Abstracts tagged "Inflammation"

Abstract Number: 9 • 2016 ACR/ARHP Annual Meeting
Effects of Alcohol Consumption on the Severity of Inflammation in Hand and Foot Joints Detected with MR Imaging
L. Mangnus¹, M. Reijnierse² and A.H.M. van der Helm- van Mil³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Moderate alcohol consumption is associated with a lower risk on RA development. (1,2) It is also associated with less severe systemic inflammation. Based on these…
Abstract Number: 1124 • 2016 ACR/ARHP Annual Meeting
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…
Abstract Number: 2257 • 2016 ACR/ARHP Annual Meeting
Regulation of Mitochondrial Proton Gradient Is Critical for NLRP3 Inflammasome Activation
Jehad H. Edwan, Raphaela Goldbach-Mansky and Robert A. Colbert, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…
Abstract Number: 159 • 2016 ACR/ARHP Annual Meeting
Assessing Agreement Among Measures of Inflammation Detected on Magnetic Resonance Imaging, Ultrasound and Clinical Findings in the Feet of Patients with Early Rheumatoid Arthritis
Karen A. Beattie¹, George Ioannidis², Sydney Scheffler³, Saara Totterman⁴, Edward Schreyer⁵ and Maggie Larche¹, ¹Medicine, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Radiology, VirtualScopics Inc., Rochester, NY, ⁵QMetrics Technologies, Rochester, NY
Background/Purpose: In metatarsalphalangeal (MTP) joints 2-5 of patients with early rheumatoid arthritis (RA), we aimed to assess the agreement between i) Magnetic Resonance Imaging (MRI)…
Abstract Number: 1125 • 2016 ACR/ARHP Annual Meeting
Targeted Lipidomics Reveals Incomplete Activation of Resolution Pathways in Knee Osteoarthritis
Hulda Jonasdottir¹, Hilde Brouwers², Mukundan Attur³, Joanneke Kwekkeboom², Jonathan Samuels³, Eric Strauss⁴, Enrike van der Linden-van der Zwaag⁵, TWJ Huizinga⁶, M. Kloppenburg⁷, REM Toes⁸, Martin Giera⁹, Steven B. Abramson³ and Andreea Ioan-Facsinay², ¹Center for Proteomics and Metabolomics, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁴Department of Orthopedic Surgery, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁵Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Centre, Leiden, Netherlands, ⁷Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Persistent inflammation is a characteristic of several joint diseases, including OA. It is nowadays appreciated that this could be a result of a failure…
Abstract Number: 2263 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA)
Giuliana Ascone¹, Irene Di Ceglie¹, Wouter de Munter¹, Birgitte Walgreen², Annet Sloetjes¹, Peter M. van der Kraan¹, Ernst Lindhout³, Mike Martens³ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental, Radboud university medical center, Nijmegen, Netherlands, ³Future Diagnostics Solutions (FDs), Wijchen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease largely driven by immune complexes and their interaction with FcγRs present on macrophages within the synovium.…
Abstract Number: 167 • 2016 ACR/ARHP Annual Meeting
Bone Mineral Density Loss in Clinically Suspect Arthralgia Is Associated with Subclinical Inflammation and Progression to Clinical Arthritis
L. Mangnus¹, H.W. van Steenbergen², M. Reijnierse³, J. Kälvesten^4,5,6 and A.H.M. van der Helm-van Mil², ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Radiology, Faculty of Health Sciences, Linköping, Sweden, ⁵Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, ⁶Sectra AB, Linköping, Sweden
Background/Purpose: Peripheral bone mineral density (BMD) can be decreased in early rheumatoid arthritis but it is unknown if BMD loss emerges already before arthritis is…
Abstract Number: 1434 • 2016 ACR/ARHP Annual Meeting
Effect of Systemic and Local Inflammation on the Insulin Resistance and Glucose/Lipid Metabolism in Rheumatoid Arthritis: Humans and CIA Mouse Model
Nuria Barbarroja¹, IVÁN ARIAS DE LA ROSA¹, Manuel Peña¹, Sergio Rodriguez-Cuenca², Yolanda Jiménez-Gómez¹, Patricia Ruiz-Limon³, Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera³, Jerusalem Calvo-Gutierrez¹, Eduardo Collantes-Estévez¹, Antonio Vidal-Puig², Chary Lopez-Pedrera¹ and Alejandro Escudero-Contreras¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…
Abstract Number: 2264 • 2016 ACR/ARHP Annual Meeting
Lack of Obesity-Related Changes in Adipocytes and Inflammatory Cells in the Infrapatellar Fat Pad (IFP): A Different Type of Fat?
Anja de Jong¹, I.R. klein-Wieringa¹, Stefan Andersen², Joanneke Kwekkeboom¹, Linda van Toorn¹, Badelog de Lange¹, Danny van Delft³, John Garcia⁴, Wu Wei⁵, Huub van der Heide³, Yvonne Bastiaansen-Jenniskens⁴, Gerjo van Osch⁴, Anne-Marie Zuurmond⁶, Vedrana Stojanovic-Susulic⁷, Rob Nelissen³, René Toes¹, Margreet Kloppenburg¹ and Andreea Ioan-Facsinay¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Charles River Nederland B.V., Leiden, Netherlands, ³Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Orthopaedics, Erasmus MC, Rotterdam, Netherlands, ⁵Orthopaedics, Erasmus MC, rotterdam, Netherlands, ⁶TNO, Leiden, Netherlands, ⁷Janssen, Pharmaceutical Companies Johnson & Johnson, Springhouse, PA
Background/Purpose: Obesity is associated with the development and progression of osteoarthritis (OA). Although the mechanisms involved in this association are poorly understood, it is well…
Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting
Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages
Pascal Rottenberg^1,2, Manuel Fréret^1,2, Sébastien Calbo¹ and Olivier Vittecoq^1,2, ¹INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, ²Rheumatology, Rouen University Hospital, Rouen, France
Background/Purpose: Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
Abstract Number: 1441 • 2016 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Knockout Attenuates Arthritis Progression and Systemic Inflammation in TNF-Tg Arthritis Mouse Models
Yahui Grace Chiu¹, Richard Bell², Dongge Li³, Edward Schwarz⁴ and Christopher T. Ritchlin⁵, ¹Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Orthopedeatrics, University of Rochester, Rochester, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Tumor necrosis factor-transgenic (TNF-Tg) mice develop systemic inflammatory polyarthritis. DC-STAMP, a multi-pass transmembrane protein, was originally identified from a dendritic cell library and required…
Abstract Number: 2288 • 2016 ACR/ARHP Annual Meeting
Inflammatory Status and Serum Uric Acid Determine High-Density Lipoprotein Cholesterol Levels in a Non-Rheumatic Population
Mariano Andrés¹, María Amparo Quintanilla², Eliseo Pascual³, Pedro Morillas² and FAPRES study group, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Servicio de Cardiología, Hospital General Universitario de Elche, Elche, Spain, ³Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: In inflammatory disorders, highest incidence of cardiovascular (CV) events paradoxically occurs at lower lipid levels [ARD.70:482], especially for high-density lipoprotein cholesterol (HDLc). Current data…
Abstract Number: 189 • 2016 ACR/ARHP Annual Meeting
Nutraceutical Therapy with Polyphenol-Rich Pomegranate Fruit Extract (POMx) Inhibits Systemic NFκB-Mediated Inflammation in a Murine Model of Endotoxemia
Nicholas A. Young¹, Misha Mobeen², Tariq M Haqqi³ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ⁴Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Background/Purpose: The pomegranate fruit is cultivated worldwide for dietary consumption, but has been used therapeutically in Eastern medicine from times dating back to ancient Egypt…
Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting
Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor
John Barnett¹, Lisa Robinson², Jonathan Soboloff³, Rosana Schafer⁴, Ida Holaskova⁵, Meenal Elliott¹, Michelle Witt², Raphael Hirsch⁶ and Harry Blair⁷, ¹Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, ²Pathology, West Virginia University, Morgantown, WV, ³Dept of Medical Genetics and Molecular Biochemistry, Temple University, Philadelphia, PA, ⁴Dept Micro, Immun & Cell Biol, West Virginia University, Morgantown, WV, ⁵West Virginia University, Morgantown, WV, ⁶Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…
Abstract Number: 2343 • 2016 ACR/ARHP Annual Meeting
A Phase 2, Multi-Center, Randomized, Double-Blind, Active-Controlled, Parallel Group Study to Evaluate the Safety and Dose Effectiveness of Intradermal Injections of Purified Apis Mellifera Toxin to Improve Pain and Physical Function in Patients with Osteoarthritis of the Knee
Douglas R. Schumacher¹, Anna Jakubowska² and Christopher M.H. Kim³, ¹Radiant Research, Columbus, OH, ²Apimeds, Inc., Jungwongu, Seongnam, Gyeonggido, Korea, The Republic of, ³CHA University, Bundanggu, Seongnam, Gyeongghido, Korea, The Republic of
Background/Purpose: This Phase 2a/b trial evaluated the safety and dose effectiveness of honeybee toxin (purified Apis melliferatoxin) injections to improve pain and physical function in…

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