washington, DC, ⁷Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Satellite cells are myogenic stem cells that are essential for myofiber repair, growth and homeostasis in postnatal life. A decline in satellite cell performance…
Abstract Number: 1471 • 2016 ACR/ARHP Annual Meeting
Myocardial 18f-Fluorodeoxyglucose (18F-FDG) Uptake in RA Patients without Clinical Cardiovascular Disease Is Higher Than in Controls and Decreases with Treatment
Isabelle Amigues¹, Jon T. Giles², Afshin Zartoshti³, Rachelle Morgenstern⁴, Raul Flores⁵, Sabahat Bokhari⁶ and Joan Bathon⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁴Cardiology, columbia university college of physicians and surgeons, New York city, NY, ⁵Medicine, Columbia University, New York Presbyterian, New York city, NY, ⁶Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Symptomatic heart failure (HF) and HF-associated mortality rates are higher in RA compared with the non-RA population, even after controlling for coronary artery…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
Abstract Number: 288 • 2016 ACR/ARHP Annual Meeting
Glucose Homeostasis Influences the Risk of Incident Knee Osteoarthritis
Jeffrey Driban¹, Charles B. Eaton², Mamta Amin³, Alina Stout⁴, Lori Lyn Price⁵, Bing Lu⁶, Grace H. Lo⁷, Timothy E. McAlindon⁸ and Mary Barbe⁹, ¹Tufts Medical Center, Boston, MA, ²Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ³Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Clinical Care Research, Tufts Medical Center, Boston, MA, ⁶Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁷Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Knee osteoarthritis (KOA), particularly accelerated KOA, is associated with older age and being overweight. Greater age and weight are associated with impaired glucose homeostasis…
Abstract Number: 1528 • 2016 ACR/ARHP Annual Meeting
Incretin Axis in Non Diabetic Rheumatoid Arthritis Patients
Beatriz Tejera¹, De Vera-González AM², Alejandra González Delgado³, Raquel López-Mejías⁴, Begoña Ubilla⁴, Fernanda Genre⁴, Jose M Olmos⁵, José L Hernández⁶, Miguel Angel Gonzalez-Gay⁴ and Ivan Ferraz-Amaro⁷, ¹Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, ²Central Laboratory Division, University Hospital of Canary Islands, Tenerife, Spain, ³Central Laboratory Division. Hospital Universitario de Canarias, Tenerife, Spain., Tenerife, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁵Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL.Universidad de Cantabria. RETICEF, Santander, Spain, ⁶Division of Internal Medicine. Hospital Universitario Marqués de Valdecilla, IDIVAL. Universidad de Cantabria. RETICEF, Santander, Spain, ⁷Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain
Background/Purpose: Cross-sectional study that encompassed 361 non-diabetes individuals; 151 patients with RA and 210 age- and sex-matched controls. IR by homeostatic model assessment (HOMA2), insulin,…
Abstract Number: 2489 • 2016 ACR/ARHP Annual Meeting
Joint Damage Appears As Severe As Inflammation According to Physician Visual Analog Scales in Patients with Rheumatoid Arthritis Regardless of Disease Severity at 2 Sites, Which May Limit Results of a Treat-to-Target Strategy
Theodore Pincus¹, Isabel Castrejón¹, Kathryn Gibson² and Joel Block³, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Liverpool Hospital and University of New South Wales, Liverpool, Australia, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of global status (DOCGL) on a 0-10 visual analog scale (VAS) was developed initially to assess inflammation in patients with rheumatoid…
Abstract Number: 289 • 2016 ACR/ARHP Annual Meeting
Metabolic and Inflammatory Links to Development of Rotator Cuff Tear in Hand Osteoarthritis
Young Sun Suh¹, Hyun-Ok Kim¹, Yun-Hong Cheon², Ki-Soo Park³, Rock-Bum Kim³, Hye Song Lim⁴, Hae Sook Noh⁴, Jae-Bum Na⁵, Hyung Bin Park⁶ and Sang-Il Lee⁷, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ³Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁴Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁵Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁶Department of Orthopedic Surgery, Gyeongsang National University School of Medicine, jinju, Korea, The Republic of, ⁷Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose: Rotator cuff tear (RCT) and hand osteroarthritis (HOA) are commonly accompanied because they share a similar pathogenesis. However, there was no previous study investigating…
Abstract Number: 1745 • 2016 ACR/ARHP Annual Meeting
Disturbance of Renal Circadian Rhythm in Lupus Nephritis
Rakesh Mishra¹, Ramalingam Bethunaickan², Weijia Zhang³ and Anne Davidson⁴, ¹Feinstein Institute, Manhasset, NY, ²Autoimmune and musculosketal diseases, Feinstein Institute for Medical Research, Manhasset, NY, ³Nephrology, Mount Sinai School of Medicine, New York, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Circadian rhythm is a universal phenomenon that allows organisms to anticipate and respond to changes in their environment by regulating sleep and feeding patterns,…
Abstract Number: 2599 • 2016 ACR/ARHP Annual Meeting
TCZ Improves the Pro-Atherothrombotic Profile of Rheumatoid Arthritis Patients Modulating Endothelial Dysfunction, Netosis and Inflammation
Patricia Ruiz-Limon¹, Rafaela Ortega-Castro², IVÁN ARIAS DE LA ROSA², Carlos Perez-Sanchez², Yolanda Jiménez-Gómez², Maria Carmen Abalos-Aguilera¹, Pilar Font-Ugalde², Eduardo Collantes-Estévez², Alejandro Escudero-Contreras², Chary Lopez-Pedrera² and Nuria Barbarroja², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Inhibition of the interleukin IL-6 receptor pathway by tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA). TCZ reduces atherosclerosis markers and improves endothelial function.…
Abstract Number: 294 • 2016 ACR/ARHP Annual Meeting
Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients with Medial Knee Osteoarthritis
Charles Oshinsky¹, Mukundan Attur², Sisi Ma³, Hua Zhou³, Fangfei Zheng¹, Meng Chen⁴, Jyoti Patel², Jonathan Samuels⁵, Virginia Pike⁶, Ravinder Regatte⁷, Jenny Bencardino⁸, Leon Rybak⁹, Steven B. Abramson¹⁰, Michael H. Pillinger¹¹ and Svetlana Krasnokutsky Samuels¹², ¹Medicine/Rheumatology, NYU School of Medicine, NEW YORK, NY, ²Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ³Bioinformatics, New York University, New York, NY, ⁴NYU School of Medicine, NEW YORK, NY, ⁵Division of Rheumatology, Department of Medicine, NYU Langone Medical Center, New York, NY, ⁶Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁷NYU Department of Radiology, NEW YORK, NY, ⁸Radiology, NYU Langone Medical Center, New York, NY, ⁹Department of Radiology, NYU Langone Medical Center, New York, NY, ¹⁰Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, ¹¹NYU School of Medicine, New York, NY, ¹²NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Osteoarthritis (OA) etiopathogenesis includes an inflammatory component. Published reports indicate that synovial fluid urate levels, even in patients without gout, associate with OA prevalence/severity.…
Abstract Number: 1756 • 2016 ACR/ARHP Annual Meeting
Novel Role of Rho Kinase in Neutrophil Netosis during UVB Induced-Skin Inflammation
Ming-Lin Liu^1,2, Meena Sharma^2,3 and Victoria P. Werth^4,5, ¹Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, ²Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, ⁴Dermatology, University of Pennsylvania, Philadelphia, PA, ⁵Philadelphia V.A. Medical Center, Philidelphia, PA
Background/Purpose: Skin inflammation appears in cutaneous or systemic lupus erythematosus. Ultraviolet B (UVB) is an important environmental trigger of skin inflammation in lupus. Mechanisms linking…
Abstract Number: 2633 • 2016 ACR/ARHP Annual Meeting
Effect of Different Biologic Agents on Lipid Profile in Rheumatoid Arthritis
Fabio Cacciapaglia¹, Simone Perniola¹, Mariangela Nivuori¹, Margherita Giannini¹, Olga Magazzino¹, Maria Giannotta¹, Florenzo Iannone² and Giovanni Lapadula¹, ¹Interdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, General Hospital, Bari, Italy, ²Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, General Hospital, Bari, Italy
Background/Purpose: o examine any change between different biologic agents on lipid profile of RA patients. Methods: Patients affected by RA, according to the 2010 EULAR/ACR…

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