Abstracts tagged "Inflammation"

Abstract Number: 82 • 2017 ACR/ARHP Annual Meeting
CKD-506, a Novel Inhibitor of Histone Deacetylase 6 (HDAC6) Has a Therapeutic Potential in Rheumatoid Arthritis and Inflammatory Bowel Disease
Jieun Shin¹, Nina Ha¹, Daekwon Bae¹, Dong-Hyeon Suh¹, Yu Jin Jang², Sehui Shon³, Ji-yeon Baek¹, Jae Hyun Jun¹, Yong Jae Lee¹, Changsik Lee¹, Sei-Hwan Kim¹, Hosung Yu¹, Young Il Choi¹, Keun Ho Ryu¹, Soung-Min Lee⁴, Yeong Wook Song², Su K Seo⁴ and Seong Kon Kim¹, ¹Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), ³Department of Molecular Medicine and Biopharmaceutical Sciences, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), ⁴Department of Microbiology and Immunology, Inje University College of Medicine, Busan, Korea, Republic of (South)
Background/Purpose: Autoimmune disease such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) is a chronic inflammatory disorder, significantly limiting quality of life. Even though…
Abstract Number: 1101 • 2017 ACR/ARHP Annual Meeting
Systematic Physician Assessment Beyond Inflammation in Routine Rheumatology Care Using Visual Analog Scale Scores for Inflammation, Damage, and Distress to Document Patient Status and Support Clinical Decisions: Analysis of Inter-Rater Reliability
Shakeel M. Jamal¹, Theodore Pincus², Isabel Castrejón², Jacquelin R. Chua¹, Aman Kugasia¹, Juan Schmukler¹, Stacy Weinberg¹ and Joel A. Block³, ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush University Medical Center, Chicago, IL
Background/Purpose: A physician global estimate of patient status (DOCGL) on a 0-10 visual analog scales (VAS) is as effective as any rheumatoid arthritis (RA) Core…
Abstract Number: 1928 • 2017 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cell Production of ED-a Fibronectin Contributes to Inflammation in Osteoarthritis
Tue Wenzel Kragstrup^1,2,3, Dong Hyun Sohn⁴, Christin Lepus³, Kazuhiro Onuma⁵, Qian Wang³, William H. Robinson³ and Jeremy Sokolove³, ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁴Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea, Republic of (South), ⁵VA Palo Alto Healthcare System and Stanford University, Stanford, CA
Background/Purpose: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation followed by…
Abstract Number: 33 • 2017 Pediatric Rheumatology Symposium
An extracellular ionic milieu renders human granulocytic S100A12 into a pro-inflammatory TLR4-binding alarmin
Christoph Kessel¹, Sabrina Fuehner¹, Bastian Zimmermann², Dirk Holzinger¹, Helmut Wittkowski¹, Claas Hinze¹ and Dirk Foell¹, ¹Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ²Biaffin GmbH & Co KG, Kassel, Germany
Background/Purpose: Granulocytic S100A12 is a member of the calgranulin-subgroup within the S100 family of calcium-binding proteins. Similar to other S100 proteins S100A12 can bind divalent…
Abstract Number: 131 • 2017 Pediatric Rheumatology Symposium
Balancing JAK/STAT-signaling with tofacitinib may foster anti-inflammatory functions of human monocytes
Friederike Cordes¹, Eva Lenker², Toni Weinhage², Georg Varga² and Dirk Foell³, ¹Gastroenterology, Internal Medicine, University of Muenster, Muenster, Germany, ²Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ³Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany
Background/Purpose: Monocytes are bridging natural and acquired immunity. Information about JAK signaling in monocytes is scarce especially in an inflammatory milieu. JAK-inhibition is a promising…
Abstract Number: 146 • 2017 Pediatric Rheumatology Symposium
Age-Related Differences in Neuronal High Mobility Group Box-1 and Resolvin D1 Receptors in Collagen-Induced Arthritis
Tracy Wilson-Gerwing and Alan Rosenberg, Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: More thorough understanding of age-related molecular interactions that drive inflammation and inflammatory pain is required to help guide evidenced-based, age appropriate treatment strategies that…
Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting
Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages
Pascal Rottenberg^1,2, Manuel Fréret^1,2, Sébastien Calbo¹ and Olivier Vittecoq^1,2, ¹INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, ²Rheumatology, Rouen University Hospital, Rouen, France
Background/Purpose: Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
Abstract Number: 1441 • 2016 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Knockout Attenuates Arthritis Progression and Systemic Inflammation in TNF-Tg Arthritis Mouse Models
Yahui Grace Chiu¹, Richard Bell², Dongge Li³, Edward Schwarz⁴ and Christopher T. Ritchlin⁵, ¹Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Orthopedeatrics, University of Rochester, Rochester, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Tumor necrosis factor-transgenic (TNF-Tg) mice develop systemic inflammatory polyarthritis. DC-STAMP, a multi-pass transmembrane protein, was originally identified from a dendritic cell library and required…
Abstract Number: 2288 • 2016 ACR/ARHP Annual Meeting
Inflammatory Status and Serum Uric Acid Determine High-Density Lipoprotein Cholesterol Levels in a Non-Rheumatic Population
Mariano Andrés¹, María Amparo Quintanilla², Eliseo Pascual³, Pedro Morillas² and FAPRES study group, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Servicio de Cardiología, Hospital General Universitario de Elche, Elche, Spain, ³Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: In inflammatory disorders, highest incidence of cardiovascular (CV) events paradoxically occurs at lower lipid levels [ARD.70:482], especially for high-density lipoprotein cholesterol (HDLc). Current data…
Abstract Number: 189 • 2016 ACR/ARHP Annual Meeting
Nutraceutical Therapy with Polyphenol-Rich Pomegranate Fruit Extract (POMx) Inhibits Systemic NFκB-Mediated Inflammation in a Murine Model of Endotoxemia
Nicholas A. Young¹, Misha Mobeen², Tariq M Haqqi³ and Wael N. Jarjour⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ⁴Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Background/Purpose: The pomegranate fruit is cultivated worldwide for dietary consumption, but has been used therapeutically in Eastern medicine from times dating back to ancient Egypt…
Abstract Number: 1442 • 2016 ACR/ARHP Annual Meeting
Suppression of Acute Arthritis By N-Methyl-3,4-Dichloropropionaniline (N-MeDCPA), a Reversible Orai Calcium Channel Inhibitor
John Barnett¹, Lisa Robinson², Jonathan Soboloff³, Rosana Schafer⁴, Ida Holaskova⁵, Meenal Elliott¹, Michelle Witt², Raphael Hirsch⁶ and Harry Blair⁷, ¹Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, ²Pathology, West Virginia University, Morgantown, WV, ³Dept of Medical Genetics and Molecular Biochemistry, Temple University, Philadelphia, PA, ⁴Dept Micro, Immun & Cell Biol, West Virginia University, Morgantown, WV, ⁵West Virginia University, Morgantown, WV, ⁶Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ⁷pathology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Bone maintenance is a balance between the removal of old bone by osteoclasts (OCL) and the production of new bone by osteoblasts. In the…
Abstract Number: 2343 • 2016 ACR/ARHP Annual Meeting
A Phase 2, Multi-Center, Randomized, Double-Blind, Active-Controlled, Parallel Group Study to Evaluate the Safety and Dose Effectiveness of Intradermal Injections of Purified Apis Mellifera Toxin to Improve Pain and Physical Function in Patients with Osteoarthritis of the Knee
Douglas R. Schumacher¹, Anna Jakubowska² and Christopher M.H. Kim³, ¹Radiant Research, Columbus, OH, ²Apimeds, Inc., Jungwongu, Seongnam, Gyeonggido, Korea, The Republic of, ³CHA University, Bundanggu, Seongnam, Gyeongghido, Korea, The Republic of
Background/Purpose: This Phase 2a/b trial evaluated the safety and dose effectiveness of honeybee toxin (purified Apis melliferatoxin) injections to improve pain and physical function in…
Abstract Number: 271 • 2016 ACR/ARHP Annual Meeting
Impaired Satellite Cell Activation and Myofiber Transition during Skeletal Muscle Regeneration in Patients with Polymyositis and Dermatomyositis
Beatriz Hanaoka¹, Prabhakara R. Nagareddy², Marilyn Campbell³, Leslie J. Crofford⁴, Charlotte A. Peterson⁵, Lisa G. Rider⁶ and Frederick W. Miller⁷, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Nutritional Sciences, University of Alabama at Birmingham, Birmingham, AL, ³University of Kentucky, Lexington, KY, ⁴Medicine, Vanderbilt University Medical Center, Nasville, TN, ⁵College of Health Sciences, University of Kentucky, Lexington, KY, ⁶Rheumatology, George Washington University, Washington, DC, ⁷Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Satellite cells are myogenic stem cells that are essential for myofiber repair, growth and homeostasis in postnatal life. A decline in satellite cell performance…
Abstract Number: 1471 • 2016 ACR/ARHP Annual Meeting
Myocardial 18f-Fluorodeoxyglucose (18F-FDG) Uptake in RA Patients without Clinical Cardiovascular Disease Is Higher Than in Controls and Decreases with Treatment
Isabelle Amigues¹, Jon T. Giles², Afshin Zartoshti³, Rachelle Morgenstern⁴, Raul Flores⁵, Sabahat Bokhari⁶ and Joan Bathon⁷, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁴Cardiology, columbia university college of physicians and surgeons, New York city, NY, ⁵Medicine, Columbia University, New York Presbyterian, New York city, NY, ⁶Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Symptomatic heart failure (HF) and HF-associated mortality rates are higher in RA compared with the non-RA population, even after controlling for coronary artery…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…

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