Abstracts tagged "Inflammation"

Abstract Number: 1583 • 2017 ACR/ARHP Annual Meeting
Increase in Arginase Activity and Related Arginine Metabolites in Patients with Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA): Potential Mechanisms for Endothelial Dysfunction
M. Elaine Husni¹, Vandana Rai², Marcia Leon Rabanal³ and Unnikrishnan Chandrasekharan⁴, ¹Cleveland Clinic, Cleveland, OH, ²Cellular and Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH, ³Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ⁴Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH
Background/Purpose: A high prevalence of CVD exists among patients with PsA and RA. The cardiovascular morbidity and mortality are hypothesized to be due in part…
Abstract Number: 864 • 2017 ACR/ARHP Annual Meeting
IL-9-Producing Innate Lymphoid Cells – Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis
Simon Rauber¹, Markus Luber¹, Stefanie Weber¹, Lisa Maul², Alina Soare³, Thomas Wohlfahrt¹, Aline Bozec⁴, Martin Herrmann⁵, Mario Zaiss², Ursula Fearon⁶, Douglas J. Veale⁷, Juan Canete⁸, Oliver Distler⁹, Felice Rivellese¹⁰, Costantino Pitzalis¹⁰, Georg Schett¹¹, Jörg Distler³ and Andreas Ramming¹², ¹Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ⁵Medicine III, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Osterreich, Germany, ⁶Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland, ⁷Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ⁸Rheumatology, Hospital Clínic and IDIBAPS, Barcelona, Spain, ⁹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁰Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹¹Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ¹²Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Transition from acute to chronic inflammation is a key step in the pathogenesis of inflammatory disease but incompletely characterized to date. Similar to the…
Abstract Number: 1666 • 2017 ACR/ARHP Annual Meeting
Anti-Mitochondrial Autoantibodies in Systemic Lupus Erythematosus and Their Association with Disease Manifestations
Yann Becker¹, Renee Claude Loignon¹, Genevieve Marcoux¹, Anne-Sophie Julien², Imene Melki¹, Lihi Eder³, Eric Wagner¹, Martin Pelletier¹, Marie-Josee Hebert⁴, Clemence Belleannee¹, Joyce Rauch⁵, Melanie Dieude⁴, Paul R. Fortin⁶ and Eric Boilard¹, ¹CHU de Quebec and Universite Laval, Quebec City, QC, Canada, ²CHU de Quebec - Universite Laval, Quebec City, QC, Canada, ³Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, ⁴CHUM and Universite de Montreal, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Medicine, CHU de Quebec - Universite de Laval, Quebec, QC, Canada
- Background/Purpose: Eukaryotic cells contain organelles called mitochondria that govern energy supply and control of cell death. Whereas damaged organs or activated cells can extrude…
Abstract Number: 146 • 2017 Pediatric Rheumatology Symposium
Age-Related Differences in Neuronal High Mobility Group Box-1 and Resolvin D1 Receptors in Collagen-Induced Arthritis
Tracy Wilson-Gerwing and Alan Rosenberg, Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: More thorough understanding of age-related molecular interactions that drive inflammation and inflammatory pain is required to help guide evidenced-based, age appropriate treatment strategies that…
Abstract Number: 33 • 2017 Pediatric Rheumatology Symposium
An extracellular ionic milieu renders human granulocytic S100A12 into a pro-inflammatory TLR4-binding alarmin
Christoph Kessel¹, Sabrina Fuehner¹, Bastian Zimmermann², Dirk Holzinger¹, Helmut Wittkowski¹, Claas Hinze¹ and Dirk Foell¹, ¹Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ²Biaffin GmbH & Co KG, Kassel, Germany
Background/Purpose: Granulocytic S100A12 is a member of the calgranulin-subgroup within the S100 family of calcium-binding proteins. Similar to other S100 proteins S100A12 can bind divalent…
Abstract Number: 131 • 2017 Pediatric Rheumatology Symposium
Balancing JAK/STAT-signaling with tofacitinib may foster anti-inflammatory functions of human monocytes
Friederike Cordes¹, Eva Lenker², Toni Weinhage², Georg Varga² and Dirk Foell³, ¹Gastroenterology, Internal Medicine, University of Muenster, Muenster, Germany, ²Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ³Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany
Background/Purpose: Monocytes are bridging natural and acquired immunity. Information about JAK signaling in monocytes is scarce especially in an inflammatory milieu. JAK-inhibition is a promising…
Abstract Number: 903 • 2016 ACR/ARHP Annual Meeting
Temporal Arteritis: Is There Any Correlation Between Ultrasonographic Arterial Wall Involvement and the Inflammatory Cellular Infiltrate at Histological Examination?
Giuseppe Germanò¹, Pierluigi Macchioni², Alberto Cavazza³, Niccolò Possemato², Mariagrazia Catanoso⁴, Luca Cimino⁵ and Carlo Salvarani⁶, ¹Unit of Rheumatology, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ²Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁴Rheumatology Service, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁵Ophthalmology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy
Background/Purpose: Ultrasonographic alterations such as the halo sign and the compression test are now accepted as surrogate markers of artery inflammation. No data have yet…
Abstract Number: 2174 • 2016 ACR/ARHP Annual Meeting
Effect of Anti-Rheumatic Treatment on Selenium Levels in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Gia Deyab¹, Ingrid Hokstad², Milada Cvancarova Småstuen³, Stefan Agewall⁴, Jon Elling Whist⁵ and Ivana Hollan^5,6,7,8, ¹Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, ²Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, ³Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, ⁴University of Oslo, Oslo, Norway, ⁵Innlandet Hospital Trust, Lillehammer, Norway, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷Harvard Medical School, Boston, MA, ⁸Lillehammer Hospital for Rheumatic Diseases, Lillahammer, Norway
Background/Purpose: The cause of the increased cardiovascular risk in inflammatory rheumatic diseases (IRDs) is still unclear. Intriguingly, selenium-deficiency, which might be caused by poor diet or…
Abstract Number: 9 • 2016 ACR/ARHP Annual Meeting
Effects of Alcohol Consumption on the Severity of Inflammation in Hand and Foot Joints Detected with MR Imaging
L. Mangnus¹, M. Reijnierse² and A.H.M. van der Helm- van Mil³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Moderate alcohol consumption is associated with a lower risk on RA development. (1,2) It is also associated with less severe systemic inflammation. Based on these…
Abstract Number: 1124 • 2016 ACR/ARHP Annual Meeting
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…
Abstract Number: 2257 • 2016 ACR/ARHP Annual Meeting
Regulation of Mitochondrial Proton Gradient Is Critical for NLRP3 Inflammasome Activation
Jehad H. Edwan, Raphaela Goldbach-Mansky and Robert A. Colbert, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…
Abstract Number: 159 • 2016 ACR/ARHP Annual Meeting
Assessing Agreement Among Measures of Inflammation Detected on Magnetic Resonance Imaging, Ultrasound and Clinical Findings in the Feet of Patients with Early Rheumatoid Arthritis
Karen A. Beattie¹, George Ioannidis², Sydney Scheffler³, Saara Totterman⁴, Edward Schreyer⁵ and Maggie Larche¹, ¹Medicine, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Radiology, VirtualScopics Inc., Rochester, NY, ⁵QMetrics Technologies, Rochester, NY
Background/Purpose: In metatarsalphalangeal (MTP) joints 2-5 of patients with early rheumatoid arthritis (RA), we aimed to assess the agreement between i) Magnetic Resonance Imaging (MRI)…
Abstract Number: 1125 • 2016 ACR/ARHP Annual Meeting
Targeted Lipidomics Reveals Incomplete Activation of Resolution Pathways in Knee Osteoarthritis
Hulda Jonasdottir¹, Hilde Brouwers², Mukundan Attur³, Joanneke Kwekkeboom², Jonathan Samuels³, Eric Strauss⁴, Enrike van der Linden-van der Zwaag⁵, TWJ Huizinga⁶, M. Kloppenburg⁷, REM Toes⁸, Martin Giera⁹, Steven B. Abramson³ and Andreea Ioan-Facsinay², ¹Center for Proteomics and Metabolomics, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁴Department of Orthopedic Surgery, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁵Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Centre, Leiden, Netherlands, ⁷Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Persistent inflammation is a characteristic of several joint diseases, including OA. It is nowadays appreciated that this could be a result of a failure…
Abstract Number: 2263 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA)
Giuliana Ascone¹, Irene Di Ceglie¹, Wouter de Munter¹, Birgitte Walgreen², Annet Sloetjes¹, Peter M. van der Kraan¹, Ernst Lindhout³, Mike Martens³ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental, Radboud university medical center, Nijmegen, Netherlands, ³Future Diagnostics Solutions (FDs), Wijchen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease largely driven by immune complexes and their interaction with FcγRs present on macrophages within the synovium.…
Abstract Number: 167 • 2016 ACR/ARHP Annual Meeting
Bone Mineral Density Loss in Clinically Suspect Arthralgia Is Associated with Subclinical Inflammation and Progression to Clinical Arthritis
L. Mangnus¹, H.W. van Steenbergen², M. Reijnierse³, J. Kälvesten^4,5,6 and A.H.M. van der Helm-van Mil², ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Radiology, Faculty of Health Sciences, Linköping, Sweden, ⁵Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, ⁶Sectra AB, Linköping, Sweden
Background/Purpose: Peripheral bone mineral density (BMD) can be decreased in early rheumatoid arthritis but it is unknown if BMD loss emerges already before arthritis is…

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