ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 299 • 2017 ACR/ARHP Annual Meeting

    Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium

    Takeshi Ueha1, Yoshitada Sakai1, Kohjin Suzuki2, Koji Fukuda3, Toshihisa Maeda3, Hanako Nishimoto3, Shinya Hayashi4, Yasushi Miura4, Ryosuke Kuroda3 and Akira Hashiramoto2, 1Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 3Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 4Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Nitric oxide (NO), a proinflammatory mediator responsible for various physiological processes, plays a central role in the pathogenesis of rheumatoid arthritis (RA). As a…
  • Abstract Number: 1335 • 2017 ACR/ARHP Annual Meeting

    p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis

    Adelheid Korb-Pap1, Anja Römer-Hillmann1, Marianne Heitzmann1, Masaru Kato2, Kerstin Klein2, Caroline Ospelt2, Steffen Gay3, Susanne Buergis4, Thomas Pap1, Thomas Weide5, André Gessner4 and Hermann Pavenstädt5, 1Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 2Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, 3Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, 4Department of Immunology, University Erlangen, Erlangen, Germany, 5Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…
  • Abstract Number: 2330 • 2017 ACR/ARHP Annual Meeting

    Evidence for Alternatively Activated (M2) Macrophage Activation in Patients with Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis

    Amita Aggarwal1, Priyanka Gaur2 and Akhilesh Yadav3, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 3Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Among juvenile idiopathic arthritis (JIA), enthesitis related arthritis (ERA) category includes most children with juvenile onset spondyloarthropathy (SpA). Synovial fluid from patients with SpA…
  • Abstract Number: 33 • 2017 Pediatric Rheumatology Symposium

    An extracellular ionic milieu renders human granulocytic S100A12 into a pro-inflammatory TLR4-binding alarmin

    Christoph Kessel1, Sabrina Fuehner1, Bastian Zimmermann2, Dirk Holzinger1, Helmut Wittkowski1, Claas Hinze1 and Dirk Foell1, 1Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, 2Biaffin GmbH & Co KG, Kassel, Germany

    Background/Purpose:  Granulocytic S100A12 is a member of the calgranulin-subgroup within the S100 family of calcium-binding proteins. Similar to other S100 proteins S100A12 can bind divalent…
  • Abstract Number: 131 • 2017 Pediatric Rheumatology Symposium

    Balancing JAK/STAT-signaling with tofacitinib may foster anti-inflammatory functions of human monocytes

    Friederike Cordes1, Eva Lenker2, Toni Weinhage2, Georg Varga2 and Dirk Foell3, 1Gastroenterology, Internal Medicine, University of Muenster, Muenster, Germany, 2Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, 3Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany

    Background/Purpose: Monocytes are bridging natural and acquired immunity. Information about JAK signaling in monocytes is scarce especially in an inflammatory milieu. JAK-inhibition is a promising…
  • Abstract Number: 146 • 2017 Pediatric Rheumatology Symposium

    Age-Related Differences in Neuronal High Mobility Group Box-1 and Resolvin D1 Receptors in Collagen-Induced Arthritis

    Tracy Wilson-Gerwing and Alan Rosenberg, Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada

    Background/Purpose: More thorough understanding of age-related molecular interactions that drive inflammation and inflammatory pain is required to help guide evidenced-based, age appropriate treatment strategies that…
  • Abstract Number: 289 • 2016 ACR/ARHP Annual Meeting

    Metabolic and Inflammatory Links to Development of Rotator Cuff Tear in Hand Osteoarthritis

    Young Sun Suh1, Hyun-Ok Kim1, Yun-Hong Cheon2, Ki-Soo Park3, Rock-Bum Kim3, Hye Song Lim4, Hae Sook Noh4, Jae-Bum Na5, Hyung Bin Park6 and Sang-Il Lee7, 1Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, 3Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, 4Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, 5Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, 6Department of Orthopedic Surgery, Gyeongsang National University School of Medicine, jinju, Korea, The Republic of, 7Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea

    Background/Purpose:  Rotator cuff tear (RCT) and hand osteroarthritis (HOA) are commonly accompanied because they share a similar pathogenesis. However, there was no previous study investigating…
  • Abstract Number: 1745 • 2016 ACR/ARHP Annual Meeting

    Disturbance of Renal Circadian Rhythm in Lupus Nephritis

    Rakesh Mishra1, Ramalingam Bethunaickan2, Weijia Zhang3 and Anne Davidson4, 1Feinstein Institute, Manhasset, NY, 2Autoimmune and musculosketal diseases, Feinstein Institute for Medical Research, Manhasset, NY, 3Nephrology, Mount Sinai School of Medicine, New York, NY, 4Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose:  Circadian rhythm is a universal phenomenon that allows organisms to anticipate and respond to changes in their environment by regulating sleep and feeding patterns,…
  • Abstract Number: 2599 • 2016 ACR/ARHP Annual Meeting

    TCZ Improves the Pro-Atherothrombotic Profile of Rheumatoid Arthritis Patients Modulating Endothelial Dysfunction, Netosis and Inflammation

    Patricia Ruiz-Limon1, Rafaela Ortega-Castro2, IVÁN ARIAS DE LA ROSA2, Carlos Perez-Sanchez2, Yolanda Jiménez-Gómez2, Maria Carmen Abalos-Aguilera1, Pilar Font-Ugalde2, Eduardo Collantes-Estévez2, Alejandro Escudero-Contreras2, Chary Lopez-Pedrera2 and Nuria Barbarroja2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain

    Background/Purpose:  Inhibition of the interleukin IL-6 receptor pathway by tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA). TCZ reduces atherosclerosis markers and improves endothelial function.…
  • Abstract Number: 294 • 2016 ACR/ARHP Annual Meeting

    Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients with Medial Knee Osteoarthritis

    Charles Oshinsky1, Mukundan Attur2, Sisi Ma3, Hua Zhou3, Fangfei Zheng1, Meng Chen4, Jyoti Patel2, Jonathan Samuels5, Virginia Pike6, Ravinder Regatte7, Jenny Bencardino8, Leon Rybak9, Steven B. Abramson10, Michael H. Pillinger11 and Svetlana Krasnokutsky Samuels12, 1Medicine/Rheumatology, NYU School of Medicine, NEW YORK, NY, 2Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, 3Bioinformatics, New York University, New York, NY, 4NYU School of Medicine, NEW YORK, NY, 5Division of Rheumatology, Department of Medicine, NYU Langone Medical Center, New York, NY, 6Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, 7NYU Department of Radiology, NEW YORK, NY, 8Radiology, NYU Langone Medical Center, New York, NY, 9Department of Radiology, NYU Langone Medical Center, New York, NY, 10Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, 11NYU School of Medicine, New York, NY, 12NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Osteoarthritis (OA) etiopathogenesis includes an inflammatory component. Published reports indicate that synovial fluid urate levels, even in patients without gout, associate with OA prevalence/severity.…
  • Abstract Number: 1756 • 2016 ACR/ARHP Annual Meeting

    Novel Role of Rho Kinase in Neutrophil Netosis during UVB Induced-Skin Inflammation

    Ming-Lin Liu1,2, Meena Sharma2,3 and Victoria P. Werth4,5, 1Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, 2Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, 4Dermatology, University of Pennsylvania, Philadelphia, PA, 5Philadelphia V.A. Medical Center, Philidelphia, PA

    Background/Purpose:  Skin inflammation appears in cutaneous or systemic lupus erythematosus. Ultraviolet B (UVB) is an important environmental trigger of skin inflammation in lupus. Mechanisms linking…
  • Abstract Number: 2633 • 2016 ACR/ARHP Annual Meeting

    Effect of Different Biologic Agents on Lipid Profile in Rheumatoid Arthritis

    Fabio Cacciapaglia1, Simone Perniola1, Mariangela Nivuori1, Margherita Giannini1, Olga Magazzino1, Maria Giannotta1, Florenzo Iannone2 and Giovanni Lapadula1, 1Interdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, General Hospital, Bari, Italy, 2Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, General Hospital, Bari, Italy

    Background/Purpose:  o examine any change between different biologic agents on lipid profile of RA patients. Methods:  Patients affected by RA, according to the 2010 EULAR/ACR…
  • Abstract Number: 515 • 2016 ACR/ARHP Annual Meeting

    The Association of Body Mass Index with the Severity of  Magnetic Resonance Imaging-Detected Inflammation at Presentation; Opposite Effects in Early Rheumatoid Arthritis Compared to Other Arthritides and an Asymptomatic Population

    L. Mangnus1, W.P. Nieuwenhuis2, H.W. van Steenbergen2, T.W.J. Huizinga3, M. Reijnierse4 and A.H.M. van der Helm-van Mil2, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: An increased body mass index (BMI) has been associated with slightly increased inflammatory markers in the population. Within rheumatoid arthritis (RA) a high BMI…
  • Abstract Number: 2129 • 2016 ACR/ARHP Annual Meeting

    Extracellular Adenosine Deficiency Plays a Role in the Pathogenesis of Osteoarthritis (OA) and Adenosine Replacement Prevents Post-Traumatic Osteoarthritis

    Carmen Corciulo1, Matin Lendhey2, Tuere Wilder1, Oran Kennedy2 and Bruce Cronstein3, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2Department of Orthopaedic Surgery, NYU-School of Medicine, New York, NY, 3Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Extracellular adenosine is highly regulated and plays an important homeostatic role via occupancy of cell surface receptors (A1R, A2AR, A2BR, A3R).  Mice lacking A2AR…
  • Abstract Number: 2706 • 2016 ACR/ARHP Annual Meeting

    Elevated Levels of Serum Myeloid Related Protein 8/14 in Ankylosing Spondylitis: Associated with Peripheral Arthritis and Active Disease

    Latika Gupta1, Shruti Bhattacharya1, Vikas Agarwal2 and Amita Aggarwal1, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2clinical Immunology, sanjay Gandhi Postgraduate Institute of Medical Sciences, lucknow, India

    Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) show Toll-like receptor 4 (TLR4) over-expression. Myeloid-related proteins (MRP) 8/14 protein complexes are calcium-binding proteins, which act…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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